Details for: TRPC5

Gene ID: 7224

Symbol: TRPC5

Ensembl ID: ENSG00000072315

Description: transient receptor potential cation channel subfamily C member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.3898
    Cell Significance Index: -21.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3342
    Cell Significance Index: -2.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2518
    Cell Significance Index: 84.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.1865
    Cell Significance Index: 33.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9801
    Cell Significance Index: 677.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9739
    Cell Significance Index: 195.3600
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.5549
    Cell Significance Index: 2.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4097
    Cell Significance Index: 146.9400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1924
    Cell Significance Index: 2.8400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1747
    Cell Significance Index: 2.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1354
    Cell Significance Index: 8.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0505
    Cell Significance Index: 10.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0254
    Cell Significance Index: 0.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0111
    Cell Significance Index: 20.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0086
    Cell Significance Index: 13.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0036
    Cell Significance Index: 6.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0253
    Cell Significance Index: -16.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0271
    Cell Significance Index: -12.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0316
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0320
    Cell Significance Index: -23.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0380
    Cell Significance Index: -20.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0418
    Cell Significance Index: -23.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0458
    Cell Significance Index: -28.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0628
    Cell Significance Index: -0.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0659
    Cell Significance Index: -18.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0769
    Cell Significance Index: -1.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0902
    Cell Significance Index: -2.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0907
    Cell Significance Index: -16.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1093
    Cell Significance Index: -18.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1125
    Cell Significance Index: -16.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1140
    Cell Significance Index: -24.0100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1226
    Cell Significance Index: -2.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1512
    Cell Significance Index: -20.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1668
    Cell Significance Index: -20.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1809
    Cell Significance Index: -20.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2067
    Cell Significance Index: -21.5200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2109
    Cell Significance Index: -2.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2268
    Cell Significance Index: -4.9000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2335
    Cell Significance Index: -2.0200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2376
    Cell Significance Index: -1.6100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2407
    Cell Significance Index: -3.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2445
    Cell Significance Index: -4.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2497
    Cell Significance Index: -2.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2579
    Cell Significance Index: -2.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2829
    Cell Significance Index: -21.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2853
    Cell Significance Index: -16.0100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3069
    Cell Significance Index: -2.9200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3239
    Cell Significance Index: -3.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3959
    Cell Significance Index: -17.5100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4007
    Cell Significance Index: -8.5700
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.4042
    Cell Significance Index: -3.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4046
    Cell Significance Index: -10.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4127
    Cell Significance Index: -19.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4164
    Cell Significance Index: -21.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4513
    Cell Significance Index: -17.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4650
    Cell Significance Index: -16.2900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4683
    Cell Significance Index: -5.6000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4993
    Cell Significance Index: -10.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5011
    Cell Significance Index: -23.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5136
    Cell Significance Index: -10.1600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5167
    Cell Significance Index: -6.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5489
    Cell Significance Index: -17.9700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5614
    Cell Significance Index: -7.2800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.5697
    Cell Significance Index: -5.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6156
    Cell Significance Index: -19.6100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.6309
    Cell Significance Index: -8.4100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6704
    Cell Significance Index: -13.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6980
    Cell Significance Index: -24.5300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.7280
    Cell Significance Index: -10.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7281
    Cell Significance Index: -15.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7450
    Cell Significance Index: -14.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7478
    Cell Significance Index: -20.3600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7579
    Cell Significance Index: -23.9700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7657
    Cell Significance Index: -19.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7701
    Cell Significance Index: -9.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8219
    Cell Significance Index: -20.5000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.8246
    Cell Significance Index: -10.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8308
    Cell Significance Index: -24.4700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.8346
    Cell Significance Index: -11.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8458
    Cell Significance Index: -24.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8479
    Cell Significance Index: -22.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8631
    Cell Significance Index: -24.7400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8674
    Cell Significance Index: -22.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9085
    Cell Significance Index: -22.7100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.9087
    Cell Significance Index: -18.4900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.9269
    Cell Significance Index: -15.5900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.9360
    Cell Significance Index: -9.7800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.9648
    Cell Significance Index: -18.9900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9689
    Cell Significance Index: -19.3200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9750
    Cell Significance Index: -23.7900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.9759
    Cell Significance Index: -5.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9914
    Cell Significance Index: -26.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0177
    Cell Significance Index: -26.7600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0214
    Cell Significance Index: -17.6600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -1.0268
    Cell Significance Index: -2.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0285
    Cell Significance Index: -22.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0323
    Cell Significance Index: -27.6600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.0557
    Cell Significance Index: -43.2600
  • Cell Name: interneuron (CL0000099)
    Fold Change: -1.0624
    Cell Significance Index: -12.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRPC5 channels are characterized by their ability to conduct calcium ions (Ca2+) and their involvement in various cellular signaling pathways. These channels are part of the TRPC family, which is a subfamily of transient receptor potential (TRP) channels. TRPC5 channels are activated by a wide range of stimuli, including calcium ions, lipids, and amino acids, and they can modulate the activity of other ion channels and receptors. **Pathways and Functions** TRPC5 channels are involved in several cellular pathways, including: 1. **Calcium signaling**: TRPC5 channels play a crucial role in regulating cytosolic calcium ion concentrations, which is essential for cell differentiation, survival, and function in the nervous system. 2. **Axon guidance**: TRPC5 channels are involved in the regulation of axon extension and guidance, which is critical for neuronal development and function. 3. **Neuronal differentiation**: TRPC5 channels are required for the differentiation of neurons, including the development of dendrites and axons. 4. **Immune cell function**: TRPC5 channels are expressed in immune cells, including conventional dendritic cells and epithelial cells of the lung, and are involved in the regulation of immune responses. 5. **Cell proliferation**: TRPC5 channels are involved in the regulation of cell population proliferation, which is essential for tissue development and repair. **Clinical Significance** Dysregulation of TRPC5 channels has been implicated in various diseases, including: 1. **Neurological disorders**: TRPC5 channels have been implicated in the pathogenesis of neurological disorders, such as epilepsy, Parkinson's disease, and Alzheimer's disease. 2. **Immune system disorders**: TRPC5 channels are involved in the regulation of immune responses, and dysregulation of these channels has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: TRPC5 channels are overexpressed in certain types of cancer, including lung and breast cancer, and have been implicated in tumor progression and metastasis. In conclusion, TRPC5 channels play a crucial role in various cellular processes, including calcium signaling, axon guidance, neuronal differentiation, and immune cell function. Dysregulation of TRPC5 channels has been implicated in various diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 3879909978

