Details for: RN7SKP244

Gene ID: 106479203

Symbol: RN7SKP244

Ensembl ID: ENSG00000252322

Description: RN7SK pseudogene 244

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.7155
    Cell Significance Index: 5.5000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0643
    Cell Significance Index: 0.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0398
    Cell Significance Index: 2.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0374
    Cell Significance Index: 0.8200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0343
    Cell Significance Index: 0.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0038
    Cell Significance Index: 0.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0006
    Cell Significance Index: 0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0005
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.8600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.6700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0040
    Cell Significance Index: -0.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0042
    Cell Significance Index: -0.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0049
    Cell Significance Index: -0.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0059
    Cell Significance Index: -0.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0059
    Cell Significance Index: -0.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0063
    Cell Significance Index: -0.1300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0064
    Cell Significance Index: -0.1300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0068
    Cell Significance Index: -0.1400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0072
    Cell Significance Index: -0.1200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0079
    Cell Significance Index: -0.1000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0095
    Cell Significance Index: -0.0800
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0097
    Cell Significance Index: -0.1200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0130
    Cell Significance Index: -0.1100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0139
    Cell Significance Index: -0.1600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0151
    Cell Significance Index: -0.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0163
    Cell Significance Index: -0.2400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0297
    Cell Significance Index: -0.2700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0303
    Cell Significance Index: -0.1800
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0342
    Cell Significance Index: -0.3800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0362
    Cell Significance Index: -0.5500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0367
    Cell Significance Index: -0.3500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0378
    Cell Significance Index: -0.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0386
    Cell Significance Index: -0.4600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0398
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0415
    Cell Significance Index: -0.5100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0419
    Cell Significance Index: -0.5300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0427
    Cell Significance Index: -0.5600
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0432
    Cell Significance Index: -0.5000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0433
    Cell Significance Index: -0.5000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0440
    Cell Significance Index: -0.5000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0443
    Cell Significance Index: -0.5300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0449
    Cell Significance Index: -0.5600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0450
    Cell Significance Index: -0.5300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0451
    Cell Significance Index: -0.5100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0454
    Cell Significance Index: -0.5500
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0455
    Cell Significance Index: -0.5500
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0479
    Cell Significance Index: -0.5200
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0483
    Cell Significance Index: -0.5800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0485
    Cell Significance Index: -0.5200
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0514
    Cell Significance Index: -0.5100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0517
    Cell Significance Index: -0.6200
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0534
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0536
    Cell Significance Index: -0.5000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0543
    Cell Significance Index: -0.5100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0557
    Cell Significance Index: -0.6100
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0613
    Cell Significance Index: -0.7300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0624
    Cell Significance Index: -0.5500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0633
    Cell Significance Index: -0.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0660
    Cell Significance Index: -0.9500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0668
    Cell Significance Index: -0.8100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0678
    Cell Significance Index: -0.5600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0724
    Cell Significance Index: -0.7500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0728
    Cell Significance Index: -0.8200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0731
    Cell Significance Index: -1.0400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0740
    Cell Significance Index: -1.0600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0753
    Cell Significance Index: -0.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RN7SKP244 is a pseudogene, meaning it possesses a similar DNA sequence to an active gene but lacks the capability to produce a functional protein. The RN7SK gene cluster, where RN7SKP244 resides, has been implicated in various cellular processes, including cell growth, differentiation, and apoptosis. The pseudogene's expression in a wide range of cell types, including intestinal epithelial cells, goblet cells, and stem cells, highlights its potential role in tissue development and maintenance. **Pathways and Functions:** The signaling pathways associated with RN7SKP244 are not yet fully elucidated. However, its expression in intestinal epithelial cells suggests a possible involvement in the Wnt/β-catenin pathway, which plays a critical role in regulating cell proliferation, differentiation, and survival. Additionally, the pseudogene's presence in goblet cells and stem cells implies a potential role in the maintenance of the intestinal epithelial barrier and the regulation of epithelial homeostasis. RN7SKP244 may also contribute to the development and progression of intestinal diseases, such as colorectal cancer, through its involvement in the regulation of cell growth, differentiation, and survival. The pseudogene's expression in abnormal and neoplastic cells further supports this notion, suggesting a possible role in tumorigenesis. **Clinical Significance:** The clinical significance of RN7SKP244 lies in its potential role in maintaining intestinal homeostasis and preventing disease. The pseudogene's expression in goblet cells and stem cells suggests a possible involvement in the regulation of the intestinal epithelial barrier, which is essential for preventing the translocation of toxins and pathogens into the bloodstream. Furthermore, the pseudogene's expression in abnormal and neoplastic cells highlights its potential role in the development and progression of intestinal diseases, such as colorectal cancer. Research into RN7SKP244 may provide valuable insights into the molecular mechanisms underlying these diseases and inform the development of novel therapeutic strategies. In conclusion, the RN7SKP244 pseudogene is a complex and enigmatic entity that warrants further investigation into its signaling pathways, functional implications, and clinical significance. As our understanding of this pseudogene continues to evolve, it is likely to reveal new avenues for the prevention and treatment of intestinal diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.