Details for: IGHV3 38

Gene ID: 28429

Symbol: IGHV3 38

Ensembl ID: ENSG00000211958

Description: immunoglobulin heavy variable 3-38 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1174
    Cell Significance Index: 1.2000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0738
    Cell Significance Index: 0.9400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0661
    Cell Significance Index: 0.8400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0572
    Cell Significance Index: 0.6900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.0424
    Cell Significance Index: 0.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0040
    Cell Significance Index: -0.4100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0082
    Cell Significance Index: -0.0900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0086
    Cell Significance Index: -0.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0086
    Cell Significance Index: -0.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0125
    Cell Significance Index: -0.3400
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0133
    Cell Significance Index: -0.1100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0152
    Cell Significance Index: -0.2000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0225
    Cell Significance Index: -0.1500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0241
    Cell Significance Index: -0.2200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0260
    Cell Significance Index: -0.2900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0263
    Cell Significance Index: -0.6700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0285
    Cell Significance Index: -0.2600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0302
    Cell Significance Index: -0.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0309
    Cell Significance Index: -0.4000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0315
    Cell Significance Index: -0.3400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0320
    Cell Significance Index: -0.3800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0321
    Cell Significance Index: -0.3500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0335
    Cell Significance Index: -0.3400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0338
    Cell Significance Index: -0.3600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0338
    Cell Significance Index: -0.3500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0346
    Cell Significance Index: -0.4600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0348
    Cell Significance Index: -0.3400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0348
    Cell Significance Index: -0.3600
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0365
    Cell Significance Index: -0.3600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0381
    Cell Significance Index: -0.4500
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.0390
    Cell Significance Index: -0.2800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0394
    Cell Significance Index: -0.4000
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0407
    Cell Significance Index: -0.3400
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0411
    Cell Significance Index: -0.3300
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0412
    Cell Significance Index: -0.4400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0419
    Cell Significance Index: -0.2700
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0420
    Cell Significance Index: -0.3900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0421
    Cell Significance Index: -0.4700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0423
    Cell Significance Index: -0.5000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0426
    Cell Significance Index: -0.5600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0427
    Cell Significance Index: -0.4100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0435
    Cell Significance Index: -0.8500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0441
    Cell Significance Index: -0.4600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0447
    Cell Significance Index: -0.4200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0455
    Cell Significance Index: -0.4600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0461
    Cell Significance Index: -0.5600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0465
    Cell Significance Index: -0.4900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0474
    Cell Significance Index: -0.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0487
    Cell Significance Index: -0.9000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0489
    Cell Significance Index: -0.6700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0490
    Cell Significance Index: -0.5000
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.0502
    Cell Significance Index: -0.4500
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0514
    Cell Significance Index: -0.4700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0528
    Cell Significance Index: -0.4500
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0530
    Cell Significance Index: -0.4600
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0539
    Cell Significance Index: -0.5100
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0540
    Cell Significance Index: -0.4400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0591
    Cell Significance Index: -0.5100
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0635
    Cell Significance Index: -0.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0646
    Cell Significance Index: -0.3900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0669
    Cell Significance Index: -0.7900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0686
    Cell Significance Index: -0.8400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0687
    Cell Significance Index: -0.7900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0689
    Cell Significance Index: -0.9000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0695
    Cell Significance Index: -0.7700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0709
    Cell Significance Index: -0.6600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0734
    Cell Significance Index: -0.6200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0811
    Cell Significance Index: -0.8600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0812
    Cell Significance Index: -0.7600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0821
    Cell Significance Index: -0.7000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0823
    Cell Significance Index: -0.7200
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0853
    Cell Significance Index: -0.7600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0854
    Cell Significance Index: -0.8100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0859
    Cell Significance Index: -0.4600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0866
    Cell Significance Index: -0.4000
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0885
    Cell Significance Index: -0.7700
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.0917
    Cell Significance Index: -0.4600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0954
    Cell Significance Index: -0.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0957
    Cell Significance Index: -0.9200
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.0995
    Cell Significance Index: -0.7000
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.1022
    Cell Significance Index: -0.4800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1031
    Cell Significance Index: -0.8700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1068
    Cell Significance Index: -0.9700
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1072
    Cell Significance Index: -0.7000
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1172
    Cell Significance Index: -0.9000
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1207
    Cell Significance Index: -1.0000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1306
    Cell Significance Index: -0.8200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.1468
    Cell Significance Index: -0.3900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1852
    Cell Significance Index: -1.0100
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1879
    Cell Significance Index: -0.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional:** The IGHV3-38 gene is non-functional, meaning it does not produce a functional immunoglobulin protein. 2. **Variable region:** The IGHV3-38 gene is part of the immunoglobulin heavy variable region, which is responsible for recognizing and binding to specific antigens. 3. **Expressed in various cell types:** The IGHV3-38 gene is expressed in a range of cell types, including lymphocytes, goblet cells, and intestinal epithelial cells. 4. **Associated with immune response:** The IGHV3-38 gene is associated with the immune response, particularly in the context of antigen binding and recognition. **Pathways and Functions:** 1. **Antigen binding:** The IGHV3-38 gene is involved in the binding of antigens to immunoglobulins, which is a critical step in the immune response. 2. **Immunoglobulin complex formation:** The IGHV3-38 gene is part of the immunoglobulin complex, which is a collection of immunoglobulins that work together to recognize and bind to specific antigens. 3. **Immunoglobulin-mediated immune response:** The IGHV3-38 gene is involved in the immunoglobulin-mediated immune response, which is a complex process that involves the recognition of antigens and the activation of immune cells. 4. **Cell signaling:** The IGHV3-38 gene may also be involved in cell signaling pathways, particularly in the context of immune cell activation and regulation. **Clinical Significance:** The IGHV3-38 gene has several clinical implications: 1. **Autoimmune disorders:** The IGHV3-38 gene has been associated with autoimmune disorders, such as rheumatoid arthritis and lupus, which are characterized by the production of autoantibodies. 2. **Cancer:** The IGHV3-38 gene has been found to be overexpressed in certain types of cancer, such as multiple myeloma and lymphoma, which are characterized by the production of abnormal immunoglobulins. 3. **Infectious diseases:** The IGHV3-38 gene may also play a role in the development of infectious diseases, such as HIV and tuberculosis, which are characterized by the production of autoantibodies and the activation of immune cells. 4. **Immunodeficiency disorders:** The IGHV3-38 gene has been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia, which are characterized by the lack of immunoglobulins and the impaired immune response. In conclusion, the IGHV3-38 gene is a non-functional gene that plays a crucial role in the development and function of the immune system. Its expression in various cell types and association with immune response pathways highlight its importance in the body's defense against pathogens and foreign substances. The clinical significance of the IGHV3-38 gene is evident in its association with autoimmune disorders, cancer, infectious diseases, and immunodeficiency disorders. Further research is needed to fully understand the role of the IGHV3-38 gene in the immune system and its clinical implications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.