Details for: KLK2

Gene ID: 3817

Symbol: KLK2

Ensembl ID: ENSG00000167751

Description: kallikrein related peptidase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 6.2472
    Cell Significance Index: 64.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.8200
    Cell Significance Index: 111.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5906
    Cell Significance Index: 34.4600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2864
    Cell Significance Index: 31.1600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.1589
    Cell Significance Index: 7.1500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.9841
    Cell Significance Index: 14.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5576
    Cell Significance Index: 106.1200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.5069
    Cell Significance Index: 4.5000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4745
    Cell Significance Index: 7.6900
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.3948
    Cell Significance Index: 1.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3728
    Cell Significance Index: 7.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3376
    Cell Significance Index: 33.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2861
    Cell Significance Index: 258.3400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.2659
    Cell Significance Index: 1.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2187
    Cell Significance Index: 23.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2115
    Cell Significance Index: 12.7000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.2012
    Cell Significance Index: 1.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1869
    Cell Significance Index: 30.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1397
    Cell Significance Index: 2.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1236
    Cell Significance Index: 8.5500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.0804
    Cell Significance Index: 0.1000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0627
    Cell Significance Index: 0.6500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0571
    Cell Significance Index: 0.1300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0339
    Cell Significance Index: 0.3600
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.0290
    Cell Significance Index: 0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0276
    Cell Significance Index: 0.9700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0197
    Cell Significance Index: 0.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0163
    Cell Significance Index: 2.0100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.0137
    Cell Significance Index: 0.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0131
    Cell Significance Index: 2.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0088
    Cell Significance Index: 0.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0061
    Cell Significance Index: 0.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0060
    Cell Significance Index: 0.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0032
    Cell Significance Index: 0.0800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0007
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0025
    Cell Significance Index: -1.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0031
    Cell Significance Index: -1.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0034
    Cell Significance Index: -0.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0034
    Cell Significance Index: -1.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0038
    Cell Significance Index: -0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0043
    Cell Significance Index: -1.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0044
    Cell Significance Index: -0.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0046
    Cell Significance Index: -1.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0047
    Cell Significance Index: -0.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0061
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0061
    Cell Significance Index: -1.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0063
    Cell Significance Index: -1.8100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0070
    Cell Significance Index: -0.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0073
    Cell Significance Index: -0.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0088
    Cell Significance Index: -1.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0091
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0093
    Cell Significance Index: -1.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0099
    Cell Significance Index: -0.7400
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0121
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0122
    Cell Significance Index: -1.4000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0146
    Cell Significance Index: -0.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0152
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0167
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0183
    Cell Significance Index: -0.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0189
    Cell Significance Index: -2.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0192
    Cell Significance Index: -2.4800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0203
    Cell Significance Index: -0.1300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0215
    Cell Significance Index: -0.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0225
    Cell Significance Index: -2.3500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0234
    Cell Significance Index: -0.7400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0249
    Cell Significance Index: -0.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0268
    Cell Significance Index: -0.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0270
    Cell Significance Index: -1.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0278
    Cell Significance Index: -0.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0280
    Cell Significance Index: -1.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0293
    Cell Significance Index: -0.9400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0299
    Cell Significance Index: -0.4800
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0325
    Cell Significance Index: -0.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0335
    Cell Significance Index: -1.5800
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0344
    Cell Significance Index: -0.3600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0369
    Cell Significance Index: -0.6200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0377
    Cell Significance Index: -0.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0389
    Cell Significance Index: -0.7600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0392
    Cell Significance Index: -0.6700
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0392
    Cell Significance Index: -0.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0452
    Cell Significance Index: -1.5700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0461
    Cell Significance Index: -0.4900
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0463
    Cell Significance Index: -0.5700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0496
    Cell Significance Index: -0.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0506
    Cell Significance Index: -2.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0507
    Cell Significance Index: -2.6600
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0509
    Cell Significance Index: -0.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0521
    Cell Significance Index: -1.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0540
    Cell Significance Index: -1.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLK2 is a 70-kDa protein that belongs to the kallikrein-related peptidase family, which consists of 15 members. It is a serine-type endopeptidase that cleaves various peptides and proteins, including growth factors, hormones, and extracellular matrix components. KLK2 is also known as hK2 and is the second member of the kallikrein family, which was first discovered in human prostate cancer cells. The protein is produced as a proenzyme, which is activated by proteolytic cleavage. **Pathways and Functions:** KLK2 is involved in various signaling pathways, including: 1. **Activation of matrix metalloproteinases (MMPs):** KLK2 activates MMPs, which are key enzymes involved in tissue remodeling and degradation of the extracellular matrix. 2. **Regulation of insulin-like growth factor (IGF) transport and uptake:** KLK2 cleaves IGF binding proteins (IGFBPs), which regulates IGF transport and uptake, influencing cell proliferation and survival. 3. **Signaling by Rho GTPases:** KLK2 activates Rho GTPases, which are involved in cell migration, proliferation, and survival. 4. **Degradation of extracellular matrix:** KLK2 cleaves extracellular matrix components, such as collagens and elastin, which regulates tissue remodeling and cell migration. KLK2 has various functions, including: 1. **Cell signaling:** KLK2 regulates cell signaling pathways, including the activation of MMPs and Rho GTPases. 2. **Tissue remodeling:** KLK2 participates in tissue remodeling, including the degradation of extracellular matrix and the activation of MMPs. 3. **Cell proliferation and survival:** KLK2 regulates cell proliferation and survival by modulating IGF signaling and Rho GTPase activity. 4. **Cancer progression:** KLK2 has been implicated in cancer progression, including prostate cancer, breast cancer, and colon cancer. **Clinical Significance:** KLK2 has been implicated in various diseases and disorders, including: 1. **Prostate cancer:** KLK2 is overexpressed in prostate cancer cells and has been associated with tumor progression and metastasis. 2. **Breast cancer:** KLK2 has been implicated in breast cancer progression and metastasis. 3. **Colon cancer:** KLK2 has been associated with colon cancer progression and metastasis. 4. **Cardiovascular disease:** KLK2 has been implicated in cardiovascular disease, including atherosclerosis and cardiac remodeling. In conclusion, KLK2 is a multifunctional protein that plays a crucial role in various physiological and pathological processes, including proteolysis, cell signaling, and tissue remodeling. Its expression and activity have been implicated in various diseases and disorders, highlighting its clinical significance. Further research is needed to fully elucidate the functional significance of KLK2 and its role in human disease.

