Details for: IVL

Gene ID: 3713

Symbol: IVL

Ensembl ID: ENSG00000163207

Description: involucrin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 10.0956
    Cell Significance Index: 163.5100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.4048
    Cell Significance Index: 75.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.3348
    Cell Significance Index: 225.1800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 3.6315
    Cell Significance Index: 49.8000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.7783
    Cell Significance Index: 35.9500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.3030
    Cell Significance Index: 19.7900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.8728
    Cell Significance Index: 21.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1207
    Cell Significance Index: 10.3200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2754
    Cell Significance Index: 3.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2436
    Cell Significance Index: 6.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2111
    Cell Significance Index: 2.8800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1311
    Cell Significance Index: 0.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0724
    Cell Significance Index: 13.0600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0522
    Cell Significance Index: 0.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0375
    Cell Significance Index: 4.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0231
    Cell Significance Index: 10.2200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0048
    Cell Significance Index: 0.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0046
    Cell Significance Index: -3.4800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0096
    Cell Significance Index: -4.3400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0184
    Cell Significance Index: -0.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0214
    Cell Significance Index: -4.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0258
    Cell Significance Index: -2.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0275
    Cell Significance Index: -3.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0356
    Cell Significance Index: -4.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0365
    Cell Significance Index: -1.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0475
    Cell Significance Index: -0.6900
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.0502
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0515
    Cell Significance Index: -8.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0557
    Cell Significance Index: -1.6400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0635
    Cell Significance Index: -0.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0706
    Cell Significance Index: -3.2900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0843
    Cell Significance Index: -1.0300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0856
    Cell Significance Index: -2.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0879
    Cell Significance Index: -4.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0918
    Cell Significance Index: -6.4900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0942
    Cell Significance Index: -1.5200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0979
    Cell Significance Index: -1.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1143
    Cell Significance Index: -3.1100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1379
    Cell Significance Index: -1.8000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1428
    Cell Significance Index: -3.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1465
    Cell Significance Index: -4.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1599
    Cell Significance Index: -4.2700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1620
    Cell Significance Index: -2.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1653
    Cell Significance Index: -3.6200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1715
    Cell Significance Index: -3.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1869
    Cell Significance Index: -2.7600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1874
    Cell Significance Index: -2.2300
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.1918
    Cell Significance Index: -1.4600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1931
    Cell Significance Index: -1.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1942
    Cell Significance Index: -3.2500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1951
    Cell Significance Index: -2.5200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1990
    Cell Significance Index: -3.8900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2099
    Cell Significance Index: -2.8300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2191
    Cell Significance Index: -2.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2283
    Cell Significance Index: -3.2700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2302
    Cell Significance Index: -3.0300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2312
    Cell Significance Index: -2.6600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2428
    Cell Significance Index: -3.1700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2443
    Cell Significance Index: -2.8500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2525
    Cell Significance Index: -3.8400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2553
    Cell Significance Index: -4.0500
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: -0.2558
    Cell Significance Index: -2.0900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2583
    Cell Significance Index: -3.3900
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2619
    Cell Significance Index: -2.7600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2620
    Cell Significance Index: -3.0800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2653
    Cell Significance Index: -0.6000
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.2655
    Cell Significance Index: -2.8100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2669
    Cell Significance Index: -1.7400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2690
    Cell Significance Index: -3.2700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2696
    Cell Significance Index: -3.2800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2703
    Cell Significance Index: -3.1400
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.2708
    Cell Significance Index: -2.8500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2721
    Cell Significance Index: -2.9500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2725
    Cell Significance Index: -3.0300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2732
    Cell Significance Index: -3.6300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2751
    Cell Significance Index: -3.2700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2752
    Cell Significance Index: -2.0000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2774
    Cell Significance Index: -3.4700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2782
    Cell Significance Index: -3.1600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2802
    Cell Significance Index: -2.8900
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.2823
    Cell Significance Index: -2.6800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2824
    Cell Significance Index: -2.8800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2826
    Cell Significance Index: -3.5500
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.2836
    Cell Significance Index: -3.0300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2843
    Cell Significance Index: -2.7500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2846
    Cell Significance Index: -4.3300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.2885
    Cell Significance Index: -3.2300
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.2887
    Cell Significance Index: -3.4900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2891
    Cell Significance Index: -3.1500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2909
    Cell Significance Index: -5.0200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2914
    Cell Significance Index: -3.3800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2933
    Cell Significance Index: -3.2200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.2949
    Cell Significance Index: -3.2700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2957
    Cell Significance Index: -4.3100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2963
    Cell Significance Index: -4.1100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2979
    Cell Significance Index: -3.5200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3005
    Cell Significance Index: -3.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3009
    Cell Significance Index: -3.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** The IVL gene is predominantly expressed in stratified epithelial cells, where it is essential for keratinization and the formation of the cornified envelope. 2. **Protein Function:** The involucrin protein is a key component of the cornified envelope and exhibits unique properties, including isopeptide cross-linking, which maintains the structural integrity of the skin. 3. **Cellular Distribution:** The IVL gene is expressed in various cell types, including neurons, erythrocytes, oligodendrocyte precursor cells, megakaryocytes, and hematopoietic stem cells. 4. **Pathway Involvement:** The IVL gene is involved in several cellular pathways, including keratinization, centrosome formation, and response to UV-B radiation. **Pathways and Functions:** 1. **Keratinization:** The IVL gene plays a crucial role in the process of keratinization, where it is involved in the formation of the cornified envelope and the regulation of keratinocyte differentiation. 2. **Cornified Envelope Formation:** The involucrin protein is essential for the formation of the cornified envelope, a specialized protein structure that provides mechanical strength and rigidity to the skin. 3. **Isopeptide Cross-linking:** The IVL gene is involved in isopeptide cross-linking, a process critical for maintaining the structural integrity of the skin. 4. **Centrosome Formation:** The IVL gene is involved in centrosome formation, a process essential for maintaining cellular structure and organization. 5. **Response to UV-B Radiation:** The IVL gene is involved in the response to UV-B radiation, where it helps to regulate cellular responses to DNA damage. **Clinical Significance:** Dysregulation of the IVL gene has been implicated in various skin disorders, including epidermolysis bullosa simplex, a genetic disorder characterized by blistering and skin fragility. Additionally, alterations in the IVL gene have been associated with other conditions, including psoriasis and atopic dermatitis. The understanding of the IVL gene's role in keratinization and cellular differentiation has significant implications for the development of novel therapeutic strategies for skin disorders. In conclusion, the involucrin gene, IVL, is a critical regulator of keratinization and cellular differentiation, with implications for skin biology and beyond. Further research is necessary to fully elucidate the functions and clinical significance of this gene, but the current understanding highlights its importance in maintaining skin integrity and responding to environmental stressors.

