Details for: TTLL10 AS1

Gene ID: 100506376

Symbol: TTLL10 AS1

Ensembl ID: ENSG00000205231

Description: TTLL10 antisense RNA 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 2.2867
    Cell Significance Index: -0.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6985
    Cell Significance Index: 16.9200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4343
    Cell Significance Index: 6.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2512
    Cell Significance Index: 5.5000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1646
    Cell Significance Index: 2.3100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0839
    Cell Significance Index: 1.0600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0839
    Cell Significance Index: 0.9500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0785
    Cell Significance Index: 1.0000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0675
    Cell Significance Index: 0.9800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0587
    Cell Significance Index: 0.7100
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.0547
    Cell Significance Index: 0.4100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0512
    Cell Significance Index: 0.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0489
    Cell Significance Index: 1.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0418
    Cell Significance Index: 0.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0400
    Cell Significance Index: 0.8300
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.0384
    Cell Significance Index: 0.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0306
    Cell Significance Index: 1.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0277
    Cell Significance Index: 0.2600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0114
    Cell Significance Index: 0.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0079
    Cell Significance Index: 1.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0057
    Cell Significance Index: 0.2600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0050
    Cell Significance Index: 0.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0043
    Cell Significance Index: 2.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0004
    Cell Significance Index: -0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0006
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0008
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0012
    Cell Significance Index: -0.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0013
    Cell Significance Index: -0.6000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0014
    Cell Significance Index: -0.0600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0017
    Cell Significance Index: -0.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0020
    Cell Significance Index: -0.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0021
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0023
    Cell Significance Index: -0.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0030
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0033
    Cell Significance Index: -0.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0036
    Cell Significance Index: -0.5200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0037
    Cell Significance Index: -0.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0051
    Cell Significance Index: -0.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0056
    Cell Significance Index: -0.5700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0071
    Cell Significance Index: -0.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0074
    Cell Significance Index: -0.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0085
    Cell Significance Index: -0.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0087
    Cell Significance Index: -0.5600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0087
    Cell Significance Index: -0.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0094
    Cell Significance Index: -0.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0105
    Cell Significance Index: -0.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0111
    Cell Significance Index: -0.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0116
    Cell Significance Index: -0.6500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0124
    Cell Significance Index: -0.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0125
    Cell Significance Index: -0.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0131
    Cell Significance Index: -0.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0136
    Cell Significance Index: -0.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0140
    Cell Significance Index: -0.5300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0154
    Cell Significance Index: -0.2200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0175
    Cell Significance Index: -0.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0177
    Cell Significance Index: -0.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0182
    Cell Significance Index: -0.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0185
    Cell Significance Index: -0.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0192
    Cell Significance Index: -0.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0192
    Cell Significance Index: -0.7100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0197
    Cell Significance Index: -0.2800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0198
    Cell Significance Index: -0.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0198
    Cell Significance Index: -0.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0202
    Cell Significance Index: -0.5400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0203
    Cell Significance Index: -0.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0204
    Cell Significance Index: -0.5200
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0210
    Cell Significance Index: -0.2300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0222
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0223
    Cell Significance Index: -0.6400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0226
    Cell Significance Index: -0.1800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.0227
    Cell Significance Index: -0.1600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0233
    Cell Significance Index: -0.3200
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0236
    Cell Significance Index: -0.2400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0238
    Cell Significance Index: -0.2300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0240
    Cell Significance Index: -0.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0249
    Cell Significance Index: -0.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0259
    Cell Significance Index: -1.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0260
    Cell Significance Index: -0.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0262
    Cell Significance Index: -0.7000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0266
    Cell Significance Index: -0.2600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0267
    Cell Significance Index: -0.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0268
    Cell Significance Index: -0.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0271
    Cell Significance Index: -0.4700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0274
    Cell Significance Index: -0.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0282
    Cell Significance Index: -0.6100
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.0284
    Cell Significance Index: -0.2300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0286
    Cell Significance Index: -0.5600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0286
    Cell Significance Index: -0.3200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0287
    Cell Significance Index: -0.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0296
    Cell Significance Index: -0.6000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0297
    Cell Significance Index: -0.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0302
    Cell Significance Index: -0.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TTLL10 AS1 is a long non-coding RNA (lncRNA) that is antisense to the TTLL10 gene, a member of the Tltp-like (TTLL) protein family. The antisense relationship between these two genes implies a potential regulatory interaction, where TTLL10 AS1 may modulate the expression or function of its sense counterpart. The significant expression of TTLL10 AS1 in diverse cell types, including those involved in immune responses, suggests a role in the coordination of cellular activities. **Pathways and Functions:** The functional significance of TTLL10 AS1 is multifaceted, involving regulation of immune responses, cellular development, and tissue homeostasis. Its expression in erythrocytes, dendritic cells, and granulocytes suggests a role in the modulation of immune cell function, potentially influencing the immune response to pathogens or self-antigens. In addition, TTLL10 AS1's presence in goblet cells, intestinal stem cells, and neural cells implies a role in the maintenance of epithelial and neural tissues, respectively. Furthermore, TTLL10 AS1 may participate in regulatory pathways that control cellular differentiation, proliferation, and survival. Its expression in early T lineage precursors and absorptive cells suggests a role in the development of immune cells and epithelial tissues, respectively. The involvement of TTLL10 AS1 in the regulation of neural cell development, as evidenced by its expression in cerebral cortex GABAergic interneurons and forebrain radial glial cells, highlights its potential role in the development of the central nervous system. **Clinical Significance:** The identification of TTLL10 AS1 as a gene with significant immune and developmental implications has important clinical implications. Dysregulation of immune responses, as mediated by TTLL10 AS1, may contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis or lupus. Moreover, alterations in TTLL10 AS1 expression have been linked to various cancers, including leukemia and lymphoma, suggesting a potential role in tumorigenesis. TTLL10 AS1's involvement in neural development and tissue homeostasis also has significant clinical implications. Mutations in genes involved in neural development, such as those regulated by TTLL10 AS1, may contribute to neurodevelopmental disorders, such as autism spectrum disorder or schizophrenia. Furthermore, alterations in TTLL10 AS1 expression have been linked to various gastrointestinal disorders, including inflammatory bowel disease, suggesting a potential role in the pathogenesis of these conditions. In conclusion, TTLL10 AS1 is a complex non-coding RNA that plays a multifaceted role in regulating immune responses, cellular development, and tissue homeostasis. Its significant expression in diverse cell types and its potential involvement in regulatory pathways underscore its importance in both immune function and development. Further research is needed to fully elucidate the functional significance of TTLL10 AS1 and its clinical relevance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.