Genular Protein ID: 1714494839

Symbol: KLK2_HUMAN

Name: Kallikrein-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2824146

Title: Primary structure of a human glandular kallikrein gene.

PubMed ID: 2824146

DOI: 10.1089/dna.1987.6.429

PubMed ID: 1726490

Title: Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species.

PubMed ID: 1726490

DOI: 10.1016/0303-7207(91)90272-t

PubMed ID: 10544017

Title: Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing.

PubMed ID: 10544017

DOI: 10.1006/bbrc.1999.1595

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 261
  • Mass: 28671
  • Checksum: 9CF7F4A1162EF42D
  • Sequence:
  • MWDLVLSIAL SVGCTGAVPL IQSRIVGGWE CEKHSQPWQV AVYSHGWAHC GGVLVHPQWV 
    LTAAHCLKKN SQVWLGRHNL FEPEDTGQRV PVSHSFPHPL YNMSLLKHQS LRPDEDSSHD 
    LMLLRLSEPA KITDVVKVLG LPTQEPALGT TCYASGWGSI EPEEFLRPRS LQCVSLHLLS 
    NDMCARAYSE KVTEFMLCAG LWTGGKDTCG GDSGGPLVCN GVLQGITSWG PEPCALPEKP 
    AVYTKVVHYR KWIKDTIAAN P

Genular Protein ID: 3058167978

Symbol: B4DU77_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 244
  • Mass: 26421
  • Checksum: 078D1FB643B276AD
  • Sequence:
  • MGTLWGCPGA PPVGAHSCPL PKEVSRTLGS GEGMAVSHRN NSGMLPPGSL LRNSQVWLGR 
    HNLFEPEDTG RRVPVSHSFP HPLYNMSLLK HQSLRPDEDS SHDLMLLRLS EPAKITDVVK 
    VLGLPTQEPA LGTTCYASGW GSIEPEEFLR PRSLQCVSLH LLSNDMCARA YSEKVTEFML 
    CAGLWTGGKD TCGGDSGGPL VCNGVLQGIT SWGPEPCALP EKPAVYTKVV HYRKWIKDTI 
    AANP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.