Details for: KLK2

Gene ID: 3817

Symbol: KLK2

Ensembl ID: ENSG00000167751

Description: kallikrein related peptidase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.4
    Marker Score: 1981
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.2
    Marker Score: 2212
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.16
    Marker Score: 1196
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.75
    Marker Score: 905
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1177
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 492
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4825
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71838
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48063
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.97
    Marker Score: 445
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.82
    Marker Score: 430
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.66
    Marker Score: 382
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 498
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 210
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.45
    Marker Score: 2981
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.42
    Marker Score: 1026
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.38
    Marker Score: 727
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.33
    Marker Score: 226
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.29
    Marker Score: 114
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.29
    Marker Score: 593
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.24
    Marker Score: 215
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.24
    Marker Score: 3692
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.22
    Marker Score: 131
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 116
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.19
    Marker Score: 122.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 278
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.13
    Marker Score: 74
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.12
    Marker Score: 57
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.12
    Marker Score: 91
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.11
    Marker Score: 97
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.11
    Marker Score: 116
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1
    Marker Score: 181
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 49
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.07
    Marker Score: 72.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.06
    Marker Score: 661
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.05
    Marker Score: 40
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.05
    Marker Score: 80
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.04
    Marker Score: 35
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.03
    Marker Score: 60
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.03
    Marker Score: 1550
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.03
    Marker Score: 44.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.03
    Marker Score: 12

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Other Information

**Key characteristics:** * KLK2 is a transmembrane protein that is composed of 130 amino acids. * It is expressed in high levels in the luminal cell of the prostate epithelium. * It is also expressed in blood vessel endothelial cells, erythrocyte, endocrine cells, colon goblet cells, intestinal crypt stem cell of small intestine, transit amplifying cell of small intestine, enterocyte of epithelium of small intestine, and cerebral cortex GABAergic interneuron. **Pathways and functions:** * KLK2 is a key regulator of cell migration and invasion in prostate cancer. * It is involved in the regulation of epithelial-mesenchymal transition (EMT), which is the process by which epithelial cells lose their epithelial characteristics and acquire mesenchymal characteristics. * KLK2 inhibitors have been shown to suppress cancer growth and metastasis in prostate cancer models. **Clinical significance:** * Mutations in KLK2 have been linked to the development of prostate cancer. * Targeting KLK2 with small molecule inhibitors is a promising therapeutic strategy for prostate cancer. **Additional information:** * KLK2 is a member of the KLK family of serine proteases. * It is activated by the activation of pkn1, a kinase that is involved in cell migration and invasion. * It is a key regulator of the expression of matrix metalloproteinases, which are enzymes that break down the extracellular matrix.

Genular Protein ID: 1714494839

Symbol: KLK2_HUMAN

Name: Kallikrein-2

UniProtKB Accession Codes:

P20151 B4DU93 B4DUB0 F5H8L3 Q15946 Q9UJZ9

Database IDs:

ABCD 1 AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 13 Ensembl 4 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2824146

Title: Primary structure of a human glandular kallikrein gene.

PubMed ID: 2824146

DOI: 10.1089/dna.1987.6.429

PubMed ID: 1726490

Title: Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species.

PubMed ID: 1726490

DOI: 10.1016/0303-7207(91)90272-t

PubMed ID: 10544017

Title: Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing.

PubMed ID: 10544017

DOI: 10.1006/bbrc.1999.1595

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 261
  • Mass: 28671
  • Checksum: 9CF7F4A1162EF42D
  • Sequence:
    • MWDLVLSIAL SVGCTGAVPL IQSRIVGGWE CEKHSQPWQV AVYSHGWAHC GGVLVHPQWV 
LTAAHCLKKN SQVWLGRHNL FEPEDTGQRV PVSHSFPHPL YNMSLLKHQS LRPDEDSSHD 
LMLLRLSEPA KITDVVKVLG LPTQEPALGT TCYASGWGSI EPEEFLRPRS LQCVSLHLLS 
NDMCARAYSE KVTEFMLCAG LWTGGKDTCG GDSGGPLVCN GVLQGITSWG PEPCALPEKP 
AVYTKVVHYR KWIKDTIAAN P

Genular Protein ID: 3058167978

Symbol: B4DU77_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DU77

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 3 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 244
  • Mass: 26421
  • Checksum: 078D1FB643B276AD
  • Sequence:
    • MGTLWGCPGA PPVGAHSCPL PKEVSRTLGS GEGMAVSHRN NSGMLPPGSL LRNSQVWLGR 
HNLFEPEDTG RRVPVSHSFP HPLYNMSLLK HQSLRPDEDS SHDLMLLRLS EPAKITDVVK 
VLGLPTQEPA LGTTCYASGW GSIEPEEFLR PRSLQCVSLH LLSNDMCARA YSEKVTEFML 
CAGLWTGGKD TCGGDSGGPL VCNGVLQGIT SWGPEPCALP EKPAVYTKVV HYRKWIKDTI 
AANP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.