Details for: ABCC3

Gene ID: 8714

Symbol: ABCC3

Ensembl ID: ENSG00000108846

Description: ATP binding cassette subfamily C member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 129.2872
    Cell Significance Index: -20.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.3240
    Cell Significance Index: -20.1200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 40.3297
    Cell Significance Index: -20.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.5076
    Cell Significance Index: -17.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.3185
    Cell Significance Index: -20.1200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 12.5835
    Cell Significance Index: 111.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5853
    Cell Significance Index: -20.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 6.9257
    Cell Significance Index: 193.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.3753
    Cell Significance Index: -16.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1064
    Cell Significance Index: -20.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.9648
    Cell Significance Index: 225.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.8328
    Cell Significance Index: 131.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 4.8180
    Cell Significance Index: 104.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.1110
    Cell Significance Index: 69.2500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 3.9535
    Cell Significance Index: 14.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.8394
    Cell Significance Index: 110.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.3532
    Cell Significance Index: 45.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.9463
    Cell Significance Index: 153.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9951
    Cell Significance Index: 217.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9922
    Cell Significance Index: -4.3600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.9617
    Cell Significance Index: 21.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7801
    Cell Significance Index: 320.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6918
    Cell Significance Index: 1527.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6231
    Cell Significance Index: 199.5700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4102
    Cell Significance Index: 21.1300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.3664
    Cell Significance Index: 8.4300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.2857
    Cell Significance Index: 12.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0767
    Cell Significance Index: 9.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.9955
    Cell Significance Index: 24.8900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.8969
    Cell Significance Index: 5.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8750
    Cell Significance Index: 30.7500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.7753
    Cell Significance Index: 6.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6759
    Cell Significance Index: 134.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5944
    Cell Significance Index: 12.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4584
    Cell Significance Index: 9.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.4299
    Cell Significance Index: 7.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3657
    Cell Significance Index: 19.0500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.3649
    Cell Significance Index: 3.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3388
    Cell Significance Index: 5.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2758
    Cell Significance Index: 52.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2723
    Cell Significance Index: 26.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2630
    Cell Significance Index: 30.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2473
    Cell Significance Index: 7.9200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2060
    Cell Significance Index: 3.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1924
    Cell Significance Index: 13.6100
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.1778
    Cell Significance Index: 0.2300
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.1763
    Cell Significance Index: 0.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1609
    Cell Significance Index: 32.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1554
    Cell Significance Index: 68.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1553
    Cell Significance Index: 10.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1376
    Cell Significance Index: 75.1400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1190
    Cell Significance Index: 0.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1037
    Cell Significance Index: 16.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0600
    Cell Significance Index: 10.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0068
    Cell Significance Index: 0.5100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0124
    Cell Significance Index: -22.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0142
    Cell Significance Index: -9.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0143
    Cell Significance Index: -22.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0170
    Cell Significance Index: -10.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0180
    Cell Significance Index: -24.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0184
    Cell Significance Index: -13.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0217
    Cell Significance Index: -7.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0256
    Cell Significance Index: -18.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0285
    Cell Significance Index: -21.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0316
    Cell Significance Index: -19.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0352
    Cell Significance Index: -4.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0370
    Cell Significance Index: -20.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0395
    Cell Significance Index: -4.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0400
    Cell Significance Index: -18.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0498
    Cell Significance Index: -2.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0650
    Cell Significance Index: -18.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0675
    Cell Significance Index: -9.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0849
    Cell Significance Index: -10.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0979
    Cell Significance Index: -11.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1138
    Cell Significance Index: -23.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1211
    Cell Significance Index: -15.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1408
    Cell Significance Index: -7.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1454
    Cell Significance Index: -1.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1518
    Cell Significance Index: -11.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1831
    Cell Significance Index: -21.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1832
    Cell Significance Index: -8.6100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1838
    Cell Significance Index: -1.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1874
    Cell Significance Index: -19.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2386
    Cell Significance Index: -14.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2452
    Cell Significance Index: -19.4200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2698
    Cell Significance Index: -2.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2849
    Cell Significance Index: -19.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3174
    Cell Significance Index: -8.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3269
    Cell Significance Index: -21.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3314
    Cell Significance Index: -20.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3651
    Cell Significance Index: -9.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3890
    Cell Significance Index: -21.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3902
    Cell Significance Index: -24.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4099
    Cell Significance Index: -5.8700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4229
    Cell Significance Index: -6.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4277
    Cell Significance Index: -18.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4356
    Cell Significance Index: -22.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4529
    Cell Significance Index: -12.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ABCC3 is a transmembrane protein belonging to the ABC family of transporters, characterized by its ATP-binding cassette domain. The protein has 12 transmembrane domains, which form a pore that allows the transport of substrates across the cell membrane. ABCC3 is highly specific for its substrates, with a wide range of ligands, including bile acids, bile salts, glucuronosides, icosanoids, and xenobiotics. The protein is also involved in the regulation of cellular responses to stimuli, stress, and chemical stress, and its expression is regulated by various transcription factors, including Nrf2. **Pathways and Functions** ABCC3 is involved in several cellular pathways, including: 1. **Bile acid and bile salt metabolism**: ABCC3 is responsible for the efflux of bile acids and bile salts from hepatocytes, which plays a critical role in the regulation of bile acid homeostasis and the prevention of bile acid toxicity. 2. **Xenobiotic transport**: ABCC3 is involved in the efflux of xenobiotics, including drugs and environmental toxins, from cells, which helps to protect against the toxic effects of these substances. 3. **Glucuronoside transport**: ABCC3 is responsible for the efflux of glucuronosides, which are metabolites of various drugs and xenobiotics, from cells. 4. **Leukotriene transport**: ABCC3 is involved in the transport of leukotrienes, which are pro-inflammatory mediators, from cells. 5. **Cellular responses to stimuli**: ABCC3 is regulated by various transcription factors, including Nrf2, which is involved in the regulation of cellular responses to oxidative stress and other stimuli. **Clinical Significance** Dysregulation of ABCC3 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of ABCC3 has been observed in various types of cancer, including breast, lung, and colon cancer, and has been associated with poor prognosis. 2. **Metabolic disorders**: ABCC3 has been implicated in the regulation of lipid metabolism and glucose homeostasis, and its dysregulation has been linked to metabolic disorders, including obesity and type 2 diabetes. 3. **Neurological disorders**: ABCC3 has been implicated in the transport of neurotransmitters and other substances across the blood-brain barrier, and its dysregulation has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Toxicity**: ABCC3 plays a critical role in the efflux of xenobiotics from cells, and its dysregulation has been linked to increased toxicity of various substances, including drugs and environmental toxins. In conclusion, ABCC3 is a critical gene involved in the transport of various substances across cellular membranes, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of ABCC3 in human health and disease.

