Details for: ABCC3

Gene ID: 8714

Symbol: ABCC3

Ensembl ID: ENSG00000108846

Description: ATP binding cassette subfamily C member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.95
    Marker Score: 3501
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.57
    Marker Score: 4040
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.26
    Marker Score: 12136
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.23
    Marker Score: 6994
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.07
    Marker Score: 13235
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.96
    Marker Score: 2035
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.89
    Marker Score: 12153
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.88
    Marker Score: 467
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.82
    Marker Score: 7867
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.8
    Marker Score: 8646
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.75
    Marker Score: 2574
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.67
    Marker Score: 8789
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.64
    Marker Score: 3099
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.57
    Marker Score: 1564
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.53
    Marker Score: 440.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.41
    Marker Score: 3209
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.41
    Marker Score: 3315
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.39
    Marker Score: 2833
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.39
    Marker Score: 3399
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.38
    Marker Score: 6790
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.38
    Marker Score: 1321
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.3
    Marker Score: 262
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.29
    Marker Score: 17371
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.29
    Marker Score: 3176
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.22
    Marker Score: 19099
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.21
    Marker Score: 842
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.17
    Marker Score: 920
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.14
    Marker Score: 2713
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.13
    Marker Score: 474
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.07
    Marker Score: 399
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.04
    Marker Score: 393
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251776
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.01
    Marker Score: 246
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71795
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48019
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.98
    Marker Score: 1556
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.97
    Marker Score: 1034.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.95
    Marker Score: 272
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1533
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5328
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.91
    Marker Score: 14648
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.86
    Marker Score: 227
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.83
    Marker Score: 891
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.81
    Marker Score: 20787
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 619
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.79
    Marker Score: 256
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.79
    Marker Score: 294.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.77
    Marker Score: 280
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.74
    Marker Score: 1571.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.73
    Marker Score: 731
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.72
    Marker Score: 422
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 660
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.72
    Marker Score: 757
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.71
    Marker Score: 5314
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.71
    Marker Score: 2529
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.71
    Marker Score: 159
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 331
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2868
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.65
    Marker Score: 844
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.64
    Marker Score: 3886.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.61
    Marker Score: 1398
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.6
    Marker Score: 329
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.59
    Marker Score: 595
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.57
    Marker Score: 344
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.57
    Marker Score: 1037
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.56
    Marker Score: 262
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.56
    Marker Score: 145
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.56
    Marker Score: 198
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.55
    Marker Score: 781
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.55
    Marker Score: 375
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.54
    Marker Score: 345
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.54
    Marker Score: 1295
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 351
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.53
    Marker Score: 818
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.53
    Marker Score: 135
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.53
    Marker Score: 605
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.53
    Marker Score: 158
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.52
    Marker Score: 365
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.52
    Marker Score: 840
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.52
    Marker Score: 350
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.52
    Marker Score: 196
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.52
    Marker Score: 288
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.51
    Marker Score: 4486
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.49
    Marker Score: 225
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 153
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 127
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.48
    Marker Score: 248
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.48
    Marker Score: 926

