Details for: FGF1

Gene ID: 2246

Symbol: FGF1

Ensembl ID: ENSG00000113578

Description: fibroblast growth factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.99
    Marker Score: 1791
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.2
    Marker Score: 1687
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.46
    Marker Score: 5402
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.75
    Marker Score: 10525
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.66
    Marker Score: 1148
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.52
    Marker Score: 33987
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168461
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.45
    Marker Score: 30999
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.43
    Marker Score: 774.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.4
    Marker Score: 4988
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.31
    Marker Score: 1506
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.29
    Marker Score: 3094
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19691
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.15
    Marker Score: 2331
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251789
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.02
    Marker Score: 1239
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.01
    Marker Score: 877
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.01
    Marker Score: 6695
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.99
    Marker Score: 472
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.97
    Marker Score: 357
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5324
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.92
    Marker Score: 8688
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.92
    Marker Score: 540
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.9
    Marker Score: 589
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.89
    Marker Score: 499
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.88
    Marker Score: 275
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.81
    Marker Score: 8391
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.8
    Marker Score: 1884
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.78
    Marker Score: 773
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.77
    Marker Score: 1007
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 464
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.77
    Marker Score: 243
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 508
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.77
    Marker Score: 730
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.76
    Marker Score: 278
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.74
    Marker Score: 365
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1173
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.73
    Marker Score: 1127
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.69
    Marker Score: 235
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.69
    Marker Score: 381
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.66
    Marker Score: 193
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.64
    Marker Score: 166
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.64
    Marker Score: 162
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.63
    Marker Score: 5397
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.62
    Marker Score: 303
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.62
    Marker Score: 1200.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 240
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 452
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.57
    Marker Score: 4791
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.51
    Marker Score: 577
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.51
    Marker Score: 227
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.51
    Marker Score: 10115
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.51
    Marker Score: 240
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.51
    Marker Score: 2124
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.5
    Marker Score: 18350
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.48
    Marker Score: 29574
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.48
    Marker Score: 154
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.47
    Marker Score: 650
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.46
    Marker Score: 122
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.44
    Marker Score: 830
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.44
    Marker Score: 158
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.42
    Marker Score: 172
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 404
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.41
    Marker Score: 1602
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.39
    Marker Score: 158
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.37
    Marker Score: 195
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.37
    Marker Score: 456
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.37
    Marker Score: 13948
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.36
    Marker Score: 348
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.36
    Marker Score: 488
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.36
    Marker Score: 494
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.35
    Marker Score: 122
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.35
    Marker Score: 1405
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.34
    Marker Score: 383
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.34
    Marker Score: 170
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 297
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.33
    Marker Score: 351
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.33
    Marker Score: 157
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.32
    Marker Score: 358
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.32
    Marker Score: 130
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.32
    Marker Score: 186
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.32
    Marker Score: 100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.31
    Marker Score: 162
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.31
    Marker Score: 525
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.31
    Marker Score: 896

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Other Information

**Key characteristics:** * FGF1 is a secreted protein that acts on the extracellular matrix. * It is a member of the fibroblast growth factor family. * It is a key regulator of cell growth and proliferation in various tissues. * It is involved in the regulation of epithelial cell migration, proliferation, and differentiation. * It is also involved in the development and maintenance of the cardiovascular system. **Pathways and functions:** * FGF1 binds to its receptor, FGFR1, which is expressed on the surface of various cell types. * Binding of FGF1 to FGFR1 triggers the activation of the PI3K/Akt signaling pathway. * This pathway is a major regulator of cell growth, proliferation, and survival. * FGF1 also activates the MAPK/MAPK3 signaling pathway, which is involved in cell growth and differentiation. * It also modulates the expression of other genes involved in cell growth and survival. **Clinical significance:** * Mutations in the FGF1 gene have been linked to several human diseases, including lung cancer, breast cancer, and cardiovascular disease. * FGF1 is a potential target for cancer therapy. * Inhibition of FGF1 signaling has been shown to inhibit cancer growth and proliferation. **Additional information:** * FGF1 is a highly conserved protein with similar sequences in mammals. * It is produced by a variety of cell types, including epithelial cells, fibroblasts, and endothelial cells. * It is a potent pro-proliferative factor, which means that it promotes cell growth. * It is a key factor in wound healing and tissue regeneration.

Genular Protein ID: 3208142669

Symbol: FGF1_HUMAN

Name: Fibroblast growth factor 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3523756

Title: Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization.

PubMed ID: 3523756

DOI: 10.1126/science.3523756

PubMed ID: 2590193

Title: Structural analysis of the gene for human acidic fibroblast growth factor.

PubMed ID: 2590193

DOI: 10.1016/0006-291x(89)91785-3

PubMed ID: 2474753

Title: Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues.

PubMed ID: 2474753

DOI: 10.1128/mcb.9.6.2387-2395.1989

PubMed ID: 1693186

Title: Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1.

PubMed ID: 1693186

PubMed ID: 1717925

Title: Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients.

PubMed ID: 1717925

PubMed ID: 1372643

Title: An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist.

PubMed ID: 1372643

DOI: 10.1084/jem.175.4.1073

PubMed ID: 7504343

Title: The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells.

PubMed ID: 7504343

DOI: 10.1097/00007890-199311000-00025

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2393407

Title: The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon.

