Details for: SIGLEC8

Gene ID: 27181

Symbol: SIGLEC8

Ensembl ID: ENSG00000105366

Description: sialic acid binding Ig like lectin 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 2.0343
    Cell Significance Index: 29.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.2936
    Cell Significance Index: 148.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5852
    Cell Significance Index: 99.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.5305
    Cell Significance Index: 392.9400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4357
    Cell Significance Index: 4.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4165
    Cell Significance Index: 87.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4141
    Cell Significance Index: 10.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3472
    Cell Significance Index: 195.8000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3225
    Cell Significance Index: 4.7000
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.1776
    Cell Significance Index: 1.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1628
    Cell Significance Index: 4.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0690
    Cell Significance Index: 43.1000
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.0466
    Cell Significance Index: 0.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0229
    Cell Significance Index: 1.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0163
    Cell Significance Index: 4.7000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0123
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0067
    Cell Significance Index: 0.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0044
    Cell Significance Index: 0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0036
    Cell Significance Index: -2.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0040
    Cell Significance Index: -2.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0057
    Cell Significance Index: -2.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0061
    Cell Significance Index: -2.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0084
    Cell Significance Index: -0.8600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0099
    Cell Significance Index: -0.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0114
    Cell Significance Index: -2.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0138
    Cell Significance Index: -2.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0151
    Cell Significance Index: -2.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0155
    Cell Significance Index: -2.2500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0157
    Cell Significance Index: -0.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0194
    Cell Significance Index: -2.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0225
    Cell Significance Index: -1.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0248
    Cell Significance Index: -3.4000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0264
    Cell Significance Index: -0.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0278
    Cell Significance Index: -2.8900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0301
    Cell Significance Index: -0.4000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0324
    Cell Significance Index: -0.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0338
    Cell Significance Index: -2.5200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0360
    Cell Significance Index: -1.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0382
    Cell Significance Index: -2.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0388
    Cell Significance Index: -2.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0437
    Cell Significance Index: -2.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0441
    Cell Significance Index: -2.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0453
    Cell Significance Index: -2.7800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0510
    Cell Significance Index: -0.5700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0520
    Cell Significance Index: -0.6800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0525
    Cell Significance Index: -0.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0542
    Cell Significance Index: -3.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0598
    Cell Significance Index: -1.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0620
    Cell Significance Index: -2.1700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0671
    Cell Significance Index: -0.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0671
    Cell Significance Index: -2.9700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0704
    Cell Significance Index: -0.6000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0784
    Cell Significance Index: -0.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0787
    Cell Significance Index: -2.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0794
    Cell Significance Index: -2.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0822
    Cell Significance Index: -1.5200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0838
    Cell Significance Index: -0.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0863
    Cell Significance Index: -2.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0864
    Cell Significance Index: -2.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0877
    Cell Significance Index: -3.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0951
    Cell Significance Index: -2.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1015
    Cell Significance Index: -2.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1017
    Cell Significance Index: -2.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1041
    Cell Significance Index: -2.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1044
    Cell Significance Index: -2.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1055
    Cell Significance Index: -2.5300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1096
    Cell Significance Index: -2.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1122
    Cell Significance Index: -2.8000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1134
    Cell Significance Index: -2.8900
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.1200
    Cell Significance Index: -1.4900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1209
    Cell Significance Index: -1.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1209
    Cell Significance Index: -3.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1245
    Cell Significance Index: -2.6900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1263
    Cell Significance Index: -2.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1278
    Cell Significance Index: -1.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1297
    Cell Significance Index: -2.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1303
    Cell Significance Index: -2.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1305
    Cell Significance Index: -2.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1316
    Cell Significance Index: -3.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1347
    Cell Significance Index: -1.5300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1360
    Cell Significance Index: -2.7300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1362
    Cell Significance Index: -2.7200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1364
    Cell Significance Index: -2.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1396
    Cell Significance Index: -2.7600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1418
    Cell Significance Index: -2.7900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1439
    Cell Significance Index: -1.9900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1513
    Cell Significance Index: -2.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1519
    Cell Significance Index: -3.5100
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.1532
    Cell Significance Index: -1.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1536
    Cell Significance Index: -2.6600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1548
    Cell Significance Index: -1.6900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1553
    Cell Significance Index: -1.6500
  • Cell Name: lung perichondrial fibroblast (CL4033026)
    Fold Change: -0.1574
    Cell Significance Index: -1.1700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1583
    Cell Significance Index: -2.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1603
    Cell Significance Index: -1.0900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1608
    Cell Significance Index: -2.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SIGLEC8 is a member of the sialic acid-binding Ig-like lectin (Siglec) family, characterized by its ability to bind sialic acid-containing molecules on the surface of cells. The protein is transmembrane, spanning the plasma membrane, and contains an Ig-like lectin domain. SIGLEC8 is expressed in various cell types, including progenitor cells, endothelial cells, and immune cells, such as granulocytes and T lymphocytes. Its expression is often regulated by developmental and tissue-specific transcription factors, ensuring its specific localization and function in different cell types. **Pathways and Functions:** SIGLEC8's primary function is to modulate immune cell adhesion and signaling by binding sialic acid-containing molecules, such as sialyl Lewis X (sLeX) and sialyl N-acetylneuraminic acid (sialyl NeuAc). This interaction regulates the adhesion of immune cells to endothelial cells, facilitating their migration to sites of inflammation and infection. SIGLEC8 also participates in cell signaling pathways, influencing the activation of immune cells, such as T cells and natural killer cells. The protein's interaction with sialic acid-containing molecules can either inhibit or enhance immune responses, depending on the context and cell type involved. **Clinical Significance:** SIGLEC8's dysregulation has been implicated in various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Alterations in SIGLEC8 expression have been observed in patients with these conditions, suggesting its potential as a biomarker or therapeutic target. Additionally, SIGLEC8's role in regulating immune cell adhesion and signaling makes it a promising candidate for the development of novel immunotherapies, such as checkpoint inhibitors and adhesion molecule modulators. In conclusion, SIGLEC8 is a critical regulator of immune responses and cell signaling, with a wide range of expression in various cell types. Its dysregulation has been implicated in immune-related disorders, making it a promising target for therapeutic intervention. Further research is needed to fully elucidate the mechanisms by which SIGLEC8 regulates immune responses and to explore its potential as a therapeutic agent. **References:** * [Insert relevant references to support the discussion] **Note:** As an expert immunologist, it is essential to conduct thorough literature reviews and consult with relevant experts in the field to ensure the accuracy and completeness of the information presented.

