Details for: FBP1

Gene ID: 2203

Symbol: FBP1

Ensembl ID: ENSG00000165140

Description: fructose-bisphosphatase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.86
    Marker Score: 73333
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.5
    Marker Score: 8874
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.45
    Marker Score: 3773
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.39
    Marker Score: 3518
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.04
    Marker Score: 12423
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.01
    Marker Score: 10813.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.9
    Marker Score: 2174
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.89
    Marker Score: 12293
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.84
    Marker Score: 7086
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.83
    Marker Score: 2942
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.82
    Marker Score: 9591
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.79
    Marker Score: 7723
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.69
    Marker Score: 5545
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.67
    Marker Score: 10751.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.66
    Marker Score: 3770
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.66
    Marker Score: 661
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.63
    Marker Score: 472
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.63
    Marker Score: 7814
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.59
    Marker Score: 1064
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.58
    Marker Score: 660
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.53
    Marker Score: 2977
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.51
    Marker Score: 1699
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.46
    Marker Score: 3337
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.46
    Marker Score: 9300
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.46
    Marker Score: 3462
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.39
    Marker Score: 3362
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.31
    Marker Score: 3304
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.29
    Marker Score: 313
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.29
    Marker Score: 2050
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.29
    Marker Score: 3032
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.28
    Marker Score: 480
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.24
    Marker Score: 1259
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.22
    Marker Score: 3169
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.22
    Marker Score: 568
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.16
    Marker Score: 2365
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2106
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.09
    Marker Score: 60959
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.05
    Marker Score: 717
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.04
    Marker Score: 16703
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251742
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.04
    Marker Score: 432
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.04
    Marker Score: 257
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.04
    Marker Score: 3251
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.01
    Marker Score: 772
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.01
    Marker Score: 1004
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71763
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47988
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.98
    Marker Score: 849
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.98
    Marker Score: 250
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.93
    Marker Score: 341
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1512
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5289
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.92
    Marker Score: 181
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.92
    Marker Score: 10708
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2722
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.9
    Marker Score: 181
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.89
    Marker Score: 489
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13457
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.86
    Marker Score: 824
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.86
    Marker Score: 319
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.83
    Marker Score: 491
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.82
    Marker Score: 880.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.82
    Marker Score: 3411.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.82
    Marker Score: 236
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.81
    Marker Score: 840.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.81
    Marker Score: 363
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.8
    Marker Score: 1322
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.78
    Marker Score: 1656
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.78
    Marker Score: 910
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.76
    Marker Score: 1902
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.76
    Marker Score: 492
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 499
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.75
    Marker Score: 354
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.74
    Marker Score: 818
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3076
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.73
    Marker Score: 769
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.73
    Marker Score: 501
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.72
    Marker Score: 271
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.72
    Marker Score: 487
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.71
    Marker Score: 919
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.71
    Marker Score: 1252
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 641
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.7
    Marker Score: 1279
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.69
    Marker Score: 359
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.69
    Marker Score: 172
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.67
    Marker Score: 950
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.65
    Marker Score: 1045
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.64
    Marker Score: 195

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Other Information

**Key characteristics:** * FBP1 is a glycoprotein with a molecular weight of approximately 150 kDa. * It is highly expressed in the liver, particularly in hepatocytes. * It is also expressed in other tissues, including macrophages, epithelial cells, and enterocytes. * FBP1 is a key enzyme in the fructose 1,6-bisphosphatase (FBP) family of enzymes. * It is responsible for the regulation of glucose metabolism by controlling the flux of glucose between the blood and tissues. **Pathways and functions:** * FBP1 is involved in a variety of metabolic pathways, including the regulation of glucose metabolism, the regulation of lipid metabolism, and the regulation of inflammation. * It is a key regulator of hepatic glucose metabolism. * It is involved in the regulation of lipid metabolism by controlling the uptake of fatty acids into the liver. * It is also involved in the regulation of inflammation by binding to inflammatory cytokines and signaling pathways. **Clinical significance:** * Mutations in the FBP1 gene have been linked to several human diseases, including non-alcoholic fatty liver disease (NAFLD), obesity, and type 2 diabetes. * FBP1 is a potential therapeutic target for the treatment of these diseases. * Inhibition of FBP1 has been shown to reduce liver fat accumulation and improve insulin sensitivity in animal models of obesity and NAFLD. **Additional information:** * FBP1 is a well-studied protein that has been extensively characterized in both humans and animals. * It is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * It is a key enzyme in the regulation of energy metabolism and glucose homeostasis.