PubMed ID: 2393407

DOI: 10.1016/0006-291x(90)91348-v

PubMed ID: 2427112

Title: Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor.

PubMed ID: 2427112

DOI: 10.1021/bi00362a017

PubMed ID: 3527167

Title: The complete amino acid sequence of human brain-derived acidic fibroblast growth factor.

PubMed ID: 3527167

DOI: 10.1016/s0006-291x(86)80540-x

PubMed ID: 3778488

Title: Amino acid sequence of human acidic fibroblast growth factor.

PubMed ID: 3778488

DOI: 10.1016/0006-291x(86)90716-3

PubMed ID: 3964259

Title: Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities.

PubMed ID: 3964259

DOI: 10.1016/0006-291x(86)90028-8

PubMed ID: 3732516

Title: Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors.

PubMed ID: 3732516

DOI: 10.1016/0014-5793(86)80812-2

PubMed ID: 1885605

Title: Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

PubMed ID: 1885605

DOI: 10.1016/s0021-9258(18)55368-0

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 11432880

Title: Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress.

PubMed ID: 11432880

DOI: 10.1074/jbc.m102925200

PubMed ID: 11964394

Title: Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor.

PubMed ID: 11964394

DOI: 10.1074/jbc.m112193200

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 18400376

Title: The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway.

PubMed ID: 18400376

DOI: 10.1016/j.canlet.2008.03.001

PubMed ID: 18441324

Title: Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.

PubMed ID: 18441324

DOI: 10.1074/jbc.m801213200

PubMed ID: 20863990

Title: Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells.

PubMed ID: 20863990

DOI: 10.1016/s0929-6646(10)60103-9

PubMed ID: 15863030

Title: Cellular signaling by fibroblast growth factor receptors.

PubMed ID: 15863030

DOI: 10.1016/j.cytogfr.2005.01.001

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 20422052

Title: A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist.

PubMed ID: 20422052

DOI: 10.1371/journal.pone.0010273

PubMed ID: 22321063

Title: Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1.

PubMed ID: 22321063

DOI: 10.1111/j.1600-0854.2012.01341.x

PubMed ID: 23469107

Title: A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis.

PubMed ID: 23469107

DOI: 10.1371/journal.pone.0057927

PubMed ID: 1702556

Title: Three-dimensional structures of acidic and basic fibroblast growth factors.

PubMed ID: 1702556

DOI: 10.1126/science.1702556

PubMed ID: 8652550

Title: X-ray crystal structure of human acidic fibroblast growth factor.

PubMed ID: 8652550

DOI: 10.1021/bi9521755

PubMed ID: 9655399

Title: Structure of a heparin-linked biologically active dimer of fibroblast growth factor.

PubMed ID: 9655399

DOI: 10.1038/31741

PubMed ID: 10830168

Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.

PubMed ID: 10830168

DOI: 10.1016/s0092-8674(00)80851-x

PubMed ID: 11069186

Title: Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin.

PubMed ID: 11069186

DOI: 10.1038/35039551

PubMed ID: 10618369

Title: Structural interactions of fibroblast growth factor receptor with its ligands.

PubMed ID: 10618369

DOI: 10.1073/pnas.97.1.49

PubMed ID: 11847269

Title: Alternative type I and I' turn conformations in the beta8/beta9 beta-hairpin of human acidic fibroblast growth factor.

PubMed ID: 11847269

DOI: 10.1110/ps.43802

PubMed ID: 14732692

Title: Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.

PubMed ID: 14732692

DOI: 10.1073/pnas.0307287101

PubMed ID: 7521397

Title: 1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate.

PubMed ID: 7521397

DOI: 10.1006/jmbi.1994.1558

PubMed ID: 8950275

Title: Three-dimensional structure of acidic fibroblast growth factor in solution: effects of binding to a heparin functional analog.

PubMed ID: 8950275

DOI: 10.1006/jmbi.1996.0631

PubMed ID: 9719643

Title: Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas.

PubMed ID: 9719643

DOI: 10.1006/jmbi.1998.1977

PubMed ID: 20145243

Title: Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.

PubMed ID: 20145243

DOI: 10.1074/jbc.m109.064618

PubMed ID: 20220137

Title: The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion.

PubMed ID: 20220137

DOI: 10.1074/jbc.m109.066357

Sequence Information:

  • Length: 155
  • Mass: 17460
  • Checksum: F586E8BFB09F1580
  • Sequence:
  • MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ 
    LSAESVGEVY IKSTETGQYL AMDTDGLLYG SQTPNEECLF LERLEENHYN TYISKKHAEK 
    NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD

Genular Protein ID: 3815569318

Symbol: Q16089_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7504343

Title: The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells.

PubMed ID: 7504343

Sequence Information:

  • Length: 59
  • Mass: 6595
  • Checksum: 9C83D1E64847148A
  • Sequence:
  • MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHNTK

Genular Protein ID: 696753056

Symbol: A8K147_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 154
  • Mass: 17332
  • Checksum: 4A6E0F07B357B2E8
  • Sequence:
  • MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ 
    LSAESVGEVY IKSTETGQYL AMDTDGLLYG STPNEECLFL ERLEENHYNT YISKKHAEKN 
    WFVGLKKNGS CKRGPRTHYG QKAILFLPLP VSSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.