Details for: OR1E2

Gene ID: 8388

Symbol: OR1E2

Ensembl ID: ENSG00000127780

Description: olfactory receptor family 1 subfamily E member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10804
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7569
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3651.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32712.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5341.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 737
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.12
    Marker Score: 228
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1
    Marker Score: 206
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.1
    Marker Score: 31.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 32.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.06
    Marker Score: 1000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 69
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 29.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.05
    Marker Score: 316
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.05
    Marker Score: 24.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.05
    Marker Score: 105
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.04
    Marker Score: 19.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.04
    Marker Score: 32.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 27.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.03
    Marker Score: 31.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.03
    Marker Score: 31.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 32.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 29.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 53.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.01
    Marker Score: 18.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.01
    Marker Score: 109
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.01
    Marker Score: 76
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 22.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.01
    Marker Score: 53.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0
    Marker Score: 31.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 89
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0
    Marker Score: 31.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 32.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0
    Marker Score: 18
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 30.5

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Other Information

**Key characteristics:** - OR1E2 is a single-exon gene encoding a protein of 337 amino acids. - The protein is a G protein-coupled receptor (GPCR) that is expressed in the olfactory epithelium. - OR1E2 is a key component of the olfactory signaling pathway, which is responsible for the detection and transmission of chemical stimuli to the brain. **Pathways and functions:** - OR1E2 is a key component of the olfactory signaling pathway, which is responsible for the detection and transmission of chemical stimuli to the brain. - The pathway begins with the binding of odorant molecules to OR1E2 on the surface of olfactory receptor neurons. - Once bound, the odorant molecules activate the receptor, which in turn activates the G protein-coupled receptor (GPCR). - The GPCR-mediated signaling pathway then leads to the activation of downstream signaling molecules, which ultimately result in the transmission of a signal to the brain. **Clinical significance:** - Mutations in OR1E2 have been linked to a number of human diseases, including anosmia (the inability to sense smell), nasal polyps, and certain types of cancer. - Understanding the role of OR1E2 in smell perception has important implications for the development of new therapies for these diseases.

Genular Protein ID: 2324500395

Symbol: OR1E2_HUMAN

Name: Olfactory receptor 1E2

UniProtKB Accession Codes:

P47887 O43877 O95632 Q0VAD5 Q0VAD6 Q9UL13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10673334

Title: Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

PubMed ID: 10673334

DOI: 10.1006/geno.1999.6030

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8004088

Title: Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

PubMed ID: 8004088

DOI: 10.1093/hmg/3.2.229

PubMed ID: 9500546

Title: Distribution of olfactory receptor genes in the human genome.

PubMed ID: 9500546

DOI: 10.1038/ng0398-243

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 323
  • Mass: 36391
  • Checksum: 19AADA692BD92D3F
  • Sequence:
    • MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR LDSHLHTPVY 
LFLSNLSFSD LCFSSVTMPK LLQNMQNQDP SIPYADCLTQ MYFFLYFSDL ESFLLVAMAY 
DRYVAICFPM HYTAICFLLH YTAIMSPMLC LSVVALSWVL TTFHAMLHTL LMARLCFCAD 
NVIPHFFCDM SALLKLACSD TRVNEWVIFI MGGLILVIPF LLILGSYARI VSSILKVPSS 
KGICKAFSTC GSHLSVVSLF YGTVIGLYLC PSANSSTLKD TVMAMMYTVV TPMLTPFIYS 
LRNRDMKGAL ERVICKRKNP FLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.