Details for: ITGA6
Gene ID: 3655
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ITGA6
Ensembl ID: ENSG00000091409
Description: integrin subunit alpha 6
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 32.89rCSI 40.91%PRS 44.88
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CSI 30.15rCSI 46.05%PRS 42.79
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CSI 29.93rCSI 31.36%PRS 39.72
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CSI 27.33rCSI 59.87%PRS 52.11
-
CSI 26.62rCSI 46.04%PRS 33.57
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CSI 24.46rCSI 39.07%PRS 45.82
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CSI 23.96rCSI 23.1%PRS 33.43
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CSI 22.22rCSI 59.9%PRS 51.04
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CSI 21rCSI 58.86%PRS 56.64
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CSI 20.44rCSI 40.59%PRS 41.88
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CSI 18rCSI 28.72%PRS 36.59
-
CSI 16.72rCSI 25.58%PRS 58.51
-
CSI 16.62rCSI 13.43%PRS 53.26
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CSI 16.11rCSI 21.54%PRS 50.52
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CSI 14.99rCSI 60.47%PRS 40.96
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CSI 14.18rCSI 22.97%PRS 40.88
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CSI 13.95rCSI 33.15%PRS 54.55
-
CSI 13.57rCSI 20.97%PRS 40.23
-
CSI 13.03rCSI 57.18%PRS 61.68
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CSI 12.74rCSI 17.7%PRS 41.83
-
CSI 12.01rCSI 22.02%PRS 66.09
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CSI 11.82rCSI 9.8%PRS 40.73
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CSI 11.22rCSI 58.93%PRS 56.99
-
CSI 10.68rCSI 32.91%PRS 54.29
-
CSI 9.49rCSI 7.95%PRS 47.32
-
CSI 8.98rCSI 6.75%PRS 45.45
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CSI 8.76rCSI 19.29%PRS 56.58
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CSI 8.52rCSI 10.92%PRS 46.84
-
CSI 8.32rCSI 5.78%PRS 50.44
-
CSI 7.88rCSI 59.19%PRS 62.39
-
CSI 7.83rCSI 7.98%PRS 55.04
-
CSI 7.77rCSI 22.49%PRS 60.29
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CSI 7.38rCSI 46.12%PRS 35.3
-
CSI 7.17rCSI 49.22%PRS 60.85
-
CSI 6.93rCSI 39.75%PRS 69.21
-
CSI 6.83rCSI 4.79%PRS 65.13
-
CSI 6.8rCSI 4.88%PRS 54.74
-
CSI 6.79rCSI 6.41%PRS 43.28
-
CSI 6.51rCSI 10.49%PRS 51.11
-
CSI 6.44rCSI 15.73%PRS 38.68
-
CSI 6.18rCSI 6.45%PRS 42.86
-
CSI 6.09rCSI 15.41%PRS 50.39
-
CSI 6.08rCSI 17.4%PRS 59.38
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CSI 6.05rCSI 53.69%PRS 72.22
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CSI 5.96rCSI 11.37%PRS 59.04
-
CSI 5.79rCSI 5.57%PRS 42.81
-
CSI 5.33rCSI 6.56%PRS 66.78
-
CSI 5.32rCSI 4.72%PRS 41.43
