Details for: DAPK3

Gene ID: 1613

Symbol: DAPK3

Ensembl ID: ENSG00000167657

Description: death associated protein kinase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.86
    Marker Score: 6604.5
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.65
    Marker Score: 36879
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.53
    Marker Score: 3365
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.51
    Marker Score: 572
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.46
    Marker Score: 6292.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.46
    Marker Score: 3079
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.38
    Marker Score: 5314
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.36
    Marker Score: 3311
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.35
    Marker Score: 3166
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.33
    Marker Score: 473
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.28
    Marker Score: 404
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19743
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.17
    Marker Score: 1098
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.13
    Marker Score: 2009
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.11
    Marker Score: 4347
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.09
    Marker Score: 370
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.08
    Marker Score: 5303
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.07
    Marker Score: 1551
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.04
    Marker Score: 659.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.03
    Marker Score: 1938
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.02
    Marker Score: 2508.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.02
    Marker Score: 34574
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1
    Marker Score: 585.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71689
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47914
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30392
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.95
    Marker Score: 269
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2392
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.94
    Marker Score: 1220
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.92
    Marker Score: 629
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.92
    Marker Score: 1338
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.92
    Marker Score: 234
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.91
    Marker Score: 9415
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.91
    Marker Score: 2471
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.91
    Marker Score: 1401
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2696
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.88
    Marker Score: 805
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.87
    Marker Score: 1053
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.85
    Marker Score: 559
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.84
    Marker Score: 465
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.84
    Marker Score: 3534.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4745
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.83
    Marker Score: 5270
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 598.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.78
    Marker Score: 1987
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.77
    Marker Score: 242
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.77
    Marker Score: 962.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.76
    Marker Score: 8600
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.76
    Marker Score: 728
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.76
    Marker Score: 786
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.76
    Marker Score: 595.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.74
    Marker Score: 9815
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.74
    Marker Score: 4407
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.74
    Marker Score: 834
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.74
    Marker Score: 916
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.74
    Marker Score: 217
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.74
    Marker Score: 1245
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.71
    Marker Score: 912
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.71
    Marker Score: 969.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.7
    Marker Score: 679
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.7
    Marker Score: 261
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7
    Marker Score: 42975
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.7
    Marker Score: 178
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.7
    Marker Score: 1581
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.7
    Marker Score: 332
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.7
    Marker Score: 360
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.69
    Marker Score: 666
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.69
    Marker Score: 3304
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2865
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.67
    Marker Score: 5791
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.67
    Marker Score: 725
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.67
    Marker Score: 1369
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.67
    Marker Score: 393
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.67
    Marker Score: 2109
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.67
    Marker Score: 429
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 608
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.67
    Marker Score: 444
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.66
    Marker Score: 1213
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.66
    Marker Score: 701
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.66
    Marker Score: 569
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.66
    Marker Score: 383
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.66
    Marker Score: 1372
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.66
    Marker Score: 1717
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.65
    Marker Score: 705
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.65
    Marker Score: 579.5
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.65
    Marker Score: 146
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.65
    Marker Score: 208
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.65
    Marker Score: 692
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.65
    Marker Score: 780
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.65
    Marker Score: 225
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.64
    Marker Score: 3864
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 425

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Other Information

**Key characteristics:** * DAPK3 is a serine/threonine kinase that is involved in both intrinsic and extrinsic apoptotic pathways. * It is a key regulator of cardiac development and function. * It is also involved in cell cycle regulation, DNA repair, and inflammation. **Pathways and functions:** * DAPK3 is a key regulator of apoptosis. It is activated by various apoptotic signals, including DNA damage, unfolded protein response, and growth factor deprivation. * It phosphorylates a number of key proteins involved in apoptosis, including Bad, Bcl-xL, and p53. * By phosphorylating these proteins, DAPK3 promotes apoptosis. * It also plays a role in cell cycle regulation. * It is involved in DNA repair and maintenance. **Clinical significance:** * Mutations in DAPK3 have been linked to a number of human diseases, including heart disease, cancer, and developmental disorders. * Inhibition of DAPK3 has been shown to promote cell survival and inhibit apoptosis. * Therefore, DAPK3 is a potential therapeutic target for diseases that are characterized by excessive cell death. **Additional information:** * DAPK3 is a highly conserved protein that is found in all eukaryotes. * It is a member of the DAPK family of serine/threonine kinases. * It is a highly regulated protein that is controlled by a variety of cellular signals.

Genular Protein ID: 1535740460

Symbol: DAPK3_HUMAN

Name: Death-associated protein kinase 3

UniProtKB Accession Codes:

O43293 A0AVN4 B3KQE2 Q05JY4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 7 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9488481

Title: ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.

PubMed ID: 9488481

DOI: 10.1128/mcb.18.3.1642

PubMed ID: 10356987

Title: ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells.

PubMed ID: 10356987

DOI: 10.1016/s0014-5793(99)00550-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17126281

Title: Novel ZIP kinase isoform lacks leucine zipper.

PubMed ID: 17126281

DOI: 10.1016/j.abb.2006.09.026

PubMed ID: 11384979

Title: Zipper-interacting protein kinase induces Ca(2+)-free smooth muscle contraction via myosin light chain phosphorylation.

PubMed ID: 11384979

DOI: 10.1074/jbc.m102753200

PubMed ID: 11781833

Title: HeLa ZIP kinase induces diphosphorylation of myosin II regulatory light chain and reorganization of actin filaments in nonmuscle cells.

