Details for: ZNF2

Gene ID: 7549

Symbol: ZNF2

Ensembl ID: ENSG00000275111

Description: zinc finger protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 16.4059
    Cell Significance Index: -6.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.0176
    Cell Significance Index: -6.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.8538
    Cell Significance Index: -7.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9192
    Cell Significance Index: 174.9300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8599
    Cell Significance Index: 14.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5719
    Cell Significance Index: 56.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4539
    Cell Significance Index: 409.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3566
    Cell Significance Index: 21.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3185
    Cell Significance Index: 51.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2829
    Cell Significance Index: 17.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2586
    Cell Significance Index: 51.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2573
    Cell Significance Index: 51.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1842
    Cell Significance Index: 12.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1042
    Cell Significance Index: 37.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0888
    Cell Significance Index: 61.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0822
    Cell Significance Index: 1.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0803
    Cell Significance Index: 14.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0706
    Cell Significance Index: 1.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0631
    Cell Significance Index: 4.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0556
    Cell Significance Index: 2.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0444
    Cell Significance Index: 1.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0396
    Cell Significance Index: 1.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0389
    Cell Significance Index: 17.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0373
    Cell Significance Index: 1.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0351
    Cell Significance Index: 4.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0285
    Cell Significance Index: 4.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0268
    Cell Significance Index: 3.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0261
    Cell Significance Index: 3.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0252
    Cell Significance Index: 13.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0208
    Cell Significance Index: 1.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0126
    Cell Significance Index: 0.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0083
    Cell Significance Index: 0.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0075
    Cell Significance Index: 0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0027
    Cell Significance Index: 5.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0023
    Cell Significance Index: -0.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0031
    Cell Significance Index: -4.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -5.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0038
    Cell Significance Index: -0.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0054
    Cell Significance Index: -2.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0062
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0094
    Cell Significance Index: -0.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0097
    Cell Significance Index: -5.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0124
    Cell Significance Index: -7.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0151
    Cell Significance Index: -1.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0174
    Cell Significance Index: -0.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0253
    Cell Significance Index: -7.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0257
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0280
    Cell Significance Index: -3.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0311
    Cell Significance Index: -6.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0327
    Cell Significance Index: -0.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0347
    Cell Significance Index: -0.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0396
    Cell Significance Index: -1.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0441
    Cell Significance Index: -2.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0450
    Cell Significance Index: -5.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0499
    Cell Significance Index: -3.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0507
    Cell Significance Index: -6.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0509
    Cell Significance Index: -1.3600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0534
    Cell Significance Index: -0.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0569
    Cell Significance Index: -1.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0570
    Cell Significance Index: -2.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0584
    Cell Significance Index: -1.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0640
    Cell Significance Index: -6.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0731
    Cell Significance Index: -1.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0811
    Cell Significance Index: -4.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0815
    Cell Significance Index: -2.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0822
    Cell Significance Index: -6.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0832
    Cell Significance Index: -5.3700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0848
    Cell Significance Index: -1.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0879
    Cell Significance Index: -4.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0910
    Cell Significance Index: -7.2100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0933
    Cell Significance Index: -1.4800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0955
    Cell Significance Index: -1.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0964
    Cell Significance Index: -3.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0969
    Cell Significance Index: -1.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0988
    Cell Significance Index: -1.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1004
    Cell Significance Index: -2.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1030
    Cell Significance Index: -2.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1064
    Cell Significance Index: -3.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1167
    Cell Significance Index: -3.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1296
    Cell Significance Index: -2.7700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1325
    Cell Significance Index: -3.7800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1331
    Cell Significance Index: -0.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1355
    Cell Significance Index: -3.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1370
    Cell Significance Index: -4.8000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1398
    Cell Significance Index: -3.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1435
    Cell Significance Index: -2.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1436
    Cell Significance Index: -4.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1503
    Cell Significance Index: -3.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1525
    Cell Significance Index: -4.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1613
    Cell Significance Index: -3.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1643
    Cell Significance Index: -4.4000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1687
    Cell Significance Index: -1.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1689
    Cell Significance Index: -2.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1768
    Cell Significance Index: -4.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1822
    Cell Significance Index: -3.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain**: ZNF2 contains a characteristic zinc finger domain, which is essential for its DNA-binding activity. This domain allows ZNF2 to recognize and bind to specific DNA sequences, thereby regulating gene expression. 2. **RNA Polymerase II-Specific**: ZNF2 is a RNA polymerase II-specific transcription factor, indicating its role in regulating the expression of genes transcribed by this enzyme. 3. **Widespread Expression**: ZNF2 is expressed in various cell types, including epithelial cells, immune cells, and cardiac cells, suggesting its involvement in multiple physiological processes. 4. **Transcriptional Regulation**: ZNF2 regulates transcription by binding to specific DNA sequences and influencing the transcriptional activity of RNA polymerase II. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity**: ZNF2's zinc finger domain allows it to bind to specific DNA sequences, regulating gene expression through this mechanism. 2. **Gene Expression (Transcription)**: ZNF2 plays a crucial role in regulating gene expression by influencing the transcriptional activity of RNA polymerase II. 3. **Generic Transcription Pathway**: ZNF2 is involved in the generic transcription pathway, which is responsible for the expression of genes involved in various cellular processes. 4. **Regulation of DNA-Templated Transcription**: ZNF2 regulates the expression of genes involved in DNA-templated transcription, which is essential for DNA replication and repair. **Clinical Significance:** 1. **Immunological Implications**: ZNF2's expression in immune cells suggests its potential role in regulating immune responses and inflammation. 2. **Cardiac Function**: ZNF2's expression in cardiac cells indicates its involvement in regulating cardiac function and potentially cardiac disease. 3. **Epithelial Cell Function**: ZNF2's expression in epithelial cells suggests its role in regulating epithelial cell function and potentially epithelial disorders. 4. **Cancer Research**: ZNF2's involvement in transcriptional regulation makes it a potential target for cancer research, particularly in the context of gene expression and epigenetic regulation. In conclusion, the Zinc Finger Protein 2 (ZNF2) gene is a crucial regulator of gene expression, with implications in various physiological and pathological processes. Further research is necessary to fully elucidate the functions and clinical significance of ZNF2, but its involvement in transcriptional regulation and widespread expression across multiple cell types make it an important area of study in the field of immunology and molecular biology.

