Details for: CTAG2

Gene ID: 30848

Symbol: CTAG2

Ensembl ID: ENSG00000126890

Description: cancer/testis antigen 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,089
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.09
    Marker Score: 1,159
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10,748
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.32
    Marker Score: 380
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,578
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,654
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,730
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,836
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,061
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,291
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 631
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 736
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,254
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 229
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.51
    Marker Score: 311
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.45
    Marker Score: 785
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.4
    Marker Score: 436
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.35
    Marker Score: 504
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.32
    Marker Score: 598
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.31
    Marker Score: 208
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.31
    Marker Score: 636
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.29
    Marker Score: 285
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.26
    Marker Score: 419
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.26
    Marker Score: 4,000
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 141
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 136
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.22
    Marker Score: 198
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.2
    Marker Score: 195
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.16
    Marker Score: 83
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.15
    Marker Score: 2,082
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.15
    Marker Score: 78
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.14
    Marker Score: 34
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.13
    Marker Score: 173
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.13
    Marker Score: 222
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.1
    Marker Score: 105
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.1
    Marker Score: 127
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.1
    Marker Score: 108
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.08
    Marker Score: 229
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.08
    Marker Score: 601
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.06
    Marker Score: 123
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.06
    Marker Score: 47
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.05
    Marker Score: 103
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 68
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.05
    Marker Score: 70
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.05
    Marker Score: 74
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.04
    Marker Score: 35
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.04
    Marker Score: 59
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.04
    Marker Score: 90
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.04
    Marker Score: 59
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.03
    Marker Score: 90
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.03
    Marker Score: 61
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 17

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CTAG2 is a member of the cancer/testis antigen (CTA) family, which comprises a group of proteins that are exclusively expressed in cancerous cells or cells of the testis. The CTAG2 gene is located on chromosome 1p36.33 and consists of 3 exons. Its protein product, CTAG2, is a 21-kDa protein that belongs to the nucleolar protein family. Notably, CTAG2 is overexpressed in various types of cancer, including testicular cancer, lung cancer, and colon cancer, suggesting its potential role as a tumor-associated antigen. **Pathways and Functions:** CTAG2 has been implicated in various cellular processes, including cell cycle regulation, apoptosis, and DNA repair. Its expression is regulated by the p53 tumor suppressor protein, which suggests its involvement in the p53 signaling pathway. CTAG2 has also been shown to interact with other proteins, including nucleophosmin and nucleolar protein B23, which are involved in ribosome biogenesis and cell cycle regulation. Furthermore, CTAG2 has been detected in the cytoplasm and nucleus of cells, where it may play a role in regulating gene expression and cell proliferation. **Clinical Significance:** CTAG2 has significant clinical implications, particularly in the context of cancer diagnosis and treatment. Its expression in cancerous cells makes it a potential target for immunotherapy, where the immune system is activated to recognize and attack cancer cells expressing CTAG2. Additionally, CTAG2 has been detected in the serum of patients with certain types of cancer, suggesting its potential as a biomarker for cancer diagnosis and prognosis. Furthermore, CTAG2 has been shown to be overexpressed in certain types of non-cancerous cells, such as goblet cells and granulocyte-monocyte progenitor cells, which may have implications for the development of novel therapeutic strategies. **Conclusion:** In conclusion, CTAG2 is a complex protein that plays a multifaceted role in various cellular processes, including cell cycle regulation, apoptosis, and DNA repair. Its expression in cancerous cells makes it a potential target for immunotherapy, while its detection in the serum of patients with certain types of cancer suggests its potential as a biomarker for cancer diagnosis and prognosis. Further research is needed to fully elucidate the functions and clinical significance of CTAG2, but its unique expression profile and potential implications in various diseases make it an exciting area of investigation in the field of immunology. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms by which CTAG2 regulates cell cycle and apoptosis. 2. The development of novel therapeutic strategies targeting CTAG2-expressing cells should be explored, particularly in the context of cancer immunotherapy. 3. The clinical significance of CTAG2 as a biomarker for cancer diagnosis and prognosis should be further investigated. 4. The expression of CTAG2 in non-cancerous cells should be explored to understand its potential implications in various diseases. **Limitations:** 1. The expression of CTAG2 in cancerous cells is limited to certain types of cancer, which may limit its potential as a universal cancer target. 2. The mechanisms by which CTAG2 regulates cell cycle and apoptosis are not fully understood, which may limit its potential as a therapeutic target. 3. The clinical significance of CTAG2 as a biomarker for cancer diagnosis and prognosis is still unclear, which may limit its potential as a diagnostic tool. **Future Directions:** 1. The development of novel therapeutic strategies targeting CTAG2-expressing cells should be explored, particularly in the context of cancer immunotherapy. 2. The clinical significance of CTAG2 as a biomarker for cancer diagnosis and prognosis should be further investigated. 3. The expression of CTAG2 in non-cancerous cells should be explored to understand its potential implications in various diseases. 4. Further studies are needed to elucidate the mechanisms by which CTAG2 regulates cell cycle and apoptosis.

Genular Protein ID: 2874223038

Symbol: CTAG2_HUMAN

Name: Cancer/testis antigen 2

UniProtKB Accession Codes:

O75638 O75637 Q0VIL6 Q14CD6 Q2Z1N4 Q9BU80 Q9UJ89 Q9Y479

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 2 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9626360

Title: LAGE-1, a new gene with tumor specificity.

PubMed ID: 9626360

DOI: 10.1002/(sici)1097-0215(19980610)76:6<903::aid-ijc22>3.0.co;2-1

PubMed ID: 10399963

Title: Interleukin-2-induced, melanoma-specific T cells recognize CAMEL, an unexpected translation product of LAGE-1.

PubMed ID: 10399963

DOI: 10.1002/(sici)1097-0215(19990730)82:3<442::aid-ijc19>3.0.co;2-z

PubMed ID: 11709543

Title: Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes.

PubMed ID: 11709543

DOI: 10.1093/hmg/10.22.2557

PubMed ID: 17899192

Title: Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients.

PubMed ID: 17899192

DOI: 10.1007/s00432-007-0312-z

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 210
  • Mass: 21090
  • Checksum: 8FB5BF04FB04E8BE
  • Sequence:
    • MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPRGGA 
PRGPHGGAAS AQDGRCPCGA RRPDSRLLEL HITMPFSSPM EAELVRRILS RDAAPLPRPG 
AVLKDFTVSG NLLFMSVRDQ DREGAGRMRV VGWGLGSASP EGQKARDLRT PKHKVSEQRP 
GTPGPPPPEG AQGDGCRGVA FNVMFSAPHI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.