Details for: PRR34 AS1

Gene ID: 150381

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: PRR34 AS1

Ensembl ID: ENSG00000197182

Description: PRR34 antisense RNA 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 11.82
    rCSI 19.84%
    PRS 85.89
  • alveolar adventitial fibroblast CL4028006
    CSI 8.64
    rCSI 13.65%
    PRS 95.42
  • lung secretory cell CL1000272
    CSI 7.36
    rCSI 18.23%
    PRS 95.72
  • mesothelial cell CL0000077
    CSI 5.56
    rCSI 21.74%
    PRS 83.17
  • glioblast CL0000030
    CSI 5.56
    rCSI 8.86%
    PRS 88.8
  • enteroendocrine cell CL0000164
    CSI 5.3
    rCSI 7.25%
    PRS 92.56
  • epicardial adipocyte CL1000309
    CSI 5.03
    rCSI 16.38%
    PRS 92.61
  • interneuron CL0000099
    CSI 4.97
    rCSI 9.98%
    PRS 90.56
  • L6b glutamatergic cortical neuron CL4023038
    CSI 4.84
    rCSI 15.13%
    PRS 86.7
  • blood vessel endothelial cell CL0000071
    CSI 4.39
    rCSI 9.1%
    PRS 93.38
  • glutamatergic neuron CL0000679
    CSI 4.37
    rCSI 8.99%
    PRS 85.31
  • vascular leptomeningeal cell CL4023051
    CSI 4.22
    rCSI 7.4%
    PRS 92.56
  • chondrocyte CL0000138
    CSI 4.18
    rCSI 6.64%
    PRS 91.36
  • melanocyte CL0000148
    CSI 4.1
    rCSI 3.04%
    PRS 92.31
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.95
    rCSI 10.22%
    PRS 92.94
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 3.86
    rCSI 4.96%
    PRS 91.52
  • subcutaneous adipocyte CL0002521
    CSI 3.74
    rCSI 19.17%
    PRS 95.78
  • Mueller cell CL0000636
    CSI 3.72
    rCSI 8.48%
    PRS 89.92
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 3.62
    rCSI 9.43%
    PRS 95.87
  • adipocyte CL0000136
    CSI 3.59
    rCSI 4.61%
    PRS 88.38
  • alveolar type 1 fibroblast cell CL4028004
    CSI 3.31
    rCSI 3.62%
    PRS 95.69
  • hepatic stellate cell CL0000632
    CSI 3.2
    rCSI 12.01%
    PRS 92.02
  • brush cell of tracheobronchial tree CL0002075
    CSI 3.11
    rCSI 9.24%
    PRS 97.59
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 3.06
    rCSI 7.45%
    PRS 83.83
  • cerebellar granule cell CL0001031
    CSI 3.03
    rCSI 4.45%
    PRS 90.98
  • endocardial cell CL0002350
    CSI 3
    rCSI 14.35%
    PRS 92.25
  • Kupffer cell CL0000091
    CSI 2.99
    rCSI 6.83%
    PRS 95.46
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.98
    rCSI 3.85%
    PRS 86.67
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.95
    rCSI 4.18%
    PRS 93.22
  • bronchus fibroblast of lung CL2000093
    CSI 2.88
    rCSI 2.34%
    PRS 94.32
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.86
    rCSI 2.21%
    PRS 96.15
  • choroid plexus epithelial cell CL0000706
    CSI 2.84
    rCSI 4.65%
    PRS 89.65
  • luminal epithelial cell of mammary gland CL0002326
    CSI 2.82
    rCSI 5.13%
    PRS 97.07
  • myoepithelial cell CL0000185
    CSI 2.81
    rCSI 7.11%
    PRS 96
  • respiratory suprabasal cell CL4033048
    CSI 2.73
    rCSI 3.5%
    PRS 95.44
  • alveolar macrophage CL0000583
    CSI 2.71
    rCSI 4.47%
    PRS 95.64
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.58
    rCSI 3.08%
    PRS 85.72
  • macroglial cell CL0000126
    CSI 2.57
    rCSI 6.6%
    PRS 91.27
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.53
    rCSI 3.15%
    PRS 83.61
  • fibroblast of cardiac tissue CL0002548
