Details for: SOX8

Gene ID: 30812

Symbol: SOX8

Ensembl ID: ENSG00000005513

Description: SRY-box transcription factor 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.4233
    Cell Significance Index: 68.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.8710
    Cell Significance Index: 96.7700
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.8470
    Cell Significance Index: 1.3200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4953
    Cell Significance Index: 36.2200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.1593
    Cell Significance Index: 17.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9429
    Cell Significance Index: 179.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5818
    Cell Significance Index: 57.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4992
    Cell Significance Index: 450.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3726
    Cell Significance Index: 7.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3357
    Cell Significance Index: 3.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3104
    Cell Significance Index: 50.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3034
    Cell Significance Index: 13.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2999
    Cell Significance Index: 32.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2059
    Cell Significance Index: 12.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1828
    Cell Significance Index: 36.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1273
    Cell Significance Index: 14.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1180
    Cell Significance Index: 3.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0721
    Cell Significance Index: 3.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0715
    Cell Significance Index: 1.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0579
    Cell Significance Index: 20.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0336
    Cell Significance Index: 1.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0035
    Cell Significance Index: 2.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0087
    Cell Significance Index: -13.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0115
    Cell Significance Index: -15.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0147
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0162
    Cell Significance Index: -12.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0168
    Cell Significance Index: -12.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0171
    Cell Significance Index: -10.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0187
    Cell Significance Index: -2.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0193
    Cell Significance Index: -0.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0220
    Cell Significance Index: -12.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0258
    Cell Significance Index: -1.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0276
    Cell Significance Index: -12.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0277
    Cell Significance Index: -12.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0293
    Cell Significance Index: -0.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0376
    Cell Significance Index: -10.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0396
    Cell Significance Index: -1.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0437
    Cell Significance Index: -6.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0468
    Cell Significance Index: -2.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0519
    Cell Significance Index: -9.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0583
    Cell Significance Index: -11.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0584
    Cell Significance Index: -12.3000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0606
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0669
    Cell Significance Index: -7.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0678
    Cell Significance Index: -11.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0710
    Cell Significance Index: -8.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0768
    Cell Significance Index: -10.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0798
    Cell Significance Index: -10.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0943
    Cell Significance Index: -3.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0977
    Cell Significance Index: -11.5200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1066
    Cell Significance Index: -0.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1096
    Cell Significance Index: -11.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1175
    Cell Significance Index: -12.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1195
    Cell Significance Index: -3.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1315
    Cell Significance Index: -6.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1496
    Cell Significance Index: -11.1500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1528
    Cell Significance Index: -3.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1538
    Cell Significance Index: -10.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1728
    Cell Significance Index: -10.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1736
    Cell Significance Index: -13.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1818
    Cell Significance Index: -11.7300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1831
    Cell Significance Index: -1.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2106
    Cell Significance Index: -6.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2272
    Cell Significance Index: -11.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2461
    Cell Significance Index: -8.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2538
    Cell Significance Index: -8.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2587
    Cell Significance Index: -7.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2864
    Cell Significance Index: -14.8800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2983
    Cell Significance Index: -3.4800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3037
    Cell Significance Index: -4.4100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3151
    Cell Significance Index: -3.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3154
    Cell Significance Index: -9.2900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3200
    Cell Significance Index: -2.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3340
    Cell Significance Index: -8.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3366
    Cell Significance Index: -10.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3424
    Cell Significance Index: -12.5700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3451
    Cell Significance Index: -4.6000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3461
    Cell Significance Index: -4.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3528
    Cell Significance Index: -11.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3624
    Cell Significance Index: -6.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3668
    Cell Significance Index: -9.1500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3735
    Cell Significance Index: -7.3000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3750
    Cell Significance Index: -6.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3813
    Cell Significance Index: -9.8000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3898
    Cell Significance Index: -6.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4020
    Cell Significance Index: -10.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4089
    Cell Significance Index: -12.0100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.4137
    Cell Significance Index: -3.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4168
    Cell Significance Index: -11.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4169
    Cell Significance Index: -10.6500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4183
    Cell Significance Index: -13.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4258
    Cell Significance Index: -5.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4269
    Cell Significance Index: -11.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4298
    Cell Significance Index: -9.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4328
    Cell Significance Index: -9.0600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4381
    Cell Significance Index: -2.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4423
    Cell Significance Index: -11.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4448
    Cell Significance Index: -8.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SOX8 is a transcription factor that belongs to the SOX family, which is characterized by the presence of a SOX box motif. This motif is essential for the binding of SOX8 to specific DNA sequences, thereby regulating gene expression. SOX8 is highly conserved across species, suggesting its importance in developmental and cellular processes. Its expression is widespread, with significant levels detected in various cell types, including those involved in adipose tissue development, enteric nervous system development, and kidney development. **Pathways and Functions:** SOX8 is involved in various signaling pathways, including those regulating cell fate commitment, differentiation, and survival. Its expression is influenced by multiple transcription factors, including AP-1, NF-κB, and FOXO1, which are involved in regulating cellular responses to stress, inflammation, and growth factors. SOX8 also interacts with other transcription factors, such as SOX11 and SOX9, to regulate the expression of target genes involved in development and differentiation. In terms of its functions, SOX8 plays a crucial role in regulating the expression of genes involved in adipose tissue development, enteric nervous system development, and kidney development. It also regulates the expression of genes involved in cell differentiation, including those involved in the development of oligodendrocytes, astrocytes, and skeletal muscle cells. Furthermore, SOX8 has been shown to regulate the expression of genes involved in cell survival, apoptosis, and inflammation. **Clinical Significance:** SOX8 has been implicated in various diseases, including cancer, inflammatory disorders, and developmental abnormalities. For example, SOX8 has been shown to be upregulated in certain types of cancer, including breast cancer and colon cancer, suggesting its potential role as a tumor suppressor gene. Additionally, SOX8 has been implicated in the development of inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis, suggesting its potential role in regulating immune responses. Furthermore, SOX8 has been shown to be involved in developmental abnormalities, including those affecting the enteric nervous system and kidney development. Its dysregulation has been implicated in various congenital abnormalities, including those affecting the development of the brain, heart, and kidneys. In conclusion, SOX8 is a critical regulator of cellular differentiation and development, with significant implications for various diseases and developmental abnormalities. Further research is needed to fully elucidate the mechanisms by which SOX8 regulates cellular processes and to explore its potential therapeutic applications. **Key Takeaways:** * SOX8 is a transcription factor that regulates various cellular processes, including differentiation, development, and survival. * Its expression is tightly regulated and is significantly upregulated in various cell types, including colon goblet cells, cardiac endothelial cells, and oligodendrocyte precursor cells. * SOX8 plays a crucial role in regulating the expression of genes involved in adipose tissue development, enteric nervous system development, and kidney development. * Its dysregulation has been implicated in various diseases, including cancer, inflammatory disorders, and developmental abnormalities. * Further research is needed to fully elucidate the mechanisms by which SOX8 regulates cellular processes and to explore its potential therapeutic applications.