Genular Protein ID: 3091550591

Symbol: SIGL8_HUMAN

Name: Sialic acid-binding Ig-like lectin 8

UniProtKB Accession Codes:

Q9NYZ4 Q7Z728

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11095983

Title: Molecular characterization of a siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the siglec8 gene.

PubMed ID: 11095983

DOI: 10.1006/bbrc.2000.3866

PubMed ID: 10856141

Title: Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils.

PubMed ID: 10856141

DOI: 10.1067/mai.2000.107127

PubMed ID: 10625619

Title: Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily.

PubMed ID: 10625619

DOI: 10.1074/jbc.275.2.861

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27357658

Title: Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8.

PubMed ID: 27357658

DOI: 10.1073/pnas.1602214113

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 499
  • Mass: 54042
  • Checksum: 086EFF989B74123C
  • Sequence:
    • MLLLLLLLPL LWGTKGMEGD RQYGDGYLLQ VQELVTVQEG LCVHVPCSFS YPQDGWTDSD 
PVHGYWFRAG DRPYQDAPVA TNNPDREVQA ETQGRFQLLG DIWSNDCSLS IRDARKRDKG 
SYFFRLERGS MKWSYKSQLN YKTKQLSVFV TALTHRPDIL ILGTLESGHS RNLTCSVPWA 
CKQGTPPMIS WIGASVSSPG PTTARSSVLT LTPKPQDHGT SLTCQVTLPG TGVTTTSTVR 
LDVSYPPWNL TMTVFQGDAT ASTALGNGSS LSVLEGQSLR LVCAVNSNPP ARLSWTRGSL 
TLCPSRSSNP GLLELPRVHV RDEGEFTCRA QNAQGSQHIS LSLSLQNEGT GTSRPVSQVT 
LAAVGGAGAT ALAFLSFCII FIIVRSCRKK SARPAAGVGD TGMEDAKAIR GSASQGPLTE 
SWKDGNPLKK PPPAVAPSSG EEGELHYATL SFHKVKPQDP QGQEATDSEY SEIKIHKRET 
AETQACLRNH NPSSKEVRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.