Details for: MICALL2 DT

Gene ID: 107986756

Symbol: MICALL2 DT

Ensembl ID: ENSG00000225981

Description: MICALL2 divergent transcript

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.5936
    Cell Significance Index: 6.7200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5352
    Cell Significance Index: 7.8000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3303
    Cell Significance Index: 4.8000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2027
    Cell Significance Index: 3.4100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1650
    Cell Significance Index: 2.3700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1172
    Cell Significance Index: 1.6500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1132
    Cell Significance Index: 1.4300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0986
    Cell Significance Index: 1.2900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0707
    Cell Significance Index: 0.7900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0661
    Cell Significance Index: 0.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0477
    Cell Significance Index: 0.9900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0351
    Cell Significance Index: 0.7200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0331
    Cell Significance Index: 0.3200
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.0164
    Cell Significance Index: 0.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0160
    Cell Significance Index: 0.4300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.0113
    Cell Significance Index: 0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0054
    Cell Significance Index: 1.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0024
    Cell Significance Index: 0.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0022
    Cell Significance Index: 0.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0021
    Cell Significance Index: 0.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0012
    Cell Significance Index: 2.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0009
    Cell Significance Index: 0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0005
    Cell Significance Index: 0.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0001
    Cell Significance Index: 0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: 0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0003
    Cell Significance Index: -0.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0006
    Cell Significance Index: -0.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0006
    Cell Significance Index: -0.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0010
    Cell Significance Index: -0.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0010
    Cell Significance Index: -0.5900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0023
    Cell Significance Index: -0.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0026
    Cell Significance Index: -0.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0027
    Cell Significance Index: -0.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0028
    Cell Significance Index: -0.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0034
    Cell Significance Index: -0.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0035
    Cell Significance Index: -0.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0043
    Cell Significance Index: -0.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0043
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0045
    Cell Significance Index: -0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0048
    Cell Significance Index: -0.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0050
    Cell Significance Index: -0.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0051
    Cell Significance Index: -0.1000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0053
    Cell Significance Index: -0.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0058
    Cell Significance Index: -0.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0060
    Cell Significance Index: -0.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0061
    Cell Significance Index: -0.3400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0065
    Cell Significance Index: -0.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0072
    Cell Significance Index: -0.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0074
    Cell Significance Index: -0.2600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0077
    Cell Significance Index: -0.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0080
    Cell Significance Index: -0.2000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0082
    Cell Significance Index: -0.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0084
    Cell Significance Index: -0.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0088
    Cell Significance Index: -0.1300
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0095
    Cell Significance Index: -0.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0100
    Cell Significance Index: -0.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0101
    Cell Significance Index: -0.2100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0107
    Cell Significance Index: -0.2600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0109
    Cell Significance Index: -0.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0110
    Cell Significance Index: -0.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0120
    Cell Significance Index: -0.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0121
    Cell Significance Index: -0.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0141
    Cell Significance Index: -0.3600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0143
    Cell Significance Index: -0.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0144
    Cell Significance Index: -0.3600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0145
    Cell Significance Index: -0.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0147
    Cell Significance Index: -0.4200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0156
    Cell Significance Index: -0.2000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0159
    Cell Significance Index: -0.3100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0160
    Cell Significance Index: -0.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0160
    Cell Significance Index: -0.4200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0164
    Cell Significance Index: -0.4000
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0167
    Cell Significance Index: -0.1700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0167
    Cell Significance Index: -0.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0179
    Cell Significance Index: -0.3500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0180
    Cell Significance Index: -0.2400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0182
    Cell Significance Index: -0.2300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0184
    Cell Significance Index: -0.2800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0187
    Cell Significance Index: -0.2800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0192
    Cell Significance Index: -0.2400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0193
    Cell Significance Index: -0.2500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0193
    Cell Significance Index: -0.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0202
    Cell Significance Index: -0.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0203
    Cell Significance Index: -0.4700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0216
    Cell Significance Index: -0.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0225
    Cell Significance Index: -0.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0230
    Cell Significance Index: -0.3300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0231
    Cell Significance Index: -0.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0232
    Cell Significance Index: -0.3500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0236
    Cell Significance Index: -0.4700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0237
    Cell Significance Index: -0.3200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0238
    Cell Significance Index: -0.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Divergent Transcript:** The MICALL2 DT transcript is a variant of the MICALL2 gene, which is characterized by an aberrant splicing pattern, resulting in a distinct transcriptome profile. 2. **Tissue-Specific Expression:** MICALL2 DT is significantly expressed in various cell types, including blood vessel endothelial cells, goblet cells, intestinal crypt stem cells, and early T lineage precursors, among others. 3. **Cellular Heterogeneity:** The expression of MICALL2 DT is observed in a diverse range of cell types, suggesting a potential role in regulating cellular processes and tissue homeostasis. **Pathways and Functions:** While the exact functions of MICALL2 DT remain unclear, several signaling pathways are hypothesized to be involved in its regulation: 1. **Notch Signaling:** The Notch signaling pathway, crucial for cell fate determination and differentiation, may play a role in the regulation of MICALL2 DT expression. 2. **Wnt/β-catenin Signaling:** The Wnt/β-catenin pathway, involved in cell proliferation and differentiation, could also influence MICALL2 DT expression. 3. **Immune Response:** Given its expression in immune cells, MICALL2 DT may be involved in regulating immune responses, including the activation and differentiation of T cells. 4. **Cell Adhesion and Migration:** The expression of MICALL2 DT in endothelial cells and goblet cells suggests a potential role in cell adhesion and migration, processes critical for tissue development and repair. **Clinical Significance:** The clinical significance of MICALL2 DT remains a topic of ongoing research. However, potential implications of its dysregulation include: 1. **Immunological Disorders:** Aberrant expression of MICALL2 DT may contribute to the development of immunological disorders, such as autoimmune diseases or cancer. 2. **Tissue Injury and Repair:** The role of MICALL2 DT in cell adhesion and migration suggests that its dysregulation may impact tissue repair and regeneration. 3. **Neurological Disorders:** The expression of MICALL2 DT in cerebral cortex GABAergic interneurons and forebrain radial glial cells implies a potential role in neurological disorders, such as epilepsy or neurodegenerative diseases. In conclusion, the MICALL2 DT transcript represents an enigmatic variant of the MICALL2 gene, with a complex expression profile and potential functions in cellular regulation and disease pathogenesis. Further research is necessary to elucidate the molecular mechanisms underlying its regulation and clinical significance, ultimately contributing to a deeper understanding of the intricate relationships between gene expression, cellular processes, and human disease.

Database document:

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