Details for: IGLV1 50

Gene ID: 28821

Symbol: IGLV1 50

Ensembl ID: ENSG00000211645

Description: immunoglobulin lambda variable 1-50 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.9579
    Cell Significance Index: 14.0100
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.3749
    Cell Significance Index: 3.1000
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0479
    Cell Significance Index: 0.5700
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.0050
    Cell Significance Index: 0.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0006
    Cell Significance Index: -0.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0011
    Cell Significance Index: -0.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0011
    Cell Significance Index: -0.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0043
    Cell Significance Index: -0.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0046
    Cell Significance Index: -0.6300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0046
    Cell Significance Index: -0.0800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0122
    Cell Significance Index: -0.1300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0125
    Cell Significance Index: -0.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0125
    Cell Significance Index: -0.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0140
    Cell Significance Index: -0.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0143
    Cell Significance Index: -0.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0147
    Cell Significance Index: -0.4800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0149
    Cell Significance Index: -0.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0151
    Cell Significance Index: -0.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0160
    Cell Significance Index: -0.5100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0162
    Cell Significance Index: -0.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0169
    Cell Significance Index: -0.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0178
    Cell Significance Index: -0.8300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0200
    Cell Significance Index: -0.3000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0225
    Cell Significance Index: -0.1500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0251
    Cell Significance Index: -0.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0251
    Cell Significance Index: -0.6300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0251
    Cell Significance Index: -0.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0278
    Cell Significance Index: -0.6000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0294
    Cell Significance Index: -0.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0304
    Cell Significance Index: -0.6500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0321
    Cell Significance Index: -0.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0334
    Cell Significance Index: -0.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0334
    Cell Significance Index: -0.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0343
    Cell Significance Index: -0.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0344
    Cell Significance Index: -0.6800
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0348
    Cell Significance Index: -0.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0370
    Cell Significance Index: -0.6400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0404
    Cell Significance Index: -0.5100
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0417
    Cell Significance Index: -0.3700
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0436
    Cell Significance Index: -0.3800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0450
    Cell Significance Index: -0.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0468
    Cell Significance Index: -0.8700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0471
    Cell Significance Index: -0.4200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0483
    Cell Significance Index: -0.6300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0517
    Cell Significance Index: -0.6200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0519
    Cell Significance Index: -0.8400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0534
    Cell Significance Index: -0.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0537
    Cell Significance Index: -0.6400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0542
    Cell Significance Index: -0.6400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0542
    Cell Significance Index: -0.6800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0542
    Cell Significance Index: -0.6200
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0547
    Cell Significance Index: -0.5000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0549
    Cell Significance Index: -0.7300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0550
    Cell Significance Index: -0.5700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0552
    Cell Significance Index: -0.7200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0561
    Cell Significance Index: -0.7200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0569
    Cell Significance Index: -0.7100
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0569
    Cell Significance Index: -0.7200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0570
    Cell Significance Index: -0.7200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0575
    Cell Significance Index: -0.7200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0577
    Cell Significance Index: -0.7200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0580
    Cell Significance Index: -0.7200
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.0583
    Cell Significance Index: -0.7200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0584
    Cell Significance Index: -0.6900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0586
    Cell Significance Index: -0.7200
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0586
    Cell Significance Index: -0.7300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0587
    Cell Significance Index: -0.6400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0592
    Cell Significance Index: -0.7600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0594
    Cell Significance Index: -0.7100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0594
    Cell Significance Index: -0.6000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0595
    Cell Significance Index: -0.6900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0608
    Cell Significance Index: -0.8000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0608
    Cell Significance Index: -0.6200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0612
    Cell Significance Index: -0.7100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0618
    Cell Significance Index: -0.6400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0623
    Cell Significance Index: -0.8300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0626
    Cell Significance Index: -0.7200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0632
    Cell Significance Index: -0.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0634
    Cell Significance Index: -0.8200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0634
    Cell Significance Index: -0.8800
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0639
    Cell Significance Index: -0.6300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0647
    Cell Significance Index: -0.8200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0670
    Cell Significance Index: -0.7100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0679
    Cell Significance Index: -0.6300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0682
    Cell Significance Index: -0.5700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0686
    Cell Significance Index: -0.7400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0686
    Cell Significance Index: -0.7000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0702
    Cell Significance Index: -0.8300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0703
    Cell Significance Index: -0.7400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0706
    Cell Significance Index: -0.8200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0711
    Cell Significance Index: -0.9300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0713
    Cell Significance Index: -0.4700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0716
    Cell Significance Index: -0.6100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0720
    Cell Significance Index: -0.7600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0729
    Cell Significance Index: -0.6700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0733
    Cell Significance Index: -0.7800
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: -0.0738
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0739
    Cell Significance Index: -0.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional**: IGLV1-50 is a non-functional gene, meaning it does not encode a functional protein. 2. **Immunoglobulin lambda variable 1-50**: This gene belongs to the immunoglobulin lambda family, which is involved in the production of antibodies. 3. **Significantly expressed cells**: IGLV1-50 is expressed in various cell types, including T cells, goblet cells, lymphocytes, and hematopoietic cells. 4. **Adaptive immune response**: IGLV1-50 is involved in the adaptive immune response, which is a specific response to pathogens or antigens. **Pathways and Functions:** 1. **Adaptive immune response**: IGLV1-50 is involved in the adaptive immune response, which is a specific response to pathogens or antigens. 2. **Immunoglobulin complex**: IGLV1-50 is part of the immunoglobulin complex, which is composed of antibodies and other proteins that work together to recognize and eliminate pathogens. 3. **Immunoglobulin production**: Although IGLV1-50 is non-functional, it is involved in the production of immunoglobulins, which are essential for immune function. 4. **Plasma membrane**: IGLV1-50 is localized to the plasma membrane, where it may interact with other proteins and lipids to regulate immune cell function. **Clinical Significance:** 1. **Immune-mediated diseases**: IGLV1-50 has been implicated in several immune-mediated diseases, including autoimmune disorders and cancer. 2. **Immunodeficiency**: The non-functional status of IGLV1-50 may contribute to immunodeficiency, a condition characterized by impaired immune function. 3. **Cancer**: IGLV1-50 has been found to be overexpressed in several types of cancer, suggesting its potential role in tumorigenesis. 4. **Gastrointestinal disorders**: The expression of IGLV1-50 in intestinal epithelial cells and goblet cells may be relevant to gastrointestinal disorders, such as inflammatory bowel disease. In conclusion, IGLV1-50 is a non-functional gene that is involved in the adaptive immune response and may have significant clinical implications in immune-mediated diseases, immunodeficiency, and cancer. Further research is needed to fully elucidate the role of IGLV1-50 in immune function and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.