Details for: WNT10B

Gene ID: 7480

Symbol: WNT10B

Ensembl ID: ENSG00000169884

Description: Wnt family member 10B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6226
    Cell Significance Index: 35.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.8698
    Cell Significance Index: 53.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7177
    Cell Significance Index: 17.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3375
    Cell Significance Index: 12.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3237
    Cell Significance Index: 14.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3104
    Cell Significance Index: 14.0700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2830
    Cell Significance Index: 4.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2792
    Cell Significance Index: 56.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2211
    Cell Significance Index: 6.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2116
    Cell Significance Index: 4.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1622
    Cell Significance Index: 30.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1495
    Cell Significance Index: 14.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1483
    Cell Significance Index: 133.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1333
    Cell Significance Index: 47.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1292
    Cell Significance Index: 89.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1216
    Cell Significance Index: 2.6400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.0757
    Cell Significance Index: 0.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0752
    Cell Significance Index: 33.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0323
    Cell Significance Index: 2.1700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.0253
    Cell Significance Index: 0.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0117
    Cell Significance Index: 1.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0069
    Cell Significance Index: 1.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0065
    Cell Significance Index: 0.2300
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.0039
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -4.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0022
    Cell Significance Index: -4.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0024
    Cell Significance Index: -0.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -3.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0029
    Cell Significance Index: -3.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0044
    Cell Significance Index: -2.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0055
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0057
    Cell Significance Index: -4.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0058
    Cell Significance Index: -3.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0090
    Cell Significance Index: -4.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0102
    Cell Significance Index: -0.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0109
    Cell Significance Index: -3.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0147
    Cell Significance Index: -1.0200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0150
    Cell Significance Index: -0.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0164
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0182
    Cell Significance Index: -3.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0194
    Cell Significance Index: -3.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0205
    Cell Significance Index: -4.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0219
    Cell Significance Index: -1.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0234
    Cell Significance Index: -0.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0272
    Cell Significance Index: -0.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0275
    Cell Significance Index: -0.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0283
    Cell Significance Index: -4.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0283
    Cell Significance Index: -0.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0283
    Cell Significance Index: -3.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0297
    Cell Significance Index: -3.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0323
    Cell Significance Index: -3.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0334
    Cell Significance Index: -0.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0347
    Cell Significance Index: -4.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0351
    Cell Significance Index: -4.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0374
    Cell Significance Index: -4.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0417
    Cell Significance Index: -0.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0421
    Cell Significance Index: -1.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0431
    Cell Significance Index: -4.4000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0431
    Cell Significance Index: -0.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0446
    Cell Significance Index: -3.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0553
    Cell Significance Index: -1.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0577
    Cell Significance Index: -2.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0580
    Cell Significance Index: -1.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0603
    Cell Significance Index: -2.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0606
    Cell Significance Index: -4.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0614
    Cell Significance Index: -3.1900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0620
    Cell Significance Index: -1.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0651
    Cell Significance Index: -4.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0672
    Cell Significance Index: -3.7700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0677
    Cell Significance Index: -0.7900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0761
    Cell Significance Index: -0.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0797
    Cell Significance Index: -3.7500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0827
    Cell Significance Index: -1.2800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0844
    Cell Significance Index: -0.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0859
    Cell Significance Index: -1.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0883
    Cell Significance Index: -3.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0890
    Cell Significance Index: -2.3800
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0973
    Cell Significance Index: -1.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0986
    Cell Significance Index: -2.5400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1049
    Cell Significance Index: -1.3600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1076
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1084
    Cell Significance Index: -2.9500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1168
    Cell Significance Index: -2.3300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1230
    Cell Significance Index: -3.8900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1239
    Cell Significance Index: -3.0900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1239
    Cell Significance Index: -1.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1240
    Cell Significance Index: -3.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1243
    Cell Significance Index: -2.1300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1244
    Cell Significance Index: -3.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1280
    Cell Significance Index: -3.1000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.1321
    Cell Significance Index: -1.3800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1321
    Cell Significance Index: -3.3000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1322
    Cell Significance Index: -2.7600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1335
    Cell Significance Index: -1.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1347
    Cell Significance Index: -2.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1399
    Cell Significance Index: -2.9900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1400
    Cell Significance Index: -1.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cellular expression**: WNT10B is widely expressed in various tissues, including the brain, heart, liver, and gastrointestinal tract. 2. **Receptor binding**: WNT10B interacts with Frizzled receptors and co-receptors to activate the canonical Wnt signaling pathway. 3. **Signaling pathways**: WNT10B is involved in multiple signaling pathways, including the Wnt/β-catenin, Wnt/β-catenin-independent, and non-canonical Wnt pathways. 4. **Cellular functions**: WNT10B regulates cell fate commitment, differentiation, proliferation, and survival in various cell types. **Pathways and Functions** WNT10B is involved in numerous signaling pathways, including: 1. **Canonical Wnt signaling pathway**: WNT10B activates the canonical Wnt signaling pathway, which regulates cell fate commitment, differentiation, and proliferation. 2. **Non-canonical Wnt signaling pathway**: WNT10B is also involved in the non-canonical Wnt signaling pathway, which regulates cell migration, polarity, and adhesion. 3. **Wnt/β-catenin-independent signaling pathway**: WNT10B interacts with other signaling molecules to regulate Wnt/β-catenin-independent pathways, which are involved in regulating cell survival and apoptosis. 4. **Regulation of cellular processes**: WNT10B regulates various cellular processes, including cell fate commitment, differentiation, proliferation, and survival. **Clinical Significance** WNT10B has been implicated in various diseases, including: 1. **Bone disorders**: WNT10B is involved in regulating bone formation and resorption, making it a potential target for treating bone disorders, such as osteoporosis. 2. **Cancer**: WNT10B is overexpressed in various types of cancer, including colon, breast, and lung cancer, suggesting its potential role in tumorigenesis. 3. **Neurological disorders**: WNT10B is involved in regulating neuronal development and function, making it a potential target for treating neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immunological disorders**: WNT10B is expressed in immune cells and plays a role in regulating immune responses, making it a potential target for treating immunological disorders, such as autoimmune diseases. In conclusion, WNT10B is a key player in the Wnt signaling pathway, regulating various cellular processes, including cell fate commitment, differentiation, proliferation, and survival. Its implications in various diseases, including bone disorders, cancer, neurological disorders, and immunological disorders, make it a promising target for therapeutic interventions. Further research is needed to fully understand the complex roles of WNT10B in maintaining tissue homeostasis and its potential applications in treating various diseases.

