Details for: TRAV14DV4

Gene ID: 28669

Symbol: TRAV14DV4

Ensembl ID: ENSG00000211792

Description: T cell receptor alpha variable 14/delta variable 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.6565
    Cell Significance Index: 3.5800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3235
    Cell Significance Index: 3.6200
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.0670
    Cell Significance Index: 0.6800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0305
    Cell Significance Index: 0.3900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0146
    Cell Significance Index: 0.1700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0050
    Cell Significance Index: 0.0500
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.0024
    Cell Significance Index: 0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0231
    Cell Significance Index: -0.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0239
    Cell Significance Index: -3.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0254
    Cell Significance Index: -2.5900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0406
    Cell Significance Index: -0.6900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0426
    Cell Significance Index: -0.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0520
    Cell Significance Index: -1.3900
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0529
    Cell Significance Index: -0.5500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0581
    Cell Significance Index: -0.8500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0599
    Cell Significance Index: -0.5100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0652
    Cell Significance Index: -0.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0670
    Cell Significance Index: -3.1500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0689
    Cell Significance Index: -1.6700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0694
    Cell Significance Index: -0.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0744
    Cell Significance Index: -3.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0783
    Cell Significance Index: -1.3500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0794
    Cell Significance Index: -0.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0826
    Cell Significance Index: -2.1100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0863
    Cell Significance Index: -0.9000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0864
    Cell Significance Index: -0.7000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0926
    Cell Significance Index: -0.9400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0928
    Cell Significance Index: -0.8800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0930
    Cell Significance Index: -0.9400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1005
    Cell Significance Index: -2.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1034
    Cell Significance Index: -2.3900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1059
    Cell Significance Index: -1.3100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1103
    Cell Significance Index: -1.3300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1122
    Cell Significance Index: -1.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1130
    Cell Significance Index: -2.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1147
    Cell Significance Index: -1.9200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1204
    Cell Significance Index: -1.9500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1218
    Cell Significance Index: -1.4400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1254
    Cell Significance Index: -1.5300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1258
    Cell Significance Index: -2.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1332
    Cell Significance Index: -1.2800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1337
    Cell Significance Index: -1.7300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1350
    Cell Significance Index: -1.0500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1357
    Cell Significance Index: -2.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1363
    Cell Significance Index: -2.5200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1376
    Cell Significance Index: -1.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1378
    Cell Significance Index: -2.3200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1393
    Cell Significance Index: -2.0300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1394
    Cell Significance Index: -1.6400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1428
    Cell Significance Index: -1.9800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1438
    Cell Significance Index: -1.8800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1438
    Cell Significance Index: -1.9400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1444
    Cell Significance Index: -1.4600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1479
    Cell Significance Index: -1.9000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1483
    Cell Significance Index: -1.2800
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1512
    Cell Significance Index: -1.0400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1538
    Cell Significance Index: -1.3000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1541
    Cell Significance Index: -1.8600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1556
    Cell Significance Index: -1.9700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1561
    Cell Significance Index: -1.6600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1569
    Cell Significance Index: -1.9800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1585
    Cell Significance Index: -2.3400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1598
    Cell Significance Index: -2.5700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1611
    Cell Significance Index: -2.1200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1622
    Cell Significance Index: -2.0800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1627
    Cell Significance Index: -1.3600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1675
    Cell Significance Index: -2.3800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1680
    Cell Significance Index: -1.9800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1691
    Cell Significance Index: -2.0100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1704
    Cell Significance Index: -1.9800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1721
    Cell Significance Index: -2.3200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1730
    Cell Significance Index: -1.9800
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1733
    Cell Significance Index: -1.9800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1743
    Cell Significance Index: -2.3900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1743
    Cell Significance Index: -1.9800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1748
    Cell Significance Index: -1.9700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1785
    Cell Significance Index: -2.0700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1789
    Cell Significance Index: -1.5100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1808
    Cell Significance Index: -1.9700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1808
    Cell Significance Index: -1.9700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1810
    Cell Significance Index: -1.9800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1817
    Cell Significance Index: -2.7600
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1819
    Cell Significance Index: -2.0200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1828
    Cell Significance Index: -1.9600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1848
    Cell Significance Index: -1.7100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1857
    Cell Significance Index: -2.3200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1864
    Cell Significance Index: -2.0100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1864
    Cell Significance Index: -1.9800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1868
    Cell Significance Index: -1.9700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1879
    Cell Significance Index: -2.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1881
    Cell Significance Index: -2.5000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1882
    Cell Significance Index: -2.4700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1893
    Cell Significance Index: -1.8500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1899
    Cell Significance Index: -2.0200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1914
    Cell Significance Index: -1.9100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1930
    Cell Significance Index: -2.5200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1947
    Cell Significance Index: -2.2400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1964
    Cell Significance Index: -1.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV14DV4 is a member of the T cell receptor alpha (TRAV) family, which is responsible for encoding the variable region of the T cell receptor (TCR) alpha chain. This gene is specifically associated with the delta (δ) variable region, which is a unique feature that sets it apart from other TRAV genes. The expression of TRAV14DV4 is predominantly found in hematopoietic cells, granulocyte-monocyte progenitor cells, leukocytes, and various subsets of T cells, including CD8-positive, alpha-beta cytotoxic T cells. **Pathways and Functions:** The TRAV14DV4 gene is involved in several key pathways that are essential for the adaptive immune response: 1. **Adaptive Immune Response:** TRAV14DV4 plays a crucial role in the development and regulation of T cell responses, which are central to the adaptive immune response. The TCR, comprising the TRAV14DV4 gene, recognizes and binds to specific antigens, triggering a cascade of signaling events that ultimately lead to the activation of T cells. 2. **Extracellular Space:** TRAV14DV4 is also involved in the regulation of the extracellular space, where it interacts with other molecules, such as immunoglobulins, to modulate the immune response. 3. **Immune Response:** TRAV14DV4 contributes to the regulation of the immune response by influencing the function and proliferation of T cells, thereby modulating the body's response to pathogens and foreign substances. 4. **Immunoglobulin Production:** TRAV14DV4 has been implicated in the regulation of immunoglobulin production, which is essential for the development of humoral immunity. **Clinical Significance:** The TRAV14DV4 gene has significant clinical implications, particularly in the context of autoimmune and inflammatory diseases: 1. **Autoimmune Diseases:** Alterations in TRAV14DV4 expression have been linked to various autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where dysregulated T cell responses contribute to disease pathology. 2. **Cancer:** TRAV14DV4 has been implicated in the development and progression of certain types of cancer, including leukemia and lymphoma, where T cell dysregulation plays a key role. 3. **Infectious Diseases:** TRAV14DV4 plays a crucial role in the regulation of the immune response to infections, and alterations in its expression have been linked to the severity of certain infectious diseases, such as HIV and tuberculosis. In conclusion, the TRAV14DV4 gene is a critical component of the adaptive immune system, playing a pivotal role in the development and regulation of T cell responses. Its clinical significance extends to various autoimmune and inflammatory diseases, as well as infectious diseases, highlighting the importance of understanding its functions and regulation in the context of immune homeostasis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.