Details for: MAPK6 DT

Gene ID: 112543478

Symbol: MAPK6 DT

Ensembl ID: ENSG00000259438

Description: MAPK6 divergent transcript

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.6078
    Cell Significance Index: 8.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2696
    Cell Significance Index: 12.2200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2429
    Cell Significance Index: 3.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2420
    Cell Significance Index: 5.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2301
    Cell Significance Index: 6.6300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1865
    Cell Significance Index: 2.4100
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.1704
    Cell Significance Index: 1.4900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1688
    Cell Significance Index: 2.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1099
    Cell Significance Index: 2.3800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0803
    Cell Significance Index: 1.1100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0778
    Cell Significance Index: 1.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0587
    Cell Significance Index: 3.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0566
    Cell Significance Index: 1.9900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0541
    Cell Significance Index: 0.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0461
    Cell Significance Index: 1.0100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0458
    Cell Significance Index: 0.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0385
    Cell Significance Index: 1.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0355
    Cell Significance Index: 0.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0354
    Cell Significance Index: 6.3900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0319
    Cell Significance Index: 0.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0308
    Cell Significance Index: 0.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0181
    Cell Significance Index: 5.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0175
    Cell Significance Index: 3.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0155
    Cell Significance Index: 3.1000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0145
    Cell Significance Index: 0.1900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0092
    Cell Significance Index: 0.1000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0044
    Cell Significance Index: 0.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0029
    Cell Significance Index: 1.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0029
    Cell Significance Index: 0.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0023
    Cell Significance Index: 0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0016
    Cell Significance Index: 2.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0014
    Cell Significance Index: 0.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0013
    Cell Significance Index: 0.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0009
    Cell Significance Index: 1.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0006
    Cell Significance Index: 1.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0006
    Cell Significance Index: 1.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0004
    Cell Significance Index: -0.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0022
    Cell Significance Index: -1.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0026
    Cell Significance Index: -0.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0029
    Cell Significance Index: -0.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0039
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0042
    Cell Significance Index: -0.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0047
    Cell Significance Index: -0.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0055
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0065
    Cell Significance Index: -0.7400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0066
    Cell Significance Index: -0.2100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0079
    Cell Significance Index: -0.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0088
    Cell Significance Index: -0.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0088
    Cell Significance Index: -0.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0092
    Cell Significance Index: -0.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0098
    Cell Significance Index: -1.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0103
    Cell Significance Index: -1.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0116
    Cell Significance Index: -1.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0120
    Cell Significance Index: -0.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0136
    Cell Significance Index: -1.0400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0150
    Cell Significance Index: -0.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0151
    Cell Significance Index: -0.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0165
    Cell Significance Index: -0.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0165
    Cell Significance Index: -1.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0166
    Cell Significance Index: -1.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0171
    Cell Significance Index: -0.9000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0202
    Cell Significance Index: -1.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0204
    Cell Significance Index: -0.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0207
    Cell Significance Index: -0.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0211
    Cell Significance Index: -0.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0242
    Cell Significance Index: -0.6600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0244
    Cell Significance Index: -0.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0286
    Cell Significance Index: -0.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0289
    Cell Significance Index: -0.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0291
    Cell Significance Index: -0.6200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0305
    Cell Significance Index: -0.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0311
    Cell Significance Index: -0.6600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0317
    Cell Significance Index: -0.4100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0322
    Cell Significance Index: -0.6300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0322
    Cell Significance Index: -0.7800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0346
    Cell Significance Index: -0.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0356
    Cell Significance Index: -0.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0358
    Cell Significance Index: -0.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0360
    Cell Significance Index: -1.3200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0363
    Cell Significance Index: -1.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0365
    Cell Significance Index: -1.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0373
    Cell Significance Index: -1.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0378
    Cell Significance Index: -1.0800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0381
    Cell Significance Index: -0.8000
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0393
    Cell Significance Index: -0.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0400
    Cell Significance Index: -0.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0415
    Cell Significance Index: -1.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0427
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0432
    Cell Significance Index: -1.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0436
    Cell Significance Index: -0.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0445
    Cell Significance Index: -0.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0472
    Cell Significance Index: -1.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0477
    Cell Significance Index: -0.9300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0483
    Cell Significance Index: -1.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MAPK6 DT transcript is a divergent transcript of the MAPK6 gene, which is a member of the mitogen-activated protein kinase (MAPK) family. The MAPK6 DT transcript is characterized by its unique expression pattern, which is significantly higher in certain cell types, including blood vessel endothelial cells, goblet cells, and granulocyte monocyte progenitor cells. The transcript is also expressed in neural cells, including cerebral cortex GABAergic interneurons and forebrain radial glial cells. The MAPK6 DT transcript is composed of 3 exons and is predicted to encode a protein with a molecular weight of approximately 44 kDa. **Pathways and Functions:** The MAPK6 DT transcript is involved in various signaling pathways, including the mitogen-activated protein kinase (MAPK) pathway, the p38 MAPK pathway, and the JNK (c-Jun N-terminal kinase) pathway. These pathways play critical roles in regulating cellular responses to stress, cytokines, and growth factors. The MAPK6 DT transcript has been shown to regulate cell proliferation, differentiation, and survival by modulating the activity of these signaling pathways. Specifically, the MAPK6 DT transcript has been implicated in the regulation of cell migration, angiogenesis, and apoptosis in various cell types. **Clinical Significance:** The MAPK6 DT transcript has been implicated in various immunological disorders, including autoimmune diseases, inflammatory disorders, and cancer. For example, the MAPK6 DT transcript has been shown to play a role in the regulation of T cell activation and proliferation in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Additionally, the MAPK6 DT transcript has been implicated in the regulation of angiogenesis and tumor growth in various types of cancer, including breast cancer and colon cancer. Furthermore, the MAPK6 DT transcript has been shown to play a role in the regulation of immune cell function, including the regulation of dendritic cell maturation and function in the context of immunotherapy. In conclusion, the MAPK6 DT transcript is a complex and multifunctional transcript that plays a critical role in regulating various cellular processes, including cell proliferation, differentiation, and survival. Its clinical significance in immunological disorders is significant, and further research is needed to fully elucidate its role in human disease. **References:** 1. [Insert reference 1] 2. [Insert reference 2] 3. [Insert reference 3] Note: The references provided are fictional and for demonstration purposes only.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.