Details for: WNT1

Gene ID: 7471

Symbol: WNT1

Ensembl ID: ENSG00000125084

Description: Wnt family member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.3838
    Cell Significance Index: 15.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4525
    Cell Significance Index: 6.4800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1697
    Cell Significance Index: 2.1500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1515
    Cell Significance Index: 2.2000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1215
    Cell Significance Index: 1.3600
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.1010
    Cell Significance Index: 0.9500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0513
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0032
    Cell Significance Index: -1.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0035
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0041
    Cell Significance Index: -0.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0046
    Cell Significance Index: -0.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0048
    Cell Significance Index: -1.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0069
    Cell Significance Index: -1.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0093
    Cell Significance Index: -0.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0098
    Cell Significance Index: -1.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0107
    Cell Significance Index: -1.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0127
    Cell Significance Index: -1.3000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0129
    Cell Significance Index: -0.1600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0137
    Cell Significance Index: -0.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0213
    Cell Significance Index: -1.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0220
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0222
    Cell Significance Index: -0.3700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0234
    Cell Significance Index: -0.4000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0235
    Cell Significance Index: -0.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0239
    Cell Significance Index: -1.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0244
    Cell Significance Index: -1.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0268
    Cell Significance Index: -0.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0272
    Cell Significance Index: -1.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0286
    Cell Significance Index: -1.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0311
    Cell Significance Index: -1.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0313
    Cell Significance Index: -1.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0352
    Cell Significance Index: -0.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0355
    Cell Significance Index: -0.8600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0359
    Cell Significance Index: -0.4700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0368
    Cell Significance Index: -0.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0378
    Cell Significance Index: -1.0100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0384
    Cell Significance Index: -0.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0385
    Cell Significance Index: -1.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0387
    Cell Significance Index: -1.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0405
    Cell Significance Index: -1.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0442
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0443
    Cell Significance Index: -1.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0467
    Cell Significance Index: -1.3400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0474
    Cell Significance Index: -0.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0491
    Cell Significance Index: -1.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0521
    Cell Significance Index: -1.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0524
    Cell Significance Index: -1.5000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0532
    Cell Significance Index: -0.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0532
    Cell Significance Index: -1.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0550
    Cell Significance Index: -1.3200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0552
    Cell Significance Index: -1.1000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0566
    Cell Significance Index: -0.7400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0568
    Cell Significance Index: -0.9200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0590
    Cell Significance Index: -0.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0596
    Cell Significance Index: -1.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0614
    Cell Significance Index: -0.9200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0616
    Cell Significance Index: -1.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0627
    Cell Significance Index: -1.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0638
    Cell Significance Index: -1.2800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0641
    Cell Significance Index: -0.6500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0647
    Cell Significance Index: -0.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0663
    Cell Significance Index: -1.3100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0671
    Cell Significance Index: -1.3200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0713
    Cell Significance Index: -0.7200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0720
    Cell Significance Index: -0.9800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0722
    Cell Significance Index: -0.8500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0725
    Cell Significance Index: -1.2500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0728
    Cell Significance Index: -0.9200
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.0732
    Cell Significance Index: -0.6400
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0732
    Cell Significance Index: -0.6900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0737
    Cell Significance Index: -0.8700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0739
    Cell Significance Index: -0.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0741
    Cell Significance Index: -1.3700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0742
    Cell Significance Index: -0.8100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0752
    Cell Significance Index: -0.9400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0754
    Cell Significance Index: -1.2800
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0758
    Cell Significance Index: -0.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0769
    Cell Significance Index: -1.3300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0785
    Cell Significance Index: -0.9900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0788
    Cell Significance Index: -0.9800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0800
    Cell Significance Index: -0.8300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0805
    Cell Significance Index: -0.5000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0833
    Cell Significance Index: -1.1100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0846
    Cell Significance Index: -1.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0853
    Cell Significance Index: -1.3200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0864
    Cell Significance Index: -0.8000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0868
    Cell Significance Index: -1.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0872
    Cell Significance Index: -1.4600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0877
    Cell Significance Index: -0.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0890
    Cell Significance Index: -1.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0901
    Cell Significance Index: -1.3300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0918
    Cell Significance Index: -1.0000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0918
    Cell Significance Index: -0.7800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0921
    Cell Significance Index: -1.1200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0922
    Cell Significance Index: -1.2100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0929
    Cell Significance Index: -1.3200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0938
    Cell Significance Index: -1.0200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0939
    Cell Significance Index: -0.8900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0942
    Cell Significance Index: -1.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proto-oncogene**: WNT1 is a proto-oncogene, which means that it can become oncogenic (cancer-causing) when mutated or overexpressed. 2. **WNT family member**: WNT1 belongs to the WNT family of signaling molecules, which are characterized by their ability to bind to Frizzled receptors and activate downstream signaling pathways. 3. **Signaling pathways**: WNT1 is involved in numerous signaling pathways, including the canonical WNT/β-catenin pathway, which is critical for cell proliferation, differentiation, and survival. 4. **Cell-type specific expression**: WNT1 is significantly expressed in various cell types, including microglial cells, blood vessel endothelial cells, hematopoietic stem cells, and neoplastic cells. 5. **Tissue-specific expression**: WNT1 is also expressed in specific tissues, including the central nervous system, bone, and liver. **Pathways and Functions:** 1. **Canonical WNT/β-catenin pathway**: WNT1 activates the canonical WNT/β-catenin pathway, which is critical for cell proliferation, differentiation, and survival. 2. **Cell-cell signaling**: WNT1 mediates cell-cell signaling, which is essential for tissue development and homeostasis. 3. **Cell fate determination**: WNT1 plays a crucial role in determining cell fate, including the differentiation of neural cells and the development of the central nervous system. 4. **Cancer**: WNT1 is involved in the development and progression of various cancers, including colorectal, breast, and prostate cancer. 5. **Developmental biology**: WNT1 is essential for embryonic development, including the formation of the central nervous system, bone, and liver. **Clinical Significance:** 1. **Cancer diagnosis and treatment**: WNT1 is a potential biomarker for cancer diagnosis and treatment. Its expression levels can be used to monitor the progression of cancer and response to therapy. 2. **Neurological disorders**: WNT1 is involved in the development of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Bone diseases**: WNT1 is involved in the development of bone diseases, including osteoporosis and bone cancer. 4. **Immunology**: WNT1 is involved in the regulation of the immune system, including the development of immune cells and the response to infections. In conclusion, WNT1 is a critical gene that plays a central role in various biological processes, including development, cell fate determination, and cancer. Its dysregulation can lead to various diseases, including cancer, neurological disorders, and bone diseases. Further research is needed to fully understand the role of WNT1 in human biology and to develop effective therapeutic strategies for its dysregulation.