Genular Protein ID: 1544512158

Symbol: SOX8_HUMAN

Name: Transcription factor SOX-8

UniProtKB Accession Codes:

P57073 Q9NZW2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 46 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10662550

Title: The SOX8 gene is located within 700 kb of the tip of chromosome 16p and is deleted in a patient with ATR-16 syndrome.

PubMed ID: 10662550

DOI: 10.1006/geno.1999.6060

PubMed ID: 31194875

Title: The SOXE transcription factors-SOX8, SOX9 and SOX10-share a bi-partite transactivation mechanism.

PubMed ID: 31194875

DOI: 10.1093/nar/gkz523

PubMed ID: 34342803

Title: The 9aaTAD Activation Domains in the Yamanaka Transcription Factors Oct4, Sox2, Myc, and Klf4.

PubMed ID: 34342803

DOI: 10.1007/s12015-021-10225-8

Sequence Information:

  • Length: 446
  • Mass: 47314
  • Checksum: AE453359051A6DB3
  • Sequence:
    • MLDMSEARSQ PPCSPSGTAS SMSHVEDSDS DAPPSPAGSE GLGRAGVAVG GARGDPAEAA 
DERFPACIRD AVSQVLKGYD WSLVPMPVRG GGGGALKAKP HVKRPMNAFM VWAQAARRKL 
ADQYPHLHNA ELSKTLGKLW RLLSESEKRP FVEEAERLRV QHKKDHPDYK YQPRRRKSAK 
AGHSDSDSGA ELGPHPGGGA VYKAEAGLGD GHHHGDHTGQ THGPPTPPTT PKTELQQAGA 
KPELKLEGRR PVDSGRQNID FSNVDISELS SEVMGTMDAF DVHEFDQYLP LGGPAPPEPG 
QAYGGAYFHA GASPVWAHKS APSASASPTE TGPPRPHIKT EQPSPGHYGD QPRGSPDYGS 
CSGQSSATPA APAGPFAGSQ GDYGDLQASS YYGAYPGYAP GLYQYPCFHS PRRPYASPLL 
NGLALPPAHS PTSHWDQPVY TTLTRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.