Details for: KRT13

Gene ID: 3860

Symbol: KRT13

Ensembl ID: ENSG00000171401

Description: keratin 13

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.69
    Marker Score: 28794
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.3
    Marker Score: 2251
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.27
    Marker Score: 28201
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.09
    Marker Score: 2434
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.93
    Marker Score: 706
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.75
    Marker Score: 2298
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.72
    Marker Score: 3080.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.46
    Marker Score: 2589
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 2.4
    Marker Score: 1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.24
    Marker Score: 3293
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.23
    Marker Score: 835
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.19
    Marker Score: 823
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.18
    Marker Score: 238
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.14
    Marker Score: 474
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.12
    Marker Score: 812
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.1
    Marker Score: 2579
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48015
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.95
    Marker Score: 1561
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5212
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.87
    Marker Score: 2119
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.87
    Marker Score: 287
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.79
    Marker Score: 776
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1246
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 565.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.73
    Marker Score: 945
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.71
    Marker Score: 430
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2813.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.6
    Marker Score: 967
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.58
    Marker Score: 184
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.56
    Marker Score: 7587.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.55
    Marker Score: 222
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.53
    Marker Score: 352
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 340
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 269
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.43
    Marker Score: 272
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.43
    Marker Score: 157
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.42
    Marker Score: 3162.5
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.42
    Marker Score: 420.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 178.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4
    Marker Score: 271
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4
    Marker Score: 440
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.4
    Marker Score: 430
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 102
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 353
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.34
    Marker Score: 226
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.33
    Marker Score: 116
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.33
    Marker Score: 2119
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.32
    Marker Score: 148
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.32
    Marker Score: 199
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.31
    Marker Score: 640
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.31
    Marker Score: 202
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.29
    Marker Score: 213
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.29
    Marker Score: 107
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.28
    Marker Score: 147
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.28
    Marker Score: 79
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.28
    Marker Score: 116
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.28
    Marker Score: 341
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.27
    Marker Score: 61
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.26
    Marker Score: 51
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.25
    Marker Score: 127
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.24
    Marker Score: 168
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.24
    Marker Score: 60
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.24
    Marker Score: 438
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.24
    Marker Score: 240
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.24
    Marker Score: 62
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.24
    Marker Score: 341
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.24
    Marker Score: 60
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.23
    Marker Score: 208
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.23
    Marker Score: 80
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.23
    Marker Score: 89
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.23
    Marker Score: 221
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.23
    Marker Score: 60
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.23
    Marker Score: 643
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.23
    Marker Score: 59
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.23
    Marker Score: 60
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.23
    Marker Score: 62
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.23
    Marker Score: 62
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.22
    Marker Score: 112
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.22
    Marker Score: 55
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.22
    Marker Score: 198
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.22
    Marker Score: 55
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.21
    Marker Score: 60
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.21
    Marker Score: 196

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Other Information

**Key characteristics:** * KRT13 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the keratin family of cytoskeletal proteins, which are responsible for the structural integrity and stability of cell membranes and the extracellular matrix. * Keratins exhibit a unique ability to form both intermediate filaments and microtubules, contributing to the unique mechanical properties of epithelial tissues. **Pathways and functions:** * KRT13 is involved in various cellular processes, including epithelial cell differentiation, survival, migration, and wound healing. * It is a key regulator of epithelial cell proliferation, migration, and differentiation. * It plays a crucial role in maintaining the integrity and barrier function of epithelial tissues by forming the cornified envelope, which protects the underlying tissues from harmful substances. * KRT13 is also involved in the regulation of cell migration and adhesion, and it contributes to the formation of the basement membrane, which provides a framework for epithelial cells. **Clinical significance:** * Mutations in the KRT13 gene have been linked to various skin disorders, including psoriasis and acne. * Dysregulation of KRT13 expression and function has been implicated in several cancers, indicating its potential role in tumor growth and metastasis. * Targeting KRT13 signaling has emerged as a promising therapeutic approach for treating skin diseases and cancer. **Conclusion:** KRT13 is a critical cytoskeletal protein that plays a vital role in maintaining the integrity and barrier function of epithelial tissues. Its dysregulation has been linked to various skin disorders and cancers, highlighting its potential clinical significance in human health.

Genular Protein ID: 939079087

Symbol: K1C13_HUMAN

Name: Keratin, type I cytoskeletal 13

UniProtKB Accession Codes:

P13646 Q53G54 Q6AZK5 Q8N240

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2475110

Title: Sequence of a human keratin 13 specific cDNA encompassing coil 1B through the 3' end.

PubMed ID: 2475110

DOI: 10.1016/0006-291x(89)90847-4

PubMed ID: 2477803

Title: The N-, but not the C-terminal domains of human keratins 13 and 15 are closely related.

