Details for: TRAV22

Gene ID: 28661

Symbol: TRAV22

Ensembl ID: ENSG00000211802

Description: T cell receptor alpha variable 22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.1008
    Cell Significance Index: 0.2700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0724
    Cell Significance Index: 0.7000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0044
    Cell Significance Index: 0.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0079
    Cell Significance Index: -0.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0106
    Cell Significance Index: -1.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0206
    Cell Significance Index: -0.9600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0225
    Cell Significance Index: -0.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0256
    Cell Significance Index: -2.6100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0278
    Cell Significance Index: -0.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0281
    Cell Significance Index: -1.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0301
    Cell Significance Index: -0.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0412
    Cell Significance Index: -0.4700
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0517
    Cell Significance Index: -0.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0603
    Cell Significance Index: -1.6100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0696
    Cell Significance Index: -1.3600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0698
    Cell Significance Index: -1.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0727
    Cell Significance Index: -1.7600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0798
    Cell Significance Index: -0.8000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0859
    Cell Significance Index: -1.4800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0901
    Cell Significance Index: -1.3300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0908
    Cell Significance Index: -1.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0962
    Cell Significance Index: -2.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0969
    Cell Significance Index: -2.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0978
    Cell Significance Index: -2.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0998
    Cell Significance Index: -2.5500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1009
    Cell Significance Index: -2.5200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1042
    Cell Significance Index: -1.7700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1097
    Cell Significance Index: -1.7600
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1128
    Cell Significance Index: -1.0300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1143
    Cell Significance Index: -1.1700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1144
    Cell Significance Index: -1.3600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1178
    Cell Significance Index: -1.2200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1183
    Cell Significance Index: -1.6600
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1244
    Cell Significance Index: -1.3500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1271
    Cell Significance Index: -1.0000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1291
    Cell Significance Index: -1.6700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1320
    Cell Significance Index: -0.7200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1346
    Cell Significance Index: -1.7600
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.1355
    Cell Significance Index: -1.4800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1366
    Cell Significance Index: -1.3800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1368
    Cell Significance Index: -1.6400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1377
    Cell Significance Index: -1.2600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1387
    Cell Significance Index: -1.5500
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1437
    Cell Significance Index: -1.3600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1455
    Cell Significance Index: -1.9800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1455
    Cell Significance Index: -2.3400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1476
    Cell Significance Index: -0.9600
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1479
    Cell Significance Index: -1.5800
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1508
    Cell Significance Index: -1.5600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1556
    Cell Significance Index: -2.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1569
    Cell Significance Index: -2.9000
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.1570
    Cell Significance Index: -1.0800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1584
    Cell Significance Index: -0.9400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1612
    Cell Significance Index: -2.7600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1615
    Cell Significance Index: -2.2200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1634
    Cell Significance Index: -2.0700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1634
    Cell Significance Index: -2.2900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1640
    Cell Significance Index: -1.4100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1649
    Cell Significance Index: -1.9900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1659
    Cell Significance Index: -2.5200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1675
    Cell Significance Index: -2.3000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1686
    Cell Significance Index: -1.9900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1694
    Cell Significance Index: -2.1400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1697
    Cell Significance Index: -1.7600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1811
    Cell Significance Index: -2.6400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.1815
    Cell Significance Index: -1.0500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1853
    Cell Significance Index: -1.8800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1951
    Cell Significance Index: -2.0300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1955
    Cell Significance Index: -1.6500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1962
    Cell Significance Index: -2.5200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1972
    Cell Significance Index: -2.3300
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.1985
    Cell Significance Index: -1.8600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1991
    Cell Significance Index: -2.3100
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2001
    Cell Significance Index: -1.9600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2021
    Cell Significance Index: -1.9700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2027
    Cell Significance Index: -2.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2028
    Cell Significance Index: -2.9500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2065
    Cell Significance Index: -2.4300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2069
    Cell Significance Index: -2.7500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2109
    Cell Significance Index: -1.8200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2130
    Cell Significance Index: -2.7800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2141
    Cell Significance Index: -2.2200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2151
    Cell Significance Index: -2.5600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2152
    Cell Significance Index: -2.0400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2187
    Cell Significance Index: -2.8700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2188
    Cell Significance Index: -2.8800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2188
    Cell Significance Index: -3.2000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2202
    Cell Significance Index: -2.0600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2216
    Cell Significance Index: -2.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2226
    Cell Significance Index: -2.1400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2230
    Cell Significance Index: -2.4800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2236
    Cell Significance Index: -2.7200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2241
    Cell Significance Index: -2.2900
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.2293
    Cell Significance Index: -2.4500
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.2319
    Cell Significance Index: -1.6000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2319
    Cell Significance Index: -2.5000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2323
    Cell Significance Index: -1.9800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.2336
    Cell Significance Index: -1.9900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2341
    Cell Significance Index: -2.3900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2344
    Cell Significance Index: -1.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Variable region of the T cell receptor alpha chain**: TRAV22 encodes a variable region of the T cell receptor alpha chain, which is essential for the recognition of antigens by T cells. 2. **Significant expression in hematopoietic cells**: TRAV22 is expressed in various hematopoietic cells, including early T lineage precursors, granulocyte-monocyte progenitors, and neutrophils. 3. **Involvement in the adaptive immune response**: TRAV22 plays a crucial role in the adaptive immune response, influencing the diversity and specificity of T cells. 4. **Expression in precursor B cells and pro-B cells**: TRAV22 is also expressed in precursor B cells and pro-B cells, suggesting its involvement in the development of B cells. **Pathways and Functions:** 1. **T cell receptor complex**: TRAV22 is a component of the T cell receptor complex, which is responsible for recognizing antigens presented by MHC molecules. 2. **Adaptive immune response**: TRAV22 influences the adaptive immune response by contributing to the diversity and specificity of T cells. 3. **Antigen recognition**: TRAV22 plays a critical role in antigen recognition, allowing T cells to distinguish between self and non-self antigens. 4. **Immune cell development**: TRAV22 is involved in the development of immune cells, including T cells and B cells. **Clinical Significance:** 1. **Autoimmune diseases**: TRAV22's involvement in the adaptive immune response makes it a potential target for therapeutic interventions in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Inflammatory diseases**: TRAV22's role in antigen recognition and immune cell development makes it a potential target for therapeutic interventions in inflammatory diseases, such as asthma and allergic reactions. 3. **Cancer immunotherapy**: TRAV22's involvement in the adaptive immune response makes it a potential target for cancer immunotherapy, allowing for the development of personalized therapies. 4. **Immunodeficiency disorders**: TRAV22's expression in hematopoietic cells makes it a potential target for therapeutic interventions in immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, TRAV22 is a critical component of the adaptive immune response, influencing the diversity and specificity of T cells. Its significant expression in various hematopoietic cells and involvement in antigen recognition and immune cell development make it a potential target for therapeutic interventions in autoimmune, inflammatory, and immunodeficiency disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.