Details for: MKNK2

Gene ID: 2872

Symbol: MKNK2

Ensembl ID: ENSG00000099875

Description: MAPK interacting serine/threonine kinase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.23
    Marker Score: 1342
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.06
    Marker Score: 2029.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.01
    Marker Score: 2143.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.98
    Marker Score: 2083
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.95
    Marker Score: 2878
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.89
    Marker Score: 19113
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.88
    Marker Score: 667
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.85
    Marker Score: 1081
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.83
    Marker Score: 4160
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.82
    Marker Score: 6752
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.8
    Marker Score: 14034.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.78
    Marker Score: 60617.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.72
    Marker Score: 3009
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.67
    Marker Score: 1139
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.64
    Marker Score: 3469
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.61
    Marker Score: 1373.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.59
    Marker Score: 5004
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.53
    Marker Score: 13161
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.53
    Marker Score: 889
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.52
    Marker Score: 1392
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.5
    Marker Score: 1060
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.49
    Marker Score: 1247
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.47
    Marker Score: 2601
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.46
    Marker Score: 10871
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.45
    Marker Score: 460
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.45
    Marker Score: 460
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.45
    Marker Score: 359
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.44
    Marker Score: 9417
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.41
    Marker Score: 421
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.38
    Marker Score: 2800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.37
    Marker Score: 641
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.37
    Marker Score: 572
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.35
    Marker Score: 1747
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.35
    Marker Score: 4001.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.35
    Marker Score: 46679
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.3
    Marker Score: 1028
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.3
    Marker Score: 869
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.3
    Marker Score: 2368
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.29
    Marker Score: 2923.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.28
    Marker Score: 371
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.28
    Marker Score: 3178.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.28
    Marker Score: 796
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.27
    Marker Score: 1529
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.26
    Marker Score: 384
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.25
    Marker Score: 753
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19513
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.24
    Marker Score: 556
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.24
    Marker Score: 1988
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.23
    Marker Score: 2466.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.23
    Marker Score: 426
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.23
    Marker Score: 1950
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.22
    Marker Score: 6420
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.22
    Marker Score: 392
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.21
    Marker Score: 1205
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.2
    Marker Score: 815
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.19
    Marker Score: 2812
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.19
    Marker Score: 1064.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.19
    Marker Score: 7606
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.19
    Marker Score: 2499
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.19
    Marker Score: 274
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.18
    Marker Score: 359
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.18
    Marker Score: 65998.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.17
    Marker Score: 1218
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.17
    Marker Score: 280
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.17
    Marker Score: 776
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.16
    Marker Score: 3245
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.16
    Marker Score: 1277
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.16
    Marker Score: 570
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.14
    Marker Score: 570
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.14
    Marker Score: 863
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.14
    Marker Score: 281
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.13
    Marker Score: 269
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.13
    Marker Score: 325
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.12
    Marker Score: 1016
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.12
    Marker Score: 1960.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.12
    Marker Score: 1266
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.11
    Marker Score: 1068
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.11
    Marker Score: 538
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.11
    Marker Score: 412
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.1
    Marker Score: 246
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.1
    Marker Score: 950
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.1
    Marker Score: 5261
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.09
    Marker Score: 397.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.08
    Marker Score: 1797
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.08
    Marker Score: 1086
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.08
    Marker Score: 235
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.07
    Marker Score: 1168.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.07
    Marker Score: 404
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.07
    Marker Score: 651
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.07
    Marker Score: 443
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.07
    Marker Score: 2686
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.06
    Marker Score: 330
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.06
    Marker Score: 505
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.06
    Marker Score: 9233
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.06
    Marker Score: 550
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.06
    Marker Score: 238
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.05
    Marker Score: 237
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.04
    Marker Score: 435
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.04
    Marker Score: 1218
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.03
    Marker Score: 1209

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Other Information

**Key characteristics:** * MKNK2 is a transmembrane protein with a molecular weight of approximately 125 kDa. * It is a serine/threonine kinase that is activated by a variety of extracellular stimuli, including growth factors and cytokines. * MKNK2 has been shown to play a role in a variety of cellular processes, including cell cycle regulation, apoptosis, and differentiation. **Pathways and functions:** * **MAPK pathway:** MKNK2 is a key regulator of the MAPK pathway, which is involved in cell growth, differentiation, and survival. MAPK pathway is activated by various growth factors and cytokines, including EGF and TGF-β. * **Calcium-dependent protein kinase pathway:** MKNK2 is also a key regulator of the calcium-dependent protein kinase pathway. This pathway is involved in cell cycle regulation, differentiation, and apoptosis. * **Cell surface receptor signaling pathway:** MKNK2 is a key regulator of the cell surface receptor signaling pathway. This pathway is involved in cell adhesion, migration, and signaling. **Clinical significance:** * Mutations in MKNK2 have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. * Inhibition of MKNK2 has been shown to be effective in treating cancer cells. * Therefore, MKNK2 is a promising target for the development of new cancer therapies.