    CSI 2.49
    rCSI 11.91%
    PRS 95.41
  • mucus secreting cell CL0000319
    CSI 2.4
    rCSI 3.81%
    PRS 97.11
  • cardiac endothelial cell CL0010008
    CSI 2.36
    rCSI 9.54%
    PRS 95.13
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.33
    rCSI 5.91%
    PRS 90.85
  • Bergmann glial cell CL0000644
    CSI 2.3
    rCSI 3.15%
    PRS 88.97
  • inhibitory interneuron CL0000498
    CSI 2.26
    rCSI 5.22%
    PRS 88.02
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 2.26
    rCSI 3.99%
    PRS 85.16
  • epithelial cell of proximal tubule CL0002306
    CSI 2.25
    rCSI 5.49%
    PRS 89.76
  • cerebral cortex endothelial cell CL1001602
    CSI 2.22
    rCSI 3.84%
    PRS 91.25
  • cardiac neuron CL0010022
    CSI 2.22
    rCSI 7.1%
    PRS 93.8
  • Schwann cell CL0002573
    CSI 2.21
    rCSI 6.29%
    PRS 91.79
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.2
    rCSI 3.99%
    PRS 90.25
  • BEST4+ enteroycte CL4030026
    CSI 2.13
    rCSI 2.65%
    PRS 93.85
  • basal cell CL0000646
    CSI 2.08
    rCSI 2.78%
    PRS 92.32
  • renal beta-intercalated cell CL0002201
    CSI 2.07
    rCSI 4.93%
    PRS 94.81
  • pulmonary artery endothelial cell CL1001568
    CSI 2
    rCSI 2.73%
    PRS 97.11
  • parietal epithelial cell CL1000452
    CSI 1.99
    rCSI 5.31%
    PRS 91.17
  • pancreatic acinar cell CL0002064
    CSI 1.97
    rCSI 2.62%
    PRS 96.13
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.97
    rCSI 3.16%
    PRS 86.6
  • GABAergic neuron CL0000617
    CSI 1.96
    rCSI 6.57%
    PRS 84.22
  • peripheral nervous system neuron CL2000032
    CSI 1.94
    rCSI 2.64%
    PRS 89.78
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.93
    rCSI 11.12%
    PRS 92.45
  • cardiac muscle cell CL0000746
    CSI 1.87
    rCSI 2.69%
    PRS 88.37
  • renal principal cell CL0005009
    CSI 1.82
    rCSI 4.72%
    PRS 93.98
  • lung pericyte CL0009089
    CSI 1.78
    rCSI 4.7%
    PRS 97
  • renal interstitial pericyte CL1001318
    CSI 1.69
    rCSI 4.66%
    PRS 93.26
  • tracheobronchial smooth muscle cell CL0019019
    CSI 1.59
    rCSI 2.8%
    PRS 96.33
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.5
    rCSI 3.36%
    PRS 85.85
  • regular atrial cardiac myocyte CL0002129
    CSI 1.34
    rCSI 4.31%
    PRS 91.53
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.26
    rCSI 4.52%
    PRS 84.08
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 1.2
    rCSI 3.75%
    PRS 88.24
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.19
    rCSI 12.62%
    PRS 91.49
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.09
    rCSI 4.13%
    PRS 85.83
  • blood vessel smooth muscle cell CL0019018
    CSI 0.91
    rCSI 7.44%
    PRS 93.56
  • glial cell CL0000125
    CSI 0.87
    rCSI 3.32%
    PRS 89.51
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.76
    rCSI 18.43%
    PRS 83.41
  • podocyte CL0000653
    CSI 0.7
    rCSI 3.1%
    PRS 94.48
  • direct pathway medium spiny neuron CL4023026
    CSI 0.7
    rCSI 16.69%
    PRS 83.55
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 0.69
    rCSI 5.94%
    PRS 90.49
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.57
    rCSI 3.55%
    PRS 89.73
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.49
    rCSI 2.87%
    PRS 86.12