Genular Protein ID: 2039338316

Symbol: WN10B_HUMAN

Name: Protein Wnt-10b

UniProtKB Accession Codes:

O00744 B2R7A5 O00747 Q4VAJ4 Q4VAJ5 Q8WZ97

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 44 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9284937

Title: Isolation, characterization and chromosomal localization of human WNT10B.

PubMed ID: 9284937

DOI: 10.1159/000134597

PubMed ID: 11713588

Title: Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45.

PubMed ID: 11713588

DOI: 10.3892/ijo.19.6.1187

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9121776

Title: A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas.

PubMed ID: 9121776

DOI: 10.1038/sj.onc.1200936

PubMed ID: 9441749

Title: Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21.

PubMed ID: 9441749

DOI: 10.1006/geno.1997.5041

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21447090

Title: The role of WNT10B in physiology and disease.

PubMed ID: 21447090

DOI: 10.1111/j.1748-1716.2011.02296.x

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

PubMed ID: 16477437

Title: WNT10B mutations in human obesity.

PubMed ID: 16477437

DOI: 10.1007/s00125-006-0144-4

PubMed ID: 18515319

Title: Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation.

PubMed ID: 18515319

DOI: 10.1093/hmg/ddn164

PubMed ID: 27321946

Title: Mutations in WNT10B are identified in individuals with oligodontia.

PubMed ID: 27321946

DOI: 10.1016/j.ajhg.2016.05.012

Sequence Information:

  • Length: 389
  • Mass: 43000
  • Checksum: F973F2CA0DB115EF
  • Sequence:
    • MLEEPRPRPP PSGLAGLLFL ALCSRALSNE ILGLKLPGEP PLTANTVCLT LSGLSKRQLG 
LCLRNPDVTA SALQGLHIAV HECQHQLRDQ RWNCSALEGG GRLPHHSAIL KRGFRESAFS 
FSMLAAGVMH AVATACSLGK LVSCGCGWKG SGEQDRLRAK LLQLQALSRG KSFPHSLPSP 
GPGSSPSPGP QDTWEWGGCN HDMDFGEKFS RDFLDSREAP RDIQARMRIH NNRVGRQVVT 
ENLKRKCKCH GTSGSCQFKT CWRAAPEFRA VGAALRERLG RAIFIDTHNR NSGAFQPRLR 
PRRLSGELVY FEKSPDFCER DPTMGSPGTR GRACNKTSRL LDGCGSLCCG RGHNVLRQTR 
VERCHCRFHW CCYVLCDECK VTEWVNVCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.