Details for: FGF1
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 3.99
Marker Score: 1791 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 3.2
Marker Score: 1687 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.46
Marker Score: 5402 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.75
Marker Score: 10525 - Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.66
Marker Score: 1148 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.52
Marker Score: 33987 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168461 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.45
Marker Score: 30999 - Cell Name: contractile cell (CL0000183)
Fold Change: 1.43
Marker Score: 774.5 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.4
Marker Score: 4988 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 866 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.31
Marker Score: 1506 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.29
Marker Score: 3094 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.26
Marker Score: 19691 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.15
Marker Score: 2331 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251789 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.02
Marker Score: 1239 - Cell Name: astrocyte (CL0000127)
Fold Change: 1.01
Marker Score: 877 - Cell Name: goblet cell (CL0000160)
Fold Change: 1.01
Marker Score: 6695 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71808 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48034 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.99
Marker Score: 472 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407 - Cell Name: podocyte (CL0000653)
Fold Change: 0.97
Marker Score: 357 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5324 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.92
Marker Score: 8688 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.92
Marker Score: 540 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2738 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.9
Marker Score: 589 - Cell Name: fat cell (CL0000136)
Fold Change: 0.89
Marker Score: 499 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.88
Marker Score: 275 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5283 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.81
Marker Score: 8391 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.8
Marker Score: 1884 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 599 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.78
Marker Score: 773 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259 - Cell Name: monocyte (CL0000576)
Fold Change: 0.77
Marker Score: 1007 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 706 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.77
Marker Score: 464 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.77
Marker Score: 243 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.77
Marker Score: 508 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.77
Marker Score: 730 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.76
Marker Score: 278 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.74
Marker Score: 365 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.73
Marker Score: 1173 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.73
Marker Score: 1127 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.69
Marker Score: 235 - Cell Name: erythrocyte (CL0000232)
Fold Change: 0.69
Marker Score: 381 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.66
Marker Score: 193 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.64
Marker Score: 166 - Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.64
Marker Score: 162 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.63
Marker Score: 5397 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.62
Marker Score: 303 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.62
Marker Score: 1200.5 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.57
Marker Score: 240 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.57
Marker Score: 452 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.57
Marker Score: 4791 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.51
Marker Score: 577 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.51
Marker Score: 227 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.51
Marker Score: 10115 - Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.51
Marker Score: 240 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.51
Marker Score: 2124 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.5
Marker Score: 18350 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.48
Marker Score: 29574 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.48
Marker Score: 154 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.47
Marker Score: 650 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.46
Marker Score: 122 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.44
Marker Score: 250 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.44
Marker Score: 830 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.44
Marker Score: 158 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.42
Marker Score: 172 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.42
Marker Score: 404 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.41
Marker Score: 1602 - Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.39
Marker Score: 158 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.37
Marker Score: 195 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.37
Marker Score: 456 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 371 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.37
Marker Score: 13948 - Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.36
Marker Score: 348 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.36
Marker Score: 488 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.36
Marker Score: 494 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.35
Marker Score: 122 - Cell Name: neuron (CL0000540)
Fold Change: 0.35
Marker Score: 1405 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.34
Marker Score: 383 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.34
Marker Score: 170 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.33
Marker Score: 297 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.33
Marker Score: 351 - Cell Name: neural cell (CL0002319)
Fold Change: 0.33
Marker Score: 157 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.32
Marker Score: 358 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.32
Marker Score: 130 - Cell Name: mast cell (CL0000097)
Fold Change: 0.32
Marker Score: 186 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.32
Marker Score: 100 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.31
Marker Score: 162 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.31
Marker Score: 525 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.31
Marker Score: 896
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Other Information
Genular Protein ID: 3208142669
Symbol: FGF1_HUMAN
Name: Fibroblast growth factor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3523756
Title: Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization.
PubMed ID: 3523756
PubMed ID: 2590193
Title: Structural analysis of the gene for human acidic fibroblast growth factor.
PubMed ID: 2590193
PubMed ID: 2474753
Title: Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues.
PubMed ID: 2474753
PubMed ID: 1693186
Title: Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1.
PubMed ID: 1693186
PubMed ID: 1717925
Title: Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients.
PubMed ID: 1717925
PubMed ID: 1372643
Title: An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist.
PubMed ID: 1372643
PubMed ID: 7504343
Title: The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells.
