Details for: CELA1

Gene ID: 1990

Symbol: CELA1

Ensembl ID: ENSG00000139610

Description: chymotrypsin like elastase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 8.6791
    Cell Significance Index: -1.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 4.8099
    Cell Significance Index: -1.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 3.5692
    Cell Significance Index: -1.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.0949
    Cell Significance Index: -1.3500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1920
    Cell Significance Index: 1.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1805
    Cell Significance Index: 2.5900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1211
    Cell Significance Index: 1.7000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1106
    Cell Significance Index: 1.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0689
    Cell Significance Index: 1.7700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0626
    Cell Significance Index: 1.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0581
    Cell Significance Index: 3.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0313
    Cell Significance Index: 0.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0069
    Cell Significance Index: 0.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0055
    Cell Significance Index: 1.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0029
    Cell Significance Index: 0.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0015
    Cell Significance Index: 0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0008
    Cell Significance Index: 1.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0005
    Cell Significance Index: 0.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0007
    Cell Significance Index: -0.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0019
    Cell Significance Index: -1.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0019
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0023
    Cell Significance Index: -0.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0023
    Cell Significance Index: -1.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0024
    Cell Significance Index: -1.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0025
    Cell Significance Index: -1.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0026
    Cell Significance Index: -0.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0027
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0035
    Cell Significance Index: -0.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0067
    Cell Significance Index: -0.7900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0079
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0086
    Cell Significance Index: -1.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0091
    Cell Significance Index: -0.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0097
    Cell Significance Index: -0.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0097
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0115
    Cell Significance Index: -1.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0116
    Cell Significance Index: -1.2100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0117
    Cell Significance Index: -0.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0117
    Cell Significance Index: -1.3600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0158
    Cell Significance Index: -0.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0162
    Cell Significance Index: -1.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0167
    Cell Significance Index: -1.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0182
    Cell Significance Index: -1.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0182
    Cell Significance Index: -1.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0194
    Cell Significance Index: -0.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0199
    Cell Significance Index: -0.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0202
    Cell Significance Index: -0.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0208
    Cell Significance Index: -1.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0241
    Cell Significance Index: -1.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0244
    Cell Significance Index: -1.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0249
    Cell Significance Index: -0.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0251
    Cell Significance Index: -0.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0271
    Cell Significance Index: -0.9500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0275
    Cell Significance Index: -0.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0276
    Cell Significance Index: -0.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0276
    Cell Significance Index: -1.2500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0279
    Cell Significance Index: -0.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0281
    Cell Significance Index: -0.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0284
    Cell Significance Index: -0.4900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0298
    Cell Significance Index: -0.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0310
    Cell Significance Index: -0.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0322
    Cell Significance Index: -1.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0347
    Cell Significance Index: -1.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0373
    Cell Significance Index: -0.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0373
    Cell Significance Index: -1.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0378
    Cell Significance Index: -1.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0399
    Cell Significance Index: -0.7800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0408
    Cell Significance Index: -0.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0409
    Cell Significance Index: -1.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0426
    Cell Significance Index: -1.1600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0435
