Details for: IL1RL2

Gene ID: 8808

Symbol: IL1RL2

Ensembl ID: ENSG00000115598

Description: interleukin 1 receptor like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.2336
    Cell Significance Index: -4.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.7007
    Cell Significance Index: 37.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.6021
    Cell Significance Index: 87.5200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4512
    Cell Significance Index: 6.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4216
    Cell Significance Index: 25.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3818
    Cell Significance Index: 10.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3780
    Cell Significance Index: 75.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1979
    Cell Significance Index: 37.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1814
    Cell Significance Index: 6.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1792
    Cell Significance Index: 9.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1790
    Cell Significance Index: 8.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1577
    Cell Significance Index: 2.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1418
    Cell Significance Index: 14.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.1325
    Cell Significance Index: -0.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1161
    Cell Significance Index: 3.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0799
    Cell Significance Index: 1.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0795
    Cell Significance Index: 71.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0710
    Cell Significance Index: 11.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0709
    Cell Significance Index: 31.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0706
    Cell Significance Index: 4.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0674
    Cell Significance Index: 1.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0645
    Cell Significance Index: 7.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0504
    Cell Significance Index: 34.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0485
    Cell Significance Index: 1.0500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0417
    Cell Significance Index: 0.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0400
    Cell Significance Index: 25.3800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.0317
    Cell Significance Index: 0.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0268
    Cell Significance Index: 1.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0180
    Cell Significance Index: 0.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0151
    Cell Significance Index: 0.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0115
    Cell Significance Index: 0.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0076
    Cell Significance Index: 1.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0071
    Cell Significance Index: 0.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0060
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0059
    Cell Significance Index: 11.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0057
    Cell Significance Index: 2.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0022
    Cell Significance Index: 0.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0020
    Cell Significance Index: 1.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0025
    Cell Significance Index: -3.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0034
    Cell Significance Index: -0.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0052
    Cell Significance Index: -0.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0054
    Cell Significance Index: -7.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0069
    Cell Significance Index: -0.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0073
    Cell Significance Index: -5.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0083
    Cell Significance Index: -6.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0094
    Cell Significance Index: -5.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0104
    Cell Significance Index: -0.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0112
    Cell Significance Index: -6.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0114
    Cell Significance Index: -3.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0116
    Cell Significance Index: -5.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0132
    Cell Significance Index: -0.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0141
    Cell Significance Index: -1.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0144
    Cell Significance Index: -1.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0179
    Cell Significance Index: -3.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0206
    Cell Significance Index: -0.1900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0231
    Cell Significance Index: -0.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0264
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0274
    Cell Significance Index: -4.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0301
    Cell Significance Index: -6.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0323
    Cell Significance Index: -1.4300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0362
    Cell Significance Index: -0.5200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0383
    Cell Significance Index: -0.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0397
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0415
    Cell Significance Index: -4.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0416
    Cell Significance Index: -1.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0420
    Cell Significance Index: -0.8200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0429
    Cell Significance Index: -0.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0456
    Cell Significance Index: -1.4600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0512
    Cell Significance Index: -0.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0517
    Cell Significance Index: -0.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0529
    Cell Significance Index: -1.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0570
    Cell Significance Index: -5.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0634
    Cell Significance Index: -5.0200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0649
    Cell Significance Index: -0.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0709
    Cell Significance Index: -5.4400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0738
    Cell Significance Index: -0.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0781
    Cell Significance Index: -1.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0795
    Cell Significance Index: -2.2800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0810
    Cell Significance Index: -0.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0828
    Cell Significance Index: -2.7100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0829
    Cell Significance Index: -2.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0834
    Cell Significance Index: -5.1300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0844
    Cell Significance Index: -0.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0860
    Cell Significance Index: -4.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0873
    Cell Significance Index: -3.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0897
    Cell Significance Index: -5.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0942
    Cell Significance Index: -2.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0982
    Cell Significance Index: -3.4400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0985
    Cell Significance Index: -1.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1063
    Cell Significance Index: -5.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1110
    Cell Significance Index: -6.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1187
    Cell Significance Index: -6.2300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1253
    Cell Significance Index: -1.6700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1272
    Cell Significance Index: -1.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1351
    Cell Significance Index: -3.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1359
    Cell Significance Index: -4.9900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1508
    Cell Significance Index: -0.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IL1RL2 is a member of the IL-1 receptor family, which is characterized by the presence of an extracellular domain with a leucine-rich repeat (LRR) motif, a transmembrane domain, and an intracellular domain. The LRR motif is essential for ligand binding, while the intracellular domain mediates signal transduction upon ligand activation. IL1RL2 is activated by IL-1α and IL-1β, two pro-inflammatory cytokines that play key roles in initiating and regulating immune responses. The gene's expression profile, as indicated by its significantly expressed cells, suggests a role in regulating immune cell differentiation and function, particularly in the context of innate and adaptive immunity. **Pathways and Functions** IL1RL2 is involved in several key signaling pathways, including: 1. **IL-1 signaling pathway**: IL1RL2 is activated by IL-1α and IL-1β, leading to the activation of downstream signaling molecules, such as MyD88, TRAF6, and NF-κB, which regulate the expression of inflammatory genes and cytokines. 2. **Cytokine signaling in immune system**: IL1RL2 plays a role in regulating the production of pro-inflammatory cytokines, such as IL-6, and anti-inflammatory cytokines, such as IL-10, by immune cells, including T cells and macrophages. 3. **Inflammatory response**: IL1RL2 is involved in the regulation of inflammatory responses, including the activation of immune cells, such as neutrophils and macrophages, and the production of pro-inflammatory cytokines. 4. **Immune system development**: IL1RL2 is expressed in lymphoid lineage-restricted progenitor cells, suggesting its role in the development and maturation of immune cells. **Clinical Significance** Dysregulation of IL1RL2 has been implicated in various diseases, including: 1. **Inflammatory bowel disease (IBD)**: IL1RL2 has been shown to play a role in the pathogenesis of IBD, including Crohn's disease and ulcerative colitis, by regulating the production of pro-inflammatory cytokines and immune cell differentiation. 2. **Autoimmune disorders**: IL1RL2 has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and systemic lupus erythematosus, by regulating the production of pro-inflammatory cytokines and immune cell activation. 3. **Cancer**: IL1RL2 has been shown to play a role in cancer progression, including the regulation of immune cell differentiation and the production of pro-inflammatory cytokines. In conclusion, IL1RL2 is a critical regulator of innate and adaptive immune responses, playing a key role in the regulation of inflammatory responses, immune cell differentiation, and cytokine production. Dysregulation of this gene has been implicated in various diseases, highlighting its importance in maintaining immune homeostasis and its potential as a therapeutic target for the treatment of immune-related disorders.