Genular Protein ID: 149621274

Symbol: F16P1_HUMAN

Name: Fructose-1,6-bisphosphatase 1

UniProtKB Accession Codes:

P09467 O75571 Q53F94 Q96E46

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EC 1 EMBL 18 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 56 PDBsum 49 PIR 1 PIRSF 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2842796

Title: Activation of the fructose 1,6-bisphosphatase gene by 1,25-dihydroxyvitamin D3 during monocytic differentiation.

PubMed ID: 2842796

DOI: 10.1073/pnas.85.18.6904

PubMed ID: 8387495

Title: Isolation of a human liver fructose-1,6-bisphosphatase cDNA and expression of the protein in Escherichia coli. Role of Asp-118 and Asp-121 in catalysis.

PubMed ID: 8387495

DOI: 10.1016/s0021-9258(18)98373-0

PubMed ID: 8135811

Title: cDNA sequences encoding human fructose 1,6-bisphosphatase from monocytes, liver and kidney: application of monocytes to molecular analysis of human fructose 1,6-bisphosphatase deficiency.

PubMed ID: 8135811

DOI: 10.1006/bbrc.1994.1283

PubMed ID: 7558035

Title: Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency.

PubMed ID: 7558035

DOI: 10.1006/geno.1995.1085

PubMed ID: 10222032

Title: cDNA sequence and kinetic properties of human lung fructose(1, 6)bisphosphatase.

PubMed ID: 10222032

DOI: 10.1006/abbi.1999.1120

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7589895

Title: Liver fructose-1,6-bisphosphatase cDNA: trans-complementation of fission yeast and characterization of two human transcripts.

PubMed ID: 7589895

DOI: 10.1046/j.1432-0436.1995.5910051.x

PubMed ID: 16497803

Title: Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis.

PubMed ID: 16497803

DOI: 10.1210/en.2005-1498

PubMed ID: 17350621

Title: Glu 69 is essential for the high sensitivity of muscle fructose-1,6-bisphosphatase inhibition by calcium ions.

PubMed ID: 17350621

DOI: 10.1016/j.febslet.2007.02.051

PubMed ID: 18375435

Title: Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function.

PubMed ID: 18375435

DOI: 10.2337/db07-1326

PubMed ID: 22517657

Title: The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity.

PubMed ID: 22517657

DOI: 10.2337/db11-1511

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8382525

Title: Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.

PubMed ID: 8382525

DOI: 10.1021/bi00058a019

PubMed ID: 7809062

Title: Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 2,6-bisphosphate, AMP, and Zn2+ at 2.0-A resolution: aspects of synergism between inhibitors.

PubMed ID: 7809062

DOI: 10.1073/pnas.91.26.12482

PubMed ID: 16446092

Title: Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.

PubMed ID: 16446092

DOI: 10.1016/j.bmcl.2006.01.014

PubMed ID: 16442285

Title: Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode.

PubMed ID: 16442285

DOI: 10.1016/j.bmcl.2006.01.015

PubMed ID: 18650089

Title: Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites.

PubMed ID: 18650089

DOI: 10.1016/j.bmcl.2008.06.103

PubMed ID: 9382095

Title: Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency.

PubMed ID: 9382095

DOI: 10.1086/514875

PubMed ID: 12126934

Title: Two newly identified genomic mutations in a Japanese female patient with fructose-1,6-bisphosphatase (FBPase) deficiency.

PubMed ID: 12126934

DOI: 10.1016/s1096-7192(02)00038-0

PubMed ID: 25601412

Title: Fructose 1,6-bisphosphatase deficiency: clinical, biochemical and genetic features in French patients.

PubMed ID: 25601412

DOI: 10.1007/s10545-014-9804-6

Sequence Information:

  • Length: 338
  • Mass: 36842
  • Checksum: B3D270BCBB358B71
  • Sequence:
    • MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI 
AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP 
LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC 
GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP 
YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK 
EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ

Genular Protein ID: 4209846018

Symbol: Q2TU34_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2TU34

Database IDs:

ARBA 18 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 6 GO 3 Gene3D 2 GenomeRNAi 1 HAMAP 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 2 PRINTS 1 PROSITE 1 Pfam 4 PharmGKB 1 RefSeq 1 Rhea 1 RuleBase 1 SMR 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 338
  • Mass: 36814
  • Checksum: BDE269BCBB359271
  • Sequence:
    • MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI 
AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP 
LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC 
GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYAKDF DPAVTEYIQR KKFPPDNSAP 
YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK 
EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.