Details for: FPR2

Gene ID: 2358

Symbol: FPR2

Ensembl ID: ENSG00000171049

Description: formyl peptide receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 54.7751
    Cell Significance Index: -8.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.1781
    Cell Significance Index: -9.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.4476
    Cell Significance Index: -9.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9346
    Cell Significance Index: -8.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.0295
    Cell Significance Index: 31.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6246
    Cell Significance Index: 11.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1123
    Cell Significance Index: 77.7000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0049
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0073
    Cell Significance Index: -11.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0082
    Cell Significance Index: -11.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0132
    Cell Significance Index: -8.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0138
    Cell Significance Index: -10.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0152
    Cell Significance Index: -0.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0182
    Cell Significance Index: -0.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0192
    Cell Significance Index: -10.8400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0204
    Cell Significance Index: -0.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0206
    Cell Significance Index: -9.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0243
    Cell Significance Index: -8.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0246
    Cell Significance Index: -7.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0317
    Cell Significance Index: -0.8100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0319
    Cell Significance Index: -0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0331
    Cell Significance Index: -6.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0355
    Cell Significance Index: -0.9900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0418
    Cell Significance Index: -1.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0453
    Cell Significance Index: -8.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0522
    Cell Significance Index: -10.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0561
    Cell Significance Index: -8.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0564
    Cell Significance Index: -9.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0656
    Cell Significance Index: -8.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0714
    Cell Significance Index: -7.2900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0770
    Cell Significance Index: -0.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0795
    Cell Significance Index: -8.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0799
    Cell Significance Index: -10.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0863
    Cell Significance Index: -10.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1023
    Cell Significance Index: -11.7200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1075
    Cell Significance Index: -1.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1233
    Cell Significance Index: -9.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1256
    Cell Significance Index: -6.5400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1506
    Cell Significance Index: -1.7800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1528
    Cell Significance Index: -0.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1567
    Cell Significance Index: -10.1100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1573
    Cell Significance Index: -2.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1575
    Cell Significance Index: -10.5900
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.1579
    Cell Significance Index: -1.1700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1646
    Cell Significance Index: -1.4500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1664
    Cell Significance Index: -1.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1666
    Cell Significance Index: -10.2400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1763
    Cell Significance Index: -2.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1773
    Cell Significance Index: -9.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1847
    Cell Significance Index: -4.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1870
    Cell Significance Index: -9.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1878
    Cell Significance Index: -8.3100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1944
    Cell Significance Index: -2.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2031
    Cell Significance Index: -10.5500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2069
    Cell Significance Index: -2.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2202
    Cell Significance Index: -4.6100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2203
    Cell Significance Index: -2.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2295
    Cell Significance Index: -8.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2321
    Cell Significance Index: -2.6400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2342
    Cell Significance Index: -4.5800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2343
    Cell Significance Index: -3.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2357
    Cell Significance Index: -11.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2433
    Cell Significance Index: -8.5300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.2450
    Cell Significance Index: -1.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2641
    Cell Significance Index: -9.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2801
    Cell Significance Index: -9.1700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2863
    Cell Significance Index: -2.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2876
    Cell Significance Index: -9.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3001
    Cell Significance Index: -8.8400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3053
    Cell Significance Index: -3.5900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3351
    Cell Significance Index: -3.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3473
    Cell Significance Index: -10.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3524
    Cell Significance Index: -8.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3564
    Cell Significance Index: -9.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3570
    Cell Significance Index: -7.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3618
    Cell Significance Index: -9.6600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3619
    Cell Significance Index: -8.7700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3649
    Cell Significance Index: -11.5400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3703
    Cell Significance Index: -4.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3746
    Cell Significance Index: -10.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3822
    Cell Significance Index: -9.5300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.3827
    Cell Significance Index: -3.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3845
    Cell Significance Index: -17.9300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3897
    Cell Significance Index: -5.4700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3903
    Cell Significance Index: -9.9500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.3919
    Cell Significance Index: -0.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3955
    Cell Significance Index: -10.4000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3985
    Cell Significance Index: -6.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4085
    Cell Significance Index: -11.7100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4093
    Cell Significance Index: -4.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4211
    Cell Significance Index: -9.2200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.4381
    Cell Significance Index: -5.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4387
    Cell Significance Index: -9.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4429
    Cell Significance Index: -9.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4453
    Cell Significance Index: -10.6800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4517
    Cell Significance Index: -11.0200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4536
    Cell Significance Index: -3.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure**: FPR2 belongs to the class A/1 rhodopsin-like receptors, characterized by a seven-transmembrane domain structure. 2. **Ligand specificity**: FPR2 binds to a variety of ligands, including formyl peptides, chemokines, and other inflammatory mediators. 3. **Signaling pathways**: FPR2 activates multiple signaling pathways, including the adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, the phospholipase C-activating G protein-coupled receptor signaling pathway, and the calcium-mediated signaling pathway. 4. **Expression**: FPR2 is expressed in various cells, including immune cells, epithelial cells, and neurons. **Pathways and Functions:** 1. **Immune response regulation**: FPR2 modulates immune responses by regulating the production of pro-inflammatory cytokines, chemokines, and other inflammatory mediators. 2. **Chemotaxis**: FPR2 promotes the chemotaxis of immune cells, such as neutrophils and monocytes, towards inflammatory sites. 3. **Inflammation**: FPR2 contributes to the development of inflammation by regulating the production of inflammatory mediators and promoting the activation of immune cells. 4. **Cell surface receptor signaling**: FPR2 is a key player in cell surface receptor signaling, mediating the interaction between ligands and the receptor. 5. **Innate immune system**: FPR2 plays a crucial role in the innate immune system, regulating the response to bacterial infections and other pathogens. **Clinical Significance:** 1. **Inflammatory disorders**: FPR2 is implicated in various inflammatory disorders, including asthma, chronic obstructive pulmonary disease (COPD), and rheumatoid arthritis. 2. **Infections**: FPR2 is involved in the regulation of the innate immune response to bacterial infections, including tuberculosis and sepsis. 3. **Cancer**: FPR2 has been implicated in the progression of certain cancers, including breast cancer and lung cancer. 4. **Neurological disorders**: FPR2 is expressed in the brain and has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FPR2 is a critical regulator of immune responses and inflammation, and its dysregulation is implicated in various diseases, including inflammatory disorders, infections, and cancer. Further research is needed to fully understand the mechanisms by which FPR2 modulates immune responses and to develop therapeutic strategies targeting this receptor.

