Gene ITGA6 - ENSG00000091409 | NCBI Gene ID: 3655

Details for: ITGA6

Gene ID: 3655

Symbol: ITGA6

Ensembl ID: ENSG00000091409

Description: integrin subunit alpha 6

Associated with

Assembly of collagen fibrils and other multimeric structures
(R-HSA-2022090)
Basigin interactions
(R-HSA-210991)
Cell-cell communication
(R-HSA-1500931)
Cell junction organization
(R-HSA-446728)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Collagen formation
(R-HSA-1474290)
Extracellular matrix organization
(R-HSA-1474244)
Hemostasis
(R-HSA-109582)
Integrin cell surface interactions
(R-HSA-216083)
Laminin interactions
(R-HSA-3000157)
Non-integrin membrane-ecm interactions
(R-HSA-3000171)
Syndecan interactions
(R-HSA-3000170)
Type i hemidesmosome assembly
(R-HSA-446107)
Adherens junction
(GO:0005912)
Cadherin binding
(GO:0045296)
Cell-cell adhesion
(GO:0098609)
Cell-matrix adhesion
(GO:0007160)
Cell-substrate adhesion
(GO:0031589)
Cell-substrate junction assembly
(GO:0007044)
Cell adhesion mediated by integrin
(GO:0033627)
Cell surface
(GO:0009986)
Cellular response to organic cyclic compound
(GO:0071407)
Ectodermal cell differentiation
(GO:0010668)
External side of plasma membrane
(GO:0009897)
Filopodium
(GO:0030175)
Focal adhesion
(GO:0005925)
Insulin-like growth factor i binding
(GO:0031994)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin alpha6-beta4 complex
(GO:0034676)
Integrin binding
(GO:0005178)
Integrin complex
(GO:0008305)
Laminin binding
(GO:0043236)
Leukocyte migration
(GO:0050900)
Metal ion binding
(GO:0046872)
Nail development
(GO:0035878)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Neuregulin binding
(GO:0038132)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell-substrate adhesion
(GO:0010811)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Skin morphogenesis
(GO:0043589)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 3.27
Marker Score: 1722
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.67
Marker Score: 23425
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.62
Marker Score: 2322
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.51
Marker Score: 4160
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.5
Marker Score: 1494
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.44
Marker Score: 1921
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.19
Marker Score: 3220
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.18
Marker Score: 4969
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.12
Marker Score: 5170.5
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.04
Marker Score: 5196
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.01
Marker Score: 42826
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.99
Marker Score: 6253
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.98
Marker Score: 4502
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.95
Marker Score: 3888
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.94
Marker Score: 1128
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.92
Marker Score: 650
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.92
Marker Score: 1575
Cell Name: enterocyte (CL0000584)
Fold Change: 1.76
Marker Score: 8426
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.74
Marker Score: 2526
Cell Name: basal cell (CL0000646)
Fold Change: 1.73
Marker Score: 2239
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.7
Marker Score: 1629
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.69
Marker Score: 1780
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.66
Marker Score: 6529
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.64
Marker Score: 6870.5
Cell Name: stem cell (CL0000034)
Fold Change: 1.63
Marker Score: 3878.5
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.62
Marker Score: 467
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.61
Marker Score: 509
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.6
Marker Score: 384
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.58
Marker Score: 336
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.57
Marker Score: 9998
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.56
Marker Score: 914
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.55
Marker Score: 1073
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.54
Marker Score: 382
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.53
Marker Score: 1439
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.52
Marker Score: 1727
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.5
Marker Score: 563
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.48
Marker Score: 3743
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.47
Marker Score: 10965
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.47
Marker Score: 1315
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167533
Cell Name: early promyelocyte (CL0002154)
Fold Change: 1.46
Marker Score: 1166
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.45
Marker Score: 5156
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 1.45
Marker Score: 771
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.42
Marker Score: 1529
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.41
Marker Score: 2978
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.41
Marker Score: 1271
Cell Name: paneth cell (CL0000510)
Fold Change: 1.35
Marker Score: 941
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.35
Marker Score: 1342
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.35
Marker Score: 3169
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.34
Marker Score: 7953.5
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.34
Marker Score: 625
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.33
Marker Score: 3573
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.3
Marker Score: 1633
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.3
Marker Score: 6373
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.27
Marker Score: 838
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.27
Marker Score: 634
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.27
Marker Score: 1401
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.24
Marker Score: 2523
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.23
Marker Score: 945
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.22
Marker Score: 2321
Cell Name: male germ cell (CL0000015)
Fold Change: 1.2
Marker Score: 346
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.2
Marker Score: 1268
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.19
Marker Score: 695
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.17
Marker Score: 1006
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.16
Marker Score: 1005
Cell Name: serous secreting cell (CL0000313)
Fold Change: 1.16
Marker Score: 463
Cell Name: astrocyte (CL0000127)
Fold Change: 1.14
Marker Score: 992
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 1.14
Marker Score: 265
Cell Name: peptic cell (CL0000155)
Fold Change: 1.1
Marker Score: 462
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.1
Marker Score: 344
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 1.1
Marker Score: 834.5
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.1
Marker Score: 473
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.09
Marker Score: 17110
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.07
Marker Score: 215
Cell Name: lung secretory cell (CL1000272)
Fold Change: 1.06
Marker Score: 949
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.06
Marker Score: 3910
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.05
Marker Score: 10615.5
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.04
Marker Score: 305
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251703
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.02
Marker Score: 395
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1
Marker Score: 374
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 1
Marker Score: 614
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71725
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47948
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.98
Marker Score: 1608.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30395
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.97
Marker Score: 404
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.97
Marker Score: 1392
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.97
Marker Score: 33442
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.96
Marker Score: 275
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.95
Marker Score: 493
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 490
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2405
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 447
Cell Name: kidney cell (CL1000497)
Fold Change: 0.94
Marker Score: 625
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.93
Marker Score: 583
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.93
Marker Score: 218
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.93
Marker Score: 1504
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5271
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.92
Marker Score: 955

