Details for: FGF16

Gene ID: 8823

Symbol: FGF16

Ensembl ID: ENSG00000196468

Description: fibroblast growth factor 16

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.53
    Marker Score: 4358
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1516
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.08
    Marker Score: 2089
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.28
    Marker Score: 1432
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.24
    Marker Score: 1179
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.17
    Marker Score: 785
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.93
    Marker Score: 1764
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.93
    Marker Score: 1205
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1370
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 485
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.72
    Marker Score: 418
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1147
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 514
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.63
    Marker Score: 9848
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.61
    Marker Score: 372
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6
    Marker Score: 380.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1060
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.48
    Marker Score: 992
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 126
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.39
    Marker Score: 261
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.38
    Marker Score: 228
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.3
    Marker Score: 319.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.27
    Marker Score: 114
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.25
    Marker Score: 245
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.24
    Marker Score: 241
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.23
    Marker Score: 219
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 120
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.22
    Marker Score: 108
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.21
    Marker Score: 286
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.2
    Marker Score: 94
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 94
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.15
    Marker Score: 83
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 133
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.14
    Marker Score: 35
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.14
    Marker Score: 73
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.13
    Marker Score: 115
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.11
    Marker Score: 163
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.11
    Marker Score: 137.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.1
    Marker Score: 23.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.09
    Marker Score: 23.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.08
    Marker Score: 19.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.08
    Marker Score: 23.5
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.08
    Marker Score: 142
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.07
    Marker Score: 56
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.07
    Marker Score: 188.5
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.07
    Marker Score: 22.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.07
    Marker Score: 352
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.07
    Marker Score: 400
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.06
    Marker Score: 79
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 147
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.06
    Marker Score: 22.5
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 20.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.05
    Marker Score: 23.5
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.05
    Marker Score: 23.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 62.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.05
    Marker Score: 53
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.05
    Marker Score: 17.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.05
    Marker Score: 22.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.04
    Marker Score: 88
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.04
    Marker Score: 23.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.04
    Marker Score: 106
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.04
    Marker Score: 22.5

Other Information

**Key Characteristics:** 1. **Structure:** FGF16 is a secreted protein that belongs to the fibroblast growth factor family. It consists of 167 amino acids and contains four fibroblast growth factor (FGF) domains. 2. **Expression:** FGF16 is widely expressed in various tissues, including the brain, heart, and skeletal muscle. It is also expressed in immune cells, such as T cells and dendritic cells. 3. **Function:** FGF16 plays a role in regulating cell growth, differentiation, and survival by binding to its receptor, FGF2R. It also interacts with other signaling molecules, such as PI3K and MAPK, to modulate cellular responses. 4. **Regulation:** FGF16 expression is regulated by various factors, including growth factors, cytokines, and transcription factors. **Pathways and Functions:** 1. **Cell Growth and Differentiation:** FGF16 regulates cell growth and differentiation by binding to its receptor, FGF2R, and activating downstream signaling pathways. 2. **Angiogenesis:** FGF16 promotes angiogenesis, the formation of new blood vessels, by stimulating the proliferation and migration of endothelial cells. 3. **Neuroprotection:** FGF16 has neuroprotective effects by promoting the survival of neurons and inhibiting apoptosis (cell death). 4. **Immune Response:** FGF16 plays a role in regulating the immune response by modulating the activity of immune cells, such as T cells and dendritic cells. **Clinical Significance:** 1. **Cancer:** FGF16 is overexpressed in various types of cancer, including breast, lung, and colon cancer. It promotes tumor growth, invasion, and metastasis. 2. **Cardiovascular Disease:** FGF16 is involved in the regulation of cardiovascular function and is implicated in the pathogenesis of cardiovascular disease. 3. **Neurological Disorders:** FGF16 has been implicated in the development and progression of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Inflammatory Disorders:** FGF16 plays a role in regulating the immune response and is implicated in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis. **Conclusion:** In conclusion, the FGF16 gene is a complex protein that plays a critical role in regulating various cellular processes, including cell growth, differentiation, and survival. Its dysregulation has been implicated in the development and progression of several diseases, including cancer, cardiovascular disorders, and neurological conditions. Further research is needed to fully understand the mechanisms by which FGF16 regulates cellular responses and to develop novel therapeutic strategies targeting this gene. **Recommendations:** 1. **Further Research:** Conducting further research on the molecular mechanisms by which FGF16 regulates cellular responses and its role in disease development and progression. 2. **Therapeutic Strategies:** Developing novel therapeutic strategies targeting FGF16 to prevent or treat diseases associated with its dysregulation. 3. **Diagnostic Markers:** Identifying FGF16 as a potential diagnostic marker for diseases associated with its dysregulation. 4. **Immunotherapy:** Exploring the use of immunotherapy targeting FGF16 to modulate the immune response and prevent disease progression.

Genular Protein ID: 3630113647

Symbol: FGF16_HUMAN

Name: Fibroblast growth factor 16

UniProtKB Accession Codes:

O43320

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 27 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9473496

Title: Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family.

PubMed ID: 9473496

DOI: 10.1006/bbrc.1998.8073

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 23709756

Title: Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion.

PubMed ID: 23709756

DOI: 10.1136/jmedgenet-2013-101659

PubMed ID: 25333065

Title: Identification of three novel FGF16 mutations in X-linked recessive fusion of the fourth and fifth metacarpals and possible correlation with heart disease.

PubMed ID: 25333065

DOI: 10.1002/mgg3.81

Sequence Information:

  • Length: 207
  • Mass: 23759
  • Checksum: D8AD160BDABDB5F8
  • Sequence:
    • MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL 
RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER 
GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH 
QKFTHFLPRP VDPSKLPSMS RDLFHYR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.