Other Information

**Key Characteristics** ABCC3 is a transmembrane protein belonging to the ABC family of transporters, characterized by its ATP-binding cassette domain. The protein has 12 transmembrane domains, which form a pore that allows the transport of substrates across the cell membrane. ABCC3 is highly specific for its substrates, with a wide range of ligands, including bile acids, bile salts, glucuronosides, icosanoids, and xenobiotics. The protein is also involved in the regulation of cellular responses to stimuli, stress, and chemical stress, and its expression is regulated by various transcription factors, including Nrf2. **Pathways and Functions** ABCC3 is involved in several cellular pathways, including: 1. **Bile acid and bile salt metabolism**: ABCC3 is responsible for the efflux of bile acids and bile salts from hepatocytes, which plays a critical role in the regulation of bile acid homeostasis and the prevention of bile acid toxicity. 2. **Xenobiotic transport**: ABCC3 is involved in the efflux of xenobiotics, including drugs and environmental toxins, from cells, which helps to protect against the toxic effects of these substances. 3. **Glucuronoside transport**: ABCC3 is responsible for the efflux of glucuronosides, which are metabolites of various drugs and xenobiotics, from cells. 4. **Leukotriene transport**: ABCC3 is involved in the transport of leukotrienes, which are pro-inflammatory mediators, from cells. 5. **Cellular responses to stimuli**: ABCC3 is regulated by various transcription factors, including Nrf2, which is involved in the regulation of cellular responses to oxidative stress and other stimuli. **Clinical Significance** Dysregulation of ABCC3 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of ABCC3 has been observed in various types of cancer, including breast, lung, and colon cancer, and has been associated with poor prognosis. 2. **Metabolic disorders**: ABCC3 has been implicated in the regulation of lipid metabolism and glucose homeostasis, and its dysregulation has been linked to metabolic disorders, including obesity and type 2 diabetes. 3. **Neurological disorders**: ABCC3 has been implicated in the transport of neurotransmitters and other substances across the blood-brain barrier, and its dysregulation has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Toxicity**: ABCC3 plays a critical role in the efflux of xenobiotics from cells, and its dysregulation has been linked to increased toxicity of various substances, including drugs and environmental toxins. In conclusion, ABCC3 is a critical gene involved in the transport of various substances across cellular membranes, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of ABCC3 in human health and disease.

Genular Protein ID: 721390770

Symbol: MRP3_HUMAN

Name: ATP-binding cassette sub-family C member 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9813153

Title: Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport.

PubMed ID: 9813153

DOI: 10.1006/bbrc.1998.9546

PubMed ID: 9738950

Title: cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).

PubMed ID: 9738950

DOI: 10.1016/s0014-5793(98)00899-0

PubMed ID: 9827529

Title: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins.

PubMed ID: 9827529

DOI: 10.1093/jnci/90.22.1735

PubMed ID: 9889399

Title: Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants.

PubMed ID: 9889399

DOI: 10.1016/s0005-2736(98)00233-8

PubMed ID: 10094960

Title: Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane.

PubMed ID: 10094960

DOI: 10.1002/hep.510290404

PubMed ID: 10359813

Title: MRP3, an organic anion transporter able to transport anti-cancer drugs.

PubMed ID: 10359813

DOI: 10.1073/pnas.96.12.6914

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9270026

Title: Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

PubMed ID: 9270026

PubMed ID: 11581266

Title: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

PubMed ID: 11581266

DOI: 10.1074/jbc.m107041200

PubMed ID: 15083066

Title: Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3).

PubMed ID: 15083066

DOI: 10.1097/00008571-200404000-00001

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28408210

Title: The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers.

PubMed ID: 28408210

DOI: 10.1016/j.xphs.2017.04.001

PubMed ID: 35307651

Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

PubMed ID: 35307651

DOI: 10.1124/dmd.121.000748

Sequence Information:

