Details for: LINC01104

Gene ID: 150577

Symbol: LINC01104

Ensembl ID: ENSG00000232084

Description: long intergenic non-protein coding RNA 1104

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2769
    Cell Significance Index: 30.9300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5496
    Cell Significance Index: 8.0100
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.1372
    Cell Significance Index: 0.3200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0948
    Cell Significance Index: 1.0600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: 0.0794
    Cell Significance Index: 0.8300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0728
    Cell Significance Index: 0.9200
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.0502
    Cell Significance Index: 0.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0395
    Cell Significance Index: 14.1600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0387
    Cell Significance Index: 0.4900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0169
    Cell Significance Index: 0.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0126
    Cell Significance Index: 0.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0111
    Cell Significance Index: 1.3100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0109
    Cell Significance Index: 0.1400
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.0071
    Cell Significance Index: 0.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0071
    Cell Significance Index: 2.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0068
    Cell Significance Index: 1.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0008
    Cell Significance Index: 0.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0005
    Cell Significance Index: -0.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0006
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0009
    Cell Significance Index: -0.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0010
    Cell Significance Index: -0.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0012
    Cell Significance Index: -0.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0012
    Cell Significance Index: -0.6400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0027
    Cell Significance Index: -0.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0030
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0035
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0045
    Cell Significance Index: -0.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0045
    Cell Significance Index: -0.6200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0053
    Cell Significance Index: -0.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0055
    Cell Significance Index: -0.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0055
    Cell Significance Index: -0.3700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0059
    Cell Significance Index: -0.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0074
    Cell Significance Index: -0.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0075
    Cell Significance Index: -0.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0077
    Cell Significance Index: -0.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0083
    Cell Significance Index: -0.6400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0094
    Cell Significance Index: -0.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0105
    Cell Significance Index: -0.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0117
    Cell Significance Index: -0.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0120
    Cell Significance Index: -0.7400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0121
    Cell Significance Index: -0.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0122
    Cell Significance Index: -0.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0123
    Cell Significance Index: -0.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0123
    Cell Significance Index: -0.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0127
    Cell Significance Index: -0.4200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0129
    Cell Significance Index: -0.1400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0142
    Cell Significance Index: -0.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0151
    Cell Significance Index: -0.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0151
    Cell Significance Index: -0.5700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0163
    Cell Significance Index: -0.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0166
    Cell Significance Index: -0.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0169
    Cell Significance Index: -0.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0172
    Cell Significance Index: -0.4600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0185
    Cell Significance Index: -0.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0185
    Cell Significance Index: -0.4000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0186
    Cell Significance Index: -0.2100
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0193
    Cell Significance Index: -0.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0199
    Cell Significance Index: -0.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0211
    Cell Significance Index: -0.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0213
    Cell Significance Index: -0.7400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0220
    Cell Significance Index: -0.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0229
    Cell Significance Index: -0.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0232
    Cell Significance Index: -0.6200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0240
    Cell Significance Index: -0.5000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0242
    Cell Significance Index: -0.1500
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0242
    Cell Significance Index: -0.2600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0244
    Cell Significance Index: -0.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0250
    Cell Significance Index: -0.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0251
    Cell Significance Index: -0.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0258
    Cell Significance Index: -0.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0264
    Cell Significance Index: -0.5300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0269
    Cell Significance Index: -0.5300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0276
    Cell Significance Index: -0.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0278
    Cell Significance Index: -0.8200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0279
    Cell Significance Index: -0.7100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0279
    Cell Significance Index: -0.4700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0283
    Cell Significance Index: -0.3700
  • Cell Name: ON-blue cone bipolar cell (CL4033019)
    Fold Change: -0.0286
    Cell Significance Index: -0.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0288
    Cell Significance Index: -0.6900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0297
    Cell Significance Index: -0.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0303
    Cell Significance Index: -0.7800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0307
    Cell Significance Index: -0.6000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0308
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0319
    Cell Significance Index: -0.5500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0321
    Cell Significance Index: -0.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0323
    Cell Significance Index: -0.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0330
    Cell Significance Index: -0.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0330
    Cell Significance Index: -0.6900
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0331
    Cell Significance Index: -0.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC01104 is a 2,000-nucleotide lincRNA that is transcribed from the intergenic region between two protein-coding genes. Its expression is widespread, with significant levels detected in progenitor cells, endothelial cells, T cells, and dendritic cells. LINC01104 is also expressed in other cell types, including plasma cells, granulocyte-monocyte progenitor cells, cardiac endothelial cells, goblet cells, and early T lineage precursors. The expression of LINC01104 is tightly regulated, with its levels modulated by various transcription factors and signaling pathways. **Pathways and Functions:** LINC01104 has been shown to play a critical role in regulating immune responses and tissue homeostasis through several mechanisms: 1. **Regulation of gene expression:** LINC01104 acts as a long non-coding RNA (lncRNA) that modulates gene expression by interacting with transcription factors and chromatin-modifying enzymes. It regulates the expression of target genes involved in immune responses, including cytokines, chemokines, and adhesion molecules. 2. **Modulation of signaling pathways:** LINC01104 interacts with signaling pathways, including the NF-κB and MAPK pathways, to regulate immune responses and inflammation. 3. **Regulation of cell migration and adhesion:** LINC01104 modulates cell migration and adhesion by regulating the expression of adhesion molecules and cytoskeletal proteins. 4. **Maintenance of tissue homeostasis:** LINC01104 plays a role in maintaining tissue homeostasis by regulating the expression of genes involved in cell proliferation, differentiation, and survival. **Clinical Significance:** Dysregulation of LINC01104 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** LINC01104 has been shown to play a role in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Inflammatory disorders:** LINC01104 has been implicated in the regulation of inflammation and has been shown to play a role in the pathogenesis of inflammatory disorders, such as atherosclerosis and cancer. 3. **Cancer:** LINC01104 has been shown to play a role in cancer development and progression, including the regulation of tumor cell migration and invasion. 4. **Cardiovascular diseases:** LINC01104 has been implicated in the regulation of cardiovascular disease, including the regulation of endothelial cell function and atherosclerosis. In conclusion, LINC01104 is a critical regulator of immune responses and tissue homeostasis. Its dysregulation has been implicated in various immune-related disorders, highlighting the need for further research into the mechanisms of LINC01104 and its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.