Details for: TRAV13 1

Gene ID: 28671

Symbol: TRAV13 1

Ensembl ID: ENSG00000211788

Description: T cell receptor alpha variable 13-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 5.2317
    Cell Significance Index: -2.4700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.5625
    Cell Significance Index: 8.5200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.5086
    Cell Significance Index: 1.5500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1486
    Cell Significance Index: 1.4900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0083
    Cell Significance Index: 0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0029
    Cell Significance Index: -2.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -2.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0082
    Cell Significance Index: -1.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0107
    Cell Significance Index: -2.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0189
    Cell Significance Index: -2.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0191
    Cell Significance Index: -2.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0211
    Cell Significance Index: -0.5700
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0257
    Cell Significance Index: -0.1900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0263
    Cell Significance Index: -0.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0350
    Cell Significance Index: -1.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0534
    Cell Significance Index: -0.9000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0555
    Cell Significance Index: -1.3500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0661
    Cell Significance Index: -0.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0687
    Cell Significance Index: -3.2300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0701
    Cell Significance Index: -1.1900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0724
    Cell Significance Index: -0.9900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0734
    Cell Significance Index: -0.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0749
    Cell Significance Index: -1.1100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0822
    Cell Significance Index: -0.7000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0911
    Cell Significance Index: -1.5700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0918
    Cell Significance Index: -1.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0952
    Cell Significance Index: -0.9200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0997
    Cell Significance Index: -0.8600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1018
    Cell Significance Index: -1.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1020
    Cell Significance Index: -2.6000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1031
    Cell Significance Index: -1.4300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1046
    Cell Significance Index: -1.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1091
    Cell Significance Index: -2.5200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1101
    Cell Significance Index: -0.8800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1114
    Cell Significance Index: -1.1300
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1195
    Cell Significance Index: -0.9900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1219
    Cell Significance Index: -1.1400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1225
    Cell Significance Index: -1.7400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1231
    Cell Significance Index: -1.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1248
    Cell Significance Index: -3.4000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1263
    Cell Significance Index: -1.3100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1283
    Cell Significance Index: -1.5100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1356
    Cell Significance Index: -1.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1381
    Cell Significance Index: -2.7000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1381
    Cell Significance Index: -1.0900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1388
    Cell Significance Index: -1.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1428
    Cell Significance Index: -2.6400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1445
    Cell Significance Index: -1.3700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1449
    Cell Significance Index: -2.2000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1449
    Cell Significance Index: -2.3300
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1450
    Cell Significance Index: -1.4200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1456
    Cell Significance Index: -1.8700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1464
    Cell Significance Index: -2.0100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1495
    Cell Significance Index: -1.9400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1578
    Cell Significance Index: -1.8300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1587
    Cell Significance Index: -2.5700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1595
    Cell Significance Index: -1.4600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1632
    Cell Significance Index: -1.2700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1641
    Cell Significance Index: -2.2500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1660
    Cell Significance Index: -2.4200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1673
    Cell Significance Index: -2.2300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1684
    Cell Significance Index: -2.3600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1705
    Cell Significance Index: -2.5500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1709
    Cell Significance Index: -1.4700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1716
    Cell Significance Index: -1.1800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1720
    Cell Significance Index: -2.9400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1757
    Cell Significance Index: -1.7700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1775
    Cell Significance Index: -2.2400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1776
    Cell Significance Index: -2.1300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1793
    Cell Significance Index: -2.3600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1799
    Cell Significance Index: -1.9400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1801
    Cell Significance Index: -1.9100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1813
    Cell Significance Index: -1.8800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1829
    Cell Significance Index: -2.3500
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1831
    Cell Significance Index: -1.5300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1851
    Cell Significance Index: -1.9900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1856
    Cell Significance Index: -2.2600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1875
    Cell Significance Index: -2.4600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1875
    Cell Significance Index: -1.5900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1882
    Cell Significance Index: -2.2400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1914
    Cell Significance Index: -1.5500
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1915
    Cell Significance Index: -1.7400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1924
    Cell Significance Index: -1.7800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1943
    Cell Significance Index: -2.1900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1943
    Cell Significance Index: -1.6400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1957
    Cell Significance Index: -2.2400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1965
    Cell Significance Index: -2.5700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1969
    Cell Significance Index: -2.5700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1972
    Cell Significance Index: -2.2400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1973
    Cell Significance Index: -1.7800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1977
    Cell Significance Index: -2.4700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1977
    Cell Significance Index: -2.3500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1985
    Cell Significance Index: -2.4200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1991
    Cell Significance Index: -2.5500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1999
    Cell Significance Index: -2.3500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2023
    Cell Significance Index: -2.6100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2028
    Cell Significance Index: -2.7000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2034
    Cell Significance Index: -2.3400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2038
    Cell Significance Index: -2.4600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2055
    Cell Significance Index: -2.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** TRAV13-1 is located on chromosome 14q32.33, a region known to harbor the TCRα gene. 2. **Expression:** TRAV13-1 is significantly expressed in various immune cells, including granulocyte-monocyte progenitor cells, early T lineage precursors, and naive thymus-derived CD4-positive, alpha-beta T cells. 3. **Function:** TRAV13-1 is involved in recognizing and binding to specific antigens, triggering an immune response. 4. **Cellular Distribution:** TRAV13-1 is expressed in multiple cell types, including neutrophils, common myeloid progenitors, and platelets, indicating its broad immunological significance. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV13-1 plays a crucial role in the adaptive immune response by recognizing and binding to specific antigens, thereby triggering an immune response. 2. **T Cell Receptor Complex:** TRAV13-1 is part of the TCR complex, which is essential for recognizing and binding to antigens. 3. **Response to Bacterium:** TRAV13-1 is involved in the response to bacterial infections, highlighting its importance in combating bacterial pathogens. 4. **T Cell Receptor Complex Signaling:** TRAV13-1 is involved in the signaling pathway of the TCR complex, which ultimately leads to the activation of T cells. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in TRAV13-1 expression have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer Immunotherapy:** TRAV13-1 has been identified as a potential target for cancer immunotherapy, as it is involved in the recognition and binding to tumor antigens. 3. **Infectious Diseases:** TRAV13-1 is involved in the response to bacterial infections, making it a potential target for the development of novel antibacterial therapies. 4. **Immunological Monitoring:** TRAV13-1 expression can serve as a biomarker for immunological monitoring, allowing for the tracking of immune responses and the assessment of treatment efficacy. In conclusion, TRAV13-1 is a gene that plays a critical role in the adaptive immune response, recognizing and binding to specific antigens, and triggering an immune response. Its broad expression in various immune cells and its involvement in multiple pathways and functions highlight its significance in immunological research and clinical applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.