PubMed ID: 2477803

DOI: 10.1093/nar/17.19.7984

PubMed ID: 2483837

Title: Synthesis of cytokeratin 13, a component characteristic of internal stratified epithelia, is not induced in human epidermal tumors.

PubMed ID: 2483837

DOI: 10.1111/j.1432-0436.1989.tb00612.x

PubMed ID: 9714826

Title: Isolation, sequence and expression of the gene encoding human keratin 13.

PubMed ID: 9714826

DOI: 10.1016/s0378-1119(98)00297-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2474541

Title: Cytokeratin 13 contains O-glycosidically linked N-acetylglucosamine residues.

PubMed ID: 2474541

DOI: 10.1016/s0021-9258(18)71636-0

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 7493031

Title: Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus.

PubMed ID: 7493031

DOI: 10.1038/ng1295-453

PubMed ID: 10561721

Title: Identification of two novel mutations in keratin 13 as the cause of white sponge naevus.

PubMed ID: 10561721

DOI: 10.1111/j.1601-0825.1999.tb00097.x

PubMed ID: 11379896

Title: A novel mutation in the keratin 13 gene causing oral white sponge nevus.

PubMed ID: 11379896

DOI: 10.1177/00220345010800031401

PubMed ID: 14600690

Title: Constitutional mutation of keratin 13 gene in familial white sponge nevus.

PubMed ID: 14600690

DOI: 10.1016/s1079-2104(03)00372-x

PubMed ID: 18616775

Title: A de novo missense mutation in the keratin 13 gene in oral white sponge naevus.

PubMed ID: 18616775

DOI: 10.1111/j.1365-2133.2008.08716.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25606422

Title: Keratin 13 mutations associated with oral white sponge nevus in two Chinese families.

PubMed ID: 25606422

DOI: 10.1016/j.mgene.2014.04.008

PubMed ID: 29476668

Title: Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus.

PubMed ID: 29476668

DOI: 10.4317/medoral.21437

Sequence Information:

  • Length: 458
  • Mass: 49588
  • Checksum: A51AECFD6195ACB4
  • Sequence:
    • MSLRLQSSSA SYGGGFGGGS CQLGGGRGVS TCSTRFVSGG SAGGYGGGVS CGFGGGAGSG 
FGGGYGGGLG GGYGGGLGGG FGGGFAGGFV DFGACDGGLL TGNEKITMQN LNDRLASYLE 
KVRALEEANA DLEVKIRDWH LKQSPASPER DYSPYYKTIE ELRDKILTAT IENNRVILEI 
DNARLAADDF RLKYENELAL RQSVEADING LRRVLDELTL SKTDLEMQIE SLNEELAYMK 
KNHEEEMKEF SNQVVGQVNV EMDATPGIDL TRVLAEMREQ YEAMAERNRR DAEEWFHTKS 
AELNKEVSTN TAMIQTSKTE ITELRRTLQG LEIELQSQLS MKAGLENTVA ETECRYALQL 
QQIQGLISSI EAQLSELRSE MECQNQEYKM LLDIKTRLEQ EIATYRSLLE GQDAKMIGFP 
SSAGSVSPRS TSVTTTSSAS VTTTSNASGR RTSDVRRP

Genular Protein ID: 3242151711

Symbol: A1A4E9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A1A4E9

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 GO 2 Gene3D 3 GenomeRNAi 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 458
  • Mass: 49586
  • Checksum: 9E033A247CD2B106
  • Sequence:
    • MSLRLQSSSA SYGGGFGGGS CQLGGGRGVS TCSTRFVSGG SAGGYGGGVS CGFGGGAGSG 
FGGGYGGGLG GGYGGGLGGG FGGGFAGGFV DFGACDGGLL TGNEKITMQN LNDRLASYLE 
KVRALEEANA DLEVKIRDWH LKQSPASPER DYSPYYKTIE ELRDKILTAT IENNRVILEI 
DNARLAVDDF RLKYENELAL RQSVEADING LRRVLDELTL SKTDLEMQIE SLNEELAYMK 
KNHEEEMKEF SNQVVGQVNV EMDATPGIDL TRVLAEMREQ YEAMAERNRR DAEEWFHAKS 
AELNKEVSTN TAMIQTSKTE ITELRRTLQG LEIELQSQLS MKAGLENTVA ETECRYALQL 
QQIQGLISSI EAQLSELRSE MECQNQEYKM LLDIKTRLEQ EIATYRSLLE GQDAKMIGFP 
SSAGSVSPRS TSVTTTSSAS VTTTSNASGR RTSDVRRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.