PubMed ID: 7504343
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2393407
Title: The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon.
PubMed ID: 2393407
PubMed ID: 2427112
Title: Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor.
PubMed ID: 2427112
DOI: 10.1021/bi00362a017
PubMed ID: 3527167
Title: The complete amino acid sequence of human brain-derived acidic fibroblast growth factor.
PubMed ID: 3527167
PubMed ID: 3778488
Title: Amino acid sequence of human acidic fibroblast growth factor.
PubMed ID: 3778488
PubMed ID: 3964259
Title: Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities.
PubMed ID: 3964259
PubMed ID: 3732516
Title: Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors.
PubMed ID: 3732516
PubMed ID: 1885605
Title: Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.
PubMed ID: 1885605
PubMed ID: 8663044
Title: Receptor specificity of the fibroblast growth factor family.
PubMed ID: 8663044
PubMed ID: 11432880
Title: Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress.
PubMed ID: 11432880
PubMed ID: 11964394
Title: Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor.
PubMed ID: 11964394
PubMed ID: 16597617
Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
PubMed ID: 16597617
PubMed ID: 18400376
Title: The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway.
PubMed ID: 18400376
PubMed ID: 18441324
Title: Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.
PubMed ID: 18441324
PubMed ID: 20863990
Title: Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells.
PubMed ID: 20863990
PubMed ID: 15863030
Title: Cellular signaling by fibroblast growth factor receptors.
PubMed ID: 15863030
PubMed ID: 20094046
Title: Fibroblast growth factor signalling: from development to cancer.
PubMed ID: 20094046
DOI: 10.1038/nrc2780
PubMed ID: 20422052
Title: A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist.
PubMed ID: 20422052
PubMed ID: 22321063
Title: Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1.
PubMed ID: 22321063
PubMed ID: 23469107
Title: A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis.
PubMed ID: 23469107
PubMed ID: 1702556
Title: Three-dimensional structures of acidic and basic fibroblast growth factors.
PubMed ID: 1702556
PubMed ID: 8652550
Title: X-ray crystal structure of human acidic fibroblast growth factor.
PubMed ID: 8652550
DOI: 10.1021/bi9521755
PubMed ID: 9655399
Title: Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
PubMed ID: 9655399
DOI: 10.1038/31741
PubMed ID: 10830168
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
PubMed ID: 10830168
PubMed ID: 11069186
Title: Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin.
PubMed ID: 11069186
DOI: 10.1038/35039551
PubMed ID: 10618369
Title: Structural interactions of fibroblast growth factor receptor with its ligands.
PubMed ID: 10618369
DOI: 10.1073/pnas.97.1.49
PubMed ID: 11847269
Title: Alternative type I and I' turn conformations in the beta8/beta9 beta-hairpin of human acidic fibroblast growth factor.
PubMed ID: 11847269
DOI: 10.1110/ps.43802
PubMed ID: 14732692
Title: Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.
PubMed ID: 14732692
PubMed ID: 7521397
Title: 1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate.
PubMed ID: 7521397
PubMed ID: 8950275
Title: Three-dimensional structure of acidic fibroblast growth factor in solution: effects of binding to a heparin functional analog.
PubMed ID: 8950275
PubMed ID: 9719643
Title: Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas.
PubMed ID: 9719643
PubMed ID: 20145243
Title: Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.
PubMed ID: 20145243
PubMed ID: 20220137
Title: The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion.
PubMed ID: 20220137
Sequence Information:
- Length: 155
- Mass: 17460
- Checksum: F586E8BFB09F1580
- Sequence:
MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ LSAESVGEVY IKSTETGQYL AMDTDGLLYG SQTPNEECLF LERLEENHYN TYISKKHAEK NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD
Genular Protein ID: 3815569318
Symbol: Q16089_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7504343
Title: The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells.
PubMed ID: 7504343
Sequence Information:
- Length: 59
- Mass: 6595
- Checksum: 9C83D1E64847148A
- Sequence:
MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHNTK
Genular Protein ID: 696753056
Symbol: A8K147_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 154
- Mass: 17332
- Checksum: 4A6E0F07B357B2E8
- Sequence:
MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ LSAESVGEVY IKSTETGQYL AMDTDGLLYG STPNEECLFL ERLEENHYNT YISKKHAEKN WFVGLKKNGS CKRGPRTHYG QKAILFLPLP VSSD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.