Symbol: TRPC5_HUMAN

Name: Short transient receptor potential channel 5

UniProtKB Accession Codes:

Q9UL62 B2RP53 O75233 Q5JXY8 Q9Y514

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 6 EMDB 8 Ensembl 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10493832

Title: Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca(2+) entry channel.

PubMed ID: 10493832

DOI: 10.1006/geno.1999.5924

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9687496

Title: A novel capacitative calcium entry channel expressed in excitable cells.

PubMed ID: 9687496

DOI: 10.1093/emboj/17.15.4274

PubMed ID: 12032305

Title: Subunit composition of mammalian transient receptor potential channels in living cells.

PubMed ID: 12032305

DOI: 10.1073/pnas.102596199

PubMed ID: 15757897

Title: MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.

PubMed ID: 15757897

DOI: 10.1074/jbc.m500391200

PubMed ID: 15895247

Title: Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes.

PubMed ID: 15895247

DOI: 10.1007/s00424-005-1419-1

PubMed ID: 16284075

Title: Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.

PubMed ID: 16284075

DOI: 10.1113/jphysiol.2005.097998

PubMed ID: 17850865

Title: RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.

PubMed ID: 17850865

DOI: 10.1016/j.ceca.2007.07.009

PubMed ID: 20164195

Title: The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5.

PubMed ID: 20164195

DOI: 10.1074/jbc.m109.068304

PubMed ID: 32110987

Title: Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.

PubMed ID: 32110987

DOI: 10.3390/cells9030547

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 973
  • Mass: 111412
  • Checksum: FBC8CBF17BE42166
  • Sequence:
    • MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLNAV EKGDYATVKQ ALQEAEIYYN 
VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL LYAIRKEVVG AVELLLSYRR 
PSGEKQVPTL MMDTQFSEFT PDITPIMLAA HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE 
CVSSSEVDSL RHSRSRLNIY KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE 
YEELSQQCKL FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE 
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI SPRSNLGLFI 
KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP TVVEWMILPW VLGFIWGEIK 
EMWDGGFTEY IHDWWNLMDF AMNSLYLATI SLKIVAYVKY NGSRPREEWE MWHPTLIAEA 
LFAISNILSS LRLISLFTAN SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF 
YYETRAIDEP NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV 
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY FDEGGTLPPP 
FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRRNLRSFT ERNADSLIQN QHYQEVIRNL 
VKRYVAAMIR NSKTHEGLTE ENFKELKQDI SSFRYEVLDL LGNRKHPRSF STSSTELSQR 
DDNNDGSGGA RAKSKSVSFN LGCKKKTCHG PPLIRTMPRS SGAQGKSKAE SSSKRSFMGP 
SLKKLGLLFS KFNGHMSEPS SEPMYTISDG IVQQHCMWQD IRYSQMEKGK AEACSQSEIN 
LSEVELGEVQ GAAQSSECPL ACSSSLHCAS SICSSNSKLL DSSEDVFETW GEACDLLMHK 
WGDGQEEQVT TRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.