Details for: B3GALT2

Gene ID: 8707

Symbol: B3GALT2

Ensembl ID: ENSG00000162630

Description: beta-1,3-galactosyltransferase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.4334
    Cell Significance Index: -9.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 23.2990
    Cell Significance Index: -11.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.1846
    Cell Significance Index: 69.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.0251
    Cell Significance Index: -6.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.9016
    Cell Significance Index: 116.5900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.6963
    Cell Significance Index: 13.0800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8095
    Cell Significance Index: 13.3400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.6530
    Cell Significance Index: 4.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5888
    Cell Significance Index: 211.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5204
    Cell Significance Index: 104.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4170
    Cell Significance Index: 25.6300
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.3443
    Cell Significance Index: 3.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3439
    Cell Significance Index: 7.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3353
    Cell Significance Index: 302.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3343
    Cell Significance Index: 33.0700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3163
    Cell Significance Index: 6.7600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2856
    Cell Significance Index: 3.8100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2552
    Cell Significance Index: 6.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2070
    Cell Significance Index: 22.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1952
    Cell Significance Index: 31.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1724
    Cell Significance Index: 10.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1671
    Cell Significance Index: 115.5500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1532
    Cell Significance Index: 1.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1059
    Cell Significance Index: 2.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1042
    Cell Significance Index: 3.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0889
    Cell Significance Index: 2.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0855
    Cell Significance Index: 4.4900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.0825
    Cell Significance Index: 0.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0757
    Cell Significance Index: 5.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0746
    Cell Significance Index: 5.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0719
    Cell Significance Index: 13.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0568
    Cell Significance Index: 11.2800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0540
    Cell Significance Index: 0.6500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0491
    Cell Significance Index: 0.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0291
    Cell Significance Index: 1.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0283
    Cell Significance Index: 3.6300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0224
    Cell Significance Index: 0.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0188
    Cell Significance Index: 0.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0162
    Cell Significance Index: 0.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0063
    Cell Significance Index: 0.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0028
    Cell Significance Index: 0.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0027
    Cell Significance Index: 4.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0024
    Cell Significance Index: -0.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0057
    Cell Significance Index: -0.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0065
    Cell Significance Index: -4.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0091
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0120
    Cell Significance Index: -8.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0134
    Cell Significance Index: -5.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0137
    Cell Significance Index: -0.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0161
    Cell Significance Index: -9.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0166
    Cell Significance Index: -12.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0181
    Cell Significance Index: -11.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0191
    Cell Significance Index: -10.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0301
    Cell Significance Index: -8.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0399
    Cell Significance Index: -7.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0449
    Cell Significance Index: -0.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0459
    Cell Significance Index: -6.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0459
    Cell Significance Index: -6.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0521
    Cell Significance Index: -6.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0540
    Cell Significance Index: -11.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0572
    Cell Significance Index: -6.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0664
    Cell Significance Index: -1.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0673
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0673
    Cell Significance Index: -11.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0706
    Cell Significance Index: -8.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0712
    Cell Significance Index: -1.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0739
    Cell Significance Index: -4.1500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0817
    Cell Significance Index: -1.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0854
    Cell Significance Index: -5.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0865
    Cell Significance Index: -11.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0872
    Cell Significance Index: -10.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1039
    Cell Significance Index: -10.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1100
    Cell Significance Index: -5.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1118
    Cell Significance Index: -11.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1121
    Cell Significance Index: -1.6900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1128
    Cell Significance Index: -1.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1315
    Cell Significance Index: -2.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1404
    Cell Significance Index: -6.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1421
    Cell Significance Index: -7.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1595
    Cell Significance Index: -6.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1658
    Cell Significance Index: -4.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1722
    Cell Significance Index: -11.1100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1744
    Cell Significance Index: -1.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1771
    Cell Significance Index: -4.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1814
    Cell Significance Index: -9.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1861
    Cell Significance Index: -6.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1898
    Cell Significance Index: -4.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2035
    Cell Significance Index: -4.3200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2036
    Cell Significance Index: -1.9300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2104
    Cell Significance Index: -2.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2127
    Cell Significance Index: -10.0000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2134
    Cell Significance Index: -1.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2392
    Cell Significance Index: -4.7300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2476
    Cell Significance Index: -3.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2632
    Cell Significance Index: -4.5100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2779
    Cell Significance Index: -8.7900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2818
    Cell Significance Index: -4.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** B3GALT2 is a type II transmembrane glycosyltransferase that catalyzes the transfer of galactose units from UDP-galactose to the growing glycosphingolipid or glycoprotein chain. This enzyme is characterized by its ability to use UDP-galactose as the donor sugar and 2-acetamido-2-deoxy-D-glucose as the acceptor sugar. B3GALT2 is also known for its involvement in the biosynthesis of Lewis blood group antigens, which are recognized by natural killer cells and other immune cells. **Pathways and Functions** B3GALT2 is involved in several key pathways, including: 1. **Blood group systems biosynthesis**: B3GALT2 is responsible for the synthesis of Lewis blood group antigens, which are recognized by natural killer cells and other immune cells. 2. **Galactosylceramide biosynthetic process**: B3GALT2 is involved in the synthesis of galactosylceramide, a glycosphingolipid that plays a role in cellular recognition and signaling. 3. **Glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity**: B3GALT2 is involved in the synthesis of glucosaminylgalactosylglucosylceramide, a glycosphingolipid that plays a role in cellular recognition and signaling. 4. **Golgi membrane**: B3GALT2 is localized to the Golgi membrane, where it is involved in the synthesis of glycosphingolipids and glycoproteins. 5. **Oligosaccharide biosynthetic process**: B3GALT2 is involved in the synthesis of oligosaccharides, which are essential for cellular recognition, signaling, and immune responses. **Clinical Significance** Dysregulation of B3GALT2 has been implicated in various diseases, including: 1. **Immune disorders**: B3GALT2 is involved in the recognition of self and non-self cells, and dysregulation of this enzyme has been implicated in autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Cancer**: B3GALT2 is involved in the synthesis of Lewis blood group antigens, which are recognized by natural killer cells and other immune cells. Dysregulation of this enzyme has been implicated in the development of certain types of cancer, such as colon cancer. 3. **Neurological disorders**: B3GALT2 is involved in the synthesis of glycosphingolipids and glycoproteins, which are essential for neuronal function and development. Dysregulation of this enzyme has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, B3GALT2 is a critical enzyme involved in the biosynthesis of glycosphingolipids and glycoproteins, playing a vital role in various cellular processes. Dysregulation of this enzyme has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of B3GALT2.

