Details for: WNT3

Gene ID: 7473

Symbol: WNT3

Ensembl ID: ENSG00000108379

Description: Wnt family member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.7977
    Cell Significance Index: 25.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3479
    Cell Significance Index: -2.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6662
    Cell Significance Index: 126.7800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4991
    Cell Significance Index: 8.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4848
    Cell Significance Index: 47.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4498
    Cell Significance Index: 9.8500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.3940
    Cell Significance Index: 1.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3574
    Cell Significance Index: 322.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3513
    Cell Significance Index: 70.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3122
    Cell Significance Index: 4.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2380
    Cell Significance Index: 38.7100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2380
    Cell Significance Index: 2.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2348
    Cell Significance Index: 6.7700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2320
    Cell Significance Index: 3.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2153
    Cell Significance Index: 23.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1826
    Cell Significance Index: 3.1300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1635
    Cell Significance Index: 1.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1556
    Cell Significance Index: 9.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1303
    Cell Significance Index: 46.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1209
    Cell Significance Index: 3.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1048
    Cell Significance Index: 20.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0976
    Cell Significance Index: 67.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0800
    Cell Significance Index: 5.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0712
    Cell Significance Index: 3.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0470
    Cell Significance Index: 1.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0078
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0042
    Cell Significance Index: 7.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0041
    Cell Significance Index: 1.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0016
    Cell Significance Index: -0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0046
    Cell Significance Index: -6.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0085
    Cell Significance Index: -5.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0100
    Cell Significance Index: -0.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0106
    Cell Significance Index: -0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0113
    Cell Significance Index: -8.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0137
    Cell Significance Index: -10.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0143
    Cell Significance Index: -7.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0155
    Cell Significance Index: -7.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0158
    Cell Significance Index: -0.8300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0162
    Cell Significance Index: -0.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0174
    Cell Significance Index: -9.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0181
    Cell Significance Index: -3.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0188
    Cell Significance Index: -0.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0199
    Cell Significance Index: -5.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0219
    Cell Significance Index: -0.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0244
    Cell Significance Index: -0.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0255
    Cell Significance Index: -3.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0361
    Cell Significance Index: -1.6900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0362
    Cell Significance Index: -0.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0401
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0450
    Cell Significance Index: -7.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0460
    Cell Significance Index: -5.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0497
    Cell Significance Index: -10.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0501
    Cell Significance Index: -2.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0502
    Cell Significance Index: -6.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0503
    Cell Significance Index: -5.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0543
    Cell Significance Index: -3.8400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0546
    Cell Significance Index: -0.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0565
    Cell Significance Index: -1.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0568
    Cell Significance Index: -7.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0583
    Cell Significance Index: -6.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0628
    Cell Significance Index: -2.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0734
    Cell Significance Index: -8.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0792
    Cell Significance Index: -3.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0823
    Cell Significance Index: -1.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0833
    Cell Significance Index: -6.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0845
    Cell Significance Index: -1.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0859
    Cell Significance Index: -6.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0868
    Cell Significance Index: -9.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1045
    Cell Significance Index: -4.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1064
    Cell Significance Index: -8.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1165