Genular Protein ID: 721390770

Symbol: MRP3_HUMAN

Name: ATP-binding cassette sub-family C member 3

UniProtKB Accession Codes:

O15438 B2RPA9 D3DTX9 O60265 O60922 O75621 O95078 O95289 O95290 Q86X85 Q9UN52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CTD 1 ChEBI 62 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 31 DrugCentral 1 EC 2 EMBL 18 EMDB 4 Ensembl 4 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 Rhea 19 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9813153

Title: Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport.

PubMed ID: 9813153

DOI: 10.1006/bbrc.1998.9546

PubMed ID: 9738950

Title: cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).

PubMed ID: 9738950

DOI: 10.1016/s0014-5793(98)00899-0

PubMed ID: 9827529

Title: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins.

PubMed ID: 9827529

DOI: 10.1093/jnci/90.22.1735

PubMed ID: 9889399

Title: Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants.

PubMed ID: 9889399

DOI: 10.1016/s0005-2736(98)00233-8

PubMed ID: 10094960

Title: Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane.

PubMed ID: 10094960

DOI: 10.1002/hep.510290404

PubMed ID: 10359813

Title: MRP3, an organic anion transporter able to transport anti-cancer drugs.

PubMed ID: 10359813

DOI: 10.1073/pnas.96.12.6914

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9270026

Title: Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

PubMed ID: 9270026

PubMed ID: 11581266

Title: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

PubMed ID: 11581266

DOI: 10.1074/jbc.m107041200

PubMed ID: 15083066

Title: Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3).

PubMed ID: 15083066

DOI: 10.1097/00008571-200404000-00001

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28408210

Title: The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers.

PubMed ID: 28408210

DOI: 10.1016/j.xphs.2017.04.001

PubMed ID: 35307651

Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

PubMed ID: 35307651

DOI: 10.1124/dmd.121.000748

Sequence Information:

