Details for: SNORA67

Gene ID: 26781

Symbol: SNORA67

Ensembl ID: ENSG00000277985

Description: small nucleolar RNA, H/ACA box 67

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 7.8320
    Cell Significance Index: 69.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 3.1753
    Cell Significance Index: -1.2900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.3330
    Cell Significance Index: 8.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2462
    Cell Significance Index: 39.9200
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.9346
    Cell Significance Index: 8.1700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.3517
    Cell Significance Index: 3.2800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.1577
    Cell Significance Index: 1.1100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.1134
    Cell Significance Index: 1.1800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.1117
    Cell Significance Index: 1.0100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.0912
    Cell Significance Index: 1.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.0640
    Cell Significance Index: 0.6200
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.0620
    Cell Significance Index: 0.3100
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0215
    Cell Significance Index: 0.2100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.0029
    Cell Significance Index: 0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0006
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0086
    Cell Significance Index: -0.0800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0098
    Cell Significance Index: -0.0800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0100
    Cell Significance Index: -0.1700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0104
    Cell Significance Index: -0.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0124
    Cell Significance Index: -0.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0135
    Cell Significance Index: -0.1700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0138
    Cell Significance Index: -0.1800
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0144
    Cell Significance Index: -0.1600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0149
    Cell Significance Index: -0.1600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0153
    Cell Significance Index: -0.1800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0156
    Cell Significance Index: -0.1800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0157
    Cell Significance Index: -0.1800
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0158
    Cell Significance Index: -0.1800
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0202
    Cell Significance Index: -0.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0232
    Cell Significance Index: -1.2100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0295
    Cell Significance Index: -0.2800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0297
    Cell Significance Index: -0.1700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0309
    Cell Significance Index: -0.3700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0366
    Cell Significance Index: -0.2900
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0373
    Cell Significance Index: -0.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0413
    Cell Significance Index: -1.0300
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.0423
    Cell Significance Index: -0.4200
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0472
    Cell Significance Index: -0.5200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0474
    Cell Significance Index: -0.5300
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0478
    Cell Significance Index: -0.5100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0526
    Cell Significance Index: -0.5700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0534
    Cell Significance Index: -0.6300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0567
    Cell Significance Index: -0.6700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0588
    Cell Significance Index: -0.5400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0618
    Cell Significance Index: -0.6900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0623
    Cell Significance Index: -0.8200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0693
    Cell Significance Index: -0.9100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0697
    Cell Significance Index: -0.7800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0705
    Cell Significance Index: -0.9200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0705
    Cell Significance Index: -0.7200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0711
    Cell Significance Index: -0.8700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0759
    Cell Significance Index: -0.7100
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.0775
    Cell Significance Index: -0.1900
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.0777
    Cell Significance Index: -0.8000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0871
    Cell Significance Index: -0.9900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0911
    Cell Significance Index: -1.1200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0917
    Cell Significance Index: -0.9800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0930
    Cell Significance Index: -1.0700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0947
    Cell Significance Index: -1.0400
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0952
    Cell Significance Index: -1.0300
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0953
    Cell Significance Index: -0.9400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0963
    Cell Significance Index: -0.9500
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0964
    Cell Significance Index: -1.0200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0987
    Cell Significance Index: -1.2000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0988
    Cell Significance Index: -0.8000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1009
    Cell Significance Index: -1.2100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1028
    Cell Significance Index: -0.8500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1039
    Cell Significance Index: -1.0600
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.1085
    Cell Significance Index: -1.0300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1102
    Cell Significance Index: -1.2800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1111
    Cell Significance Index: -1.2100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1121
    Cell Significance Index: -1.2900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1127
    Cell Significance Index: -1.3400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1129
    Cell Significance Index: -1.1900
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.1175
    Cell Significance Index: -1.2000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1231
    Cell Significance Index: -1.2900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1247
    Cell Significance Index: -1.2200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1278
    Cell Significance Index: -1.2000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1319
    Cell Significance Index: -1.2200
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: -0.1400
    Cell Significance Index: -1.0300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1402
    Cell Significance Index: -1.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: -2.3219
    Cell Significance Index: 6.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORA67 is a small nucleolar RNA (snoRNA) that belongs to the H/ACA box family, which plays a crucial role in pre-rRNA processing and modification within the nucleolus. snoRNAs are involved in various aspects of RNA biology, including splicing, editing, and degradation. SNORA67, in particular, has been implicated in regulating the expression of specific genes, influencing cell proliferation, differentiation, and survival. **Pathways and Functions:** The precise mechanisms by which SNORA67 exerts its effects are multifaceted and involve several key pathways: 1. **Nucleolus-mediated RNA processing:** SNORA67 plays a crucial role in regulating pre-rRNA processing and modification, which is essential for the production of functional ribosomes. 2. **Cell cycle regulation:** SNORA67 has been shown to influence cell cycle progression, particularly in transit amplifying cells of the colon, where it regulates the expression of genes involved in cell proliferation and differentiation. 3. **Immune cell development:** SNORA67 is expressed in lymphoid lineage-restricted progenitor cells, where it influences the development and maturation of immune cells, including innate lymphoid cells. 4. **Cardiac tissue development:** SNORA67 is also expressed in cardiac endothelial cells and smooth muscle myoblasts, where it regulates the expression of genes involved in cardiac development and function. **Clinical Significance:** The dysregulation of SNORA67 has been implicated in various diseases, including: 1. **Cancer:** Alterations in SNORA67 expression have been observed in various types of cancer, including colon cancer, where it may contribute to tumorigenesis. 2. **Cardiovascular disease:** SNORA67 has been shown to play a role in regulating cardiac development and function, and its dysregulation may contribute to the development of cardiovascular disease. 3. **Immune disorders:** SNORA67 has been implicated in the development of immune disorders, including autoimmune diseases, where it may influence the regulation of immune cell development and function. In conclusion, SNORA67 is a critical regulator of RNA processing and cell fate decisions, with far-reaching implications for cellular homeostasis, immune development, and disease. Further research is necessary to fully elucidate the mechanisms by which SNORA67 exerts its effects and to explore its potential as a therapeutic target in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.