Genular Protein ID: 2708099870

Symbol: ZNF2_HUMAN

Name: Zinc finger protein 2.2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1945843

Title: Members of the zinc finger protein gene family sharing a conserved N-terminal module.

PubMed ID: 1945843

DOI: 10.1093/nar/19.20.5661

Sequence Information:

  • Length: 425
  • Mass: 48707
  • Checksum: 8CB40D3EDB62147E
  • Sequence:
  • MAAVSPTTRC QESVTFEDVA VVFTDEEWSR LVPIQRDLYK EVMLENYNSI VSLGLPVPQP 
    DVIFQLKRGD KPWMVDLHGS EEREWPESVS LDWETKPEIH DASDKKSEGS LRECLGRQSP 
    LCPKFEVHTP NGRMGTEKQS PSGETRKKSL SRDKGLRRRS ALSREILTKE RHQECSDCGK 
    TFFDHSSLTR HQRTHTGEKP YDCRECGKAF SHRSSLSRHL MSHTGESPYE CSVCSKAFFD 
    RSSLTVHQRI HTGEKPFQCN ECGKAFFDRS SLTRHQRIHT GESPYECHQC GKAFSQKSIL 
    TRHQLIHTGR KPYECNECGK AFYGVSSLNR HQKAHAGDPR YQCNECGKAF FDRSSLTQHQ 
    KIHTGDKPYE CSECGKAFSQ RCRLTRHQRV HTGEKPFECT VCGKVFSSKS SVIQHQRRYA 
    KQGID

Genular Protein ID: 693785852

Symbol: Q68CY6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 345
  • Mass: 39523
  • Checksum: 5E847DCBB3A478A4
  • Sequence:
  • MLENYNSIVS LDWETKPEIH DASDKKSEGS LRECLGRQSP LCPKFEVHTP NGRMGTEKQS 
    PSGETRKKSL SRDKGLRRRS ALSREILTKE RHQECSDCGK TFFDHSSLTR HQRTHTGEKP 
    YDCRECGKAF SHRSSLSRHL MSHTGESPYE CSVCSKAFFD RSSLTVHQRI HTGEKPFQCN 
    ECGKAFFDRS SLTRHQRIHT GESPYECHQC GKAFSQKSIL TRHQLIHTGR KPYECNECGK 
    AFYGVSSLNR HQKAHAGDPR YQCNECGKAF FDRSSLTQHQ KIHTGDKPYE CSECGKAFSQ 
    RCRLTRHQRV HTGEKPFECT VCGKVFSSKS SVIQHQRRYA KQGID

Genular Protein ID: 223477116

Symbol: A0A087WYR5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 438
  • Mass: 50200
  • Checksum: DFEDF9FAC1ADA634
  • Sequence:
  • MAAVSPTTRC QESVTFEDVA VVFTDEEWSR LVPIQRDLYK EVMLENYNSI VSLGLPVPQP 
    DVIFQLKRGD KPWMVDLHGS EEREWPESVS LAQEKNCICF LFVPDWETKP EIHDASDKKS 
    EGSLRECLGR QSPLCPKFEV HTPNGRMGTE KQSPSGETRK KSLSRDKGLR RRSALSREIL 
    TKERHQECSD CGKTFFDHSS LTRHQRTHTG EKPYDCRECG KAFSHRSSLS RHLMSHTGES 
    PYECSVCSKA FFDRSSLTVH QRIHTGEKPF QCNECGKAFF DRSSLTRHQR IHTGESPYEC 
    HQCGKAFSQK SILTRHQLIH TGRKPYECNE CGKAFYGVSS LNRHQKAHAG DPRYQCNECG 
    KAFFDRSSLT QHQKIHTGDK PYECSECGKA FSQRCRLTRH QRVHTGEKPF ECTVCGKVFS 
    SKSSVIQHQR RYAKQGID

Genular Protein ID: 3357166052

Symbol: B4DR15_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 438
  • Mass: 50170
  • Checksum: 7FE43691DAC6B496
  • Sequence:
  • MAAVSPTTRC QESVTFEDVA VVFTDEEWSR LVPIQRDLYK EVMLENYNSI VSLGLPVPQP 
    DVIFQLKRGD KPWMVDLHGS EEREWPESVS LAQEKNCICF LFVPDWETKP EIHDASDKKS 
    EGSLRECLGR QGPLCPKFEV HTPNGRMGTE KQSPSGETRK KSLSRDKGLR RRSALSREIL 
    TKERHQECSD CGKTFFDHSS LTRHQRTHTG EKPYDCRECG KAFSHRSSLS RHLMSHTGES 
    PYECSVCSKA FFDRSSLTVH QRIHTGEKPF QCNECGKAFF DRSSLTRHQR IHTGESPYEC 
    HQCGKAFSQK SILTRHQLIH TGRKPYECNE CGKAFYGVSS LNRHQKAHAG DPRYQCNECG 
    KAFFDRSSLT QHQKIHTGDK PYECSECGKA FSQRCRLTRH QRVHTGEKPF ECTVCGKVFS 
    SKSSVIQHQR RYAKQGID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.