Details for: AXIN2

Gene ID: 8313

Symbol: AXIN2

Ensembl ID: ENSG00000168646

Description: axin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3091
    Cell Significance Index: 1182.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1622
    Cell Significance Index: 126.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8316
    Cell Significance Index: 12.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7157
    Cell Significance Index: 14.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6394
    Cell Significance Index: 28.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6377
    Cell Significance Index: 126.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5939
    Cell Significance Index: 17.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5596
    Cell Significance Index: 38.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5231
    Cell Significance Index: 104.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3815
    Cell Significance Index: 37.7400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.2974
    Cell Significance Index: 3.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2879
    Cell Significance Index: 103.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2668
    Cell Significance Index: 5.7800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2527
    Cell Significance Index: 1.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2264
    Cell Significance Index: 5.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1970
    Cell Significance Index: 15.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1891
    Cell Significance Index: 22.0400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1859
    Cell Significance Index: 1.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1757
    Cell Significance Index: 77.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1413
    Cell Significance Index: 97.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1272
    Cell Significance Index: 24.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1134
    Cell Significance Index: 15.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1046
    Cell Significance Index: 2.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0837
    Cell Significance Index: 5.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0737
    Cell Significance Index: 1.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0665
    Cell Significance Index: 11.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0509
    Cell Significance Index: 1.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0508
    Cell Significance Index: 3.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0452
    Cell Significance Index: 24.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0407
    Cell Significance Index: 1.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0361
    Cell Significance Index: 1.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0283
    Cell Significance Index: 0.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0269
    Cell Significance Index: 1.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0198
    Cell Significance Index: 1.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0122
    Cell Significance Index: 0.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0090
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0060
    Cell Significance Index: 11.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0012
    Cell Significance Index: 0.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0018
    Cell Significance Index: -1.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0030
    Cell Significance Index: -0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0065
    Cell Significance Index: -10.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0066
    Cell Significance Index: -0.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0074
    Cell Significance Index: -4.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0104
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0125
    Cell Significance Index: -9.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0135
    Cell Significance Index: -9.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0139
    Cell Significance Index: -6.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0161
    Cell Significance Index: -2.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0175
    Cell Significance Index: -9.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0204
    Cell Significance Index: -12.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0287
    Cell Significance Index: -8.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0490
    Cell Significance Index: -6.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0490
    Cell Significance Index: -8.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0491
    Cell Significance Index: -5.6300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0531
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0562
    Cell Significance Index: -11.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0589
    Cell Significance Index: -1.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0666
    Cell Significance Index: -3.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0730
    Cell Significance Index: -9.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0848
    Cell Significance Index: -2.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0866
    Cell Significance Index: -9.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0879
    Cell Significance Index: -4.1000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0882
    Cell Significance Index: -1.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0935
    Cell Significance Index: -9.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0970
    Cell Significance Index: -11.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1030
    Cell Significance Index: -3.5800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1241
    Cell Significance Index: -1.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1274
    Cell Significance Index: -3.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1278
    Cell Significance Index: -9.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1328
    Cell Significance Index: -10.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1330
    Cell Significance Index: -3.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1370
    Cell Significance Index: -6.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1409
    Cell Significance Index: -2.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1417
    Cell Significance Index: -3.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1440
    Cell Significance Index: -7.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1459
    Cell Significance Index: -3.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1570
    Cell Significance Index: -5.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1639
    Cell Significance Index: -10.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1693
    Cell Significance Index: -2.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1739
    Cell Significance Index: -4.4700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1762
    Cell Significance Index: -2.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1774
    Cell Significance Index: -5.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1829
    Cell Significance Index: -4.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1837
    Cell Significance Index: -5.8500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1995
    Cell Significance Index: -2.0700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2101
    Cell Significance Index: -1.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2111
    Cell Significance Index: -4.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2132
    Cell Significance Index: -6.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2255
    Cell Significance Index: -7.9000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2620
    Cell Significance Index: -5.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2633
    Cell Significance Index: -9.6700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2701
    Cell Significance Index: -4.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2828
    Cell Significance Index: -14.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2854
    Cell Significance Index: -5.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2894
    Cell Significance Index: -4.9600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2916
    Cell Significance Index: -5.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3011
    Cell Significance Index: -4.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** AXIN2 is a 115-kDa protein that belongs to the Axin family of proteins. It is a multifunctional protein that interacts with multiple partners, including β-catenin, β-catenin-AP2 (adenovirus protein 2), and TCF/LEF transcription factors. AXIN2's structure consists of three domains: an N-terminal domain, a central domain, and a C-terminal domain. The central domain is responsible for binding to β-catenin and other proteins, while the N-terminal domain interacts with TCF/LEF transcription factors. The C-terminal domain is involved in protein-protein interactions and protein degradation. **Pathways and Functions** AXIN2 is involved in various signaling pathways, including: 1. **Canonical Wnt Signaling Pathway**: AXIN2 regulates the activity of β-catenin, a central effector molecule in Wnt signaling. The Wnt/β-catenin complex is essential for controlling cell proliferation, differentiation, and survival in different tissues. 2. **Beta-catenin destruction complex**: AXIN2 is a key component of the β-catenin destruction complex, which regulates the activity of β-catenin by promoting its degradation. 3. **Beta-catenin binding**: AXIN2 binds to β-catenin, regulating its activity and localization within the cell. 4. **Wnt signaling pathway**: AXIN2 regulates the activity of Wnt signaling pathway, which is involved in various cellular processes, including cell development, differentiation, and survival. 5. **Cellular response to dexamethasone stimulus**: AXIN2 is involved in the cellular response to dexamethasone, a glucocorticoid hormone. 6. **Bone mineralization**: AXIN2 regulates the activity of osteoblasts, cells responsible for bone mineralization. 7. **Osteoblast differentiation**: AXIN2 is involved in the regulation of osteoblast differentiation, a process essential for bone development. **Clinical Significance** AXIN2's dysregulation has been implicated in various diseases, including: 1. **Cardiovascular diseases**: AXIN2's involvement in the Wnt/β-catenin pathway has been linked to cardiovascular diseases, including aortic valve morphogenesis and mitral valve morphogenesis. 2. **Bone diseases**: AXIN2's dysregulation has been implicated in bone diseases, including osteoporosis and osteoblast differentiation disorders. 3. **Cancer**: AXIN2's involvement in the Wnt/β-catenin pathway has been linked to cancer development and progression. 4. **Neurological disorders**: AXIN2's dysregulation has been implicated in neurological disorders, including cerebral cortex GABAergic interneuron development and somitogenesis. In conclusion, AXIN2 is a multifunctional protein that plays a crucial role in various cellular processes, including cell development, differentiation, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of AXIN2 in maintaining cellular homeostasis and tissue development.