    Cell Significance Index: -0.5800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0437
    Cell Significance Index: -0.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0437
    Cell Significance Index: -1.2600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0438
    Cell Significance Index: -0.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0452
    Cell Significance Index: -1.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0459
    Cell Significance Index: -1.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0462
    Cell Significance Index: -0.9800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0467
    Cell Significance Index: -1.0100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0471
    Cell Significance Index: -0.6700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0489
    Cell Significance Index: -0.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0492
    Cell Significance Index: -1.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0502
    Cell Significance Index: -0.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0513
    Cell Significance Index: -1.0300
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0522
    Cell Significance Index: -0.5300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0531
    Cell Significance Index: -0.6200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0531
    Cell Significance Index: -1.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0538
    Cell Significance Index: -1.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0540
    Cell Significance Index: -1.4200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0541
    Cell Significance Index: -1.1300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0559
    Cell Significance Index: -1.3700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0565
    Cell Significance Index: -1.1500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0569
    Cell Significance Index: -0.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0571
    Cell Significance Index: -1.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0579
    Cell Significance Index: -0.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0584
    Cell Significance Index: -1.4600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0590
    Cell Significance Index: -1.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** CELA1 is widely expressed in various tissues, including the pancreas, intestine, kidney, and brain, where it is predominantly found in endothelial cells, goblet cells, and stem cells. 2. **Molecular Structure:** CELA1 belongs to the chymotrypsin-like elastase family, characterized by a conserved catalytic domain and a distinctive C-terminal extension. 3. **Enzymatic Activity:** CELA1 exhibits serine-type endopeptidase activity, cleaving peptide bonds in protein substrates, and is involved in proteolytic cascades that regulate tissue remodeling and inflammation. **Pathways and Functions:** 1. **Inflammatory Response:** CELA1 is implicated in the regulation of inflammatory responses, particularly in the context of tissue injury and repair. It modulates the activity of pro-inflammatory cytokines and enzymes, influencing the severity and duration of inflammatory reactions. 2. **Tissue Remodeling:** CELA1 is involved in the remodeling of tissues, such as the pancreas, intestine, and kidney, where it regulates the degradation and reorganization of extracellular matrix components. 3. **Cell Differentiation:** CELA1 plays a role in the regulation of cell differentiation, particularly in the development of goblet cells and stem cells. It influences the expression of transcription factors and signaling pathways that control cell fate decisions. 4. **Angiogenesis:** CELA1 is a positive regulator of angiogenesis, a process essential for tissue growth and repair. It modulates the activity of pro-angiogenic factors and enzymes, promoting the formation of new blood vessels. **Clinical Significance:** 1. **Pancreatic Diseases:** CELA1 has been implicated in various pancreatic disorders, including pancreatitis, pancreatic cancer, and pancreatitis-induced diabetes. Its dysregulation may contribute to the pathogenesis of these diseases. 2. **Inflammatory Bowel Disease:** CELA1 expression is altered in inflammatory bowel disease (IBD), a chronic inflammatory condition affecting the intestine. Its dysregulation may contribute to the development and progression of IBD. 3. **Neurological Disorders:** CELA1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to the pathogenesis of these conditions. 4. **Cancer:** CELA1 has been identified as a potential biomarker and therapeutic target in cancer, particularly in pancreatic and lung cancers, where its dysregulation is associated with tumor progression and metastasis. In conclusion, CELA1 is a multifunctional serine-type endopeptidase that plays a crucial role in regulating various physiological processes, including inflammation, tissue remodeling, and cell differentiation. Its dysregulation is implicated in various diseases, including pancreatic disorders, inflammatory bowel disease, neurological disorders, and cancer. Further research is needed to elucidate the complex mechanisms underlying CELA1's functions and to explore its therapeutic potential in these diseases.

Genular Protein ID: 2394111408

Symbol: CELA1_HUMAN

Name: Chymotrypsin-like elastase family member 1

UniProtKB Accession Codes:

Q9UNI1 Q5MLF0 Q6DJT0 Q6ISM6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 17 DrugCentral 1 EC 2 EMBL 5 Ensembl 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10620133

Title: Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism.

PubMed ID: 10620133

DOI: 10.1046/j.1523-1747.2000.00825.x

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 258
  • Mass: 27798
  • Checksum: 684EDE8F1F011F8D
  • Sequence:
    • MLVLYGHSTQ DLPETNARVV GGTEAGRNSW PSQISLQYRS GGSRYHTCGG TLIRQNWVMT 
AAHCVDYQKT FRVVAGDHNL SQNDGTEQYV SVQKIVVHPY WNSDNVAAGY DIALLRLAQS 
VTLNSYVQLG VLPQEGAILA NNSPCYITGW GKTKTNGQLA QTLQQAYLPS VDYAICSSSS 
YWGSTVKNTM VCAGGDGVRS GCQGDSGGPL HCLVNGKYSV HGVTSFVSSR GCNVSRKPTV 
FTQVSAYISW INNVIASN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.