Details for: OR1E2

Gene ID: 8388

Symbol: OR1E2

Ensembl ID: ENSG00000127780

Description: olfactory receptor family 1 subfamily E member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0787
    Cell Significance Index: 0.8800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0763
    Cell Significance Index: 1.2400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0661
    Cell Significance Index: 0.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0093
    Cell Significance Index: 0.3300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.0090
    Cell Significance Index: 0.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0020
    Cell Significance Index: 0.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0044
    Cell Significance Index: -0.1400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0044
    Cell Significance Index: -0.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0055
    Cell Significance Index: -0.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0060
    Cell Significance Index: -0.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0063
    Cell Significance Index: -0.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0069
    Cell Significance Index: -0.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0095
    Cell Significance Index: -0.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0095
    Cell Significance Index: -0.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0100
    Cell Significance Index: -0.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0104
    Cell Significance Index: -0.2200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0104
    Cell Significance Index: -0.2100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0105
    Cell Significance Index: -0.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0111
    Cell Significance Index: -0.2200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0111
    Cell Significance Index: -0.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0116
    Cell Significance Index: -0.2000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0126
    Cell Significance Index: -0.1700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0129
    Cell Significance Index: -0.1100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0135
    Cell Significance Index: -0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0135
    Cell Significance Index: -0.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0138
    Cell Significance Index: -0.2700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0153
    Cell Significance Index: -0.2000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0158
    Cell Significance Index: -0.1900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0158
    Cell Significance Index: -0.1900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0169
    Cell Significance Index: -0.1800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0171
    Cell Significance Index: -0.2300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0176
    Cell Significance Index: -0.1600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0188
    Cell Significance Index: -0.2200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0211
    Cell Significance Index: -0.2300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0215
    Cell Significance Index: -0.2300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0215
    Cell Significance Index: -0.2900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0218
    Cell Significance Index: -0.2500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0221
    Cell Significance Index: -0.2400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0221
    Cell Significance Index: -0.3300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0222
    Cell Significance Index: -0.2100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0226
    Cell Significance Index: -0.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0230
    Cell Significance Index: -0.3400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0232
    Cell Significance Index: -0.1800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0240
    Cell Significance Index: -0.3100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0242
    Cell Significance Index: -0.3100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0244
    Cell Significance Index: -0.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0254
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0257
    Cell Significance Index: -0.3100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0260
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0268
    Cell Significance Index: -0.3300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0276
    Cell Significance Index: -0.2800
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.0279
    Cell Significance Index: -0.3400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0297
    Cell Significance Index: -0.2700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0303
    Cell Significance Index: -0.3000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0305
    Cell Significance Index: -0.2900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0306
    Cell Significance Index: -0.2900
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0308
    Cell Significance Index: -0.2800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0312
    Cell Significance Index: -0.2800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0312
    Cell Significance Index: -0.3300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0326
    Cell Significance Index: -0.2900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0326
    Cell Significance Index: -0.3400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0330
    Cell Significance Index: -0.3100
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0363
    Cell Significance Index: -0.3000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0387
    Cell Significance Index: -0.3300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0412
    Cell Significance Index: -0.3400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0417
    Cell Significance Index: -0.3400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0417
    Cell Significance Index: -0.4400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0430
    Cell Significance Index: -0.5200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0442
    Cell Significance Index: -0.3400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0444
    Cell Significance Index: -0.4000
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0453
    Cell Significance Index: -0.4800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0460
    Cell Significance Index: -0.4100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0504
    Cell Significance Index: -0.2700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0547
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0563
    Cell Significance Index: -0.3400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0678
    Cell Significance Index: -0.5200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0715
    Cell Significance Index: -0.4500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0736
    Cell Significance Index: -0.3400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1247
    Cell Significance Index: -0.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Olfactory Receptor**: OR1E2 is a G protein-coupled receptor (GPCR) that responds to chemical stimuli, specifically odorant molecules, and triggers a signaling cascade to convey this information to the brain. 2. **Expression in Gastrointestinal Tract**: OR1E2 is expressed in various cell types of the gastrointestinal tract, including goblet cells, intestinal epithelial cells, and intestinal enteroendocrine cells, suggesting a role in the regulation of gut function and homeostasis. 3. **Signaling Pathways**: OR1E2 activates G protein-coupled receptor signaling pathways, which involve the activation of G proteins, adenylate cyclase, and the production of cAMP, leading to various downstream effects, including changes in ion channel activity and gene expression. 4. **Tissue-Specific Expression**: The expression of OR1E2 is tissue-specific, with high levels found in the gastrointestinal tract and low levels in other tissues, suggesting a specialized role in gut function. **Pathways and Functions** 1. **Detection of Chemical Stimuli**: OR1E2 responds to odorant molecules, which bind to the receptor and trigger a signaling cascade that conveys this information to the brain, allowing for the perception of smell. 2. **G Protein-Coupled Receptor Signaling**: OR1E2 activates G protein-coupled receptor signaling pathways, which involve the activation of G proteins, adenylate cyclase, and the production of cAMP, leading to various downstream effects, including changes in ion channel activity and gene expression. 3. **Regulation of Gut Function**: OR1E2 may play a role in regulating gut function and homeostasis, particularly in the gastrointestinal tract, where it is expressed in various cell types. 4. **Immune Response**: OR1E2 may also play a role in the immune response, particularly in the context of the gut-associated lymphoid tissue (GALT), where it is expressed in immune cells. **Clinical Significance** 1. **Gastrointestinal Disorders**: Alterations in OR1E2 expression or function may contribute to gastrointestinal disorders, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and gastroesophageal reflux disease (GERD). 2. **Cancer**: OR1E2 may play a role in the development and progression of certain cancers, particularly those that originate in the gastrointestinal tract, such as colon cancer and gastric cancer. 3. **Neurological Disorders**: OR1E2 may also play a role in neurological disorders, such as Parkinson's disease and Alzheimer's disease, where olfactory dysfunction is a common feature. 4. **Pharmacological Targeting**: OR1E2 may serve as a target for the development of novel therapeutic agents, particularly in the context of gastrointestinal disorders and cancer. In conclusion, OR1E2 is a critical receptor involved in the detection of chemical stimuli involved in sensory perception of smell, and its expression and function are tightly regulated in various cell types of the gastrointestinal tract. The receptor's role in regulating gut function and homeostasis, as well as its potential involvement in gastrointestinal disorders and cancer, highlights its clinical significance. Further research is needed to fully elucidate the functions and clinical implications of OR1E2.

