Details for: SOX14

Gene ID: 8403

Symbol: SOX14

Ensembl ID: ENSG00000168875

Description: SRY-box transcription factor 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0404
    Cell Significance Index: 0.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0196
    Cell Significance Index: 0.2800
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.0106
    Cell Significance Index: 0.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0105
    Cell Significance Index: 0.2800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0016
    Cell Significance Index: -1.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0019
    Cell Significance Index: -1.1000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0050
    Cell Significance Index: -2.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0090
    Cell Significance Index: -1.8000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0090
    Cell Significance Index: -0.1100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0105
    Cell Significance Index: -0.2100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0105
    Cell Significance Index: -0.1500
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0115
    Cell Significance Index: -0.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0118
    Cell Significance Index: -2.3400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0135
    Cell Significance Index: -0.1400
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0146
    Cell Significance Index: -0.1300
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: -0.0163
    Cell Significance Index: -0.1200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0165
    Cell Significance Index: -0.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0170
    Cell Significance Index: -2.3300
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0180
    Cell Significance Index: -0.1700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0181
    Cell Significance Index: -0.2200
  • Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
    Fold Change: -0.0184
    Cell Significance Index: -0.1600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0193
    Cell Significance Index: -0.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0232
    Cell Significance Index: -0.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0255
    Cell Significance Index: -1.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0285
    Cell Significance Index: -0.7800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0295
    Cell Significance Index: -0.3900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0313
    Cell Significance Index: -0.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0318
    Cell Significance Index: -1.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0388
    Cell Significance Index: -2.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0413
    Cell Significance Index: -1.8700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0427
    Cell Significance Index: -0.5900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0440
    Cell Significance Index: -0.7600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0442
    Cell Significance Index: -0.6500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0469
    Cell Significance Index: -0.4800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0484
    Cell Significance Index: -0.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0494
    Cell Significance Index: -2.3200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0497
    Cell Significance Index: -0.5900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0499
    Cell Significance Index: -0.5900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0535
    Cell Significance Index: -0.6400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0536
    Cell Significance Index: -0.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0537
    Cell Significance Index: -0.5200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0617
    Cell Significance Index: -0.5500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0625
    Cell Significance Index: -0.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0627
    Cell Significance Index: -2.3000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0647
    Cell Significance Index: -0.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0649
    Cell Significance Index: -2.2800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0651
    Cell Significance Index: -0.7600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0665
    Cell Significance Index: -1.6600
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0673
    Cell Significance Index: -0.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0696
    Cell Significance Index: -1.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0738
    Cell Significance Index: -2.1300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0741
    Cell Significance Index: -0.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0744
    Cell Significance Index: -0.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0756
    Cell Significance Index: -1.6100
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0783
    Cell Significance Index: -0.8100
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0814
    Cell Significance Index: -0.5800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0815
    Cell Significance Index: -0.9700
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0815
    Cell Significance Index: -0.7800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0840
    Cell Significance Index: -0.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0924
    Cell Significance Index: -2.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0964
    Cell Significance Index: -2.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0988
    Cell Significance Index: -2.9100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0990
    Cell Significance Index: -0.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1023
    Cell Significance Index: -2.7400
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.1031
    Cell Significance Index: -0.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1032
    Cell Significance Index: -2.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1071
    Cell Significance Index: -2.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1098
