Gene KRT34 - ENSG00000131737 | NCBI Gene ID: 3885

Details for: KRT34

Gene ID: 3885

Symbol: KRT34

Ensembl ID: ENSG00000131737

Description: keratin 34

Associated with

Developmental biology
(R-HSA-1266738)
Formation of the cornified envelope
(R-HSA-6809371)
Keratinization
(R-HSA-6805567)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Epidermis development
(GO:0008544)
Epithelial cell differentiation
(GO:0030855)
Extracellular space
(GO:0005615)
Intermediate filament
(GO:0005882)
Intermediate filament organization
(GO:0045109)
Protein binding
(GO:0005515)
Structural molecule activity
(GO:0005198)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: progenitor cell (CL0011026)
Fold Change: 4.64
Marker Score: 29914
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 3.16
Marker Score: 3185
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7693
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.1
Marker Score: 2783
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71841
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48066
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5357
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.94
Marker Score: 1524
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5293
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 714
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.78
Marker Score: 402
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.67
Marker Score: 533
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 282
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.14
Marker Score: 195
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.12
Marker Score: 79
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.1
Marker Score: 142
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.08
Marker Score: 135
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.08
Marker Score: 24
Cell Name: macrophage (CL0000235)
Fold Change: 0.08
Marker Score: 85
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.07
Marker Score: 154
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.07
Marker Score: 48
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.07
Marker Score: 77
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.05
Marker Score: 21
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.04
Marker Score: 14
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.04
Marker Score: 15
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.04
Marker Score: 9
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.04
Marker Score: 10
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.03
Marker Score: 9
Cell Name: basal cell (CL0000646)
Fold Change: 0.03
Marker Score: 44
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.03
Marker Score: 12
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.03
Marker Score: 16
Cell Name: myometrial cell (CL0002366)
Fold Change: 0.03
Marker Score: 8
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.02
Marker Score: 8
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.02
Marker Score: 13
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.02
Marker Score: 40
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.02
Marker Score: 20
Cell Name: decidual cell (CL2000002)
Fold Change: 0.02
Marker Score: 95
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.02
Marker Score: 9
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.02
Marker Score: 38
Cell Name: microglial cell (CL0000129)
Fold Change: 0.02
Marker Score: 39
Cell Name: leukocyte (CL0000738)
Fold Change: 0.02
Marker Score: 12
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.02
Marker Score: 50
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.02
Marker Score: 7
Cell Name: melanocyte (CL0000148)
Fold Change: 0.02
Marker Score: 8
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.02
Marker Score: 23
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.02
Marker Score: 201
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.02
Marker Score: 47
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.02
Marker Score: 125
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.02
Marker Score: 58
Cell Name: mast cell (CL0000097)
Fold Change: 0.02
Marker Score: 9
Cell Name: astrocyte (CL0000127)
Fold Change: 0.02
Marker Score: 13
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.01
Marker Score: 11
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.01
Marker Score: 33
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.01
Marker Score: 119
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.01
Marker Score: 14
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.01
Marker Score: 7
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.01
Marker Score: 11
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.01
Marker Score: 26
Cell Name: pericyte (CL0000669)
Fold Change: 0.01
Marker Score: 6
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.01
Marker Score: 7
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.01
Marker Score: 12
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.01
Marker Score: 95
Cell Name: fibroblast (CL0000057)
Fold Change: 0.01
Marker Score: 9
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.01
Marker Score: 9
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.01
Marker Score: 8
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.01
Marker Score: 32
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.01
Marker Score: 8
Cell Name: neuron (CL0000540)
Fold Change: 0.01
Marker Score: 32
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.01
Marker Score: 5
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.01
Marker Score: 5
Cell Name: club cell (CL0000158)
Fold Change: 0.01
Marker Score: 8
Cell Name: stromal cell (CL0000499)
Fold Change: 0.01
Marker Score: 8
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.01
Marker Score: 6
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.01
Marker Score: 34
Cell Name: B cell (CL0000236)
Fold Change: 0.01
Marker Score: 6
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.01
Marker Score: 22
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.01
Marker Score: 9
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 0.01
Marker Score: 8
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.01
Marker Score: 8
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.01
Marker Score: 8
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.01
Marker Score: 5
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.01
Marker Score: 9
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.01
Marker Score: 7
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.01
Marker Score: 6
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.01
Marker Score: 8
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.01
Marker Score: 67
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0
Marker Score: 6
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0
Marker Score: 20
Cell Name: monocyte (CL0000576)
Fold Change: 0
Marker Score: 6
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0
Marker Score: 5
Cell Name: supporting cell (CL0000630)
Fold Change: 0
Marker Score: 8
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0
Marker Score: 8
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0
Marker Score: 8
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0
Marker Score: 6
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0
Marker Score: 8
Cell Name: natural killer cell (CL0000623)
Fold Change: 0
Marker Score: 5
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0
Marker Score: 9
Cell Name: T cell (CL0000084)
Fold Change: 0
Marker Score: 6

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Other Information

Description

**Key characteristics** * KRT34 is a transmembrane protein that is expressed in stratified squamous epithelia. * It is a key component of the cornified envelope, which is a protective barrier that surrounds cells in stratified squamous epithelia. * It is also involved in the organization of the intermediate filament, which is a cytoskeletal protein that is responsible for maintaining the integrity of the skin and hair. * It is significantly expressed in the skin, hair, and nails. **Pathways and functions** * KRT34 is involved in the formation of the cornified envelope. * It is a key component of the skin's barrier function, protecting cells from damage by physical and chemical insults. * It is also involved in the maintenance of skin integrity, preventing the entry of pathogens and toxins. * It is involved in the organization of the intermediate filament, a cytoskeletal protein that is responsible for maintaining the integrity of the skin and hair. * It is a key regulator of epithelial cell differentiation. **Clinical significance** Mutations in KRT34 have been linked to a number of skin disorders, including psoriasis and ichthyosis vulgaris. These disorders are characterized by the formation of dry, cracked skin that is susceptible to infection. KRT34 is also a key regulator of skin cancer, and mutations in the gene can increase the risk of developing skin cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.