Genular Protein ID: 2324500395

Symbol: OR1E2_HUMAN

Name: Olfactory receptor 1E2

UniProtKB Accession Codes:

P47887 O43877 O95632 Q0VAD5 Q0VAD6 Q9UL13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10673334

Title: Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

PubMed ID: 10673334

DOI: 10.1006/geno.1999.6030

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8004088

Title: Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

PubMed ID: 8004088

DOI: 10.1093/hmg/3.2.229

PubMed ID: 9500546

Title: Distribution of olfactory receptor genes in the human genome.

PubMed ID: 9500546

DOI: 10.1038/ng0398-243

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 323
  • Mass: 36391
  • Checksum: 19AADA692BD92D3F
  • Sequence:
    • MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR LDSHLHTPVY 
LFLSNLSFSD LCFSSVTMPK LLQNMQNQDP SIPYADCLTQ MYFFLYFSDL ESFLLVAMAY 
DRYVAICFPM HYTAICFLLH YTAIMSPMLC LSVVALSWVL TTFHAMLHTL LMARLCFCAD 
NVIPHFFCDM SALLKLACSD TRVNEWVIFI MGGLILVIPF LLILGSYARI VSSILKVPSS 
KGICKAFSTC GSHLSVVSLF YGTVIGLYLC PSANSSTLKD TVMAMMYTVV TPMLTPFIYS 
LRNRDMKGAL ERVICKRKNP FLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.