Hover over a box to see details here...

**Key characteristics:** * ITGA6 is a transmembrane protein with a single extracellular domain that is responsible for binding to various extracellular matrix proteins. * It is a key component of the integrin signaling pathway, which is involved in cell adhesion, migration, and signaling. * ITGA6 is a highly conserved protein, with similar sequences found in mammals, birds, and fish. **Pathways and functions:** * ITGA6 is involved in cell-cell adhesion by binding to extracellular matrix proteins such as collagen, fibronectin, and laminin. * It is also involved in cell migration by binding to extracellular matrix proteins and signaling through the integrin signaling pathway. * ITGA6 is also involved in cell signaling, where it can interact with various intracellular proteins. **Clinical significance:** * Mutations in ITGA6 have been linked to several human diseases, including pulmonary hypertension, aortic dissections, and cancer. * ITGA6 is a promising target for cancer immunotherapy, as it is often overexpressed on cancer cells. * Inhibition of ITGA6 signaling has been shown to inhibit tumor growth and metastasis. **Additional points:** * ITGA6 is a highly important protein in cell adhesion and signaling. * It is involved in the formation of new blood vessels, the maintenance of tissue integrity, and the regulation of inflammation. * ITGA6 is a promising target for cancer immunotherapy due to its role in tumor cell adhesion and migration.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Integrin alpha-6

Genular Protein ID: 1788695242

Symbol: ITA6_HUMAN

Name: Integrin alpha-6

UniProtKB Accession Codes:

P23229 B2RMU9 B4DG69 B4DKB8 C4AM96 G5E9H1 Q08443 Q0MRC7 Q14646 Q16508 Q53RX7 Q59HB7 Q86VL6 Q9UCT1 Q9UN03

Database IDs:

Citations:

PubMed ID: 1976638

Title: Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4.

PubMed ID: 1976638

DOI: 10.1083/jcb.111.4.1593

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2070796

Title: Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes.

PubMed ID: 2070796

DOI: 10.1111/j.1432-1033.1991.tb16140.x

PubMed ID: 1946438

Title: Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains.

PubMed ID: 1946438

DOI: 10.1073/pnas.88.22.10183

PubMed ID: 1476731

Title: An efficient and reliable method for cloning PCR-amplification products: a survey of point mutations in integrin cDNA.

PubMed ID: 1476731

PubMed ID: 8496190

Title: Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line.

PubMed ID: 8496190

DOI: 10.1016/s0021-9258(18)82138-x

PubMed ID: 8253814

Title: Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development.

PubMed ID: 8253814

DOI: 10.1016/s0021-9258(19)74380-4

PubMed ID: 7583007

Title: An alternatively spliced exon in the extracellular domain of the human alpha 6 integrin subunit -- functional analysis of the alpha 6 integrin variants.

PubMed ID: 7583007

DOI: 10.3109/15419069509081283

PubMed ID: 2649503

Title: Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines.

PubMed ID: 2649503

DOI: 10.1016/s0021-9258(18)83380-4

PubMed ID: 2542022

Title: A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.

PubMed ID: 2542022

DOI: 10.1002/j.1460-2075.1989.tb03425.x

PubMed ID: 1953640

Title: Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing.

PubMed ID: 1953640

DOI: 10.1042/bj2790419

PubMed ID: 8360143

Title: The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor.

PubMed ID: 8360143

DOI: 10.1016/s0021-9258(17)46641-5

PubMed ID: 7681434

Title: Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit.

PubMed ID: 7681434

DOI: 10.1083/jcb.121.1.179

PubMed ID: 9185503

Title: A homozygous mutation in the integrin alpha6 gene in junctional epidermolysis bullosa with pyloric atresia.

PubMed ID: 9185503

DOI: 10.1172/jci119474

PubMed ID: 11359780

Title: Identification of a novel structural variant of the alpha 6 integrin.

