FGF16 | ENSG00000196468 | NCBI 8823

Details for: FGF16

Gene ID: 8823

Symbol: FGF16

Ensembl ID: ENSG00000196468

Description: fibroblast growth factor 16

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr3 ligand binding and activation
(R-HSA-190239)
Fgfr3 mutant receptor activation
(R-HSA-2033514)
Fgfr3c ligand binding and activation
(R-HSA-190372)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr3
(R-HSA-1839130)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Cell-cell signaling
(GO:0007267)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Neurogenesis
(GO:0022008)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell chemotaxis to fibroblast growth factor
(GO:2000546)
Positive regulation of mapk cascade
(GO:0043410)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)
Regulation of endothelial cell proliferation
(GO:0001936)
Regulation of map kinase activity
(GO:0043405)
Regulation of sprouting angiogenesis
(GO:1903670)
Response to temperature stimulus
(GO:0009266)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 3.8243
Cell Significance Index: -0.9700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.3900
Cell Significance Index: 33.6700
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.3032
Cell Significance Index: 3.2000
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.2640
Cell Significance Index: 3.7100
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1973
Cell Significance Index: 3.8500
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.0971
Cell Significance Index: 1.2300
Cell Name: keratocyte (CL0002363)
Fold Change: 0.0914
Cell Significance Index: 1.4500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0890
Cell Significance Index: 10.3700
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 0.0732
Cell Significance Index: 0.5000
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0332
Cell Significance Index: 0.4800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0251
Cell Significance Index: 1.2700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0005
Cell Significance Index: -0.8900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0006
Cell Significance Index: -1.1600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0008
Cell Significance Index: -1.3000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0008
Cell Significance Index: -0.5600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0009
Cell Significance Index: -1.2300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0010
Cell Significance Index: -0.5700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0016
Cell Significance Index: -1.0500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0016
Cell Significance Index: -0.3300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0016
Cell Significance Index: -1.1900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0018
Cell Significance Index: -0.0200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0024
Cell Significance Index: -0.8600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0027
Cell Significance Index: -1.2300
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0034
Cell Significance Index: -0.6700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0050
Cell Significance Index: -0.8600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0054
Cell Significance Index: -0.7400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0060
Cell Significance Index: -1.0900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0066
Cell Significance Index: -0.9500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0075
Cell Significance Index: -0.1600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0083
Cell Significance Index: -1.0200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0099
Cell Significance Index: -1.1400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0123
Cell Significance Index: -0.7600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0132
Cell Significance Index: -1.0100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0133
Cell Significance Index: -0.8200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0139
Cell Significance Index: -0.6500
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.0143
Cell Significance Index: -0.1700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0155
Cell Significance Index: -0.8100
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0164
Cell Significance Index: -0.2000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0174
Cell Significance Index: -1.1700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0177
Cell Significance Index: -0.3700
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: -0.0199
Cell Significance Index: -0.1800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0205
Cell Significance Index: -1.0700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0226
Cell Significance Index: -1.2700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0228
Cell Significance Index: -1.0700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0240
Cell Significance Index: -0.6300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0247
Cell Significance Index: -0.6600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0262
Cell Significance Index: -0.7500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0262
Cell Significance Index: -0.7000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0276
Cell Significance Index: -0.7500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0292
Cell Significance Index: -1.2900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0294
Cell Significance Index: -1.0300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0299
Cell Significance Index: -1.2300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0305
Cell Significance Index: -1.0000
Cell Name: erythroblast (CL0000765)
Fold Change: -0.0310
Cell Significance Index: -0.3700
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0310
Cell Significance Index: -0.4400
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.0311
Cell Significance Index: -0.3000
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0314
Cell Significance Index: -0.4100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0317
Cell Significance Index: -0.5300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0326
Cell Significance Index: -0.9600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0333
Cell Significance Index: -0.8500
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0336
Cell Significance Index: -0.5800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0339
Cell Significance Index: -1.0800
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0342
Cell Significance Index: -0.4900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0346
Cell Significance Index: -1.3100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0350
Cell Significance Index: -0.9000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0353
Cell Significance Index: -0.9900
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: -0.0412
Cell Significance Index: -0.4900
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0413
Cell Significance Index: -1.0300
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0413
Cell Significance Index: -1.1800
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0415
Cell Significance Index: -0.4700
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0425
Cell Significance Index: -1.0600
Cell Name: ependymal cell (CL0000065)
Fold Change: -0.0475
Cell Significance Index: -0.5600
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0481
Cell Significance Index: -1.5200
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0488
Cell Significance Index: -1.1700
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0498
Cell Significance Index: -1.2700
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0499
Cell Significance Index: -1.0600
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.0501
Cell Significance Index: -0.5600
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0503
Cell Significance Index: -0.7300
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0506
Cell Significance Index: -0.4900
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0509
Cell Significance Index: -1.1000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0524
Cell Significance Index: -1.3100
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0527
Cell Significance Index: -1.1000
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0538
Cell Significance Index: -1.0800
Cell Name: fibroblast of breast (CL4006000)
Fold Change: -0.0541
Cell Significance Index: -0.3400
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0541
Cell Significance Index: -1.0700
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.0547
Cell Significance Index: -0.6600
Cell Name: adventitial cell (CL0002503)
Fold Change: -0.0550
Cell Significance Index: -0.5100
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0550
Cell Significance Index: -0.8900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0552
Cell Significance Index: -1.0800
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: -0.0561
Cell Significance Index: -0.4200
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0564
Cell Significance Index: -1.1100
Cell Name: rod bipolar cell (CL0000751)
Fold Change: -0.0567
Cell Significance Index: -0.6500
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0573
Cell Significance Index: -0.9800
Cell Name: tendon cell (CL0000388)
Fold Change: -0.0574
Cell Significance Index: -0.7800
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.0579
Cell Significance Index: -0.6400
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0586
Cell Significance Index: -0.6400
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0590
Cell Significance Index: -1.4400
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.0591
Cell Significance Index: -0.6000
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0592
Cell Significance Index: -1.1800
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0597
Cell Significance Index: -1.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Structure:** FGF16 is a secreted protein that belongs to the fibroblast growth factor family. It consists of 167 amino acids and contains four fibroblast growth factor (FGF) domains. 2. **Expression:** FGF16 is widely expressed in various tissues, including the brain, heart, and skeletal muscle. It is also expressed in immune cells, such as T cells and dendritic cells. 3. **Function:** FGF16 plays a role in regulating cell growth, differentiation, and survival by binding to its receptor, FGF2R. It also interacts with other signaling molecules, such as PI3K and MAPK, to modulate cellular responses. 4. **Regulation:** FGF16 expression is regulated by various factors, including growth factors, cytokines, and transcription factors. **Pathways and Functions:** 1. **Cell Growth and Differentiation:** FGF16 regulates cell growth and differentiation by binding to its receptor, FGF2R, and activating downstream signaling pathways. 2. **Angiogenesis:** FGF16 promotes angiogenesis, the formation of new blood vessels, by stimulating the proliferation and migration of endothelial cells. 3. **Neuroprotection:** FGF16 has neuroprotective effects by promoting the survival of neurons and inhibiting apoptosis (cell death). 4. **Immune Response:** FGF16 plays a role in regulating the immune response by modulating the activity of immune cells, such as T cells and dendritic cells. **Clinical Significance:** 1. **Cancer:** FGF16 is overexpressed in various types of cancer, including breast, lung, and colon cancer. It promotes tumor growth, invasion, and metastasis. 2. **Cardiovascular Disease:** FGF16 is involved in the regulation of cardiovascular function and is implicated in the pathogenesis of cardiovascular disease. 3. **Neurological Disorders:** FGF16 has been implicated in the development and progression of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Inflammatory Disorders:** FGF16 plays a role in regulating the immune response and is implicated in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis. **Conclusion:** In conclusion, the FGF16 gene is a complex protein that plays a critical role in regulating various cellular processes, including cell growth, differentiation, and survival. Its dysregulation has been implicated in the development and progression of several diseases, including cancer, cardiovascular disorders, and neurological conditions. Further research is needed to fully understand the mechanisms by which FGF16 regulates cellular responses and to develop novel therapeutic strategies targeting this gene. **Recommendations:** 1. **Further Research:** Conducting further research on the molecular mechanisms by which FGF16 regulates cellular responses and its role in disease development and progression. 2. **Therapeutic Strategies:** Developing novel therapeutic strategies targeting FGF16 to prevent or treat diseases associated with its dysregulation. 3. **Diagnostic Markers:** Identifying FGF16 as a potential diagnostic marker for diseases associated with its dysregulation. 4. **Immunotherapy:** Exploring the use of immunotherapy targeting FGF16 to modulate the immune response and prevent disease progression.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 16

