Details for: TRPC4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: decidual cell (CL2000002)
Fold Change: 9.2265
Cell Significance Index: 148.0300 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 5.6103
Cell Significance Index: 86.8000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.8630
Cell Significance Index: 81.7000 - Cell Name: chandelier cell (CL4023083)
Fold Change: 1.9252
Cell Significance Index: 15.5500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.7724
Cell Significance Index: 38.8100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.2017
Cell Significance Index: 73.8600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.1357
Cell Significance Index: 407.3400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.9857
Cell Significance Index: 66.2800 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.8702
Cell Significance Index: 11.2900 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.8488
Cell Significance Index: 6.5100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8282
Cell Significance Index: 166.1400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.6984
Cell Significance Index: 16.7500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.5482
Cell Significance Index: 33.6100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4792
Cell Significance Index: 331.4600 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.4554
Cell Significance Index: 11.0300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1662
Cell Significance Index: 7.3500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1451
Cell Significance Index: 6.5800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0976
Cell Significance Index: 88.1300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0643
Cell Significance Index: 12.2400 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0552
Cell Significance Index: 1.3800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.0531
Cell Significance Index: 1.0500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0462
Cell Significance Index: 6.3500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0220
Cell Significance Index: 1.6900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0174
Cell Significance Index: 2.5300 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.0164
Cell Significance Index: 0.3300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.0085
Cell Significance Index: 0.1800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0058
Cell Significance Index: 0.5700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0014
Cell Significance Index: -0.0200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0014
Cell Significance Index: -0.1800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0028
Cell Significance Index: -5.3400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0031
Cell Significance Index: -5.6300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0035
Cell Significance Index: -5.3400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0054
Cell Significance Index: -7.2800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0145
Cell Significance Index: -10.7600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0167
Cell Significance Index: -10.5900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0169
Cell Significance Index: -0.6400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0171
Cell Significance Index: -7.7700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0269
Cell Significance Index: -16.7700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0280
Cell Significance Index: -15.7800 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0285
Cell Significance Index: -0.3800 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0299
Cell Significance Index: -16.3200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0367
Cell Significance Index: -7.2800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0425
Cell Significance Index: -6.9100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0445
Cell Significance Index: -12.7900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0450
Cell Significance Index: -1.5800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0566
Cell Significance Index: -9.6600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0684
Cell Significance Index: -12.3300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0745
Cell Significance Index: -15.6900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0815
Cell Significance Index: -9.3400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0970
Cell Significance Index: -10.5600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1095
Cell Significance Index: -13.4600 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1207
Cell Significance Index: -2.5200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1328
Cell Significance Index: -15.4800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1361
Cell Significance Index: -13.9000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1438
Cell Significance Index: -14.9700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1805
Cell Significance Index: -10.1300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1889
Cell Significance Index: -5.2800 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.2040
Cell Significance Index: -2.4400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2054
Cell Significance Index: -14.2100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2278
Cell Significance Index: -7.9800 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.2354
Cell Significance Index: -2.2400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2575
Cell Significance Index: -7.4200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2678
Cell Significance Index: -6.7000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2700
Cell Significance Index: -8.8400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2760
Cell Significance Index: -8.7900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2770
Cell Significance Index: -14.4300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2784
Cell Significance Index: -12.9800 - Cell Name: neuron (CL0000540)
Fold Change: -0.2891
Cell Significance Index: -2.7400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2979
Cell Significance Index: -5.1100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3051
Cell Significance Index: -14.3400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3068
Cell Significance Index: -16.1100 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3249
Cell Significance Index: -8.1100 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.3348
Cell Significance Index: -10.5900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3397
Cell Significance Index: -17.6500 - Cell Name: radial glial cell (CL0000681)
Fold Change: -0.3438
Cell Significance Index: -2.0400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3490
Cell Significance Index: -8.9700 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3497
Cell Significance Index: -15.2100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3709
Cell Significance Index: -12.8900 - Cell Name: neural cell (CL0002319)
Fold Change: -0.3926
Cell Significance Index: -4.5800 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.4208
Cell Significance Index: -5.3100 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.4433
Cell Significance Index: -8.8400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4444
Cell Significance Index: -13.0900 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.4553
Cell Significance Index: -4.9600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4786
Cell Significance Index: -17.5700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.4858
Cell Significance Index: -10.5300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4994
Cell Significance Index: -10.7900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5142
Cell Significance Index: -13.7300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5173
Cell Significance Index: -14.8300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.5193
Cell Significance Index: -10.8700 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.5289
Cell Significance Index: -10.4100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5352
Cell Significance Index: -11.4400 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.5521
Cell Significance Index: -7.3600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.5709
Cell Significance Index: -15.5400 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.5745
Cell Significance Index: -11.6900 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5778
Cell Significance Index: -8.5300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5809
Cell Significance Index: -15.5400 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.5916
Cell Significance Index: -6.8700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5953
Cell Significance Index: -15.9500 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.5974
Cell Significance Index: -7.6600 - Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: -0.6021
Cell Significance Index: -6.1900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1538410314
Symbol: TRPC4_HUMAN
Name: Short transient receptor potential channel 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11042129
Title: Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3.
