Details for: IRS4

Gene ID: 8471

Symbol: IRS4

Ensembl ID: ENSG00000133124

Description: insulin receptor substrate 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.1559
    Cell Significance Index: 17.8300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.1212
    Cell Significance Index: 36.2600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.9825
    Cell Significance Index: 12.4100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.5244
    Cell Significance Index: 6.6400
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.4051
    Cell Significance Index: 3.1200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2308
    Cell Significance Index: 2.5800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1367
    Cell Significance Index: 1.8800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1166
    Cell Significance Index: 1.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0832
    Cell Significance Index: 57.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0688
    Cell Significance Index: 0.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0304
    Cell Significance Index: 0.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0232
    Cell Significance Index: 2.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0160
    Cell Significance Index: 0.4200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0148
    Cell Significance Index: 0.1800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0115
    Cell Significance Index: 0.1600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0047
    Cell Significance Index: 0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0023
    Cell Significance Index: 0.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0006
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0024
    Cell Significance Index: -1.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0028
    Cell Significance Index: -1.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0032
    Cell Significance Index: -0.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0043
    Cell Significance Index: -1.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0053
    Cell Significance Index: -1.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0058
    Cell Significance Index: -0.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0098
    Cell Significance Index: -0.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0106
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0106
    Cell Significance Index: -1.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0107
    Cell Significance Index: -0.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0110
    Cell Significance Index: -0.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0111
    Cell Significance Index: -0.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0133
    Cell Significance Index: -1.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0152
    Cell Significance Index: -0.7900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0204
    Cell Significance Index: -0.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0215
    Cell Significance Index: -1.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0245
    Cell Significance Index: -1.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0257
    Cell Significance Index: -0.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0270
    Cell Significance Index: -0.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0286
    Cell Significance Index: -1.7600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0287
    Cell Significance Index: -0.6200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0305
    Cell Significance Index: -0.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0315
    Cell Significance Index: -1.4700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0353
    Cell Significance Index: -0.8800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0376
    Cell Significance Index: -0.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0389
    Cell Significance Index: -1.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0397
    Cell Significance Index: -1.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0405
    Cell Significance Index: -1.1600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0424
    Cell Significance Index: -1.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0441
    Cell Significance Index: -0.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0443
    Cell Significance Index: -0.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0453
    Cell Significance Index: -1.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0457
    Cell Significance Index: -1.7300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0464
    Cell Significance Index: -0.4400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0483
    Cell Significance Index: -0.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0484
    Cell Significance Index: -0.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0493
    Cell Significance Index: -1.1400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0500
    Cell Significance Index: -1.2500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0503
    Cell Significance Index: -0.7300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0512
    Cell Significance Index: -0.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0526
    Cell Significance Index: -0.6800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0537
    Cell Significance Index: -1.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0551
    Cell Significance Index: -1.4800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0583
    Cell Significance Index: -0.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0594
    Cell Significance Index: -1.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0607
    Cell Significance Index: -2.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0625
    Cell Significance Index: -1.5000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0628
