Details for: FUT3

Gene ID: 2525

Symbol: FUT3

Ensembl ID: ENSG00000171124

Description: fucosyltransferase 3 (Lewis blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.23
    Marker Score: 1519
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.61
    Marker Score: 1075
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.52
    Marker Score: 4782
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.48
    Marker Score: 1232
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.24
    Marker Score: 5947
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.24
    Marker Score: 611
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.17
    Marker Score: 10098
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.17
    Marker Score: 1121
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.97
    Marker Score: 969
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.95
    Marker Score: 2262
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.94
    Marker Score: 354
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.87
    Marker Score: 275
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.85
    Marker Score: 396.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 329
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.78
    Marker Score: 1844
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.77
    Marker Score: 1179
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.73
    Marker Score: 5735
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.72
    Marker Score: 175
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.71
    Marker Score: 752
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.71
    Marker Score: 4515
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.68
    Marker Score: 476.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.67
    Marker Score: 694
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.64
    Marker Score: 8533
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.62
    Marker Score: 180
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.62
    Marker Score: 153
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.61
    Marker Score: 986
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.61
    Marker Score: 547
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.55
    Marker Score: 159
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.54
    Marker Score: 381
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.53
    Marker Score: 590
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.51
    Marker Score: 146
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.49
    Marker Score: 384
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.48
    Marker Score: 1383
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.47
    Marker Score: 858
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.47
    Marker Score: 546
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.46
    Marker Score: 117
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.45
    Marker Score: 3331
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.45
    Marker Score: 133
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.43
    Marker Score: 115
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.4
    Marker Score: 2639.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.37
    Marker Score: 117
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.37
    Marker Score: 194
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.34
    Marker Score: 194.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.34
    Marker Score: 1155
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.34
    Marker Score: 227
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.33
    Marker Score: 240
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.32
    Marker Score: 135
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.32
    Marker Score: 413
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.32
    Marker Score: 469
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.31
    Marker Score: 498
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.31
    Marker Score: 704
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.31
    Marker Score: 2662
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.3
    Marker Score: 83
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3
    Marker Score: 125
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.3
    Marker Score: 682
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.3
    Marker Score: 1974
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.29
    Marker Score: 559
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.29
    Marker Score: 84
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.28
    Marker Score: 81
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.27
    Marker Score: 175.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.27
    Marker Score: 126
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.27
    Marker Score: 82
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.27
    Marker Score: 514
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.26
    Marker Score: 71
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 72
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.24
    Marker Score: 686.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.23
    Marker Score: 3647
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.23
    Marker Score: 412
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.23
    Marker Score: 332
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.23
    Marker Score: 251
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.22
    Marker Score: 1171
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.19
    Marker Score: 113
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.19
    Marker Score: 47
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.19
    Marker Score: 378
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.19
    Marker Score: 97
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.18
    Marker Score: 109
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.18
    Marker Score: 117
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.18
    Marker Score: 2818
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.17
    Marker Score: 34
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 330.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.15
    Marker Score: 5178

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Other Information

**Key characteristics:** - The FUT3 gene is located on chromosome 15q21. - It is a single gene with a predicted protein length of 1,074 amino acids. - The protein contains a signal sequence for N-glycosylation, which is a modification of proteins that can affect their function. - FUT3 is expressed in many cell types, including squamous epithelial cells, nasal mucosa goblet cells, colon epithelial cells, keratinocytes, enterocytes, bronchial goblet cells, epithelial cells of the esophagus, intestine goblet cells, and cerebral cortex GABAergic interneurons. **Pathways and functions:** - FUT3 protein is involved in the synthesis of Lewis blood group antigens. - It is a key enzyme in the biosynthesis of Lewis blood group antigens. - The protein is also involved in the metabolism of carbohydrates, proteins, and N-glycans. **Clinical significance:** - Mutations in the FUT3 gene can lead to the synthesis of abnormal Lewis blood group antigens, which can cause blood type incompatibility. - These mutations can be associated with Rh-negative disease, a condition in which the body is unable to produce the Rh antigen, which is found on the surface of red blood cells of people with type O blood. - FUT3 mutations are also associated with the condition known as Lewis disease, which is characterized by the presence of Lewis antigens on red blood cells in people of the Lewis blood group.

Genular Protein ID: 535020183

Symbol: FUT3_HUMAN

Name: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

UniProtKB Accession Codes:

P21217 B5U7U9 B5U7V0 Q32NE7 Q99448 Q99449

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 70 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 14 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 2 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 7 Rhea 28 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1977660

Title: A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.

PubMed ID: 1977660

DOI: 10.1101/gad.4.8.1288

PubMed ID: 8240337

Title: Alpha (1,3/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals.

PubMed ID: 8240337

DOI: 10.1006/bbrc.1993.2295

PubMed ID: 7650030

Title: Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.