  • Length: 1527
  • Mass: 169343
  • Checksum: 0D1F879B6F18370C
  • Sequence:
    • MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP CYLLYLRHHC 
RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA PAPVFFVTPL VVGVTMLLAT 
LLIQYERLQG VQSSGVLIIF WFLCVVCAIV PFRSKILLAK AEGEISDPFR FTTFYIHFAL 
VLSALILACF REKPPFFSAK NVDPNPYPET SAGFLSRLFF WWFTKMAIYG YRHPLEEKDL 
WSLKEEDRSQ MVVQQLLEAW RKQEKQTARH KASAAPGKNA SGEDEVLLGA RPRPRKPSFL 
KALLATFGSS FLISACFKLI QDLLSFINPQ LLSILIRFIS NPMAPSWWGF LVAGLMFLCS 
MMQSLILQHY YHYIFVTGVK FRTGIMGVIY RKALVITNSV KRASTVGEIV NLMSVDAQRF 
MDLAPFLNLL WSAPLQIILA IYFLWQNLGP SVLAGVAFMV LLIPLNGAVA VKMRAFQVKQ 
MKLKDSRIKL MSEILNGIKV LKLYAWEPSF LKQVEGIRQG ELQLLRTAAY LHTTTTFTWM 
CSPFLVTLIT LWVYVYVDPN NVLDAEKAFV SVSLFNILRL PLNMLPQLIS NLTQASVSLK 
RIQQFLSQEE LDPQSVERKT ISPGYAITIH SGTFTWAQDL PPTLHSLDIQ VPKGALVAVV 
GPVGCGKSSL VSALLGEMEK LEGKVHMKGS VAYVPQQAWI QNCTLQENVL FGKALNPKRY 
QQTLEACALL ADLEMLPGGD QTEIGEKGIN LSGGQRQRVS LARAVYSDAD IFLLDDPLSA 
VDSHVAKHIF DHVIGPEGVL AGKTRVLVTH GISFLPQTDF IIVLADGQVS EMGPYPALLQ 
RNGSFANFLC NYAPDEDQGH LEDSWTALEG AEDKEALLIE DTLSNHTDLT DNDPVTYVVQ 
KQFMRQLSAL SSDGEGQGRP VPRRHLGPSE KVQVTEAKAD GALTQEEKAA IGTVELSVFW 
DYAKAVGLCT TLAICLLYVG QSAAAIGANV WLSAWTNDAM ADSRQNNTSL RLGVYAALGI 
LQGFLVMLAA MAMAAGGIQA ARVLHQALLH NKIRSPQSFF DTTPSGRILN CFSKDIYVVD 
EVLAPVILML LNSFFNAIST LVVIMASTPL FTVVILPLAV LYTLVQRFYA ATSRQLKRLE 
SVSRSPIYSH FSETVTGASV IRAYNRSRDF EIISDTKVDA NQRSCYPYII SNRWLSIGVE 
FVGNCVVLFA ALFAVIGRSS LNPGLVGLSV SYSLQVTFAL NWMIRMMSDL ESNIVAVERV 
KEYSKTETEA PWVVEGSRPP EGWPPRGEVE FRNYSVRYRP GLDLVLRDLS LHVHGGEKVG 
IVGRTGAGKS SMTLCLFRIL EAAKGEIRID GLNVADIGLH DLRSQLTIIP QDPILFSGTL 
RMNLDPFGSY SEEDIWWALE LSHLHTFVSS QPAGLDFQCS EGGENLSVGQ RQLVCLARAL 
LRKSRILVLD EATAAIDLET DNLIQATIRT QFDTCTVLTI AHRLNTIMDY TRVLVLDKGV 
VAEFDSPANL IAARGIFYGM ARDAGLA

Genular Protein ID: 3399721916

Symbol: Q86VN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86VN9

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 573
  • Mass: 64738
  • Checksum: B7CD551085F1CA88
  • Sequence:
    • PMDALCGSGE LGSKFWDSNL SVHTENPDLT PCFQNSLLAW VPCIYLWVAL PCYLLYLRHH 
CRGYIILSHL SKLKMVLGVL LWCVSWADLF YSFHGLVHGR APAPVFFVTP LVVGVTMLLA 
TLLIQYERLQ GVQSSGVLII FWFLCVVCAI VPFRSKILLA KAEGEISDPF RFTTFYIHFA 
LVLSALILAC FREKPPFFSA KNVDPNPYPE TSAGFLSRLF FWWFTKMAIY GYRHPLEEKD 
LWSLKEEDRS QMVVQQLLEA WRKQEKQTAR HKASAAPGKN ASGEDEVLLG ARPRPRKPSF 
LKALLATFGS SFLISACFKL IQDLLSFINP QLLSILIRFI SNPMAPSWWG FLVAGLMFLC 
SMMQSLILQH YYHYIFVTGV KFRTGIMGVI YRKALVITNS VKRASTVGEI VNLMSVDAQR 
FMDLAPFLNL LWSAPLQIIL AIYFLWQNLG PSVLAGVAFM VLLIPLNGAV AVKMRAFQVK 
QMKLKDSRIK LMSEILNGIK VLKLYAWEPS FLKQVEGIRQ GELQLLRTAA YLHTTTTFTW 
MCSPFLVRLG TGLGPCLHGS GCPGMARAHW TLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.