Genular Protein ID: 3532590798

Symbol: FPR2_HUMAN

Name: N-formyl peptide receptor 2

UniProtKB Accession Codes:

P25090 A8K3E2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EMDB 4 Ensembl 3 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1612600

Title: Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.

PubMed ID: 1612600

DOI: 10.1016/0888-7543(92)90265-t

PubMed ID: 1511907

Title: Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils.

PubMed ID: 1511907

DOI: 10.1016/0378-1119(92)90208-7

PubMed ID: 1374236

Title: Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor.

PubMed ID: 1374236

DOI: 10.1016/0006-291x(92)90629-y

PubMed ID: 1373134

Title: A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family.

PubMed ID: 1373134

DOI: 10.1016/s0021-9258(18)42563-x

PubMed ID: 7505609

Title: Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors.

PubMed ID: 7505609

DOI: 10.1093/intimm/5.10.1239

PubMed ID: 9547339

Title: Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release.

PubMed ID: 9547339

DOI: 10.1084/jem.187.8.1285

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9151906

Title: Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors.

PubMed ID: 9151906

DOI: 10.1084/jem.185.9.1693

PubMed ID: 11689470

Title: Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.

PubMed ID: 11689470

DOI: 10.1096/fj.01-0251com

PubMed ID: 15465011

Title: N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.

PubMed ID: 15465011

DOI: 10.1016/j.bbrc.2004.09.046

PubMed ID: 30098280

Title: Staphylococcal superantigen-like protein 13 activates neutrophils via formyl peptide receptor 2.

PubMed ID: 30098280

DOI: 10.1111/cmi.12941

Sequence Information:

  • Length: 351
  • Mass: 38964
  • Checksum: DC6A1D77AFC0D780
  • Sequence:
    • METNFSTPLN EYEEVSYESA GYTVLRILPL VVLGVTFVLG VLGNGLVIWV AGFRMTRTVT 
TICYLNLALA DFSFTATLPF LIVSMAMGEK WPFGWFLCKL IHIVVDINLF GSVFLIGFIA 
LDRCICVLHP VWAQNHRTVS LAMKVIVGPW ILALVLTLPV FLFLTTVTIP NGDTYCTFNF 
ASWGGTPEER LKVAITMLTA RGIIRFVIGF SLPMSIVAIC YGLIAAKIHK KGMIKSSRPL 
RVLTAVVASF FICWFPFQLV ALLGTVWLKE MLFYGKYKII DILVNPTSSL AFFNSCLNPM 
LYVFVGQDFR ERLIHSLPTS LERALSEDSA PTNDTAANSA SPPAETELQA M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.