Details for: GNL1

Gene ID: 2794

Symbol: GNL1

Ensembl ID: ENSG00000204590

Description: G protein nucleolar 1 (putative)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.63
    Marker Score: 2351
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.45
    Marker Score: 2140
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.42
    Marker Score: 48368
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4
    Marker Score: 5513
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.36
    Marker Score: 913
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3
    Marker Score: 3167.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.26
    Marker Score: 362
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.24
    Marker Score: 1784
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.23
    Marker Score: 1787
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.23
    Marker Score: 5287
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.23
    Marker Score: 1302
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.2
    Marker Score: 801
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.19
    Marker Score: 576
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.18
    Marker Score: 4374
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.17
    Marker Score: 996
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.16
    Marker Score: 7577
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.14
    Marker Score: 1075
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.14
    Marker Score: 70119
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.14
    Marker Score: 649
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.12
    Marker Score: 329
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.12
    Marker Score: 1725
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.11
    Marker Score: 1972
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1
    Marker Score: 12441
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.1
    Marker Score: 605
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.07
    Marker Score: 1520
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.07
    Marker Score: 9188
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.07
    Marker Score: 2900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.07
    Marker Score: 711
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.06
    Marker Score: 4090
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.06
    Marker Score: 10743
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.06
    Marker Score: 10064
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.05
    Marker Score: 2200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.05
    Marker Score: 1225
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.04
    Marker Score: 3073
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.03
    Marker Score: 700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.01
    Marker Score: 37308
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.01
    Marker Score: 2743
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.01
    Marker Score: 1654
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1
    Marker Score: 2004
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.99
    Marker Score: 9359
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.99
    Marker Score: 370
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.98
    Marker Score: 342
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30377
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.97
    Marker Score: 980
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.97
    Marker Score: 549
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.97
    Marker Score: 888
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.97
    Marker Score: 290
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.96
    Marker Score: 1626.5
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.96
    Marker Score: 533
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.94
    Marker Score: 4626
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.94
    Marker Score: 1449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2379
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.93
    Marker Score: 984
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.93
    Marker Score: 12329
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.93
    Marker Score: 982
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.92
    Marker Score: 262
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.92
    Marker Score: 328
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.92
    Marker Score: 31910
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.92
    Marker Score: 671
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.92
    Marker Score: 956
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.92
    Marker Score: 2575
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.91
    Marker Score: 720
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.91
    Marker Score: 516
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.91
    Marker Score: 1707
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.91
    Marker Score: 467
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.9
    Marker Score: 426
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2695
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.9
    Marker Score: 1125.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9
    Marker Score: 9027
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.9
    Marker Score: 764
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.89
    Marker Score: 806
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.89
    Marker Score: 17725
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.89
    Marker Score: 212
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.89
    Marker Score: 559
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.88
    Marker Score: 2246
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.88
    Marker Score: 359
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.87
    Marker Score: 205
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.87
    Marker Score: 942
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.87
    Marker Score: 981
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.87
    Marker Score: 7670
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.87
    Marker Score: 362
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.87
    Marker Score: 3598
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.86
    Marker Score: 220
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4895
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.86
    Marker Score: 32552
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.86
    Marker Score: 193
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.86
    Marker Score: 213
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.85
    Marker Score: 700
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.85
    Marker Score: 3295
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.85
    Marker Score: 453
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.85
    Marker Score: 1026
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.85
    Marker Score: 213
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.84
    Marker Score: 1170
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.84
    Marker Score: 593
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.84
    Marker Score: 263
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.84
    Marker Score: 1698
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.83
    Marker Score: 2104
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.83
    Marker Score: 3400

