Details for: LIPF

Gene ID: 8513

Symbol: LIPF

Ensembl ID: ENSG00000182333

Description: lipase F, gastric type

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6100
    Cell Significance Index: 14.7800
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.1700
    Cell Significance Index: 0.8100
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.1238
    Cell Significance Index: 1.1000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0123
    Cell Significance Index: 0.0800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0074
    Cell Significance Index: 0.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0033
    Cell Significance Index: 0.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0003
    Cell Significance Index: -0.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0053
    Cell Significance Index: -0.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0058
    Cell Significance Index: -0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0064
    Cell Significance Index: -12.0500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0072
    Cell Significance Index: -0.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0073
    Cell Significance Index: -0.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0097
    Cell Significance Index: -6.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0119
    Cell Significance Index: -0.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0139
    Cell Significance Index: -0.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0189
    Cell Significance Index: -10.3100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0189
    Cell Significance Index: -0.2800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0214
    Cell Significance Index: -0.2300
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0224
    Cell Significance Index: -0.3100
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0240
    Cell Significance Index: -0.2300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0243
    Cell Significance Index: -0.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0268
    Cell Significance Index: -3.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0286
    Cell Significance Index: -10.2700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0293
    Cell Significance Index: -0.2000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0308
    Cell Significance Index: -0.2300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0320
    Cell Significance Index: -0.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0322
    Cell Significance Index: -5.8100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0352
    Cell Significance Index: -0.3200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0367
    Cell Significance Index: -0.3500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0381
    Cell Significance Index: -0.0900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0405
    Cell Significance Index: -0.3900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0428
    Cell Significance Index: -0.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0486
    Cell Significance Index: -5.9700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0489
    Cell Significance Index: -0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0511
    Cell Significance Index: -14.6900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0528
    Cell Significance Index: -0.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0599
    Cell Significance Index: -12.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0722
    Cell Significance Index: -7.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0759
    Cell Significance Index: -10.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0783
    Cell Significance Index: -6.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0832
    Cell Significance Index: -14.2000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0857
    Cell Significance Index: -0.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1215
    Cell Significance Index: -24.1100
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.1237
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1240
    Cell Significance Index: -14.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1588
    Cell Significance Index: -10.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2374
    Cell Significance Index: -13.3200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2405
    Cell Significance Index: -4.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2469
    Cell Significance Index: -7.2700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3261
    Cell Significance Index: -3.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3482
    Cell Significance Index: -15.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3501
    Cell Significance Index: -11.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3739
    Cell Significance Index: -12.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3743
    Cell Significance Index: -10.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3785
    Cell Significance Index: -13.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3833
    Cell Significance Index: -10.2700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3910
    Cell Significance Index: -4.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4096
    Cell Significance Index: -15.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4189
    Cell Significance Index: -7.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4485
    Cell Significance Index: -9.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4795
    Cell Significance Index: -12.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4939
    Cell Significance Index: -12.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5161
    Cell Significance Index: -11.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5162
    Cell Significance Index: -10.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5256
    Cell Significance Index: -11.1600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5342
    Cell Significance Index: -11.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5356
    Cell Significance Index: -7.6700
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.5361
    Cell Significance Index: -6.1500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5361
    Cell Significance Index: -10.6900
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.5546
    Cell Significance Index: -6.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5554
    Cell Significance Index: -11.1500
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.5641
    Cell Significance Index: -5.9700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.5869
    Cell Significance Index: -4.6700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.5987
    Cell Significance Index: -6.9600
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.5991
    Cell Significance Index: -6.3000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.6117
    Cell Significance Index: -5.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6200
    Cell Significance Index: -12.2600
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.6210
    Cell Significance Index: -7.3900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.6258
    Cell Significance Index: -5.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6419
    Cell Significance Index: -30.1700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.6421
    Cell Significance Index: -8.3800
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.6428
    Cell Significance Index: -6.1900
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.6441
    Cell Significance Index: -6.9500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.6577
    Cell Significance Index: -9.8400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.6607
    Cell Significance Index: -7.9900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.6714
    Cell Significance Index: -7.9800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6736
    Cell Significance Index: -13.1700
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.6812
    Cell Significance Index: -7.4400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7105
    Cell Significance Index: -12.2900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.7284
    Cell Significance Index: -8.8600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.7335
    Cell Significance Index: -9.2900
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.7340
    Cell Significance Index: -7.2900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.7434
    Cell Significance Index: -8.7600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.7554
    Cell Significance Index: -11.0100
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.7621
    Cell Significance Index: -7.1000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.7645
    Cell Significance Index: -10.6900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.7818
    Cell Significance Index: -9.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gastric lipase**: LIPF is specifically secreted into the gastric lumen, where it hydrolyzes triglycerides into monoglycerides and free fatty acids. 2. **Triglyceride lipase activity**: LIPF exhibits triglyceride lipase activity, making it a key player in lipid digestion and metabolism. 3. **Expression in various cell types**: LIPF is expressed in progenitor cells, enteroendocrine cells, blood vessel endothelial cells, and immune cells, including CD8-positive T cells and natural T-regulatory cells. 4. **Intracellular localization**: LIPF is primarily localized to the intracellular membrane-bounded organelle, where it can be involved in lipid metabolism and signaling pathways. **Pathways and Functions:** LIPF is involved in several key pathways and functions, including: 1. **Digestion and absorption of dietary lipids**: LIPF breaks down triglycerides into monoglycerides and free fatty acids, facilitating their absorption and utilization by the body. 2. **Lipid catabolic process**: LIPF is involved in the catabolism of triglycerides, releasing fatty acids and glycerol for energy production and storage. 3. **Lipid binding**: LIPF binds to triglycerides, facilitating their hydrolysis and release of fatty acids and glycerol. 4. **Malate dehydrogenase activity**: LIPF exhibits malate dehydrogenase activity, which is involved in the metabolism of malate and other organic acids. 5. **Mitochondrial function**: LIPF is localized to the mitochondria, where it can be involved in lipid metabolism and energy production. **Clinical Significance:** Dysregulation of LIPF has been implicated in various diseases, including: 1. **Lipid metabolism disorders**: Altered LIPF expression has been linked to lipid metabolism disorders, such as hypertriglyceridemia and dyslipidemia. 2. **Gastrointestinal disorders**: Abnormal LIPF expression has been observed in gastrointestinal disorders, such as gastric ulcers and inflammatory bowel disease. 3. **Immune system dysregulation**: LIPF expression in immune cells has been linked to immune system dysregulation, including autoimmune diseases and inflammatory responses. In conclusion, LIPF is a crucial enzyme involved in lipid digestion and metabolism, with significant implications for our understanding of lipid metabolism disorders and immune system regulation. Further research is needed to fully elucidate the functional significance of LIPF and its role in human disease.