Genular Protein ID: 3630113647

Symbol: FGF16_HUMAN

Name: Fibroblast growth factor 16

UniProtKB Accession Codes:

O43320

Database IDs:

Citations:

PubMed ID: 9473496

Title: Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family.

PubMed ID: 9473496

DOI: 10.1006/bbrc.1998.8073

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 23709756

Title: Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion.

PubMed ID: 23709756

DOI: 10.1136/jmedgenet-2013-101659

PubMed ID: 25333065

Title: Identification of three novel FGF16 mutations in X-linked recessive fusion of the fourth and fifth metacarpals and possible correlation with heart disease.

PubMed ID: 25333065

DOI: 10.1002/mgg3.81

Sequence Information:

Length: 207
Mass: 23759
Checksum: D8AD160BDABDB5F8
Sequence:

MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL 
RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER 
GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH 
QKFTHFLPRP VDPSKLPSMS RDLFHYR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FGF16

Associated with

Cells (max top 100)

Other Information

Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family. PubMed ID: 9473496

The DNA sequence of the human X chromosome. PubMed ID: 15772651

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. PubMed ID: 16597617

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion. PubMed ID: 23709756

Identification of three novel FGF16 mutations in X-linked recessive fusion of the fourth and fifth metacarpals and possible correlation with heart disease. PubMed ID: 25333065