Genular Protein ID: 2387374190

Symbol: MKNK2_HUMAN

Name: MAP kinase-interacting serine/threonine-protein kinase 2

UniProtKB Accession Codes:

Q9HBH9 Q6GPI3 Q9HBH8 Q9UHR0 Q9Y2N6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 5 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 12 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11013076

Title: Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta.

PubMed ID: 11013076

DOI: 10.1006/geno.2000.6299

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11154262

Title: The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.

PubMed ID: 11154262

DOI: 10.1128/mcb.21.3.743-754.2001

PubMed ID: 11463832

Title: Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.

PubMed ID: 11463832

DOI: 10.1128/mcb.21.16.5500-5511.2001

PubMed ID: 12897141

Title: The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.

PubMed ID: 12897141

DOI: 10.1128/mcb.23.16.5692-5705.2003

PubMed ID: 16111636

Title: The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1.

PubMed ID: 16111636

DOI: 10.1016/j.immuni.2005.06.009

PubMed ID: 17965020

Title: The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha.

PubMed ID: 17965020

DOI: 10.1074/jbc.m705286200

PubMed ID: 18299328

Title: Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2.

PubMed ID: 18299328

DOI: 10.1074/jbc.m708816200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20722422

Title: Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.

PubMed ID: 20722422

DOI: 10.1021/jm1005513

PubMed ID: 20823271

Title: Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.

PubMed ID: 20823271

DOI: 10.1128/mcb.00448-10

PubMed ID: 20664001

Title: Negative regulatory effects of Mnk kinases in the generation of chemotherapy-induced antileukemic responses.

PubMed ID: 20664001

DOI: 10.1124/mol.110.064642

PubMed ID: 20927323

Title: Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.

PubMed ID: 20927323

DOI: 10.1593/neo.10704

PubMed ID: 21149447

Title: Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis.

PubMed ID: 21149447

DOI: 10.1074/jbc.m110.197921

PubMed ID: 18508592

Title: The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).

PubMed ID: 18508592

DOI: 10.2741/3086

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16216586

Title: Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.

PubMed ID: 16216586

DOI: 10.1016/j.str.2005.07.013

PubMed ID: 16917500

Title: Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment.

PubMed ID: 16917500

DOI: 10.1038/sj.emboj.7601285

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 465
  • Mass: 51875
  • Checksum: D6D4BE6C541012B1
  • Sequence:
    • MVQKKPAELQ GFHRSFKGQN PFELAFSLDQ PDHGDSDFGL QCSARPDMPA SQPIDIPDAK 
KRGKKKKRGR ATDSFSGRFE DVYQLQEDVL GEGAHARVQT CINLITSQEY AVKIIEKQPG 
HIRSRVFREV EMLYQCQGHR NVLELIEFFE EEDRFYLVFE KMRGGSILSH IHKRRHFNEL 
EASVVVQDVA SALDFLHNKG IAHRDLKPEN ILCEHPNQVS PVKICDFDLG SGIKLNGDCS 
PISTPELLTP CGSAEYMAPE VVEAFSEEAS IYDKRCDLWS LGVILYILLS GYPPFVGRCG 
SDCGWDRGEA CPACQNMLFE SIQEGKYEFP DKDWAHISCA AKDLISKLLV RDAKQRLSAA 
QVLQHPWVQG CAPENTLPTP MVLQRNSCAK DLTSFAAEAI AMNRQLAQHD EDLAEEEAAG 
QGQPVLVRAT SRCLQLSPPS QSKLAQRRQR ASLSSAPVVL VGDHA

Genular Protein ID: 367638665

Symbol: B3KS07_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KS07

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 11 DNASU 1 EC 2 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 Rhea 6 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 149
  • Mass: 16329
  • Checksum: 08CBACC307607CE3
  • Sequence:
    • MLFESIQEGK YEFPDKDWAH ISCAAKDLIS KLLVRDAKQR LSAAQVLQHP WVQGCAPENT 
LPTPMVLQRN SCAKDLTSFA AEAIAMNRQL AQHDEDLAEE EAAGQGQPVL VRATSRCLQL 
SPPSQSKLAQ RRQRASLSSA PVVLVGDHA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.