PubMed ID: 11042129
DOI: 10.1042/bj3510735
PubMed ID: 11163362
Title: Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.
PubMed ID: 11163362
PubMed ID: 11713258
Title: Functional differences between TRPC4 splice variants.
PubMed ID: 11713258
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8646775
Title: trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.
PubMed ID: 8646775
PubMed ID: 12154080
Title: The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells.
PubMed ID: 12154080
PubMed ID: 12032305
Title: Subunit composition of mammalian transient receptor potential channels in living cells.
PubMed ID: 12032305
PubMed ID: 16254212
Title: Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4.
PubMed ID: 16254212
PubMed ID: 15757897
Title: MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.
PubMed ID: 15757897
PubMed ID: 16144838
Title: Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4.
PubMed ID: 16144838
PubMed ID: 17850865
Title: RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.
PubMed ID: 17850865
PubMed ID: 18048348
Title: The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels.
PubMed ID: 18048348
PubMed ID: 20164195
Title: The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5.
PubMed ID: 20164195
PubMed ID: 19996314
Title: Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction.
PubMed ID: 19996314
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 977
- Mass: 112101
- Checksum: 77E4D27C374D660E
- Sequence:
MAQFYYKRNV NAPYRDRIPL RIVRAESELS PSEKAYLNAV EKGDYASVKK SLEEAEIYFK ININCIDPLG RTALLIAIEN ENLELIELLL SFNVYVGDAL LHAIRKEVVG AVELLLNHKK PSGEKQVPPI LLDKQFSEFT PDITPIILAA HTNNYEIIKL LVQKGVSVPR PHEVRCNCVE CVSSSDVDSL RHSRSRLNIY KALASPSLIA LSSEDPFLTA FQLSWELQEL SKVENEFKSE YEELSRQCKQ FAKDLLDQTR SSRELEIILN YRDDNSLIEE QSGNDLARLK LAIKYRQKEF VAQPNCQQLL ASRWYDEFPG WRRRHWAVKM VTCFIIGLLF PVFSVCYLIA PKSPLGLFIR KPFIKFICHT ASYLTFLFLL LLASQHIDRS DLNRQGPPPT IVEWMILPWV LGFIWGEIKQ MWDGGLQDYI HDWWNLMDFV MNSLYLATIS LKIVAFVKYS ALNPRESWDM WHPTLVAEAL FAIANIFSSL RLISLFTANS HLGPLQISLG RMLLDILKFL FIYCLVLLAF ANGLNQLYFY YEETKGLTCK GIRCEKQNNA FSTLFETLQS LFWSIFGLIN LYVTNVKAQH EFTEFVGATM FGTYNVISLV VLLNMLIAMM NNSYQLIADH ADIEWKFART KLWMSYFEEG GTLPTPFNVI PSPKSLWYLI KWIWTHLCKK KMRRKPESFG TIGRRAADNL RRHHQYQEVM RNLVKRYVAA MIRDAKTEEG LTEENFKELK QDISSFRFEV LGLLRGSKLS TIQSANASKE SSNSADSDEK SDSEGNSKDK KKNFSLFDLT TLIHPRSAAI ASERHNISNG SALVVQEPPR EKQRKVNFVT DIKNFGLFHR RSKQNAAEQN ANQIFSVSEE VARQQAAGPL ERNIQLESRG LASRGDLSIP GLSEQCVLVD HRERNTDTLG LQVGKRVCPF KSEKVVVEDT VPIIPKEKHA KEEDSSIDYD LNLPDTVTHE DYVTTRL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.