Genular Protein ID: 1048871352

Symbol: AXIN2_HUMAN

Name: Axin-2

UniProtKB Accession Codes:

Q9Y2T1 Q3MJ88 Q9H3M6 Q9UH84

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 42 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10049590

Title: Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24.

PubMed ID: 10049590

DOI: 10.1006/geno.1998.5650

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11017067

Title: Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling.

PubMed ID: 11017067

DOI: 10.1038/79859

PubMed ID: 15042511

Title: Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer.

PubMed ID: 15042511

DOI: 10.1086/386293

PubMed ID: 16601693

Title: Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.

PubMed ID: 16601693

DOI: 10.1038/sj.emboj.7601057

PubMed ID: 19759537

Title: Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

PubMed ID: 19759537

DOI: 10.1038/nature08356

PubMed ID: 21383061

Title: The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling.

PubMed ID: 21383061

DOI: 10.1128/mcb.01094-10

PubMed ID: 21478859

Title: RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.

PubMed ID: 21478859

DOI: 10.1038/ncb2222

PubMed ID: 28546513

Title: The SIAH E3 ubiquitin ligases promote Wnt/beta-catenin signaling through mediating Wnt-induced Axin degradation.

PubMed ID: 28546513

DOI: 10.1101/gad.300053.117

PubMed ID: 16820935

Title: Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population.

