FGF1 | ENSG00000113578 | NCBI 2246

Details for: FGF1

Gene ID: 2246

Symbol: FGF1

Ensembl ID: ENSG00000113578

Description: fibroblast growth factor 1

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Fgfr1b ligand binding and activation
(R-HSA-190370)
Fgfr1c ligand binding and activation
(R-HSA-190373)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2b ligand binding and activation
(R-HSA-190377)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr3 ligand binding and activation
(R-HSA-190239)
Fgfr3 mutant receptor activation
(R-HSA-2033514)
Fgfr3b ligand binding and activation
(R-HSA-190371)
Fgfr3c ligand binding and activation
(R-HSA-190372)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr1
(R-HSA-1839122)
Signaling by activated point mutants of fgfr3
(R-HSA-1839130)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Activation of protein kinase b activity
(GO:0032148)
Anatomical structure morphogenesis
(GO:0009653)
Angiogenesis
(GO:0001525)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Heparin binding
(GO:0008201)
Hsp70 protein binding
(GO:0030544)
Integrin binding
(GO:0005178)
Lung development
(GO:0030324)
Neurogenesis
(GO:0022008)
Organ induction
(GO:0001759)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell migration
(GO:0010595)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)
S100 protein binding
(GO:0044548)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.5842
Cell Significance Index: -14.4100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2258
Cell Significance Index: 94.0700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.1117
Cell Significance Index: 161.6000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.0913
Cell Significance Index: 14.8900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.8257
Cell Significance Index: 12.7800
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.6322
Cell Significance Index: 8.8400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2754
Cell Significance Index: 190.5000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2565
Cell Significance Index: 46.2400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2025
Cell Significance Index: 40.6300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2024
Cell Significance Index: 40.1600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1962
Cell Significance Index: 12.0600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1670
Cell Significance Index: 75.7900
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.1656
Cell Significance Index: 2.0900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.1395
Cell Significance Index: 2.0600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1056
Cell Significance Index: 37.8900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0838
Cell Significance Index: 128.9500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0682
Cell Significance Index: 30.1500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0242
Cell Significance Index: 32.9200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0229
Cell Significance Index: 43.1300
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0096
Cell Significance Index: 17.6700
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0146
Cell Significance Index: -0.2500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0174
Cell Significance Index: -11.0800
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0186
Cell Significance Index: -0.4500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0187
Cell Significance Index: -0.3200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0335
Cell Significance Index: -24.8300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0337
Cell Significance Index: -25.4800
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0392
Cell Significance Index: -21.4100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0400
Cell Significance Index: -25.0100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0453
Cell Significance Index: -25.5200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0594
Cell Significance Index: -1.6600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0611
Cell Significance Index: -17.5900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0824
Cell Significance Index: -10.1300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0956
Cell Significance Index: -4.4600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1013
Cell Significance Index: -13.9100
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1167
Cell Significance Index: -1.0800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1185
Cell Significance Index: -24.9700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1235
Cell Significance Index: -12.8600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1264
Cell Significance Index: -21.5800
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.1278
Cell Significance Index: -2.2100
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1364
Cell Significance Index: -17.4800
Cell Name: Mueller cell (CL0000636)
Fold Change: -0.1579
Cell Significance Index: -1.2200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1707
Cell Significance Index: -17.4400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1778
Cell Significance Index: -22.9700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1985
Cell Significance Index: -14.0400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2056
Cell Significance Index: -23.9600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2183
Cell Significance Index: -25.0200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2215
Cell Significance Index: -12.4300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2407
Cell Significance Index: -15.1700
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2719
Cell Significance Index: -6.5200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2751
Cell Significance Index: -5.8800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2855
Cell Significance Index: -19.2000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3093
Cell Significance Index: -24.5000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3099
Cell Significance Index: -23.1000
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3355
Cell Significance Index: -7.1200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3397
Cell Significance Index: -4.8700
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.3440
Cell Significance Index: -4.1700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3531