    Cell Significance Index: -2.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1104
    Cell Significance Index: -2.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1141
    Cell Significance Index: -2.2900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1260
    Cell Significance Index: -0.8200
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.1275
    Cell Significance Index: -1.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1309
    Cell Significance Index: -2.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1311
    Cell Significance Index: -2.8700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1317
    Cell Significance Index: -0.3000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1341
    Cell Significance Index: -1.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1383
    Cell Significance Index: -2.3300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1395
    Cell Significance Index: -1.3300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1432
    Cell Significance Index: -1.5500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1446
    Cell Significance Index: -2.3200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1455
    Cell Significance Index: -1.7700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1468
    Cell Significance Index: -2.3600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1482
    Cell Significance Index: -1.9700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1483
    Cell Significance Index: -2.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1511
    Cell Significance Index: -2.5900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1515
    Cell Significance Index: -1.7900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1524
    Cell Significance Index: -1.6600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1526
    Cell Significance Index: -1.9200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1534
    Cell Significance Index: -2.3300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1557
    Cell Significance Index: -1.5000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1562
    Cell Significance Index: -1.4200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1665
    Cell Significance Index: -2.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1722
    Cell Significance Index: -2.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Regulator**: SOX14 acts as a transcriptional regulator, binding to specific DNA sequences and modulating the expression of target genes. 2. **Diverse Expression Pattern**: SOX14 is expressed in various cell types, including neurons, endothelial cells, goblet cells, and stem cells, indicating its role in multiple developmental and physiological processes. 3. **SOX Family Member**: SOX14 is a member of the SOX transcription factor family, which is characterized by its ability to bind to specific DNA sequences and regulate gene expression. 4. **Role in Development and Differentiation**: SOX14 is involved in the development and differentiation of neurons, endothelial cells, and other cell types, highlighting its critical role in tissue formation and maintenance. **Pathways and Functions** 1. **Neuronal Development**: SOX14 regulates the expression of genes involved in neuronal development, including the specification of neuronal fate and the regulation of neural differentiation. 2. **Circadian Rhythm Regulation**: SOX14 is involved in the entrainment of the circadian clock, a process critical for maintaining physiological homeostasis and regulating various physiological processes. 3. **Gene Expression Regulation**: SOX14 modulates the expression of target genes through its ability to bind to specific DNA sequences and recruit co-regulatory proteins. 4. **Cellular Differentiation**: SOX14 is involved in the regulation of cellular differentiation, including the differentiation of endothelial cells, goblet cells, and other cell types. **Clinical Significance** 1. **Neurological Disorders**: Alterations in SOX14 expression have been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and neurodegenerative diseases. 2. **Circadian Rhythm Disorders**: Disruptions in SOX14 expression have been linked to circadian rhythm disorders, including delayed sleep phase syndrome and non-24-hour sleep-wake disorder. 3. **Cancer**: SOX14 has been identified as a potential oncogene, with its overexpression linked to the development and progression of certain types of cancer, including breast cancer and leukemia. 4. **Regenerative Medicine**: SOX14 has been identified as a potential target for regenerative medicine therapies, with its ability to regulate stem cell differentiation and maintenance making it a promising candidate for tissue engineering and repair applications. In summary, SOX14 is a critical gene involved in various cellular processes, including development, differentiation, and regulation of gene expression. Its diverse expression pattern and role in multiple developmental and physiological processes highlight its significance in maintaining tissue homeostasis and regulating various physiological processes. Further research is needed to fully elucidate the functional significance of SOX14 and its potential applications in regenerative medicine and disease treatment.

Genular Protein ID: 1675237894

Symbol: SOX14_HUMAN

Name: Transcription factor SOX-14

UniProtKB Accession Codes:

O95416 B2RAC0 Q3KPH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10441749

Title: The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3.

PubMed ID: 10441749

DOI: 10.1007/s003359901118

PubMed ID: 9925951

Title: Characterisation and mapping of the human SOX14 gene.

PubMed ID: 9925951

DOI: 10.1159/000015149

PubMed ID: 10830911

Title: Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases.

PubMed ID: 10830911

DOI: 10.1007/s004390000266

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9827568

Title: Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR.

PubMed ID: 9827568

DOI: 10.1016/s0014-5793(98)01294-0

Sequence Information:

  • Length: 240
  • Mass: 26485
  • Checksum: 7F574AFDA571D903
  • Sequence:
    • MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS EAEKRPYIDE 
AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG DTDPLKAAGL PVGASDGLLS 
APEKARAFLP PASAPYSLLD PAQFSSSAIQ KMGEVPHTLA TGALPYASTL GYQNGAFGSL 
SCPSQHTHTH PSPTNPGYVV PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.