PubMed ID: 16820935

Sequence Information:

  • Length: 843
  • Mass: 93568
  • Checksum: 23E9C72187A9230C
  • Sequence:
    • MSSAMLVTCL PDPSSSFRED APRPPVPGEE GETPPCQPGV GKGQVTKPMP VSSNTRRNED 
GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE REKCVDTLDF WFACNGFRQM 
NLKDTKTLRV AKAIYKRYIE NNSIVSKQLK PATKTYIRDG IKKQQIDSIM FDQAQTEIQS 
VMEENAYQMF LTSDIYLEYV RSGGENTAYM SNGGLGSLKV VCGYLPTLNE EEEWTCADFK 
CKLSPTVVGL SSKTLRATAS VRSTETVDSG YRSFKRSDPV NPYHIGSGYV FAPATSANDS 
EISSDALTDD SMSMTDSSVD GIPPYRVGSK KQLQREMHRS VKANGQVSLP HFPRTHRLPK 
EMTPVEPATF AAELISRLEK LKLELESRHS LEERLQQIRE DEEREGSELT LNSREGAPTQ 
HPLSLLPSGS YEEDPQTILD DHLSRVLKTP GCQSPGVGRY SPRSRSPDHH HHHHSQYHSL 
LPPGGKLPPA AASPGACPLL GGKGFVTKQT TKHVHHHYIH HHAVPKTKEE IEAEATQRVH 
CFCPGGSEYY CYSKCKSHSK APETMPSEQF GGSRGSTLPK RNGKGTEPGL ALPAREGGAP 
GGAGALQLPR EEGDRSQDVW QWMLESERQS KPKPHSAQST KKAYPLESAR SSPGERASRH 
HLWGGNSGHP RTTPRAHLFT QDPAMPPLTP PNTLAQLEEA CRRLAEVSKP PKQRCCVASQ 
QRDRNHSATV QTGATPFSNP SLAPEDHKEP KKLAGVHALQ ASELVVTYFF CGEEIPYRRM 
LKAQSLTLGH FKEQLSKKGN YRYYFKKASD EFACGAVFEE IWEDETVLPM YEGRILGKVE 
RID

Genular Protein ID: 1165707405

Symbol: E7ES00_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ES00

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 4 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 2 SAM 1 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 778
  • Mass: 86681
  • Checksum: 91BCD661773DD6C8
  • Sequence:
    • MSSAMLVTCL PDPSSSFRED APRPPVPGEE GETPPCQPGV GKGQVTKPMP VSSNTRRNED 
GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE REKCVDTLDF WFACNGFRQM 
NLKDTKTLRV AKAIYKRYIE NNSIVSKQLK PATKTYIRDG IKKQQIDSIM FDQAQTEIQS 
VMEENAYQMF LTSDIYLEYV RSGGENTAYM SNGGLGSLKV VCGYLPTLNE EEEWTCADFK 
CKLSPTVVGL SSKTLRATAS VRSTETVDSG YRSFKRSDPV NPYHIGSGYV FAPATSANDS 
EISSDALTDD SMSMTDSSVD GIPPYRVGSK KQLQREMHRS VKANGQVSLP HFPRTHRLPK 
EMTPVEPATF AAELISRLEK LKLELESRHS LEERLQQIRE DEEREGSELT LNSREGAPTQ 
HPLSLLPSGS YEEDPQTILD DHLSRVLKTP GCQSPGVGRY SPRSRSPDHH HHHHSQYHSL 
LPPGGKLPPA AASPGACPLL GGKGFVTKQT TKHVHHHYIH HHAVPKTKEE IEAEATQRVH 
CFCPGGSEYY CYSKCKSHSK APETMPSEQF GAQSTKKAYP LESARSSPGE RASRHHLWGG 
NSGHPRTTPR AHLFTQDPAM PPLTPPNTLA QLEEACRRLA EVSKPPKQRC CVASQQRDRN 
HSATVQTGAT PFSNPSLAPE DHKEPKKLAG VHALQASELV VTYFFCGEEI PYRRMLKAQS 
LTLGHFKEQL SKKGNYRYYF KKASDEFACG AVFEEIWEDE TVLPMYEGRI LGKVERID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.