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CSI 5.24rCSI 6.16%PRS 45.88
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CSI 5.2rCSI 13.56%PRS 41.37
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CSI 5.18rCSI 8.24%PRS 35.97
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CSI 5.16rCSI 24.73%PRS 44.04
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CSI 5.15rCSI 10.69%PRS 40.4
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CSI 5.03rCSI 15.71%PRS 28.8
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CSI 5.01rCSI 11.75%PRS 51.5
-
CSI 4.92rCSI 7.21%PRS 74.82
-
CSI 4.89rCSI 35.77%PRS 68.69
-
CSI 4.84rCSI 4.26%PRS 32.15
-
CSI 4.74rCSI 5.55%PRS 57.45
-
CSI 4.69rCSI 3.7%PRS 30.81
-
CSI 4.66rCSI 7.16%PRS 44.75
-
CSI 4.66rCSI 11.53%PRS 40.44
-
CSI 4.64rCSI 4.97%PRS 40.21
-
CSI 4.63rCSI 25.7%PRS 66.53
-
CSI 4.63rCSI 8.28%PRS 40.77
-
CSI 4.62rCSI 4.78%PRS 47.93
-
CSI 4.62rCSI 6.28%PRS 54.99
-
CSI 4.53rCSI 4.64%PRS 60.78
-
CSI 4.44rCSI 24.26%PRS 46.23
-
CSI 4.33rCSI 8.18%PRS 65.71
-
CSI 4.2rCSI 9.79%PRS 60.45
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CSI 4.16rCSI 11.11%PRS 35.77
-
CSI 4.1rCSI 6.5%PRS 52.33
-
CSI 3.96rCSI 5.71%PRS 55.83
-
CSI 3.92rCSI 4.77%PRS 49.77
-
CSI 3.86rCSI 2.28%PRS 56.74
-
CSI 3.77rCSI 5.56%PRS 59.4
-
CSI 3.7rCSI 3.94%PRS 57.3
-
CSI 3.61rCSI 4.93%PRS 44.79
-
CSI 3.6rCSI 4.81%PRS 43.85
-
CSI 3.57rCSI 12.69%PRS 55.28
-
CSI 3.57rCSI 2.41%PRS 52.06
-
CSI 3.44rCSI 4.42%PRS 38.4
-
CSI 3.43rCSI 5.76%PRS 27.66
-
CSI 3.39rCSI 9.65%PRS 42.44
-
CSI 3.38rCSI 2.35%PRS 54.86
-
CSI 3.31rCSI 23.41%PRS 37.44
-
CSI 3.31rCSI 12.6%PRS 36.43
-
CSI 3.21rCSI 5.17%PRS 33.64
-
CSI 3.2rCSI 7.17%PRS 28.35
-
CSI 3.15rCSI 5.53%PRS 35.13
-
CSI 3.14rCSI 6.92%PRS 46.02
-
CSI 3.03rCSI 4.96%PRS 33.59
-
CSI 3rCSI 8.17%PRS 71.66
-
CSI 2.99rCSI 4.31%PRS 52.16
-
CSI 2.87rCSI 5.07%PRS 26.74
-
CSI 2.8rCSI 19.99%PRS 48.23
-
CSI 2.79rCSI 8.94%PRS 39.46
-
CSI 2.76rCSI 7.61%PRS 39.29
-
CSI 2.74rCSI 3.28%PRS 61.29
-
CSI 0.3rCSI 2.5%PRS 67.8%
-
CSI 0.4rCSI 3.6%PRS 69.5%
-
CSI 0.5rCSI 11.3%PRS 69.5%
-
CSI 0.6rCSI 2.7%PRS 53.7%
-
CSI 0.6rCSI 2.6%PRS 65.2%
-
CSI 0.6rCSI 2.6%PRS 58.8%
-
CSI 0.7rCSI 3.1%PRS 68.0%
-
CSI 0.7rCSI 3.1%PRS 58.2%
-
CSI 0.7rCSI 0.6%PRS 54.1%
-
CSI 0.8rCSI 2.7%PRS 50.1%
-
CSI 0.9rCSI 6.2%PRS 66.9%
-
CSI 1.0rCSI 10.1%PRS 44.1%
-
CSI 1.0rCSI 8.7%PRS 81.0%
-
CSI 1.0rCSI 5.5%PRS 64.8%
-
CSI 1.0rCSI 3.7%PRS 26.6%
-
CSI 1.1rCSI 5.8%PRS 57.7%
-
CSI 1.1rCSI 2.9%PRS 45.3%
-
CSI 1.1rCSI 2.5%PRS 61.9%
-
CSI 1.2rCSI 1.7%PRS 49.5%
-
CSI 1.2rCSI 1.8%PRS 42.0%
-
CSI 1.3rCSI 5.8%PRS 40.9%
-
CSI 1.3rCSI 3.3%PRS 33.5%
-
CSI 1.3rCSI 2.7%PRS 49.0%
-
CSI 1.4rCSI 3.3%PRS 44.7%
-
CSI 1.4rCSI 3.0%PRS 57.2%
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CSI 1.5rCSI 5.8%PRS 28.6%
