Details for: TRPC4

Gene ID: 7223

Symbol: TRPC4

Ensembl ID: ENSG00000133107

Description: transient receptor potential cation channel subfamily C member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual cell (CL2000002)
    Fold Change: 9.2265
    Cell Significance Index: 148.0300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.6103
    Cell Significance Index: 86.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.8630
    Cell Significance Index: 81.7000
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 1.9252
    Cell Significance Index: 15.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.7724
    Cell Significance Index: 38.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2017
    Cell Significance Index: 73.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1357
    Cell Significance Index: 407.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9857
    Cell Significance Index: 66.2800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.8702
    Cell Significance Index: 11.2900
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.8488
    Cell Significance Index: 6.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8282
    Cell Significance Index: 166.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6984
    Cell Significance Index: 16.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.5482
    Cell Significance Index: 33.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4792
    Cell Significance Index: 331.4600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4554
    Cell Significance Index: 11.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1662
    Cell Significance Index: 7.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1451
    Cell Significance Index: 6.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0976
    Cell Significance Index: 88.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0643
    Cell Significance Index: 12.2400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0552
    Cell Significance Index: 1.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0531
    Cell Significance Index: 1.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0462
    Cell Significance Index: 6.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0220
    Cell Significance Index: 1.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0174
    Cell Significance Index: 2.5300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0164
    Cell Significance Index: 0.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0085
    Cell Significance Index: 0.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0058
    Cell Significance Index: 0.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0014
    Cell Significance Index: -0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0035
    Cell Significance Index: -5.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0054
    Cell Significance Index: -7.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0167
    Cell Significance Index: -10.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0169
    Cell Significance Index: -0.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0171
    Cell Significance Index: -7.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0269
    Cell Significance Index: -16.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0280
    Cell Significance Index: -15.7800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0285
    Cell Significance Index: -0.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0299
    Cell Significance Index: -16.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0367
    Cell Significance Index: -7.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0425
    Cell Significance Index: -6.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0445
    Cell Significance Index: -12.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0450
    Cell Significance Index: -1.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0566
    Cell Significance Index: -9.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0684
    Cell Significance Index: -12.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0745
    Cell Significance Index: -15.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0815
    Cell Significance Index: -9.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0970
    Cell Significance Index: -10.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1095
    Cell Significance Index: -13.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1207
    Cell Significance Index: -2.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1328
    Cell Significance Index: -15.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1361
    Cell Significance Index: -13.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1438
    Cell Significance Index: -14.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1805
    Cell Significance Index: -10.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1889
    Cell Significance Index: -5.2800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2040
    Cell Significance Index: -2.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2054
    Cell Significance Index: -14.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2278
    Cell Significance Index: -7.9800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2354
    Cell Significance Index: -2.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2575
    Cell Significance Index: -7.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2678
    Cell Significance Index: -6.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2700
    Cell Significance Index: -8.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2760
    Cell Significance Index: -8.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2770
    Cell Significance Index: -14.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2784
    Cell Significance Index: -12.9800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2891
    Cell Significance Index: -2.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2979
    Cell Significance Index: -5.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3051
    Cell Significance Index: -14.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3068
    Cell Significance Index: -16.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3249
    Cell Significance Index: -8.1100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3348
    Cell Significance Index: -10.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3397
    Cell Significance Index: -17.6500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3438
    Cell Significance Index: -2.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3490
    Cell Significance Index: -8.9700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3497
    Cell Significance Index: -15.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3709
    Cell Significance Index: -12.8900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3926
    Cell Significance Index: -4.5800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4208
    Cell Significance Index: -5.3100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4433
    Cell Significance Index: -8.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4444
    Cell Significance Index: -13.0900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4553
    Cell Significance Index: -4.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4786
    Cell Significance Index: -17.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4858
    Cell Significance Index: -10.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4994
    Cell Significance Index: -10.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5142
    Cell Significance Index: -13.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5173
    Cell Significance Index: -14.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5193
    Cell Significance Index: -10.8700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5289
    Cell Significance Index: -10.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5352
    Cell Significance Index: -11.4400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.5521
    Cell Significance Index: -7.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5709
    Cell Significance Index: -15.5400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5745
    Cell Significance Index: -11.6900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5778
    Cell Significance Index: -8.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5809
    Cell Significance Index: -15.5400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.5916
    Cell Significance Index: -6.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5953
    Cell Significance Index: -15.9500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.5974
    Cell Significance Index: -7.6600
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.6021
    Cell Significance Index: -6.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium Channel Activity:** TRPC4 is a non-selective cation channel that allows the influx of calcium ions into cells, playing a critical role in regulating cytosolic calcium concentrations. 2. **Cell-Cell Junction Formation:** TRPC4 interacts with cadherins and beta-catenin, facilitating cell-cell junction formation and maintaining tissue integrity. 3. **Axon Guidance:** TRPC4 is involved in axon guidance, a process essential for neuronal development and plasticity. 4. **Immune Cell Regulation:** TRPC4 is expressed in immune cells, such as inhibitory interneurons, enterocytes, and goblet cells, suggesting its role in regulating immune responses. **Pathways and Functions:** TRPC4 is involved in various signaling pathways, including: 1. **Calcium Signaling:** TRPC4 regulates cytosolic calcium concentrations, influencing cellular processes such as muscle contraction, neurotransmitter release, and cell-cell communication. 2. **Neurotransmitter Release:** TRPC4 is involved in the regulation of gamma-aminobutyric acid (GABA) secretion, a key neurotransmitter in the nervous system. 3. **Cell Adhesion:** TRPC4 interacts with cadherins and beta-catenin, facilitating cell-cell junction formation and maintaining tissue integrity. 4. **Immune Response:** TRPC4 is expressed in immune cells, suggesting its role in regulating immune responses and maintaining immune homeostasis. **Clinical Significance:** 1. **Neurological Disorders:** Dysregulation of TRPC4 has been implicated in neurological disorders, such as epilepsy and schizophrenia, highlighting its potential as a therapeutic target. 2. **Immune System Dysregulation:** TRPC4's role in immune cell regulation suggests its potential as a therapeutic target in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Gastrointestinal Disorders:** TRPC4's expression in enterocytes and goblet cells suggests its potential role in gastrointestinal disorders, such as inflammatory bowel disease. 4. **Cancer:** TRPC4's involvement in cell growth and proliferation suggests its potential role in cancer development and progression. In conclusion, TRPC4 is a multi-functional channel that plays a critical role in regulating cellular homeostasis, immune responses, and neurological function. Further research is needed to fully elucidate the mechanisms underlying TRPC4's functions and to explore its therapeutic potential in various diseases.

