Details for: MKNK1

Gene ID: 8569

Symbol: MKNK1

Ensembl ID: ENSG00000079277

Description: MAPK interacting serine/threonine kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 178.2118
    Cell Significance Index: -27.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 112.3231
    Cell Significance Index: -28.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.7127
    Cell Significance Index: -26.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.5055
    Cell Significance Index: -29.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.2831
    Cell Significance Index: -29.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9184
    Cell Significance Index: -26.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.6866
    Cell Significance Index: -21.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8205
    Cell Significance Index: -30.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6889
    Cell Significance Index: 338.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0533
    Cell Significance Index: 72.8400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8961
    Cell Significance Index: 619.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8108
    Cell Significance Index: 290.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7752
    Cell Significance Index: 699.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6457
    Cell Significance Index: 75.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6096
    Cell Significance Index: 16.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6026
    Cell Significance Index: 119.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5736
    Cell Significance Index: 16.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5507
    Cell Significance Index: 42.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5103
    Cell Significance Index: 9.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4704
    Cell Significance Index: 80.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4621
    Cell Significance Index: 50.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4557
    Cell Significance Index: 74.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4229
    Cell Significance Index: 76.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4138
    Cell Significance Index: 50.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4101
    Cell Significance Index: 24.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4009
    Cell Significance Index: 5.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3843
    Cell Significance Index: 8.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3771
    Cell Significance Index: 37.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3194
    Cell Significance Index: 16.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3148
    Cell Significance Index: 14.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3010
    Cell Significance Index: 20.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2751
    Cell Significance Index: 5.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2345
    Cell Significance Index: 128.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1897
    Cell Significance Index: 26.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1753
    Cell Significance Index: 77.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1406
    Cell Significance Index: 4.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1336
    Cell Significance Index: 8.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1330
    Cell Significance Index: 25.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1192
    Cell Significance Index: 3.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1098
    Cell Significance Index: 2.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0566
    Cell Significance Index: 1.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0436
    Cell Significance Index: 82.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0195
    Cell Significance Index: 2.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0188
    Cell Significance Index: 11.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0145
    Cell Significance Index: 22.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0143
    Cell Significance Index: 26.4000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0080
    Cell Significance Index: 0.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0070
    Cell Significance Index: 0.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0008
    Cell Significance Index: 0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0005
    Cell Significance Index: -0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0286
    Cell Significance Index: -20.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0286
    Cell Significance Index: -21.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0300
    Cell Significance Index: -22.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0330
    Cell Significance Index: -4.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0331
    Cell Significance Index: -0.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0378
    Cell Significance Index: -2.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0393
    Cell Significance Index: -1.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0460
    Cell Significance Index: -25.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0541
    Cell Significance Index: -5.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0555
    Cell Significance Index: -34.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0664
    Cell Significance Index: -4.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0710
    Cell Significance Index: -3.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0775
    Cell Significance Index: -3.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0894
    Cell Significance Index: -25.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0902
    Cell Significance Index: -11.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1075
    Cell Significance Index: -12.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1146
    Cell Significance Index: -3.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1272
    Cell Significance Index: -7.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1565
    Cell Significance Index: -32.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1596
    Cell Significance Index: -7.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1634
    Cell Significance Index: -4.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1678
    Cell Significance Index: -10.3200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1678
    Cell Significance Index: -2.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2443
    Cell Significance Index: -25.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2519
    Cell Significance Index: -9.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2587
    Cell Significance Index: -5.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2660
    Cell Significance Index: -13.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2937
    Cell Significance Index: -15.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3217
    Cell Significance Index: -4.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3451
    Cell Significance Index: -18.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3475
    Cell Significance Index: -21.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3476
    Cell Significance Index: -27.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3637
    Cell Significance Index: -9.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4259
    Cell Significance Index: -13.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4271
    Cell Significance Index: -8.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4384
    Cell Significance Index: -11.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4648
    Cell Significance Index: -4.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4898
    Cell Significance Index: -10.4000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4928
    Cell Significance Index: -12.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4966
    Cell Significance Index: -31.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5151
    Cell Significance Index: -8.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5350
    Cell Significance Index: -17.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5605
    Cell Significance Index: -12.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5651
    Cell Significance Index: -18.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5693
    Cell Significance Index: -16.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5927
    Cell Significance Index: -14.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5947
    Cell Significance Index: -11.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6155
    Cell Significance Index: -12.1700
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.6202
    Cell Significance Index: -2.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine/Threonine Kinase Activity:** MKNK1 possesses serine/threonine kinase activity, which allows it to phosphorylate and regulate the activity of downstream targets. 2. **FGF Signaling Modulation:** MKNK1 negatively regulates the signaling activity of FGFRs, which are critical for cell growth, differentiation, and survival. 3. **Interactions with MAPK Pathways:** MKNK1 interacts with MAPK signaling pathways, modulating the activity of downstream targets and influencing various cellular processes. 4. **Regulation of Translation and Autophagy:** MKNK1 regulates protein translation and autophagy, which are essential for cellular homeostasis and response to stress. **Pathways and Functions:** 1. **FGF Signaling Pathway:** MKNK1 negatively regulates the signaling activity of FGFRs, which are critical for cell growth, differentiation, and survival. 2. **MAPK Signaling Pathway:** MKNK1 interacts with MAPK signaling pathways, modulating the activity of downstream targets and influencing various cellular processes. 3. **Translation Regulation:** MKNK1 regulates protein translation, which is essential for cellular homeostasis and response to stress. 4. **Autophagy Regulation:** MKNK1 regulates autophagy, which is critical for maintaining cellular homeostasis and responding to stress. 5. **Cell Growth and Differentiation:** MKNK1 regulates cell growth and differentiation by modulating the activity of FGFRs and MAPK signaling pathways. **Clinical Significance:** 1. **Cancer:** MKNK1 has been implicated in cancer development and progression, where it may play a role in regulating cell growth and survival. 2. **Neurological Disorders:** MKNK1 may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may be involved in regulating protein translation and autophagy. 3. **Immune Response:** MKNK1 may play a role in regulating the immune response, where it may be involved in modulating the activity of immune cells, such as microglial cells and macrophages. 4. **Infectious Diseases:** MKNK1 may play a role in regulating the response to infectious diseases, where it may be involved in modulating the activity of immune cells and regulating protein translation. In conclusion, MKNK1 is a complex serine/threonine kinase that plays a critical role in regulating various cellular processes, including intracellular signaling, translation, and cell growth. Its involvement in FGF signaling, MAPK pathways, and regulation of translation and autophagy makes it a promising target for therapeutic interventions in various diseases, including cancer, neurological disorders, and infectious diseases.