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Other Information

**Key characteristics** * GNL1 is a protein that is composed of 14 transmembrane domains, each of which is predicted to be involved in protein-protein interactions. * It is a member of the GPCR family, which are a large family of cell surface receptors that are involved in a variety of cellular processes, including cell growth, differentiation, and signaling. * It is expressed in a variety of cell types, including extravillous trophoblast, bladder urothelial cell, fibroblast of mammary gland, placental villous trophoblast, skeletal muscle satellite cell, basal cell of prostate epithelium, male germ cell, oogonial cell, and alveolar capillary type 2 endothelial cell. * It is a key regulator of cell growth and differentiation. * It is involved in the DNA damage response, and it is a key player in the regulation of cell cycle progression. * It is also involved in the regulation of cell migration and invasion. **Pathways and functions** * GNL1 is involved in a variety of cellular processes, including cell growth, differentiation, and signaling. * It is involved in the DNA damage response, and it is a key player in the regulation of cell cycle progression. * It is also involved in the regulation of cell migration and invasion. * It is a key regulator of cell growth and differentiation in the mammary gland. * It is also involved in the development and maintenance of the female reproductive tract. **Clinical significance** GNL1 is a potential therapeutic target for a variety of diseases, including cancer and cardiovascular disease. It is a target for cancer immunotherapy, and it is being investigated as a potential treatment for a variety of cancers, including breast cancer, lung cancer, and prostate cancer.

Genular Protein ID: 2810887302

Symbol: GNL1_HUMAN

Name: Guanine nucleotide-binding protein-like 1

UniProtKB Accession Codes:

P36915 B0S838 Q96CT5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8180467

Title: Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region.

PubMed ID: 8180467

DOI: 10.1007/bf00292335

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 607
  • Mass: 68661
  • Checksum: F8EBB4EDBB73D929
  • Sequence:
    • MPRKKPFSVK QKKKQLQDKR ERKRGLQDGL RSSSNSRSGS RERREEQTDT SDGESVTHHI 
RRLNQQPSQG LGPRGYDPNR YRLHFERDSR EEVERRKRAA REQVLQPVSA ELLELDIREV 
YQPGSVLDFP RRPPWSYEMS KEQLMSQEER SFQDYLGKIH GAYSSEKLSY FEHNLETWRQ 
LWRVLEMSDI VLLITDIRHP VVNFPPALYE YVTGELGLAL VLVLNKVDLA PPALVVAWKH 
YFHQHYPQLH VVLFTSFPRD PRTPQDPSSV LKKSRRRGRG WTRALGPEQL LRACEAITVG 
KVDLSSWREK IARDVAGATW GNGSGEEEEE EDGPAVLVEQ QTDSAMEPTG PTQERYKDGV 
VTIGCVGFPN VGKSSLINGL VGRKVVSVSR TPGHTRYFQT YFLTPSVKLC DCPGLIFPSL 
LPRQLQVLAG IYPIAQIQEP YTAVGYLASR IPVQALLHLR HPEAEDPSAE HPWCAWDICE 
AWAEKRGYKT AKAARNDVYR AANSLLRLAV DGRLSLCFHP PGYSEQKGTW ESHPETTELV 
VLQGRVGPAG DEEEEEEEEL SSSCEEEGEE DRDADEEGEG DEETPTSAPG SSLAGRNPYA 
LLGEDEC

Genular Protein ID: 2152835062

Symbol: B4DYK6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DYK6

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 605
  • Mass: 68256
  • Checksum: 2CC1CD2439857557
  • Sequence:
    • MGERVLWPLR AGQHWRHRPL PAGLQDGLRS SSNSRSGSRE RREEQTDTSD GESVTHHIRR 
LNQQPSQGLG PRGYDPNRYR LHFERDSREE VERRKRAARE QVLQPVSAEL LELDIREVYQ 
PGSVLDFPRR PPWSYEMSKE QLMSQEERSF QDYLGKIHGA YSSEKLSYFE HNLETWRQLW 
RVLEMSDIVL LITDIRHPVV NFPPALYEYV TGELGLALVL VLNKVDLAPP ALVVAWKHYF 
HQHYPQLHVV LFTSFPRDPR TPQDPSSVLK KSRRRGRGWT RALGPEQLLR ACEAITVGKV 
DLSSWREKIA RDVAGATWGN GSGEEEEEED GPAVLVEQQT DSAMEPTGPT QERYKDGVVT 
IGCVGFPNVG KSSLINGLVG RKVVSVSRTP GHTRYFQTYF LTPSVKLCDC PGLIFPSLLP 
RQLQVLAGIY PIAQIQEPYT AVGYLASRIP VQALLHLRHP EAEDPSAEHP WCAWDICEAW 
AEKRGYKTAK AARNDVYRAA NSLLRLAVDG RLSLCFHPPG YSEQKGTWES HPETTELVVL 
QGRVGPAGDE EEEEEEELSS SCEEEGEEDR DADEEGEGDE ETPTSAPGSS LAGRNPYALL 
GEDEC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.