PubMed ID: 11359780

DOI: 10.1074/jbc.m102811200

PubMed ID: 15023541

Title: Extracellular alpha 6 integrin cleavage by urokinase-type plasminogen activator in human prostate cancer.

PubMed ID: 15023541

DOI: 10.1016/j.yexcr.2003.11.023

PubMed ID: 15611341

Title: Palmitoylation supports assembly and function of integrin-tetraspanin complexes.

PubMed ID: 15611341

DOI: 10.1083/jcb.200404100

PubMed ID: 15466886

Title: alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.

PubMed ID: 15466886

DOI: 10.1242/jcs.01423

PubMed ID: 16754960

Title: Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.

PubMed ID: 16754960

DOI: 10.1083/jcb.200509019

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 17303120

Title: Integrin alpha6 cleavage: a novel modification to modulate cell migration.

PubMed ID: 17303120

DOI: 10.1016/j.yexcr.2007.01.006

PubMed ID: 20682778

Title: Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.

PubMed ID: 20682778

DOI: 10.1074/jbc.m110.113878

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22314500

Title: Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6beta4.

PubMed ID: 22314500

DOI: 10.1007/s00018-012-0924-6

PubMed ID: 22351760

Title: Cross-talk between integrin alpha6beta4 and insulin-like growth factor-1 receptor (IGF1R) through direct alpha6beta4 binding to IGF1 and subsequent alpha6beta4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions.

PubMed ID: 22351760

DOI: 10.1074/jbc.m111.304170

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27607025

Title: Compound heterozygosity for novel splice site mutations of ITGA6 in lethal junctional epidermolysis bullosa with pyloric atresia.

PubMed ID: 27607025

DOI: 10.1111/1346-8138.13575

PubMed ID: 28873464

Title: Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.

PubMed ID: 28873464

DOI: 10.1371/journal.pone.0184285

Sequence Information:

Length: 1130
Mass: 126606
Checksum: B53712888B7FE3B6
Sequence:

MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM HWQLQPEDKR 
LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD NDADPTSESK EDQWMGVTVQ 
SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR 
GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG 
GETEHDESLV PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG LASSFGYDVA 
VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW NNVKPIRLNG TKDSMFGIAV 
KNIGDINQDG YPDIAVGAPY DDLGKVFIYH GSANGINTKP TQVLKGISPY FGYSIAGNMD 
LDRNSYPDVA VGSLSDSVTI FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS 
CFEYTANPAG YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE PKTAHIDVHF 
LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV PELVLKDQKD IALEITVTNS 
PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS AYRELRAFPE KQLSCVANQN GSQADCELGN 
PFKRNSNVTF YLVLSTTEVT FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG 
VAKPSQVYFG GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 
GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD NRKFSLFAER 
KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF LEEYSKLNYL DILMRAFIDV 
TAAAENIRLP NAGTQVRVTV FPSKTVAQYS GVPWWIILVA ILAGILMLAL LVFILWKCGF 
FKRSRYDDSV PRYHAVRIRK EEREIKDEKY IDNLEKKQWI TKWNENESYS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ITGA6

Associated with

Cells (max top 100)

Other Information

Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4. PubMed ID: 1976638

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes. PubMed ID: 2070796

Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains. PubMed ID: 1946438

An efficient and reliable method for cloning PCR-amplification products: a survey of point mutations in integrin cDNA. PubMed ID: 1476731

Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line. PubMed ID: 8496190

Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development. PubMed ID: 8253814

An alternatively spliced exon in the extracellular domain of the human alpha 6 integrin subunit -- functional analysis of the alpha 6 integrin variants. PubMed ID: 7583007

Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines. PubMed ID: 2649503

A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors. PubMed ID: 2542022

Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing. PubMed ID: 1953640

The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor. PubMed ID: 8360143

Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit. PubMed ID: 7681434

A homozygous mutation in the integrin alpha6 gene in junctional epidermolysis bullosa with pyloric atresia. PubMed ID: 9185503

Identification of a novel structural variant of the alpha 6 integrin. PubMed ID: 11359780

Extracellular alpha 6 integrin cleavage by urokinase-type plasminogen activator in human prostate cancer. PubMed ID: 15023541

Palmitoylation supports assembly and function of integrin-tetraspanin complexes. PubMed ID: 15611341

alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor. PubMed ID: 15466886

Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. PubMed ID: 16754960

Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. PubMed ID: 16263699

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Integrin alpha6 cleavage: a novel modification to modulate cell migration. PubMed ID: 17303120

Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling. PubMed ID: 20682778

Initial characterization of the human central proteome. PubMed ID: 21269460

Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6beta4. PubMed ID: 22314500

Cross-talk between integrin alpha6beta4 and insulin-like growth factor-1 receptor (IGF1R) through direct alpha6beta4 binding to IGF1 and subsequent alpha6beta4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions. PubMed ID: 22351760

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Compound heterozygosity for novel splice site mutations of ITGA6 in lethal junctional epidermolysis bullosa with pyloric atresia. PubMed ID: 27607025

Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling. PubMed ID: 28873464