Genular Protein ID: 3138063521

Symbol: ILRL2_HUMAN

Name: Interleukin-1 receptor-like 2

UniProtKB Accession Codes:

Q9HB29 A4FU63 Q13525 Q45H74 Q53TU8 Q587I8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10882729

Title: Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling.

PubMed ID: 10882729

DOI: 10.1074/jbc.m004077200

PubMed ID: 8898719

Title: Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2).

PubMed ID: 8898719

DOI: 10.1016/s0165-5728(96)00047-1

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11466363

Title: Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.

PubMed ID: 11466363

DOI: 10.4049/jimmunol.167.3.1440

PubMed ID: 16646978

Title: The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes.

PubMed ID: 16646978

DOI: 10.1186/ar1946

PubMed ID: 24829417

Title: IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.

PubMed ID: 24829417

DOI: 10.4049/jimmunol.1301481

Sequence Information:

  • Length: 575
  • Mass: 65405
  • Checksum: 7AC0FCAB43A2A6CD
  • Sequence:
    • MWSLLLCGLS IALPLSVTAD GCKDIFMKNE ILSASQPFAF NCTFPPITSG EVSVTWYKNS 
SKIPVSKIIQ SRIHQDETWI LFLPMEWGDS GVYQCVIKGR DSCHRIHVNL TVFEKHWCDT 
SIGGLPNLSD EYKQILHLGK DDSLTCHLHF PKSCVLGPIK WYKDCNEIKG ERFTVLETRL 
LVSNVSAEDR GNYACQAILT HSGKQYEVLN GITVSITERA GYGGSVPKII YPKNHSIEVQ 
LGTTLIVDCN VTDTKDNTNL RCWRVNNTLV DDYYDESKRI REGVETHVSF REHNLYTVNI 
TFLEVKMEDY GLPFMCHAGV STAYIILQLP APDFRAYLIG GLIALVAVAV SVVYIYNIFK 
IDIVLWYRSA FHSTETIVDG KLYDAYVLYP KPHKESQRHA VDALVLNILP EVLERQCGYK 
LFIFGRDEFP GQAVANVIDE NVKLCRRLIV IVVPESLGFG LLKNLSEEQI AVYSALIQDG 
MKVILIELEK IEDYTVMPES IQYIKQKHGA IRWHGDFTEQ SQCMKTKFWK TVRYHMPPRR 
CRPFPPVQLL QHTPCYRTAG PELGSRRKKC TLTTG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.