Details for: TRAV13 1

Gene ID: 28671

Symbol: TRAV13 1

Ensembl ID: ENSG00000211788

Description: T cell receptor alpha variable 13-1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 503
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.73
    Marker Score: 1,249
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.65
    Marker Score: 2,008
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 389
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.51
    Marker Score: 231
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.43
    Marker Score: 777
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.38
    Marker Score: 1,647
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 213
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.3
    Marker Score: 326
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.29
    Marker Score: 15,546
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.29
    Marker Score: 570
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.28
    Marker Score: 403
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.26
    Marker Score: 385
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.26
    Marker Score: 111
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.23
    Marker Score: 169
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.22
    Marker Score: 163
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.2
    Marker Score: 62
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.2
    Marker Score: 123
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.19
    Marker Score: 457
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.18
    Marker Score: 130
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.18
    Marker Score: 2,055
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.17
    Marker Score: 1,682
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.17
    Marker Score: 129
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 89
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.16
    Marker Score: 123
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.15
    Marker Score: 431
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.15
    Marker Score: 146
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.15
    Marker Score: 130
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 81
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.14
    Marker Score: 122
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.13
    Marker Score: 149
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.13
    Marker Score: 110
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.13
    Marker Score: 119
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.12
    Marker Score: 83
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.12
    Marker Score: 50
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 107
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.08
    Marker Score: 62
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.08
    Marker Score: 66
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.08
    Marker Score: 81
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.07
    Marker Score: 50
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.06
    Marker Score: 50
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 72
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.05
    Marker Score: 132
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 82
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.05
    Marker Score: 112
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 49
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.04
    Marker Score: 86
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.03
    Marker Score: 132
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.03
    Marker Score: 97
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: T-helper 2 cell (CL0000546)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 42
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 19

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** TRAV13-1 is located on chromosome 14q32.33, a region known to harbor the TCRα gene. 2. **Expression:** TRAV13-1 is significantly expressed in various immune cells, including granulocyte-monocyte progenitor cells, early T lineage precursors, and naive thymus-derived CD4-positive, alpha-beta T cells. 3. **Function:** TRAV13-1 is involved in recognizing and binding to specific antigens, triggering an immune response. 4. **Cellular Distribution:** TRAV13-1 is expressed in multiple cell types, including neutrophils, common myeloid progenitors, and platelets, indicating its broad immunological significance. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV13-1 plays a crucial role in the adaptive immune response by recognizing and binding to specific antigens, thereby triggering an immune response. 2. **T Cell Receptor Complex:** TRAV13-1 is part of the TCR complex, which is essential for recognizing and binding to antigens. 3. **Response to Bacterium:** TRAV13-1 is involved in the response to bacterial infections, highlighting its importance in combating bacterial pathogens. 4. **T Cell Receptor Complex Signaling:** TRAV13-1 is involved in the signaling pathway of the TCR complex, which ultimately leads to the activation of T cells. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in TRAV13-1 expression have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer Immunotherapy:** TRAV13-1 has been identified as a potential target for cancer immunotherapy, as it is involved in the recognition and binding to tumor antigens. 3. **Infectious Diseases:** TRAV13-1 is involved in the response to bacterial infections, making it a potential target for the development of novel antibacterial therapies. 4. **Immunological Monitoring:** TRAV13-1 expression can serve as a biomarker for immunological monitoring, allowing for the tracking of immune responses and the assessment of treatment efficacy. In conclusion, TRAV13-1 is a gene that plays a critical role in the adaptive immune response, recognizing and binding to specific antigens, and triggering an immune response. Its broad expression in various immune cells and its involvement in multiple pathways and functions highlight its significance in immunological research and clinical applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.