Genular Protein ID: 375784489

Symbol: B3GT2_HUMAN

Name: UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2

UniProtKB Accession Codes:

O43825 B2RAB1 Q9BZQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 16 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 5 SABIO-RK 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9417100

Title: Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains.

PubMed ID: 9417100

DOI: 10.1074/jbc.273.1.433

PubMed ID: 9582303

Title: A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-N-acetyl-galactosamine beta-1,3-galactosyltransferase family.

PubMed ID: 9582303

DOI: 10.1074/jbc.273.21.12770

PubMed ID: 11318611

Title: Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.

PubMed ID: 11318611

DOI: 10.1006/geno.2001.6500

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 422
  • Mass: 49213
  • Checksum: BA62942D6AFB4B0C
  • Sequence:
    • MLQWRRRHCC FAKMTWNAKR SLFRTHLIGV LSLVFLFAMF LFFNHHDWLP GRAGFKENPV 
TYTFRGFRST KSETNHSSLR NIWKETVPQT LRPQTATNSN NTDLSPQGVT GLENTLSANG 
SIYNEKGTGH PNSYHFKYII NEPEKCQEKS PFLILLIAAE PGQIEARRAI RQTWGNESLA 
PGIQITRIFL LGLSIKLNGY LQRAILEESR QYHDIIQQEY LDTYYNLTIK TLMGMNWVAT 
YCPHIPYVMK TDSDMFVNTE YLINKLLKPD LPPRHNYFTG YLMRGYAPNR NKDSKWYMPP 
DLYPSERYPV FCSGTGYVFS GDLAEKIFKV SLGIRRLHLE DVYVGICLAK LRIDPVPPPN 
EFVFNHWRVS YSSCKYSHLI TSHQFQPSEL IKYWNHLQQN KHNACANAAK EKAGRYRHRK 
LH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.