Genular Protein ID: 2861302180

Symbol: INVO_HUMAN

Name: Involucrin

UniProtKB Accession Codes:

P07476 Q5T7P4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2873896

Title: Structure and evolution of the human involucrin gene.

PubMed ID: 2873896

DOI: 10.1016/0092-8674(86)90884-6

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9115270

Title: S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes.

PubMed ID: 9115270

DOI: 10.1074/jbc.272.18.12035

PubMed ID: 1601889

Title: Biophysical characterization of involucrin reveals a molecule ideally suited to function as an intermolecular cross-bridge of the keratinocyte cornified envelope.

PubMed ID: 1601889

DOI: 10.1016/s0021-9258(19)49829-3

PubMed ID: 2461365

Title: The glutamine residues reactive in transglutaminase-catalyzed cross-linking of involucrin.

PubMed ID: 2461365

DOI: 10.1016/s0021-9258(19)81327-3

PubMed ID: 9651377

Title: Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope.

PubMed ID: 9651377

DOI: 10.1074/jbc.273.28.17763

PubMed ID: 15147942

Title: Identification and characterization of a novel component of the cornified envelope, cornifelin.

PubMed ID: 15147942

DOI: 10.1016/j.bbrc.2004.04.109

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 585
  • Mass: 68479
  • Checksum: 775D2AFB90F647E8
  • Sequence:
    • MSQQHTLPVT LSPALSQELL KTVPPPVNTH QEQMKQPTPL PPPCQKVPVE LPVEVPSKQE 
EKHMTAVKGL PEQECEQQQK EPQEQELQQQ HWEQHEEYQK AENPEQQLKQ EKTQRDQQLN 
KQLEEEKKLL DQQLDQELVK RDEQLGMKKE QLLELPEQQE GHLKHLEQQE GQLKHPEQQE 
GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPQQQE 
GQLELSEQQE GQLELSEQQE GQLKHLEHQE GQLEVPEEQM GQLKYLEQQE GQLKHLDQQE 
KQPELPEQQM GQLKHLEQQE GQPKHLEQQE GQLEQLEEQE GQLKHLEQQE GQLEHLEHQE 
GQLGLPEQQV LQLKQLEKQQ GQPKHLEEEE GQLKHLVQQE GQLKHLVQQE GQLEQQERQV 
EHLEQQVGQL KHLEEQEGQL KHLEQQQGQL EVPEQQVGQP KNLEQEEKQL ELPEQQEGQV 
KHLEKQEAQL ELPEQQVGQP KHLEQQEKHL EHPEQQDGQL KHLEQQEGQL KDLEQQKGQL 
EQPVFAPAPG QVQDIQPALP TKGEVLLPVE HQQQKQEVQW PPKHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.