Details for: CTAG2

Gene ID: 30848

Symbol: CTAG2

Ensembl ID: ENSG00000126890

Description: cancer/testis antigen 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 7.9077
    Cell Significance Index: -1.2300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 6.1888
    Cell Significance Index: 53.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 4.7311
    Cell Significance Index: -1.2000
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.8736
    Cell Significance Index: 4.3700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4821
    Cell Significance Index: 3.6400
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.2858
    Cell Significance Index: 0.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.2754
    Cell Significance Index: 10.1100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2655
    Cell Significance Index: 3.8700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1892
    Cell Significance Index: 2.3400
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.1610
    Cell Significance Index: 1.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0703
    Cell Significance Index: 1.8800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0395
    Cell Significance Index: 0.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0336
    Cell Significance Index: 0.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0061
    Cell Significance Index: 1.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0042
    Cell Significance Index: 0.5800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0004
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0009
    Cell Significance Index: -0.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0009
    Cell Significance Index: -0.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0023
    Cell Significance Index: -0.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0024
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0026
    Cell Significance Index: -0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0027
    Cell Significance Index: -0.5500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0034
    Cell Significance Index: -0.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0052
    Cell Significance Index: -0.6400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0077
    Cell Significance Index: -0.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0098
    Cell Significance Index: -0.1100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0103
    Cell Significance Index: -1.2100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0167
    Cell Significance Index: -0.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0167
    Cell Significance Index: -1.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0168
    Cell Significance Index: -1.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0184
    Cell Significance Index: -0.5900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0187
    Cell Significance Index: -0.2700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0196
    Cell Significance Index: -0.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0202
    Cell Significance Index: -0.9400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0203
    Cell Significance Index: -0.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0209
    Cell Significance Index: -0.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0217
    Cell Significance Index: -0.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0236
    Cell Significance Index: -1.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0242
    Cell Significance Index: -0.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0246
    Cell Significance Index: -1.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0278
    Cell Significance Index: -1.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0294
    Cell Significance Index: -0.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0315
    Cell Significance Index: -1.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0325
    Cell Significance Index: -0.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0330
    Cell Significance Index: -1.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0338
    Cell Significance Index: -0.3500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0357
    Cell Significance Index: -0.9100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0408
    Cell Significance Index: -0.5600
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0409
    Cell Significance Index: -0.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0410
    Cell Significance Index: -1.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0415
    Cell Significance Index: -1.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0506
    Cell Significance Index: -0.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0507
    Cell Significance Index: -0.9900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0509
    Cell Significance Index: -0.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0521
    Cell Significance Index: -1.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0528
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0540
    Cell Significance Index: -0.6800
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0555
    Cell Significance Index: -0.4200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0560
    Cell Significance Index: -0.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0563
    Cell Significance Index: -1.1300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0577
    Cell Significance Index: -1.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0583
    Cell Significance Index: -1.2600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0590
    Cell Significance Index: -0.7900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0595
    Cell Significance Index: -0.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0607
    Cell Significance Index: -1.4700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0616
    Cell Significance Index: -0.6500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0618
    Cell Significance Index: -1.2900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0619
    Cell Significance Index: -1.5100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0620
    Cell Significance Index: -1.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0642
    Cell Significance Index: -0.9200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0642
    Cell Significance Index: -0.9600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0647
    Cell Significance Index: -1.2900
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0662
    Cell Significance Index: -0.6000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0683
    Cell Significance Index: -1.3500
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.0691
    Cell Significance Index: -0.6800
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0696
    Cell Significance Index: -0.6700
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0703
    Cell Significance Index: -0.7500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0711
    Cell Significance Index: -1.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0718
    Cell Significance Index: -1.0600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0726
    Cell Significance Index: -0.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0730
    Cell Significance Index: -1.3500
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0747
    Cell Significance Index: -0.7000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0768
    Cell Significance Index: -0.9600
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.0768
    Cell Significance Index: -0.5900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0769
    Cell Significance Index: -1.3300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0783
    Cell Significance Index: -0.9800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0788
    Cell Significance Index: -1.0300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0789
    Cell Significance Index: -0.9600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0795
    Cell Significance Index: -0.9600
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: -0.0796
    Cell Significance Index: -0.6500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0804
    Cell Significance Index: -1.0300
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0815
    Cell Significance Index: -0.8700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0825
    Cell Significance Index: -0.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CTAG2 is a member of the cancer/testis antigen (CTA) family, which comprises a group of proteins that are exclusively expressed in cancerous cells or cells of the testis. The CTAG2 gene is located on chromosome 1p36.33 and consists of 3 exons. Its protein product, CTAG2, is a 21-kDa protein that belongs to the nucleolar protein family. Notably, CTAG2 is overexpressed in various types of cancer, including testicular cancer, lung cancer, and colon cancer, suggesting its potential role as a tumor-associated antigen. **Pathways and Functions:** CTAG2 has been implicated in various cellular processes, including cell cycle regulation, apoptosis, and DNA repair. Its expression is regulated by the p53 tumor suppressor protein, which suggests its involvement in the p53 signaling pathway. CTAG2 has also been shown to interact with other proteins, including nucleophosmin and nucleolar protein B23, which are involved in ribosome biogenesis and cell cycle regulation. Furthermore, CTAG2 has been detected in the cytoplasm and nucleus of cells, where it may play a role in regulating gene expression and cell proliferation. **Clinical Significance:** CTAG2 has significant clinical implications, particularly in the context of cancer diagnosis and treatment. Its expression in cancerous cells makes it a potential target for immunotherapy, where the immune system is activated to recognize and attack cancer cells expressing CTAG2. Additionally, CTAG2 has been detected in the serum of patients with certain types of cancer, suggesting its potential as a biomarker for cancer diagnosis and prognosis. Furthermore, CTAG2 has been shown to be overexpressed in certain types of non-cancerous cells, such as goblet cells and granulocyte-monocyte progenitor cells, which may have implications for the development of novel therapeutic strategies. **Conclusion:** In conclusion, CTAG2 is a complex protein that plays a multifaceted role in various cellular processes, including cell cycle regulation, apoptosis, and DNA repair. Its expression in cancerous cells makes it a potential target for immunotherapy, while its detection in the serum of patients with certain types of cancer suggests its potential as a biomarker for cancer diagnosis and prognosis. Further research is needed to fully elucidate the functions and clinical significance of CTAG2, but its unique expression profile and potential implications in various diseases make it an exciting area of investigation in the field of immunology. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms by which CTAG2 regulates cell cycle and apoptosis. 2. The development of novel therapeutic strategies targeting CTAG2-expressing cells should be explored, particularly in the context of cancer immunotherapy. 3. The clinical significance of CTAG2 as a biomarker for cancer diagnosis and prognosis should be further investigated. 4. The expression of CTAG2 in non-cancerous cells should be explored to understand its potential implications in various diseases. **Limitations:** 1. The expression of CTAG2 in cancerous cells is limited to certain types of cancer, which may limit its potential as a universal cancer target. 2. The mechanisms by which CTAG2 regulates cell cycle and apoptosis are not fully understood, which may limit its potential as a therapeutic target. 3. The clinical significance of CTAG2 as a biomarker for cancer diagnosis and prognosis is still unclear, which may limit its potential as a diagnostic tool. **Future Directions:** 1. The development of novel therapeutic strategies targeting CTAG2-expressing cells should be explored, particularly in the context of cancer immunotherapy. 2. The clinical significance of CTAG2 as a biomarker for cancer diagnosis and prognosis should be further investigated. 3. The expression of CTAG2 in non-cancerous cells should be explored to understand its potential implications in various diseases. 4. Further studies are needed to elucidate the mechanisms by which CTAG2 regulates cell cycle and apoptosis.