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CSI 1.6rCSI 3.1%PRS 68.2%
-
CSI 1.6rCSI 2.4%PRS 53.1%
-
CSI 1.6rCSI 7.4%PRS 70.5%
-
CSI 1.7rCSI 3.3%PRS 44.1%
-
CSI 1.7rCSI 3.1%PRS 58.3%
-
CSI 1.7rCSI 2.3%PRS 46.7%
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CSI 1.8rCSI 4.7%PRS 38.7%
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CSI 1.9rCSI 5.2%PRS 43.2%
-
CSI 1.9rCSI 11.4%PRS 29.0%
-
CSI 2.0rCSI 6.9%PRS 57.9%
-
CSI 2.0rCSI 2.9%PRS 45.0%
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CSI 2.0rCSI 51.4%PRS 68.7%
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CSI 2.1rCSI 40.3%PRS 68.0%
-
CSI 2.1rCSI 2.7%PRS 38.4%
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CSI 2.1rCSI 3.3%PRS 46.8%
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CSI 2.2rCSI 3.8%PRS 57.8%
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CSI 2.2rCSI 2.3%PRS 41.8%
-
CSI 2.3rCSI 2.7%PRS 52.9%
-
CSI 2.4rCSI 4.5%PRS 62.2%
-
CSI 2.4rCSI 6.2%PRS 47.6%
-
CSI 2.4rCSI 3.3%PRS 39.1%
-
CSI 2.5rCSI 3.5%PRS 39.5%
-
CSI 2.5rCSI 3.5%PRS 47.5%
-
CSI 2.6rCSI 6.9%PRS 64.8%
-
CSI 2.6rCSI 6.1%PRS 68.1%
-
CSI 2.7rCSI 41.2%PRS 68.2%
-
CSI 2.7rCSI 2.2%PRS 42.7%
-
CSI 2.7rCSI 3.3%PRS 61.3%
-
CSI 2.8rCSI 7.6%PRS 39.3%
-
CSI 2.8rCSI 8.9%PRS 39.5%
-
CSI 2.8rCSI 20.0%PRS 48.2%
-
CSI 2.9rCSI 5.1%PRS 26.7%
-
CSI 3.0rCSI 4.3%PRS 52.2%
-
CSI 3.0rCSI 8.2%PRS 71.7%
-
CSI 3.0rCSI 5.0%PRS 33.6%
-
CSI 3.1rCSI 6.9%PRS 46.0%
-
CSI 3.2rCSI 5.5%PRS 35.1%
-
CSI 3.2rCSI 7.2%PRS 28.4%
-
CSI 3.2rCSI 5.2%PRS 33.6%
-
CSI 3.3rCSI 12.6%PRS 36.4%
-
CSI 3.3rCSI 23.4%PRS 37.4%
-
CSI 3.4rCSI 2.4%PRS 54.9%
-
CSI 3.4rCSI 9.7%PRS 42.4%
-
CSI 3.4rCSI 5.8%PRS 27.7%
-
CSI 3.4rCSI 4.4%PRS 38.4%
-
CSI 3.6rCSI 2.4%PRS 52.1%
-
CSI 3.6rCSI 12.7%PRS 55.3%
-
CSI 3.6rCSI 4.8%PRS 43.9%
-
CSI 3.6rCSI 4.9%PRS 44.8%
-
CSI 3.7rCSI 3.9%PRS 57.3%
-
CSI 3.8rCSI 5.6%PRS 59.4%
-
CSI 3.9rCSI 2.3%PRS 56.7%
-
CSI 3.9rCSI 4.8%PRS 49.8%
-
CSI 4.0rCSI 5.7%PRS 55.8%
-
CSI 4.1rCSI 6.5%PRS 52.3%
-
CSI 4.2rCSI 11.1%PRS 35.8%
-
CSI 4.2rCSI 9.8%PRS 60.5%
-
CSI 4.3rCSI 8.2%PRS 65.7%
-
CSI 4.4rCSI 24.3%PRS 46.2%
-
CSI 4.5rCSI 4.6%PRS 60.8%
-
CSI 4.6rCSI 6.3%PRS 55.0%
-
CSI 4.6rCSI 4.8%PRS 47.9%
-
CSI 4.6rCSI 8.3%PRS 40.8%
-
CSI 4.6rCSI 25.7%PRS 66.5%
-
CSI 4.6rCSI 5.0%PRS 40.2%
-
CSI 4.7rCSI 11.5%PRS 40.4%
-
CSI 4.7rCSI 7.2%PRS 44.8%
-
CSI 4.7rCSI 3.7%PRS 30.8%
-
CSI 4.7rCSI 5.6%PRS 57.5%
-
CSI 4.8rCSI 4.3%PRS 32.2%
-
CSI 4.9rCSI 35.8%PRS 68.7%
-
CSI 4.9rCSI 7.2%PRS 74.8%
-
CSI 5.0rCSI 11.8%PRS 51.5%
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CSI 5.0rCSI 15.7%PRS 28.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1788695242
Symbol: ITA6_HUMAN
Name: Integrin alpha-6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1976638
Title: Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4.