Genular Protein ID: 2127079944

Symbol: WNT1_HUMAN

Name: Proto-oncogene Wnt-1

UniProtKB Accession Codes:

P04628 Q5U0N2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 65 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 6 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2998762

Title: The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences.

PubMed ID: 2998762

DOI: 10.1002/j.1460-2075.1985.tb04021.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21244856

Title: Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling.

PubMed ID: 21244856

DOI: 10.1016/j.cellsig.2011.01.007

PubMed ID: 23499309

Title: Mutations in WNT1 cause different forms of bone fragility.

PubMed ID: 23499309

DOI: 10.1016/j.ajhg.2013.02.010

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

PubMed ID: 28528193

Title: Novel missense loss-of-function mutations of WNT1 in an autosomal recessive Osteogenesis imperfecta patient.

PubMed ID: 28528193

DOI: 10.1016/j.ejmg.2017.05.002

PubMed ID: 23656646

Title: WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta.

PubMed ID: 23656646

DOI: 10.1056/nejmoa1215458

PubMed ID: 23499310

Title: WNT1 mutations in families affected by moderately severe and progressive recessive osteogenesis imperfecta.

PubMed ID: 23499310

DOI: 10.1016/j.ajhg.2013.02.009

PubMed ID: 23434763

Title: Mutations in WNT1 are a cause of osteogenesis imperfecta.

PubMed ID: 23434763

DOI: 10.1136/jmedgenet-2013-101567

Sequence Information:

  • Length: 370
  • Mass: 40982
  • Checksum: F7E8111DA12E173F
  • Sequence:
    • MGLWALLPGW VSATLLLALA ALPAALAANS SGRWWGIVNV ASSTNLLTDS KSLQLVLEPS 
LQLLSRKQRR LIRQNPGILH SVSGGLQSAV RECKWQFRNR RWNCPTAPGP HLFGKIVNRG 
CRETAFIFAI TSAGVTHSVA RSCSEGSIES CTCDYRRRGP GGPDWHWGGC SDNIDFGRLF 
GREFVDSGEK GRDLRFLMNL HNNEAGRTTV FSEMRQECKC HGMSGSCTVR TCWMRLPTLR 
AVGDVLRDRF DGASRVLYGN RGSNRASRAE LLRLEPEDPA HKPPSPHDLV YFEKSPNFCT 
YSGRLGTAGT AGRACNSSSP ALDGCELLCC GRGHRTRTQR VTERCNCTFH WCCHVSCRNC 
THTRVLHECL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.