Details for: IVL

Gene ID: 3713

Symbol: IVL

Ensembl ID: ENSG00000163207

Description: involucrin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162082
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 10.94
    Marker Score: 6059
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8279
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 4.51
    Marker Score: 2561
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 4.04
    Marker Score: 5578
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.89
    Marker Score: 30406
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6845
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.61
    Marker Score: 1376
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2
    Marker Score: 836
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.94
    Marker Score: 16729
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5
    Marker Score: 2215
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7575
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3652
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.11
    Marker Score: 732
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32725
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 737
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.61
    Marker Score: 413
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.58
    Marker Score: 1096
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.57
    Marker Score: 602.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.54
    Marker Score: 773
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.48
    Marker Score: 397
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.44
    Marker Score: 105
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.38
    Marker Score: 774.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.35
    Marker Score: 313
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.29
    Marker Score: 4475
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.26
    Marker Score: 159
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.26
    Marker Score: 1574
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.25
    Marker Score: 221
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.21
    Marker Score: 339
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2
    Marker Score: 221
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.19
    Marker Score: 307
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.19
    Marker Score: 206
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.18
    Marker Score: 88
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.18
    Marker Score: 2383
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.16
    Marker Score: 93
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.15
    Marker Score: 122
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 439
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.13
    Marker Score: 101
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.13
    Marker Score: 130
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.13
    Marker Score: 68
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.12
    Marker Score: 332
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.11
    Marker Score: 98
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.1
    Marker Score: 118
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.09
    Marker Score: 160
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.09
    Marker Score: 17
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.09
    Marker Score: 91.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.08
    Marker Score: 104
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.07
    Marker Score: 482
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.07
    Marker Score: 382
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 66
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.05
    Marker Score: 90
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.05
    Marker Score: 96
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.03
    Marker Score: 161
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.03
    Marker Score: 47
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 20

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Other Information

**Key characteristics:** * IVL is a large protein (800 amino acids) that is highly conserved across species. * It is a member of the immunoglobulin superfamily and shares structural similarities with other members of the involucrin family. * IVL is a key regulator of cell differentiation and survival. * It is involved in the formation of the cornified envelope, a specialized lipid-rich membrane that surrounds cells and protects them from the surrounding environment. * IVL also plays a role in keratinization, a process that involves the formation of a strong, protective barrier on the surface of cells. * It is involved in the regulation of cell migration, adhesion, and signaling. **Pathways and functions:** * IVL is involved in the formation of the cornified envelope. * It is also involved in the regulation of cell migration, adhesion, and signaling. * IVL is a key regulator of keratinization. * It is involved in the development of the central nervous system and the immune system. **Clinical significance:** * Mutations in the IVL gene have been linked to several human diseases, including skin cancer, psoriasis, and corneal dystrophy. * IVL is a promising target for cancer immunotherapy, as it is frequently overexpressed on cancer cells. * Inhibition of IVL has been shown to inhibit cancer cell growth and metastasis. **Conclusion:** IVL is a critical protein for the health and function of various cell types. Its overexpression is associated with several human diseases, highlighting its importance in cellular processes. IVL is a promising target for cancer immunotherapy due to its high expression on cancer cells.

Genular Protein ID: 2861302180

Symbol: INVO_HUMAN

Name: Involucrin

UniProtKB Accession Codes:

P07476 Q5T7P4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2873896

Title: Structure and evolution of the human involucrin gene.

PubMed ID: 2873896

DOI: 10.1016/0092-8674(86)90884-6

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9115270

Title: S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes.

PubMed ID: 9115270

DOI: 10.1074/jbc.272.18.12035

PubMed ID: 1601889

Title: Biophysical characterization of involucrin reveals a molecule ideally suited to function as an intermolecular cross-bridge of the keratinocyte cornified envelope.

PubMed ID: 1601889

DOI: 10.1016/s0021-9258(19)49829-3

PubMed ID: 2461365

Title: The glutamine residues reactive in transglutaminase-catalyzed cross-linking of involucrin.

PubMed ID: 2461365

DOI: 10.1016/s0021-9258(19)81327-3

PubMed ID: 9651377

Title: Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope.

PubMed ID: 9651377

DOI: 10.1074/jbc.273.28.17763

PubMed ID: 15147942

Title: Identification and characterization of a novel component of the cornified envelope, cornifelin.

PubMed ID: 15147942

DOI: 10.1016/j.bbrc.2004.04.109

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 585
  • Mass: 68479
  • Checksum: 775D2AFB90F647E8
  • Sequence:
    • MSQQHTLPVT LSPALSQELL KTVPPPVNTH QEQMKQPTPL PPPCQKVPVE LPVEVPSKQE 
EKHMTAVKGL PEQECEQQQK EPQEQELQQQ HWEQHEEYQK AENPEQQLKQ EKTQRDQQLN 
KQLEEEKKLL DQQLDQELVK RDEQLGMKKE QLLELPEQQE GHLKHLEQQE GQLKHPEQQE 
GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPQQQE 
GQLELSEQQE GQLELSEQQE GQLKHLEHQE GQLEVPEEQM GQLKYLEQQE GQLKHLDQQE 
KQPELPEQQM GQLKHLEQQE GQPKHLEQQE GQLEQLEEQE GQLKHLEQQE GQLEHLEHQE 
GQLGLPEQQV LQLKQLEKQQ GQPKHLEEEE GQLKHLVQQE GQLKHLVQQE GQLEQQERQV 
EHLEQQVGQL KHLEEQEGQL KHLEQQQGQL EVPEQQVGQP KNLEQEEKQL ELPEQQEGQV 
KHLEKQEAQL ELPEQQVGQP KHLEQQEKHL EHPEQQDGQL KHLEQQEGQL KDLEQQKGQL 
EQPVFAPAPG QVQDIQPALP TKGEVLLPVE HQQQKQEVQW PPKHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.