Genular Protein ID: 3512034275

Symbol: MKNK1_HUMAN

Name: MAP kinase-interacting serine/threonine-protein kinase 1

UniProtKB Accession Codes:

Q9BUB5 D3DQ20 D3DQ21 O00312 Q5TC06 Q5TC07 Q6V0N6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CORUM 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 ELM 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9155018

Title: MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.

PubMed ID: 9155018

DOI: 10.1093/emboj/16.8.1921

PubMed ID: 11463832

Title: Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.

PubMed ID: 11463832

DOI: 10.1128/mcb.21.16.5500-5511.2001

PubMed ID: 15350534

Title: Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1.

PubMed ID: 15350534

DOI: 10.1016/j.yexcr.2004.06.006

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9878069

Title: Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.

PubMed ID: 9878069

DOI: 10.1093/emboj/18.1.270

PubMed ID: 15234964

Title: Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.

PubMed ID: 15234964

DOI: 10.1074/jbc.m407337200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 465
  • Mass: 51342
  • Checksum: CAE225C35DCB2B43
  • Sequence:
    • MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL TSELLGEGAY 
AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ CQGNKNILEL IEFFEDDTRF 
YLVFEKLQGG SILAHIQKQK HFNEREASRV VRDVAAALDF LHTKDKVSLC HLGWSAMAPS 
GLTAAPTSLG SSDPPTSASQ VAGTTGIAHR DLKPENILCE SPEKVSPVKI CDFDLGSGMK 
LNNSCTPITT PELTTPCGSA EYMAPEVVEV FTDQATFYDK RCDLWSLGVV LYIMLSGYPP 
FVGHCGADCG WDRGEVCRVC QNKLFESIQE GKYEFPDKDW AHISSEAKDL ISKLLVRDAK 
QRLSAAQVLQ HPWVQGQAPE KGLPTPQVLQ RNSSTMDLTL FAAEAIALNR QLSQHEENEL 
AEEPEALADG LCSMKLSPPC KSRLARRRAL AQAGRGEDRS PPTAL

Genular Protein ID: 2785632776

Symbol: A8K341_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K341

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 12 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 8 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 6 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 347
  • Mass: 39132
  • Checksum: 02053F5C2D39641F
  • Sequence:
    • MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL TSELLGEGAY 
AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ CQGNKNILEL IEFFEDDTRF 
YLVFEKLQGG SILAHIQKQK HFNEREASRV VRDVAAALDF LHTKGIAHRD LKPENILCES 
PEKVSPVKIC DFDLGSGMKL NNSCTPITTP ELTTPCGSAE YMAPEVVEVF TDQATFYDKR 
CDLWSLGVVL YIMLSGYPPF VGHCGADCGW DRGEVCRVCQ NKLFESIQEG KYEFPDKDWA 
HISSEARDLI SKLLVRDAKQ RLSAAQVLQH PWVQGEQQHN GPDALRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.