    Cell Significance Index: -0.7400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0649
    Cell Significance Index: -0.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0652
    Cell Significance Index: -1.8600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0660
    Cell Significance Index: -1.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0678
    Cell Significance Index: -1.4200
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0704
    Cell Significance Index: -0.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0705
    Cell Significance Index: -1.8900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0715
    Cell Significance Index: -1.1500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0717
    Cell Significance Index: -0.8700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0719
    Cell Significance Index: -1.5000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0721
    Cell Significance Index: -0.9100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0736
    Cell Significance Index: -0.8700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0749
    Cell Significance Index: -1.1200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0769
    Cell Significance Index: -1.0800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0777
    Cell Significance Index: -1.1800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0783
    Cell Significance Index: -1.0300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0805
    Cell Significance Index: -1.0700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0813
    Cell Significance Index: -1.0300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0838
    Cell Significance Index: -0.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0844
    Cell Significance Index: -0.9200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0852
    Cell Significance Index: -1.2100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0856
    Cell Significance Index: -1.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0860
    Cell Significance Index: -1.4400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0863
    Cell Significance Index: -1.1100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0876
    Cell Significance Index: -1.1500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0878
    Cell Significance Index: -1.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0891
    Cell Significance Index: -1.4300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0892
    Cell Significance Index: -1.4700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0893
    Cell Significance Index: -1.1500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0895
    Cell Significance Index: -1.5200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0899
    Cell Significance Index: -1.0700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0902
    Cell Significance Index: -0.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IRS4 is a 140-kDa phosphoprotein, belonging to the insulin receptor substrate family. It is highly expressed in various cell types, including hematopoietic cells, endothelial cells, and immune cells such as macrophages and dendritic cells. IRS4 is characterized by its ability to interact with multiple signaling molecules, including the insulin receptor, phosphatidylinositol 3-kinase (PI3K), and the type 1 insulin-like growth factor receptor (IGF1R). This multifunctional nature of IRS4 enables it to regulate a wide range of cellular processes, including glucose metabolism, cell growth, and differentiation. **Pathways and Functions** IRS4 is integral to the insulin signaling pathway, which is crucial for maintaining glucose homeostasis. Upon insulin binding to the insulin receptor, IRS4 is phosphorylated and activated, triggering a cascade of downstream signaling events that regulate glucose uptake, glycogen synthesis, and lipogenesis. The IRS4-PI3K pathway is also involved in cell survival and apoptosis, with IRS4 acting as a negative regulator of apoptosis. Additionally, IRS4 interacts with the IGF1R pathway, which is involved in cell growth and differentiation. The functions of IRS4 are multifaceted, including: * Glucose metabolism: IRS4 regulates glucose uptake, glycogen synthesis, and lipogenesis in response to insulin. * Cell survival: IRS4 acts as a negative regulator of apoptosis, promoting cell survival in response to insulin. * Cell growth: IRS4 regulates cell growth and differentiation in response to insulin and IGF1R signaling. * Immune function: IRS4 is expressed in immune cells, where it regulates immune responses and inflammation. **Clinical Significance** Dysregulation of the IRS4 pathway has been implicated in various metabolic disorders, including insulin resistance, type 2 diabetes, and metabolic syndrome. Mutations in the IRS4 gene have been associated with congenital insulin resistance, a rare genetic disorder characterized by impaired glucose metabolism and insulin resistance. Furthermore, IRS4 has been shown to play a role in the pathogenesis of other diseases, including: * Cancer: IRS4 is overexpressed in various types of cancer, including breast, lung, and colon cancer, where it promotes cell growth and survival. * Atherosclerosis: IRS4 is involved in the development of atherosclerosis, a cardiovascular disease characterized by inflammation and lipid accumulation in the arterial wall. * Autoimmune diseases: IRS4 has been implicated in the pathogenesis of autoimmune diseases, including rheumatoid arthritis and lupus, where it regulates immune responses and inflammation. In conclusion, IRS4 is a critical component of the insulin signaling pathway, playing a pivotal role in glucose metabolism, cell survival, and immune function. Dysregulation of the IRS4 pathway has been implicated in various metabolic disorders and diseases, highlighting its importance as a therapeutic target for the treatment of these conditions.