Cell Significance Index: -11.5600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3652
Cell Significance Index: -18.9700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3755
Cell Significance Index: -17.6500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3786
Cell Significance Index: -10.1100
Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.3787
Cell Significance Index: -4.0600
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.3804
Cell Significance Index: -5.2600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3876
Cell Significance Index: -13.5800
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.3891
Cell Significance Index: -4.9900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3906
Cell Significance Index: -20.5100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4119
Cell Significance Index: -13.1200
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.4167
Cell Significance Index: -10.4000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4476
Cell Significance Index: -19.8000
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.4717
Cell Significance Index: -14.9200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.5020
Cell Significance Index: -22.7600
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.5128
Cell Significance Index: -10.1400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5255
Cell Significance Index: -19.9000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5563
Cell Significance Index: -14.3000
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.5972
Cell Significance Index: -11.9900
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.6022
Cell Significance Index: -13.0100
Cell Name: flat midget bipolar cell (CL4033033)
Fold Change: -0.6122
Cell Significance Index: -7.6100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.6172
Cell Significance Index: -16.8000
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.6175
Cell Significance Index: -8.7900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6358
Cell Significance Index: -23.3400
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6501
Cell Significance Index: -7.7500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.6542
Cell Significance Index: -18.6700
Cell Name: astrocyte (CL0000127)
Fold Change: -0.6597
Cell Significance Index: -7.5500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.6799
Cell Significance Index: -23.8900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6945
Cell Significance Index: -24.1300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.7176
Cell Significance Index: -20.5700
Cell Name: neural cell (CL0002319)
Fold Change: -0.7235
Cell Significance Index: -8.4400
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.7235
Cell Significance Index: -18.0700
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.7359
Cell Significance Index: -18.3500
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.7398
Cell Significance Index: -15.4400
Cell Name: mural cell (CL0008034)
Fold Change: -0.7524
Cell Significance Index: -9.1600
Cell Name: macroglial cell (CL0000126)
Fold Change: -0.7549
Cell Significance Index: -8.7400
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.7614
Cell Significance Index: -19.4000
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.7949
Cell Significance Index: -10.9000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.8212
Cell Significance Index: -23.6600
Cell Name: retinal cone cell (CL0000573)
Fold Change: -0.8267
Cell Significance Index: -10.3200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8270
Cell Significance Index: -24.3600
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.8329
Cell Significance Index: -11.9600
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.8389
Cell Significance Index: -17.0700
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.8472
Cell Significance Index: -18.5500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.8625
Cell Significance Index: -23.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** FGF1 is a small, secreted protein with a molecular weight of approximately 18 kDa. It is highly conserved across species, with high sequence identity between human and mouse FGF1. FGF1 is produced by various cell types, including epithelial cells, fibroblasts, and hematopoietic stem cells. It is secreted into the extracellular environment, where it binds to FGFRs on the surface of target cells, triggering a signaling cascade. **Pathways and Functions** FGF1 signaling pathways are complex and multifaceted, involving various downstream effectors and regulatory mechanisms. The primary pathway involves the binding of FGF1 to FGFRs, which triggers the activation of tyrosine kinases and the recruitment of adapter proteins. This leads to the phosphorylation and activation of downstream signaling molecules, including MAPK, PI3K, and RAS. FGF1 signaling has been implicated in various cellular processes, including: 1. **Cell proliferation and differentiation**: FGF1 promotes cell growth and differentiation by regulating the expression of growth-regulatory genes. 2. **Angiogenesis**: FGF1 stimulates the formation of new blood vessels by promoting endothelial cell migration, proliferation, and differentiation. 3. **Organogenesis**: FGF1 plays a role in the development and patterning of organs, including the lung, heart, and brain. 4. **Wound healing**: FGF1 promotes tissue repair by regulating the expression of growth factors and cytokines. 5. **Cancer**: FGF1 has been implicated in tumorigenesis, cancer progression, and metastasis. **Clinical Significance** FGF1 has been implicated in various diseases and disorders, including: 1. **Cancer**: FGF1 overexpression has been observed in various types of cancer, including lung, breast, and colon cancer. 2. **Neurological disorders**: FGF1 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cardiovascular disease**: FGF1 has been implicated in cardiovascular disease, including atherosclerosis and cardiac remodeling. 4. **Neurodevelopmental disorders**: FGF1 has been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. 5. **Wound healing and tissue repair**: FGF1 has been used as a therapeutic agent to promote wound healing and tissue repair. In conclusion, FGF1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell proliferation, differentiation, migration, and survival. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of FGF1 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 3208142669

