Details for: IHH

Gene ID: 3549

Symbol: IHH

Ensembl ID: ENSG00000163501

Description: Indian hedgehog signaling molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.0783
    Cell Significance Index: 139.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.3785
    Cell Significance Index: 35.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9001
    Cell Significance Index: -5.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7729
    Cell Significance Index: 38.4100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.6858
    Cell Significance Index: 18.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6084
    Cell Significance Index: 261.5900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.3253
    Cell Significance Index: 33.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3217
    Cell Significance Index: 1193.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2127
    Cell Significance Index: 34.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1277
    Cell Significance Index: 67.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0810
    Cell Significance Index: 117.5800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.8508
    Cell Significance Index: 14.3100
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.7012
    Cell Significance Index: 6.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6125
    Cell Significance Index: 42.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5587
    Cell Significance Index: 11.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5124
    Cell Significance Index: 50.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5029
    Cell Significance Index: 95.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4296
    Cell Significance Index: 9.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4103
    Cell Significance Index: 13.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3377
    Cell Significance Index: 67.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3149
    Cell Significance Index: 4.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2560
    Cell Significance Index: 2.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1540
    Cell Significance Index: 3.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1390
    Cell Significance Index: 7.2200
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.1183
    Cell Significance Index: 0.8600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0915
    Cell Significance Index: 1.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0727
    Cell Significance Index: 2.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0303
    Cell Significance Index: 5.4600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0245
    Cell Significance Index: 1.0700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0071
    Cell Significance Index: 0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0014
    Cell Significance Index: 0.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0019
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0034
    Cell Significance Index: -2.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0044
    Cell Significance Index: -1.9900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0048
    Cell Significance Index: -0.0300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0053
    Cell Significance Index: -1.8900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0057
    Cell Significance Index: -0.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0058
    Cell Significance Index: -0.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0067
    Cell Significance Index: -4.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0084
    Cell Significance Index: -2.4100
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.0099
    Cell Significance Index: -0.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0100
    Cell Significance Index: -1.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0104
    Cell Significance Index: -0.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0114
    Cell Significance Index: -2.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0132
    Cell Significance Index: -2.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0133
    Cell Significance Index: -0.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0139
    Cell Significance Index: -0.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0159
    Cell Significance Index: -1.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0166
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0176
    Cell Significance Index: -3.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0180
    Cell Significance Index: -0.1900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0210
    Cell Significance Index: -0.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0268
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0279
    Cell Significance Index: -3.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0294
    Cell Significance Index: -4.2700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0342
    Cell Significance Index: -0.3700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0373
    Cell Significance Index: -0.4400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0387
    Cell Significance Index: -0.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0396
    Cell Significance Index: -0.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0440
    Cell Significance Index: -2.9600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0454
    Cell Significance Index: -0.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0464
    Cell Significance Index: -1.2200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0466
    Cell Significance Index: -0.5000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0496
    Cell Significance Index: -1.2400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0509
    Cell Significance Index: -0.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0523
    Cell Significance Index: -4.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0584
    Cell Significance Index: -1.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0617
    Cell Significance Index: -3.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0623
    Cell Significance Index: -3.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0678
    Cell Significance Index: -3.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0685
    Cell Significance Index: -3.5700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0693
    Cell Significance Index: -1.0100
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0718
    Cell Significance Index: -0.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0742
    Cell Significance Index: -2.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0743
    Cell Significance Index: -3.4700
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.0752
    Cell Significance Index: -0.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0821
    Cell Significance Index: -3.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0826
    Cell Significance Index: -3.8800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0830
    Cell Significance Index: -0.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0831
    Cell Significance Index: -5.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0852
    Cell Significance Index: -2.7900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0852
    Cell Significance Index: -0.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0855
    Cell Significance Index: -3.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0873
    Cell Significance Index: -2.7800
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0874
    Cell Significance Index: -0.5400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0882
    Cell Significance Index: -1.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0892
    Cell Significance Index: -2.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1034
    Cell Significance Index: -2.9500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1038
    Cell Significance Index: -1.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1114
    Cell Significance Index: -2.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1115
    Cell Significance Index: -1.6500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1152
    Cell Significance Index: -2.7900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1181
    Cell Significance Index: -3.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1186
    Cell Significance Index: -3.4000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1230
    Cell Significance Index: -3.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1287
    Cell Significance Index: -2.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1307
    Cell Significance Index: -2.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IHH is a secreted glycoprotein, consisting of 150 amino acids, with a molecular weight of approximately 23 kDa. It is highly conserved across species, with high sequence similarity to other Hedgehog proteins. IHH is produced by various cell types, including epithelial cells, neural cells, and mesenchymal cells, and is secreted into the extracellular matrix. It is highly glycosylated, with N- and O-glycans, which are essential for its stability and function. **Pathways and Functions** IHH signaling involves a complex interplay of molecules, including Patched, Smoothened, and Gli proteins. The signaling pathway can be divided into three main stages: 1. **Ligand binding**: IHH binds to Patched, a transmembrane receptor, which inhibits Smoothened, a G-protein coupled receptor. 2. **Smoothened activation**: Binding of IHH to Patched activates Smoothened, leading to the activation of the Gli transcription factors. 3. **Gli transcriptional activation**: Activated Gli proteins translocate to the nucleus, where they regulate gene expression by binding to specific DNA sequences. IHH signaling is involved in various developmental and pathological processes, including: * **Embryonic development**: IHH plays a crucial role in embryonic development, including gastrulation, neurulation, and organogenesis. * **Tissue patterning**: IHH signaling regulates tissue patterning, including the formation of limbs, digits, and organs. * **Cell fate specification**: IHH signaling determines cell fate, including the differentiation of neural cells, epithelial cells, and mesenchymal cells. * **Cancer**: IHH signaling is often dysregulated in cancer, contributing to tumorigenesis and metastasis. * **Bone development**: IHH signaling regulates bone development, including osteoblast differentiation and bone resorption. **Clinical Significance** Dysregulation of IHH signaling has been implicated in various diseases, including: * **Cancer**: IHH signaling is often overexpressed in cancer, including breast, lung, and colon cancer. * **Bone disorders**: IHH signaling dysregulation contributes to bone disorders, including osteoporosis and bone cancer. * **Neurological disorders**: IHH signaling is involved in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). * **Developmental disorders**: IHH signaling dysregulation contributes to developmental disorders, including achondroplasia and diastrophic dysplasia. In conclusion, IHH is a critical signaling molecule involved in various developmental and pathological processes. Its dysregulation contributes to various diseases, highlighting the need for further research into the molecular mechanisms underlying IHH signaling and its role in human disease.