Genular Protein ID: 2874021322

Symbol: IRS4_HUMAN

Name: Insulin receptor substrate 4

UniProtKB Accession Codes:

O14654

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9261155

Title: A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family.

PubMed ID: 9261155

DOI: 10.1074/jbc.272.34.21403

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 9553137

Title: Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells.

PubMed ID: 9553137

DOI: 10.1074/jbc.273.17.10726

PubMed ID: 9614078

Title: Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.

PubMed ID: 9614078

DOI: 10.1074/jbc.273.24.14780

PubMed ID: 10531310

Title: Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation.

PubMed ID: 10531310

DOI: 10.1074/jbc.274.44.31179

PubMed ID: 10594015

Title: IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis.

PubMed ID: 10594015

DOI: 10.1128/mcb.20.1.126-138.2000

PubMed ID: 11316748

Title: The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II.

PubMed ID: 11316748

DOI: 10.1210/endo.142.5.8135

PubMed ID: 11912194

Title: Insulin receptor substrate 4 associates with the protein IRAS.

PubMed ID: 11912194

DOI: 10.1074/jbc.m111838200

PubMed ID: 12639902

Title: Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.

PubMed ID: 12639902

DOI: 10.1210/en.2002-220723

PubMed ID: 15316024

Title: Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.

PubMed ID: 15316024

DOI: 10.1074/jbc.m404537200

PubMed ID: 15331607

Title: Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation.

PubMed ID: 15331607

DOI: 10.1074/jbc.m408067200

PubMed ID: 15870689

Title: Interaction between Brk kinase and insulin receptor substrate-4.

PubMed ID: 15870689

DOI: 10.1038/sj.onc.1208721

PubMed ID: 17408801

Title: Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation.

PubMed ID: 17408801

DOI: 10.1016/j.jhep.2007.01.031

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 30061370

Title: Mutations in IRS4 are associated with central hypothyroidism.

PubMed ID: 30061370

DOI: 10.1136/jmedgenet-2017-105113

Sequence Information:

  • Length: 1257
  • Mass: 133768
  • Checksum: 4D512D65A7A80374
  • Sequence:
    • MASCSFTRDQ ATRRLRGAAA AAAAALAAVV TTPLLSSGTP TALIGTGSSC PGAMWLSTAT 
GSRSDSESEE EDLPVGEEVC KRGYLRKQKH GHRRYFVLKL ETADAPARLE YYENARKFRH 
SVRAAAAAAA AAASGAAIPP LIPPRRVITL YQCFSVSQRA DARYRHLIAL FTQDEYFAMV 
AENESEQESW YLLLSRLILE SKRRRCGTLG AQPDGEPAAL AAAAAAEPPF YKDVWQVIVK 
PRGLGHRKEL SGVFRLCLTD EEVVFVRLNT EVASVVVQLL SIRRCGHSEQ YFFLEVGRST 
VIGPGELWMQ VDDCVVAQNM HELFLEKMRA LCADEYRARC RSYSISIGAH LLTLLSARRH 
LGLVPLEPGG WLRRSRFEQF CHLRAIGDGE DEMLFTRRFV TPSEPVAHSR RGRLHLPRGR 
RSRRAVSVPA SFFRRLAPSP ARPRHPAEAP NNGARLSSEV SGSGSGNFGE EGNPQGKEDQ 
EGSGGDYMPM NNWGSGNGRG SGGGQGSNGQ GSSSHSSGGN QCSGEGQGSR GGQGSNGQGS 
GGNQCSRDGQ GTAGGHGSGG GQRPGGGHGS GGGQGPGDGH GSGGGKNSGG GKGSGSGKGS 
DGDGERGKSL KKRSYFGKLT QSKQQQMPPP PPPPPPPPPA GGTGGKGKSG GRFRLYFCVD 
RGATKECKEA KEVKDAEIPE GAARGPHRAR AFDEDEDDPY VPMRPGVATP LVSSSDYMPM 
APQNVSASKK RHSRSPFEDS RGYMMMFPRV SPPPAPSPPK APDTNKEDDS KDNDSESDYM 
FMAPGAGAIP KNPRNPQGGS SSKSWSSYFS LPNPFRSSPL GQNDNSEYVP MLPGKFLGRG 
LDKEVSYNWD PKDAASKPSG EGSFSKPGDG GSPSKPSDHE PPKNKAKRPN RLSFITKGYK 
IKPKPQKPTH EQREADSSSD YVNMDFTKRE SNTPAPSTQG LPDSWGIIAE PRQSAFSNYV 
NVEFGVPFPN PANDLSDLLR AIPRANPLSL DSARWPLPPL PLSATGSNAI EEEGDYIEVI 
FNSAMTPAMA LADSAIRYDA ETGRIYVVDP FSECCMDISL SPSRCSEPPP VARLLQEEEQ 
ERRRPQSRSQ SFFAAARAAV SAFPTDSLER DLSPSSAPAV ASAAEPTLAL SQVVAAASAL 
AAAPGIGAAA AAAGFDSASA RWFQPVANAA DAEAVRGAQD VAGGSNPGAH NPSANLARGD 
NQAGGAAAAA AAPEPPPRSR RVPRPPERED SDNDDDTHVR MDFARRDNQF DSPKRGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.