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

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  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary **[PRR34 AS1](/details-gene/150381)** is a long non-coding RNA (lncRNA) located on chromosome 22q13.31. Its function is not well-characterized, but as an antisense transcript, it is presumed to play a regulatory role, potentially modulating the expression of its sense-strand counterpart, `PRR34`. **Overall** expression analysis reveals a highly specific and diverse cellular landscape. The gene shows its most significant expression in the central nervous system, particularly as a defining marker for [lamp5 GABAergic cortical interneurons](/details-cell/CL4023011). It is also highly significant in several non-neuronal cell types, including [alveolar adventitial fibroblasts](/details-cell/CL4028006) and [lung secretory cells](/details-cell/CL1000272), suggesting context-dependent roles in both neuronal function and tissue homeostasis in organs such as the lung. Notably, its expression in [glioblasts](/details-cell/CL0000030) indicates a potential relevance in oncology. ## Cellular Roles and Expression Landscape The expression profile of **[PRR34 AS1](/details-gene/150381)** points to distinct and specialized roles across multiple biological systems, with a predominant signature in the central nervous system (CNS) and pulmonary tissues. The most significant expression is observed in [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 11.82), a specific subtype of inhibitory neuron, suggesting **[PRR34 AS1](/details-gene/150381)** may be critical for establishing or maintaining the identity of this cell. Its importance in the CNS is further supported by significant expression in other neuronal and brain-associated cells, including general [interneurons](/details-cell/CL0000099), [L6b glutamatergic cortical neurons](/details-cell/CL4023038), and [vascular leptomeningeal cells](/details-cell/CL4023051). Beyond the CNS, **[PRR34 AS1](/details-gene/150381)** demonstrates a strong presence in the lung, with high significance scores in both structural [alveolar adventitial fibroblasts](/details-cell/CL4028006) (CSI: 8.64) and functional [lung secretory cells](/details-cell/CL1000272) (CSI: 7.36). This dual role suggests its involvement in both tissue maintenance and specialized physiological processes within the pulmonary system. The gene's expression extends to a diverse array of other specialized cell types, including [mesothelial cells](/details-cell/CL0000077), [enteroendocrine cells](/details-cell/CL0000164), and [chondrocytes](/details-cell/CL0000138), indicating a broader, albeit highly cell-specific, regulatory function. Of particular clinical interest is its notable significance in [glioblasts](/details-cell/CL0000030) (CSI: 5.56), the malignant cells of glioblastoma, highlighting a potential role in brain cancer pathology. ## Pathways and Molecular Function The precise molecular function of **[PRR34 AS1](/details-gene/150381)** remains to be elucidated, as there are currently no curated Gene Ontology (GO) or Reactome pathway annotations for this lncRNA. As an antisense transcript, it is mechanistically poised to regulate the gene expression of its sense-strand partner, *PRR34*. This regulation could occur at multiple levels, including transcriptional interference, modulation of mRNA stability, or alteration of chromatin structure at the target gene locus. The functional consequences of this regulation are likely tied to the cellular contexts in which **[PRR34 AS1](/details-gene/150381)** is expressed. For example, in [lamp5 GABAergic cortical interneurons](/details-cell/CL4023011), it may be involved in pathways governing neuronal differentiation or synaptic function. In [alveolar adventitial fibroblasts](/details-cell/CL4028006), its activity may intersect with pathways related to extracellular matrix organization or cellular response to tissue injury. ## Research Directions The diverse and highly specific expression pattern of **[PRR34 AS1](/details-gene/150381)**, especially its prominence in both healthy specialized neurons and malignant brain cells, opens several avenues for future investigation. ### Proposed Hypotheses 1. **Role in Neuronal Specification:** Given its exceptionally high significance in [lamp5 GABAergic cortical interneurons](/details-cell/CL4023011), **[PRR34 AS1](/details-gene/150381)** may act as a master regulator that defines the transcriptional program of this specific neuronal subtype, potentially by modulating key developmental transcription factors. 2. **Function in Glioblastoma Pathogenesis:** The expression of **[PRR34 AS1](/details-gene/150381)** in [glioblasts](/details-cell/CL0000030) suggests it could function as an onco-lncRNA. It may contribute to tumor progression by promoting cell proliferation, inhibiting apoptosis, or enhancing cellular invasion, thereby representing a novel biomarker or therapeutic target for glioblastoma. 3. **Involvement in Lung Fibrosis:** The high expression in [alveolar adventitial fibroblasts](/details-cell/CL4028006) suggests a potential role for **[PRR34 AS1](/details-gene/150381)** in the lung's response to injury. It could be a key regulator of fibroblast activation and differentiation into myofibroblasts, a critical step in the development of pulmonary fibrosis. ### Suggested Experiment To test the hypothesis that **[PRR34 AS1](/details-gene/150381)** functions as an onco-lncRNA in glioblastoma, a series of functional knockdown experiments could be performed. Using antisense oligonucleotides (ASOs) or a CRISPR-interference (CRISPRi) system to specifically suppress **[PRR34 AS1](/details-gene/150381)** in patient-derived glioblastoma stem cell lines, researchers could assess the impact on key cancer hallmarks. Changes in cell viability (MTS assay), proliferation (BrdU incorporation), and invasion (transwell migration assay) would be quantified. Subsequent RNA-sequencing of the knockdown cells would identify dysregulated genes and pathways, providing mechanistic insight into how **[PRR34 AS1](/details-gene/150381)** contributes to the malignant phenotype. ### Therapeutic Potential The potential expression of **[PRR34 AS1](/details-gene/150381)** in [glioblasts](/details-cell/CL0000030) makes it an intriguing candidate for targeted therapy. As an RNA molecule, it is amenable to targeting by nucleic acid-based drugs such as ASOs, which can be designed for high specificity. If its role in promoting glioblastoma growth is confirmed, a strategy of therapeutic **inhibition** would be pursued. However, its high expression in specific healthy neuron populations necessitates a cautious approach, as on-target toxicity in the CNS would be a significant concern that must be thoroughly evaluated.