    Cell Significance Index: -3.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1207
    Cell Significance Index: -6.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1358
    Cell Significance Index: -7.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1360
    Cell Significance Index: -2.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1412
    Cell Significance Index: -8.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1445
    Cell Significance Index: -4.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1465
    Cell Significance Index: -7.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1496
    Cell Significance Index: -3.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1609
    Cell Significance Index: -5.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1655
    Cell Significance Index: -4.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1661
    Cell Significance Index: -4.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1667
    Cell Significance Index: -5.8400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1830
    Cell Significance Index: -3.8200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1941
    Cell Significance Index: -1.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2001
    Cell Significance Index: -3.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2031
    Cell Significance Index: -4.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2032
    Cell Significance Index: -5.1900
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.2105
    Cell Significance Index: -1.8600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2109
    Cell Significance Index: -4.1700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2294
    Cell Significance Index: -5.7300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2348
    Cell Significance Index: -10.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2389
    Cell Significance Index: -5.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2409
    Cell Significance Index: -8.3700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2444
    Cell Significance Index: -2.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2495
    Cell Significance Index: -6.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2553
    Cell Significance Index: -5.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Wnt family member**: WNT3 is a member of the Wnt family, which consists of 19 genes that encode proteins involved in signaling pathways. 2. **Canonical Wnt signaling pathway**: WNT3 is a ligand that activates the canonical Wnt signaling pathway, which plays a crucial role in regulating cell fate commitment, morphogenesis, and differentiation. 3. **Anterior/posterior axis specification**: WNT3 is involved in the regulation of anterior/posterior axis specification, which is essential for embryonic development. 4. **Axon guidance**: WNT3 is also involved in axon guidance, which is critical for the development and maintenance of the nervous system. 5. **Expression in various tissues**: WNT3 is expressed in various tissues, including the kidney, colon, and brain, where it regulates cell fate commitment, morphogenesis, and differentiation. **Pathways and Functions:** 1. **Canonical Wnt signaling pathway**: WNT3 activates the canonical Wnt signaling pathway, which involves the binding of WNT3 to Frizzled receptors and the activation of downstream signaling molecules, including β-catenin and TCF/LEF transcription factors. 2. **Cell fate commitment**: WNT3 regulates cell fate commitment by modulating the expression of genes involved in cell differentiation and proliferation. 3. **Morphogenesis**: WNT3 is involved in the regulation of morphogenesis, which is the process of cell shape and organization during development. 4. **Differentiation**: WNT3 regulates differentiation by modulating the expression of genes involved in cell differentiation and proliferation. 5. **Neurogenesis**: WNT3 is involved in the regulation of neurogenesis, which is the process of neural cell generation and differentiation. **Clinical Significance:** 1. **Cancer**: WNT3 has been implicated in several types of cancer, including colorectal cancer, breast cancer, and lung cancer. 2. **Neurological disorders**: WNT3 has been implicated in several neurological disorders, including Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. 3. **Developmental disorders**: WNT3 has been implicated in several developmental disorders, including Down syndrome and Turner syndrome. 4. **Therapeutic target**: WNT3 has been identified as a potential therapeutic target for the treatment of cancer and neurological disorders. In conclusion, the WNT3 gene is a complex and multifaceted regulator of developmental and cellular processes. Its involvement in various signaling pathways, including the canonical Wnt signaling pathway, highlights its importance in regulating cell fate commitment, morphogenesis, and differentiation. The WNT3 gene has been implicated in several diseases, including cancer and neurological disorders, making it a promising therapeutic target for the treatment of these conditions.

Genular Protein ID: 3108330587

Symbol: WNT3_HUMAN

Name: Proto-oncogene Wnt-3

UniProtKB Accession Codes:

P56703 Q2M237 Q9H1J9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 GO 40 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11604997

Title: Molecular cloning and characterization of human WNT3.

PubMed ID: 11604997

DOI: 10.3892/ijo.19.5.977

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8244403

Title: Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene.

PubMed ID: 8244403

DOI: 10.1006/geno.1993.1412

PubMed ID: 14872406

Title: Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family.

PubMed ID: 14872406

DOI: 10.1086/382196

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

Sequence Information:

  • Length: 355
  • Mass: 39645
  • Checksum: 85D15F2C7884A64F
  • Sequence:
    • MEPHLLGLLL GLLLGGTRVL AGYPIWWSLA LGQQYTSLGS QPLLCGSIPG LVPKQLRFCR 
NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI FGPVLDKATR ESAFVHAIAS 
AGVAFAVTRS CAEGTSTICG CDSHHKGPPG EGWKWGGCSE DADFGVLVSR EFADARENRP 
DARSAMNKHN NEAGRTTILD HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS 
ASEMVVEKHR ESRGWVETLR AKYSLFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC 
NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECIRIYD VHTCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.