Genular Protein ID: 190415057

Symbol: IHH_HUMAN

Name: HHG-2

UniProtKB Accession Codes:

Q14623 B9EGM5 O43322 Q8N4B9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 17 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 60 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 9 RefSeq 1 Rhea 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7590746

Title: Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog.

PubMed ID: 7590746

DOI: 10.1006/geno.1995.1104

PubMed ID: 7720571

Title: Products, genetic linkage and limb patterning activity of a murine hedgehog gene.

PubMed ID: 7720571

DOI: 10.1242/dev.120.11.3339

PubMed ID: 9593755

Title: Identification of a palmitic acid-modified form of human Sonic hedgehog.

PubMed ID: 9593755

DOI: 10.1074/jbc.273.22.14037

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 20839884

Title: Human plasma very low density lipoprotein carries Indian hedgehog.

PubMed ID: 20839884

DOI: 10.1021/pr100403q

PubMed ID: 24342078

Title: A new role for Hedgehogs in juxtacrine signaling.

PubMed ID: 24342078

DOI: 10.1016/j.mod.2013.12.002

PubMed ID: 20519495

Title: All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.

PubMed ID: 20519495

DOI: 10.1074/jbc.m110.131680

PubMed ID: 21537345

Title: Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels.

PubMed ID: 21537345

DOI: 10.1038/cr.2011.76

PubMed ID: 11455389

Title: Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1.

PubMed ID: 11455389

DOI: 10.1038/ng577

PubMed ID: 12384778

Title: A novel mutation in the IHH gene causes brachydactyly type A1: a 95-year-old mystery resolved.

PubMed ID: 12384778

DOI: 10.1007/s00439-002-0815-2

PubMed ID: 12632327

Title: Homozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips.

PubMed ID: 12632327

DOI: 10.1086/374318

Sequence Information:

  • Length: 411
  • Mass: 45251
  • Checksum: 4DA90C83F5ABF758
  • Sequence:
    • MSPARLRPRL HFCLVLLLLL VVPAAWGCGP GRVVGSRRRP PRKLVPLAYK QFSPNVPEKT 
LGASGRYEGK IARSSERFKE LTPNYNPDII FKDEENTGAD RLMTQRCKDR LNSLAISVMN 
QWPGVKLRVT EGWDEDGHHS EESLHYEGRA VDITTSDRDR NKYGLLARLA VEAGFDWVYY 
ESKAHVHCSV KSEHSAAAKT GGCFPAGAQV RLESGARVAL SAVRPGDRVL AMGEDGSPTF 
SDVLIFLDRE PHRLRAFQVI ETQDPPRRLA LTPAHLLFTA DNHTEPAARF RATFASHVQP 
GQYVLVAGVP GLQPARVAAV STHVALGAYA PLTKHGTLVV EDVVASCFAA VADHHLAQLA 
FWPLRLFHSL AWGSWTPGEG VHWYPQLLYR LGRLLLEEGS FHPLGMSGAG S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.