PubMed ID: 1976638
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2070796
Title: Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes.
PubMed ID: 2070796
PubMed ID: 1946438
Title: Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains.
PubMed ID: 1946438
PubMed ID: 1476731
Title: An efficient and reliable method for cloning PCR-amplification products: a survey of point mutations in integrin cDNA.
PubMed ID: 1476731
PubMed ID: 8496190
Title: Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line.
PubMed ID: 8496190
PubMed ID: 8253814
Title: Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development.
PubMed ID: 8253814
PubMed ID: 7583007
Title: An alternatively spliced exon in the extracellular domain of the human alpha 6 integrin subunit -- functional analysis of the alpha 6 integrin variants.
PubMed ID: 7583007
PubMed ID: 2649503
Title: Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines.
PubMed ID: 2649503
PubMed ID: 2542022
Title: A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.
PubMed ID: 2542022
PubMed ID: 1953640
Title: Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing.
PubMed ID: 1953640
DOI: 10.1042/bj2790419
PubMed ID: 8360143
Title: The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor.
PubMed ID: 8360143
PubMed ID: 7681434
Title: Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit.
PubMed ID: 7681434
PubMed ID: 9185503
Title: A homozygous mutation in the integrin alpha6 gene in junctional epidermolysis bullosa with pyloric atresia.
PubMed ID: 9185503
DOI: 10.1172/jci119474
PubMed ID: 11359780
Title: Identification of a novel structural variant of the alpha 6 integrin.
PubMed ID: 11359780
PubMed ID: 15023541
Title: Extracellular alpha 6 integrin cleavage by urokinase-type plasminogen activator in human prostate cancer.
PubMed ID: 15023541
PubMed ID: 15611341
Title: Palmitoylation supports assembly and function of integrin-tetraspanin complexes.
PubMed ID: 15611341
PubMed ID: 15466886
Title: alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.
PubMed ID: 15466886
DOI: 10.1242/jcs.01423
PubMed ID: 15557282
Title: Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion.
PubMed ID: 15557282
PubMed ID: 16754960
Title: Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.
PubMed ID: 16754960
PubMed ID: 16263699
Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.
PubMed ID: 16263699
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 17303120
Title: Integrin alpha6 cleavage: a novel modification to modulate cell migration.
PubMed ID: 17303120
PubMed ID: 20682778
Title: Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.
PubMed ID: 20682778
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22314500
Title: Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6beta4.
PubMed ID: 22314500
PubMed ID: 22351760
Title: Cross-talk between integrin alpha6beta4 and insulin-like growth factor-1 receptor (IGF1R) through direct alpha6beta4 binding to IGF1 and subsequent alpha6beta4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions.
PubMed ID: 22351760
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27607025
Title: Compound heterozygosity for novel splice site mutations of ITGA6 in lethal junctional epidermolysis bullosa with pyloric atresia.
PubMed ID: 27607025
PubMed ID: 28873464
Title: Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.
PubMed ID: 28873464
Sequence Information:
- Length: 1130
- Mass: 126606
- Checksum: B53712888B7FE3B6
- Sequence:
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD NRKFSLFAER KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF LEEYSKLNYL DILMRAFIDV TAAAENIRLP NAGTQVRVTV FPSKTVAQYS GVPWWIILVA ILAGILMLAL LVFILWKCGF FKRSRYDDSV PRYHAVRIRK EEREIKDEKY IDNLEKKQWI TKWNENESYS