PubMed ID: 11781833

DOI: 10.1038/sj.onc.1205055

PubMed ID: 12917339

Title: ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.

PubMed ID: 12917339

DOI: 10.1128/mcb.23.17.6174-6186.2003

PubMed ID: 15292222

Title: Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase.

PubMed ID: 15292222

DOI: 10.1074/jbc.m403676200

PubMed ID: 15096528

Title: ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts.

PubMed ID: 15096528

DOI: 10.1083/jcb.200309056

PubMed ID: 15367680

Title: Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions.

PubMed ID: 15367680

DOI: 10.1128/mcb.24.19.8611-8626.2004

PubMed ID: 16219639

Title: Physical and functional interactions between STAT3 and ZIP kinase.

PubMed ID: 16219639

DOI: 10.1093/intimm/dxh331

PubMed ID: 15910542

Title: TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3.

PubMed ID: 15910542

DOI: 10.1111/j.1365-2605.2005.00522.x

PubMed ID: 15611134

Title: Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation.

PubMed ID: 15611134

DOI: 10.1074/jbc.m412538200

PubMed ID: 16756490

Title: The death-associated protein kinases: structure, function, and beyond.

PubMed ID: 16756490

DOI: 10.1146/annurev.biochem.75.103004.142615

PubMed ID: 17158456

Title: ROCK1 phosphorylates and activates zipper-interacting protein kinase.

PubMed ID: 17158456

DOI: 10.1074/jbc.m609990200

PubMed ID: 17953487

Title: ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene.

PubMed ID: 17953487

DOI: 10.1371/journal.pgen.0030180

Title: Dlk/ZIP kinase, a novel Ser/Thr-specific protein kinase with multiple functions.

DOI: 10.1002/sita.200600112

PubMed ID: 18995835

Title: DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression.

PubMed ID: 18995835

DOI: 10.1016/j.molcel.2008.09.019

PubMed ID: 18084323

Title: ZIP kinase plays a crucial role in androgen receptor-mediated transcription.

PubMed ID: 18084323

DOI: 10.1038/sj.onc.1210995

PubMed ID: 21487036

Title: Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase.

PubMed ID: 21487036

DOI: 10.1158/0008-5472.can-10-3543

PubMed ID: 20854903

Title: Phosphorylation-dependent control of ZIPK nuclear import is species specific.

PubMed ID: 20854903

DOI: 10.1016/j.cellsig.2010.09.016

PubMed ID: 21169990

Title: Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy.

PubMed ID: 21169990

DOI: 10.1038/emboj.2010.338

PubMed ID: 21454679

Title: Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4).

PubMed ID: 21454679

DOI: 10.1074/jbc.m110.189829

PubMed ID: 21408167

Title: New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform.

PubMed ID: 21408167

DOI: 10.1371/journal.pone.0017344

PubMed ID: 23454120

Title: Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics.

PubMed ID: 23454120

DOI: 10.1016/j.bbrc.2013.02.046

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18239682

Title: Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.

PubMed ID: 18239682

DOI: 10.1038/emboj.2008.8

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 454
  • Mass: 52536
  • Checksum: 56773008A6A61CF0
  • Sequence:
    • MSTFRQEDVE DHYEMGEELG SGQFAIVRKC RQKGTGKEYA AKFIKKRRLS SSRRGVSREE 
IEREVNILRE IRHPNIITLH DIFENKTDVV LILELVSGGE LFDFLAEKES LTEDEATQFL 
KQILDGVHYL HSKRIAHFDL KPENIMLLDK NVPNPRIKLI DFGIAHKIEA GNEFKNIFGT 
PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGE TKQETLTNIS AVNYDFDEEY 
FSNTSELAKD FIRRLLVKDP KRRMTIAQSL EHSWIKAIRR RNVRGEDSGR KPERRRLKTT 
RLKEYTIKSH SSLPPNNSYA DFERFSKVLE EAAAAEEGLR ELQRSRRLCH EDVEALAAIY 
EEKEAWYREE SDSLGQDLRR LRQELLKTEA LKRQAQEEAK GALLGTSGLK RRFSRLENRY 
EALAKQVASE MRFVQDLVRA LEQEKLQGVE CGLR

Genular Protein ID: 2635231996

Symbol: B3KNJ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KNJ3

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 454
  • Mass: 52506
  • Checksum: F739E549E87CC9BE
  • Sequence:
    • MSTFRQEDVE DHYEMGEELG SGQFAIVRKC RQKGTGKEYA AKFIKKRRLS SSRRGVSREE 
IEREVNILRE IRHPNIITLH DIFENKTDVV LILELVSGGE LFDFLAEKES LTEDEATQFL 
KQILDGVHYL HSKRIAHFDL KPENIMLLDK NVPNPRIKLI DFGIAHKIEA GNEFKNIFGT 
PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGE TKQETLTNIS AVNYDFDEEY 
FSNTGELAKD FIRRLLVKDP KRRMTIAQSL EHSWIKAIRR RNVRGEDSGR KPERRRLKTT 
RLKEYTIKSH SSLPPNNSYA DFERFSKVLE EAAAAEEGLR ELQRSRRLCH EDVEALAAIY 
EEKEAWYREE SDSLGQDLRR LRQELLKTEA LKRQAQEEAK GALLGTSGLK RRFSRLENRY 
EALAKQVASE MRFVQDLVRA LEQEKLQGVE CGLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.