Details for: IHH

Gene ID: 3549

Symbol: IHH

Ensembl ID: ENSG00000163501

Description: Indian hedgehog signaling molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.54
    Marker Score: 3194
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.98
    Marker Score: 311
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5330
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.93
    Marker Score: 2188
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.87
    Marker Score: 2746
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 491
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1368
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8
    Marker Score: 793.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.76
    Marker Score: 725
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 681
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 470
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.62
    Marker Score: 2602
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.6
    Marker Score: 571
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.56
    Marker Score: 1333
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.56
    Marker Score: 429
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.54
    Marker Score: 200
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.53
    Marker Score: 308
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5
    Marker Score: 207
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.5
    Marker Score: 2389
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.46
    Marker Score: 100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.42
    Marker Score: 795
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.41
    Marker Score: 2624
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 6023
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.36
    Marker Score: 405
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.35
    Marker Score: 2336
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.34
    Marker Score: 178
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.32
    Marker Score: 726
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.32
    Marker Score: 115
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.32
    Marker Score: 506
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3
    Marker Score: 75.5
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.3
    Marker Score: 90
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.3
    Marker Score: 112
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.28
    Marker Score: 206.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.28
    Marker Score: 164
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.28
    Marker Score: 68
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.28
    Marker Score: 684
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.26
    Marker Score: 70
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 153
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.24
    Marker Score: 69
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.23
    Marker Score: 61
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.22
    Marker Score: 146
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.22
    Marker Score: 444
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.2
    Marker Score: 50
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.19
    Marker Score: 89
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.19
    Marker Score: 132
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.19
    Marker Score: 291
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.18
    Marker Score: 71
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.18
    Marker Score: 46
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.17
    Marker Score: 277
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.17
    Marker Score: 89
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.17
    Marker Score: 77
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.17
    Marker Score: 39
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.16
    Marker Score: 99
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.16
    Marker Score: 50
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.15
    Marker Score: 142
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.15
    Marker Score: 51
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.15
    Marker Score: 63
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.15
    Marker Score: 101
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 69
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.14
    Marker Score: 52
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.13
    Marker Score: 88
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.12
    Marker Score: 143
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.12
    Marker Score: 396
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.11
    Marker Score: 190
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.11
    Marker Score: 117
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1
    Marker Score: 171
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 84
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.09
    Marker Score: 172
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.08
    Marker Score: 81
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.08
    Marker Score: 126
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 72
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.07
    Marker Score: 87
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.07
    Marker Score: 89

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Other Information

**Key characteristics:** - IHH is a transmembrane protein that belongs to the Hedgehog (HH) family of growth factor receptors. - It is a key regulator of epithelial cell proliferation, survival, and differentiation. - IHH signaling is involved in various developmental processes, including gastrulation, tissue segmentation, and organogenesis. **Pathways and functions:** - IHH signaling is initiated by the binding of its ligand, Sonic hedgehog (Shh) to its receptor, Indian hedgehog (IHH). - This binding triggers the activation of the Smoo signaling pathway, which is a major regulator of epithelial cell behavior. - IHH also interacts with other growth factor receptors, such as the epidermal growth factor receptor (EGF), which can influence IHH signaling. - Through these interactions, IHH modulates the expression of various genes involved in epithelial cell differentiation, migration, and proliferation. **Clinical significance:** - Mutations in the IHH gene are associated with several human diseases, including lissencephaly, a neural tube defect that affects brain development. - IHH signaling pathways are also involved in cancer development and progression. - Targeting IHH signaling has emerged as a potential therapeutic strategy for cancer treatment. **Additional information:** - IHH is highly conserved across different species, including humans, mice, and zebrafish. - It is a key regulator of epithelial cell survival, proliferation, and differentiation. - IHH signaling is also involved in wound healing, tissue repair, and stem cell differentiation.

Genular Protein ID: 190415057

Symbol: IHH_HUMAN

Name: HHG-2

UniProtKB Accession Codes:

Q14623 B9EGM5 O43322 Q8N4B9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 17 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 60 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 8 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 9 RefSeq 1 Rhea 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7590746

Title: Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog.

PubMed ID: 7590746

DOI: 10.1006/geno.1995.1104

PubMed ID: 7720571

Title: Products, genetic linkage and limb patterning activity of a murine hedgehog gene.

PubMed ID: 7720571

DOI: 10.1242/dev.120.11.3339

PubMed ID: 9593755

Title: Identification of a palmitic acid-modified form of human Sonic hedgehog.

PubMed ID: 9593755

DOI: 10.1074/jbc.273.22.14037

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 20839884

Title: Human plasma very low density lipoprotein carries Indian hedgehog.

PubMed ID: 20839884

DOI: 10.1021/pr100403q

PubMed ID: 24342078

Title: A new role for Hedgehogs in juxtacrine signaling.

PubMed ID: 24342078

DOI: 10.1016/j.mod.2013.12.002

PubMed ID: 20519495

Title: All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.

PubMed ID: 20519495

DOI: 10.1074/jbc.m110.131680

PubMed ID: 21537345

Title: Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels.

PubMed ID: 21537345

DOI: 10.1038/cr.2011.76

PubMed ID: 11455389

Title: Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1.

PubMed ID: 11455389

DOI: 10.1038/ng577

PubMed ID: 12384778

Title: A novel mutation in the IHH gene causes brachydactyly type A1: a 95-year-old mystery resolved.

PubMed ID: 12384778

DOI: 10.1007/s00439-002-0815-2

PubMed ID: 12632327

Title: Homozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips.

PubMed ID: 12632327

DOI: 10.1086/374318

Sequence Information:

  • Length: 411
  • Mass: 45251
  • Checksum: 4DA90C83F5ABF758
  • Sequence:
    • MSPARLRPRL HFCLVLLLLL VVPAAWGCGP GRVVGSRRRP PRKLVPLAYK QFSPNVPEKT 
LGASGRYEGK IARSSERFKE LTPNYNPDII FKDEENTGAD RLMTQRCKDR LNSLAISVMN 
QWPGVKLRVT EGWDEDGHHS EESLHYEGRA VDITTSDRDR NKYGLLARLA VEAGFDWVYY 
ESKAHVHCSV KSEHSAAAKT GGCFPAGAQV RLESGARVAL SAVRPGDRVL AMGEDGSPTF 
SDVLIFLDRE PHRLRAFQVI ETQDPPRRLA LTPAHLLFTA DNHTEPAARF RATFASHVQP 
GQYVLVAGVP GLQPARVAAV STHVALGAYA PLTKHGTLVV EDVVASCFAA VADHHLAQLA 
FWPLRLFHSL AWGSWTPGEG VHWYPQLLYR LGRLLLEEGS FHPLGMSGAG S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.