Genular Protein ID: 1538410314

Symbol: TRPC4_HUMAN

Name: Short transient receptor potential channel 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11042129

Title: Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3.

PubMed ID: 11042129

DOI: 10.1042/bj3510735

PubMed ID: 11163362

Title: Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

PubMed ID: 11163362

DOI: 10.1016/s0014-5793(00)02362-0

PubMed ID: 11713258

Title: Functional differences between TRPC4 splice variants.

PubMed ID: 11713258

DOI: 10.1074/jbc.m109850200

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8646775

Title: trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.

PubMed ID: 8646775

DOI: 10.1016/s0092-8674(00)81233-7

PubMed ID: 12154080

Title: The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells.

PubMed ID: 12154080

DOI: 10.1242/jcs.115.17.3497

PubMed ID: 12032305

Title: Subunit composition of mammalian transient receptor potential channels in living cells.

PubMed ID: 12032305

DOI: 10.1073/pnas.102596199

PubMed ID: 16254212

Title: Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4.

PubMed ID: 16254212

DOI: 10.1161/01.res.0000193597.65217.00

PubMed ID: 15757897

Title: MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.

PubMed ID: 15757897

DOI: 10.1074/jbc.m500391200

PubMed ID: 16144838

Title: Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4.

PubMed ID: 16144838

DOI: 10.1074/jbc.m503646200

PubMed ID: 17850865

Title: RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.

PubMed ID: 17850865

DOI: 10.1016/j.ceca.2007.07.009

PubMed ID: 18048348

Title: The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels.

PubMed ID: 18048348

DOI: 10.1074/jbc.m709729200

PubMed ID: 20164195

Title: The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5.

PubMed ID: 20164195

DOI: 10.1074/jbc.m109.068304

PubMed ID: 19996314

Title: Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction.

PubMed ID: 19996314

DOI: 10.1074/jbc.m109.060301

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 977
  • Mass: 112101
  • Checksum: 77E4D27C374D660E
  • Sequence:
  • MAQFYYKRNV NAPYRDRIPL RIVRAESELS PSEKAYLNAV EKGDYASVKK SLEEAEIYFK 
    ININCIDPLG RTALLIAIEN ENLELIELLL SFNVYVGDAL LHAIRKEVVG AVELLLNHKK 
    PSGEKQVPPI LLDKQFSEFT PDITPIILAA HTNNYEIIKL LVQKGVSVPR PHEVRCNCVE 
    CVSSSDVDSL RHSRSRLNIY KALASPSLIA LSSEDPFLTA FQLSWELQEL SKVENEFKSE 
    YEELSRQCKQ FAKDLLDQTR SSRELEIILN YRDDNSLIEE QSGNDLARLK LAIKYRQKEF 
    VAQPNCQQLL ASRWYDEFPG WRRRHWAVKM VTCFIIGLLF PVFSVCYLIA PKSPLGLFIR 
    KPFIKFICHT ASYLTFLFLL LLASQHIDRS DLNRQGPPPT IVEWMILPWV LGFIWGEIKQ 
    MWDGGLQDYI HDWWNLMDFV MNSLYLATIS LKIVAFVKYS ALNPRESWDM WHPTLVAEAL 
    FAIANIFSSL RLISLFTANS HLGPLQISLG RMLLDILKFL FIYCLVLLAF ANGLNQLYFY 
    YEETKGLTCK GIRCEKQNNA FSTLFETLQS LFWSIFGLIN LYVTNVKAQH EFTEFVGATM 
    FGTYNVISLV VLLNMLIAMM NNSYQLIADH ADIEWKFART KLWMSYFEEG GTLPTPFNVI 
    PSPKSLWYLI KWIWTHLCKK KMRRKPESFG TIGRRAADNL RRHHQYQEVM RNLVKRYVAA 
    MIRDAKTEEG LTEENFKELK QDISSFRFEV LGLLRGSKLS TIQSANASKE SSNSADSDEK 
    SDSEGNSKDK KKNFSLFDLT TLIHPRSAAI ASERHNISNG SALVVQEPPR EKQRKVNFVT 
    DIKNFGLFHR RSKQNAAEQN ANQIFSVSEE VARQQAAGPL ERNIQLESRG LASRGDLSIP 
    GLSEQCVLVD HRERNTDTLG LQVGKRVCPF KSEKVVVEDT VPIIPKEKHA KEEDSSIDYD 
    LNLPDTVTHE DYVTTRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.