Details for: HOXC11

Gene ID: 3227

Symbol: HOXC11

Ensembl ID: ENSG00000123388

Description: homeobox C11

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.46
    Marker Score: 3025
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 4.19
    Marker Score: 5183
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.42
    Marker Score: 3342
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.26
    Marker Score: 4116
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.19
    Marker Score: 2209
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.13
    Marker Score: 1209
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2206
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.47
    Marker Score: 1465.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.18
    Marker Score: 622
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.17
    Marker Score: 2009.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7677
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.09
    Marker Score: 454
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.08
    Marker Score: 1030
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.06
    Marker Score: 438
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.02
    Marker Score: 689
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48031
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.98
    Marker Score: 450.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5338
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.92
    Marker Score: 609
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 478
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1186.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2976
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.66
    Marker Score: 420
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.63
    Marker Score: 1297
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 470
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.51
    Marker Score: 1059
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.47
    Marker Score: 249
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.44
    Marker Score: 139
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.35
    Marker Score: 251
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.35
    Marker Score: 202
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 293
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.32
    Marker Score: 494
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.28
    Marker Score: 872
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.27
    Marker Score: 289.5
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.27
    Marker Score: 125
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.23
    Marker Score: 59
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.21
    Marker Score: 42
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.19
    Marker Score: 182
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.19
    Marker Score: 53
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.18
    Marker Score: 358
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.18
    Marker Score: 299
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.18
    Marker Score: 413
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.17
    Marker Score: 39
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.16
    Marker Score: 88
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.16
    Marker Score: 44
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.15
    Marker Score: 44
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.15
    Marker Score: 73
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.15
    Marker Score: 283
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.14
    Marker Score: 219
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.14
    Marker Score: 117
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.14
    Marker Score: 93
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.13
    Marker Score: 36
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.13
    Marker Score: 83
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.13
    Marker Score: 30
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.11
    Marker Score: 1775
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.11
    Marker Score: 68
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 672
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 112
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.11
    Marker Score: 196
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.1
    Marker Score: 43
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.1
    Marker Score: 39
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.09
    Marker Score: 448
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.09
    Marker Score: 44
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.09
    Marker Score: 48

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Other Information

**Key characteristics** - HOXC11 is a homeobox protein, which are a large family of transcription factors that play a crucial role in early development. - It is expressed in a variety of cell types during embryonic development, including erythrocyte, oligodendrocyte precursor cell, double negative thymocyte, microglial cell, blood vessel endothelial cell, megakaryocyte, plasma cell, colon goblet cell, enterocyte of epithelium of large intestine, hematopoietic stem cell. - It is involved in a number of important developmental processes, including the formation of the body, the development of the nervous system, and the specification of the anterior/posterior axis. **Pathways and functions** - HOXC11 is a key regulator of embryonic digit morphogenesis. - It is required for the specification of the anterior/posterior axis in the developing embryo. - It is also involved in the formation of the urogenital ridge, which gives rise to the urinary bladder and reproductive organs. - HOXC11 is also involved in the development of the kidney, metanephros, and endoderm. **Clinical significance** - Mutations in HOXC11 have been linked to a number of human diseases, including Angelman syndrome and DiGeorge syndrome. - These disorders are caused by mutations in genes that are involved in the regulation of HOXC11. - Understanding the role of HOXC11 in development could lead to the development of new treatments for these diseases.

Genular Protein ID: 1501711734

Symbol: HXC11_HUMAN

Name: Homeobox protein Hox-C11

UniProtKB Accession Codes:

O43248 A8K7D1 Q96DH2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9582375

Title: The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription.

PubMed ID: 9582375

DOI: 10.1074/jbc.273.21.13297

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

Sequence Information:

  • Length: 304
  • Mass: 33748
  • Checksum: EB357DEBB3DE165F
  • Sequence:
    • MFNSVNLGNF CSPSRKERGA DFGERGSCAS NLYLPSCTYY MPEFSTVSSF LPQAPSRQIS 
YPYSAQVPPV REVSYGLEPS GKWHHRNSYS SCYAAADELM HRECLPPSTV TEILMKNEGS 
YGGHHHPSAP HATPAGFYSS VNKNSVLPQA FDRFFDNAYC GGGDPPAEPP CSGKGEAKGE 
PEAPPASGLA SRAEAGAEAE AEEENTNPSS SGSAHSVAKE PAKGAAPNAP RTRKKRCPYS 
KFQIRELERE FFFNVYINKE KRLQLSRMLN LTDRQVKIWF QNRRMKEKKL SRDRLQYFSG 
NPLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.