  • Length: 1527
  • Mass: 169343
  • Checksum: 0D1F879B6F18370C
  • Sequence:
  • MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP CYLLYLRHHC 
    RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA PAPVFFVTPL VVGVTMLLAT 
    LLIQYERLQG VQSSGVLIIF WFLCVVCAIV PFRSKILLAK AEGEISDPFR FTTFYIHFAL 
    VLSALILACF REKPPFFSAK NVDPNPYPET SAGFLSRLFF WWFTKMAIYG YRHPLEEKDL 
    WSLKEEDRSQ MVVQQLLEAW RKQEKQTARH KASAAPGKNA SGEDEVLLGA RPRPRKPSFL 
    KALLATFGSS FLISACFKLI QDLLSFINPQ LLSILIRFIS NPMAPSWWGF LVAGLMFLCS 
    MMQSLILQHY YHYIFVTGVK FRTGIMGVIY RKALVITNSV KRASTVGEIV NLMSVDAQRF 
    MDLAPFLNLL WSAPLQIILA IYFLWQNLGP SVLAGVAFMV LLIPLNGAVA VKMRAFQVKQ 
    MKLKDSRIKL MSEILNGIKV LKLYAWEPSF LKQVEGIRQG ELQLLRTAAY LHTTTTFTWM 
    CSPFLVTLIT LWVYVYVDPN NVLDAEKAFV SVSLFNILRL PLNMLPQLIS NLTQASVSLK 
    RIQQFLSQEE LDPQSVERKT ISPGYAITIH SGTFTWAQDL PPTLHSLDIQ VPKGALVAVV 
    GPVGCGKSSL VSALLGEMEK LEGKVHMKGS VAYVPQQAWI QNCTLQENVL FGKALNPKRY 
    QQTLEACALL ADLEMLPGGD QTEIGEKGIN LSGGQRQRVS LARAVYSDAD IFLLDDPLSA 
    VDSHVAKHIF DHVIGPEGVL AGKTRVLVTH GISFLPQTDF IIVLADGQVS EMGPYPALLQ 
    RNGSFANFLC NYAPDEDQGH LEDSWTALEG AEDKEALLIE DTLSNHTDLT DNDPVTYVVQ 
    KQFMRQLSAL SSDGEGQGRP VPRRHLGPSE KVQVTEAKAD GALTQEEKAA IGTVELSVFW 
    DYAKAVGLCT TLAICLLYVG QSAAAIGANV WLSAWTNDAM ADSRQNNTSL RLGVYAALGI 
    LQGFLVMLAA MAMAAGGIQA ARVLHQALLH NKIRSPQSFF DTTPSGRILN CFSKDIYVVD 
    EVLAPVILML LNSFFNAIST LVVIMASTPL FTVVILPLAV LYTLVQRFYA ATSRQLKRLE 
    SVSRSPIYSH FSETVTGASV IRAYNRSRDF EIISDTKVDA NQRSCYPYII SNRWLSIGVE 
    FVGNCVVLFA ALFAVIGRSS LNPGLVGLSV SYSLQVTFAL NWMIRMMSDL ESNIVAVERV 
    KEYSKTETEA PWVVEGSRPP EGWPPRGEVE FRNYSVRYRP GLDLVLRDLS LHVHGGEKVG 
    IVGRTGAGKS SMTLCLFRIL EAAKGEIRID GLNVADIGLH DLRSQLTIIP QDPILFSGTL 
    RMNLDPFGSY SEEDIWWALE LSHLHTFVSS QPAGLDFQCS EGGENLSVGQ RQLVCLARAL 
    LRKSRILVLD EATAAIDLET DNLIQATIRT QFDTCTVLTI AHRLNTIMDY TRVLVLDKGV 
    VAEFDSPANL IAARGIFYGM ARDAGLA

Genular Protein ID: 3399721916

Symbol: Q86VN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 573
  • Mass: 64738
  • Checksum: B7CD551085F1CA88
  • Sequence:
  • PMDALCGSGE LGSKFWDSNL SVHTENPDLT PCFQNSLLAW VPCIYLWVAL PCYLLYLRHH 
    CRGYIILSHL SKLKMVLGVL LWCVSWADLF YSFHGLVHGR APAPVFFVTP LVVGVTMLLA 
    TLLIQYERLQ GVQSSGVLII FWFLCVVCAI VPFRSKILLA KAEGEISDPF RFTTFYIHFA 
    LVLSALILAC FREKPPFFSA KNVDPNPYPE TSAGFLSRLF FWWFTKMAIY GYRHPLEEKD 
    LWSLKEEDRS QMVVQQLLEA WRKQEKQTAR HKASAAPGKN ASGEDEVLLG ARPRPRKPSF 
    LKALLATFGS SFLISACFKL IQDLLSFINP QLLSILIRFI SNPMAPSWWG FLVAGLMFLC 
    SMMQSLILQH YYHYIFVTGV KFRTGIMGVI YRKALVITNS VKRASTVGEI VNLMSVDAQR 
    FMDLAPFLNL LWSAPLQIIL AIYFLWQNLG PSVLAGVAFM VLLIPLNGAV AVKMRAFQVK 
    QMKLKDSRIK LMSEILNGIK VLKLYAWEPS FLKQVEGIRQ GELQLLRTAA YLHTTTTFTW 
    MCSPFLVRLG TGLGPCLHGS GCPGMARAHW TLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.