Symbol: FGF1_HUMAN

Name: Fibroblast growth factor 1

UniProtKB Accession Codes:

P05230 B2R5T0 D3DQF2 P07502 Q16588

Database IDs:

Citations:

PubMed ID: 3523756

Title: Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization.

PubMed ID: 3523756

DOI: 10.1126/science.3523756

PubMed ID: 2590193

Title: Structural analysis of the gene for human acidic fibroblast growth factor.

PubMed ID: 2590193

DOI: 10.1016/0006-291x(89)91785-3

PubMed ID: 2474753

Title: Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues.

PubMed ID: 2474753

DOI: 10.1128/mcb.9.6.2387-2395.1989

PubMed ID: 1693186

Title: Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1.

PubMed ID: 1693186

PubMed ID: 1717925

Title: Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients.

PubMed ID: 1717925

PubMed ID: 1372643

Title: An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist.

PubMed ID: 1372643

DOI: 10.1084/jem.175.4.1073

PubMed ID: 7504343

Title: The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells.

PubMed ID: 7504343

DOI: 10.1097/00007890-199311000-00025

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2393407

Title: The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon.

PubMed ID: 2393407

DOI: 10.1016/0006-291x(90)91348-v

PubMed ID: 2427112

Title: Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor.

PubMed ID: 2427112

DOI: 10.1021/bi00362a017

PubMed ID: 3527167

Title: The complete amino acid sequence of human brain-derived acidic fibroblast growth factor.

PubMed ID: 3527167

DOI: 10.1016/s0006-291x(86)80540-x

PubMed ID: 3778488

Title: Amino acid sequence of human acidic fibroblast growth factor.

PubMed ID: 3778488

DOI: 10.1016/0006-291x(86)90716-3

PubMed ID: 3964259

Title: Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities.

PubMed ID: 3964259

DOI: 10.1016/0006-291x(86)90028-8

PubMed ID: 3732516

Title: Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors.

PubMed ID: 3732516

DOI: 10.1016/0014-5793(86)80812-2

PubMed ID: 1885605

Title: Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

PubMed ID: 1885605

DOI: 10.1016/s0021-9258(18)55368-0

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 11432880

Title: Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress.

PubMed ID: 11432880

DOI: 10.1074/jbc.m102925200

PubMed ID: 11964394

Title: Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor.

PubMed ID: 11964394

DOI: 10.1074/jbc.m112193200

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 18400376

Title: The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway.

PubMed ID: 18400376

DOI: 10.1016/j.canlet.2008.03.001

PubMed ID: 18441324

Title: Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.

PubMed ID: 18441324

DOI: 10.1074/jbc.m801213200

PubMed ID: 20863990

Title: Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells.

PubMed ID: 20863990

DOI: 10.1016/s0929-6646(10)60103-9

PubMed ID: 15863030

Title: Cellular signaling by fibroblast growth factor receptors.

PubMed ID: 15863030

DOI: 10.1016/j.cytogfr.2005.01.001

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 20422052

Title: A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist.

PubMed ID: 20422052

DOI: 10.1371/journal.pone.0010273

PubMed ID: 22321063

Title: Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1.

PubMed ID: 22321063

DOI: 10.1111/j.1600-0854.2012.01341.x

PubMed ID: 23469107

Title: A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis.

PubMed ID: 23469107

DOI: 10.1371/journal.pone.0057927

PubMed ID: 1702556

Title: Three-dimensional structures of acidic and basic fibroblast growth factors.

PubMed ID: 1702556

DOI: 10.1126/science.1702556

PubMed ID: 8652550

Title: X-ray crystal structure of human acidic fibroblast growth factor.

PubMed ID: 8652550

DOI: 10.1021/bi9521755

PubMed ID: 9655399

Title: Structure of a heparin-linked biologically active dimer of fibroblast growth factor.

PubMed ID: 9655399

DOI: 10.1038/31741

PubMed ID: 10830168

Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.

PubMed ID: 10830168

DOI: 10.1016/s0092-8674(00)80851-x

PubMed ID: 11069186

Title: Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin.

PubMed ID: 11069186

DOI: 10.1038/35039551

PubMed ID: 10618369

Title: Structural interactions of fibroblast growth factor receptor with its ligands.

PubMed ID: 10618369

DOI: 10.1073/pnas.97.1.49

PubMed ID: 11847269

Title: Alternative type I and I' turn conformations in the beta8/beta9 beta-hairpin of human acidic fibroblast growth factor.

PubMed ID: 11847269

DOI: 10.1110/ps.43802

PubMed ID: 14732692

Title: Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.

PubMed ID: 14732692

DOI: 10.1073/pnas.0307287101

PubMed ID: 7521397

Title: 1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate.

PubMed ID: 7521397

DOI: 10.1006/jmbi.1994.1558

PubMed ID: 8950275

Title: Three-dimensional structure of acidic fibroblast growth factor in solution: effects of binding to a heparin functional analog.

PubMed ID: 8950275

DOI: 10.1006/jmbi.1996.0631

PubMed ID: 9719643

Title: Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas.

PubMed ID: 9719643

DOI: 10.1006/jmbi.1998.1977

PubMed ID: 20145243

Title: Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.

PubMed ID: 20145243

DOI: 10.1074/jbc.m109.064618

PubMed ID: 20220137

Title: The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion.