Genular Protein ID: 29848534

Symbol: LIPF_HUMAN

Name: Gastric triacylglycerol lipase

UniProtKB Accession Codes:

P07098 B7Z723 F5H1P4 Q2M1P6 Q5VXI7 Q5VXI8 Q658L8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 11 ESTHER 1 Ensembl 4 EvolutionaryTrace 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 5 Rhea 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3304425

Title: Molecular cloning of a human gastric lipase and expression of the enzyme in yeast.

PubMed ID: 3304425

DOI: 10.1016/0167-4781(87)90083-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2753032

Title: Human gastric lipase. The N-terminal tetrapeptide is essential for lipid binding and lipase activity.

PubMed ID: 2753032

DOI: 10.1111/j.1432-1033.1989.tb14855.x

PubMed ID: 2243091

Title: Stereoselectivity of lipases. II. Stereoselective hydrolysis of triglycerides by gastric and pancreatic lipases.

PubMed ID: 2243091

DOI: 10.1016/s0021-9258(17)30500-8

PubMed ID: 10358049

Title: Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest.

PubMed ID: 10358049

DOI: 10.1074/jbc.274.24.16995

Sequence Information:

  • Length: 398
  • Mass: 45238
  • Checksum: CD3EE1621C014F0F
  • Sequence:
    • MWLLLTMASL ISVLGTTHGL FGKLHPGSPE VTMNISQMIT YWGYPNEEYE VVTEDGYILE 
VNRIPYGKKN SGNTGQRPVV FLQHGLLASA TNWISNLPNN SLAFILADAG YDVWLGNSRG 
NTWARRNLYY SPDSVEFWAF SFDEMAKYDL PATIDFIVKK TGQKQLHYVG HSQGTTIGFI 
AFSTNPSLAK RIKTFYALAP VATVKYTKSL INKLRFVPQS LFKFIFGDKI FYPHNFFDQF 
LATEVCSREM LNLLCSNALF IICGFDSKNF NTSRLDVYLS HNPAGTSVQN MFHWTQAVKS 
GKFQAYDWGS PVQNRMHYDQ SQPPYYNVTA MNVPIAVWNG GKDLLADPQD VGLLLPKLPN 
LIYHKEIPFY NHLDFIWAMD APQEVYNDIV SMISEDKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.