PubMed ID: 7650030

DOI: 10.1074/jbc.270.34.20112

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7721776

Title: Acceptor specificity of different length constructs of human recombinant alpha 1,3/4-fucosyltransferases. Replacement of the stem region and the transmembrane domain of fucosyltransferase V by protein A results in an enzyme with GDP-fucose hydrolyzing activity.

PubMed ID: 7721776

DOI: 10.1074/jbc.270.15.8712

PubMed ID: 11058871

Title: Peritoneal colonization by human pancreatic cancer cells is inhibited by antisense FUT3 sequence.

PubMed ID: 11058871

DOI: 10.1002/1097-0215(20001115)88:4<558::aid-ijc7>3.0.co;2-b

PubMed ID: 12668675

Title: Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides.

PubMed ID: 12668675

DOI: 10.1074/jbc.m211034200

PubMed ID: 27453266

Title: Effect of FUT3 gene silencing with miRNA on proliferation, invasion and migration abilities of human KATO-III gastric cancer cell line.

PubMed ID: 27453266

PubMed ID: 29593094

Title: Distinct human alpha(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.

PubMed ID: 29593094

DOI: 10.1074/jbc.ra117.000775

PubMed ID: 8240322

Title: Genotypic heterogeneity among Lewis negative individuals.

PubMed ID: 8240322

DOI: 10.1006/bbrc.1993.2280

PubMed ID: 8219240

Title: Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals.

PubMed ID: 8219240

PubMed ID: 8063716

Title: Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees.

PubMed ID: 8063716

DOI: 10.1016/s0021-9258(17)31919-1

PubMed ID: 7961897

Title: Molecular genetic analysis of the human Lewis histo-blood group system.

PubMed ID: 7961897

DOI: 10.1016/s0021-9258(19)62041-7

PubMed ID: 8801770

Title: DNA sequencing and screening for point mutations in the human Lewis 'FUT3' gene enables molecular genotyping of the human Lewis blood group system.

PubMed ID: 8801770

DOI: 10.1111/j.1423-0410.1996.tb01300.x

PubMed ID: 9268337

Title: Significance of individual point mutations, T202C and C314T, in the human Lewis 'FUT3' gene for expression of Lewis antigens by the human alpha'1,3/1,4'-fucosyltransferase, Fuc-TIII.

PubMed ID: 9268337

DOI: 10.1074/jbc.272.35.21994

PubMed ID: 10211701

Title: Significance of each of three missense mutations, G484A, G667A, and G808A, present in an inactive allele of the human Lewis gene (FUT3) for alpha(1,3/1,4)fucosyltransferase inactivation.

PubMed ID: 10211701

DOI: 10.1023/a:1006981724233

PubMed ID: 9703429

Title: Five novel missense mutations of the Lewis gene 'FUT3' in African 'Xhosa' and Caucasian populations in South Africa.

PubMed ID: 9703429

DOI: 10.1007/s004390050760

Sequence Information:

  • Length: 361
  • Mass: 42117
  • Checksum: 5EC3A1E3DBA51842
  • Sequence:
    • MDPLGAAKPQ WPWRRCLAAL LFQLLVAVCF FSYLRVSRDD ATGSPRAPSG SSRQDTTPTR 
PTLLILLRTW PFHIPVALSR CSEMVPGTAD CHITADRKVY PQADMVIVHH WDIMSNPKSR 
LPPSPRPQGQ RWIWFNLEPP PNCQHLEALD RYFNLTMSYR SDSDIFTPYG WLEPWSGQPA 
HPPLNLSAKT ELVAWAVSNW KPDSARVRYY QSLQAHLKVD VYGRSHKPLP KGTMMETLSR 
YKFYLAFENS LHPDYITEKL WRNALEAWAV PVVLGPSRSN YERFLPPDAF IHVDDFQSPK 
DLARYLQELD KDHARYLSYF RWRETLRPRS FSWALDFCKA CWKLQQESRY QTVRSIAAWF 
T

Genular Protein ID: 553090567

Symbol: A8K737_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K737

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CAZy 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 9 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 3 PharmGKB 1 RefSeq 4 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 361
  • Mass: 42117
  • Checksum: BF4398044F19C284
  • Sequence:
    • MDPLGAAKPQ WPWRRCLAAL LFQLLVAVCF FSYLRVSRDD ATGSPRAPSG SSRQDTTPTR 
PTLLILLWTW PFHIPVALSR CSEMVPGTAD CHITADRKVY PQADTVIVHH WDIMSNPKSR 
LPPSPRPQGQ RWIWFNLEPP PNCQHLEALD RYFNLTMSYR SDSDIFTPYG WLEPWSGQPA 
HPPLNLSAKT ELVAWAVSNW KPDSARVRYY QSLQAHLKVD VYGRSHKPLP KGTMMETLSR 
YKFYLAFENS LHPDYITEKL WRNALEAWAV PVVLGPSRSN YERFLPPDAF IHVDDFQSPK 
DLARYLQELD KDHARYLSYF RWRETLRPRS FSWALDFCKA CWKLQQESRY QTVRSIAAWF 
T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.