Genular Protein ID: 2874223038

Symbol: CTAG2_HUMAN

Name: Cancer/testis antigen 2

UniProtKB Accession Codes:

O75638 O75637 Q0VIL6 Q14CD6 Q2Z1N4 Q9BU80 Q9UJ89 Q9Y479

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 2 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9626360

Title: LAGE-1, a new gene with tumor specificity.

PubMed ID: 9626360

DOI: 10.1002/(sici)1097-0215(19980610)76:6<903::aid-ijc22>3.0.co;2-1

PubMed ID: 10399963

Title: Interleukin-2-induced, melanoma-specific T cells recognize CAMEL, an unexpected translation product of LAGE-1.

PubMed ID: 10399963

DOI: 10.1002/(sici)1097-0215(19990730)82:3<442::aid-ijc19>3.0.co;2-z

PubMed ID: 11709543

Title: Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes.

PubMed ID: 11709543

DOI: 10.1093/hmg/10.22.2557

PubMed ID: 17899192

Title: Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients.

PubMed ID: 17899192

DOI: 10.1007/s00432-007-0312-z

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 210
  • Mass: 21090
  • Checksum: 8FB5BF04FB04E8BE
  • Sequence:
    • MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPRGGA 
PRGPHGGAAS AQDGRCPCGA RRPDSRLLEL HITMPFSSPM EAELVRRILS RDAAPLPRPG 
AVLKDFTVSG NLLFMSVRDQ DREGAGRMRV VGWGLGSASP EGQKARDLRT PKHKVSEQRP 
GTPGPPPPEG AQGDGCRGVA FNVMFSAPHI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.