PubMed ID: 20220137

DOI: 10.1074/jbc.m109.066357

Sequence Information:

Length: 155
Mass: 17460
Checksum: F586E8BFB09F1580
Sequence:

MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ 
LSAESVGEVY IKSTETGQYL AMDTDGLLYG SQTPNEECLF LERLEENHYN TYISKKHAEK 
NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD

Genular Protein ID: 3815569318

Symbol: Q16089_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q16089

Database IDs:

Citations:

PubMed ID: 7504343

Title: The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells.

PubMed ID: 7504343

Sequence Information:

Length: 59
Mass: 6595
Checksum: 9C83D1E64847148A
Sequence:

MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHNTK

Genular Protein ID: 696753056

Symbol: A8K147_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K147

Database IDs:

Sequence Information:

Length: 154
Mass: 17332
Checksum: 4A6E0F07B357B2E8
Sequence:

MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ 
LSAESVGEVY IKSTETGQYL AMDTDGLLYG STPNEECLFL ERLEENHYNT YISKKHAEKN 
WFVGLKKNGS CKRGPRTHYG QKAILFLPLP VSSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FGF1

Associated with

Cells (max top 100)

Other Information

Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. PubMed ID: 3523756

Structural analysis of the gene for human acidic fibroblast growth factor. PubMed ID: 2590193

Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues. PubMed ID: 2474753

Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. PubMed ID: 1693186

Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients. PubMed ID: 1717925

An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist. PubMed ID: 1372643

The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells. PubMed ID: 7504343

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon. PubMed ID: 2393407

Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor. PubMed ID: 2427112

The complete amino acid sequence of human brain-derived acidic fibroblast growth factor. PubMed ID: 3527167

Amino acid sequence of human acidic fibroblast growth factor. PubMed ID: 3778488

Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities. PubMed ID: 3964259

Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors. PubMed ID: 3732516

Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors. PubMed ID: 1885605

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044

Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress. PubMed ID: 11432880

Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor. PubMed ID: 11964394

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. PubMed ID: 16597617

The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. PubMed ID: 18400376

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. PubMed ID: 18441324

Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells. PubMed ID: 20863990

Cellular signaling by fibroblast growth factor receptors. PubMed ID: 15863030

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist. PubMed ID: 20422052

Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1. PubMed ID: 22321063

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. PubMed ID: 23469107

Three-dimensional structures of acidic and basic fibroblast growth factors. PubMed ID: 1702556

X-ray crystal structure of human acidic fibroblast growth factor. PubMed ID: 8652550

Structure of a heparin-linked biologically active dimer of fibroblast growth factor. PubMed ID: 9655399

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. PubMed ID: 10830168

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. PubMed ID: 11069186

Structural interactions of fibroblast growth factor receptor with its ligands. PubMed ID: 10618369

Alternative type I and I' turn conformations in the beta8/beta9 beta-hairpin of human acidic fibroblast growth factor. PubMed ID: 11847269

Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. PubMed ID: 14732692

1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate. PubMed ID: 7521397

Three-dimensional structure of acidic fibroblast growth factor in solution: effects of binding to a heparin functional analog. PubMed ID: 8950275

Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas. PubMed ID: 9719643

Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. PubMed ID: 20145243

The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion. PubMed ID: 20220137

The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells. PubMed ID: 7504343

Database document:

PubMed ID: 3523756

PubMed ID: 2590193

PubMed ID: 2474753

PubMed ID: 1693186

PubMed ID: 1717925

PubMed ID: 1372643

PubMed ID: 7504343

PubMed ID: 14702039

PubMed ID: 15372022

PubMed ID: 15489334

PubMed ID: 2393407

PubMed ID: 2427112

PubMed ID: 3527167

PubMed ID: 3778488

PubMed ID: 3964259

PubMed ID: 3732516

PubMed ID: 1885605

PubMed ID: 8663044

PubMed ID: 11432880

PubMed ID: 11964394

PubMed ID: 16597617

PubMed ID: 18400376

PubMed ID: 18441324

PubMed ID: 20863990

PubMed ID: 15863030

PubMed ID: 20094046

PubMed ID: 20422052

PubMed ID: 22321063

PubMed ID: 23469107

PubMed ID: 1702556

PubMed ID: 8652550

PubMed ID: 9655399

PubMed ID: 10830168

PubMed ID: 11069186

PubMed ID: 10618369

PubMed ID: 11847269

PubMed ID: 14732692

PubMed ID: 7521397

PubMed ID: 8950275

PubMed ID: 9719643

PubMed ID: 20145243

PubMed ID: 20220137

PubMed ID: 7504343