Details for: KRT34

Gene ID: 3885

Symbol: KRT34

Ensembl ID: ENSG00000131737

Description: keratin 34

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.5192
    Cell Significance Index: 5.9800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.3354
    Cell Significance Index: 3.4600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2645
    Cell Significance Index: 3.6700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1716
    Cell Significance Index: 2.2200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1707
    Cell Significance Index: 2.4300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1041
    Cell Significance Index: 1.6700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0557
    Cell Significance Index: 0.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0408
    Cell Significance Index: 0.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0362
    Cell Significance Index: 1.8800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0349
    Cell Significance Index: 0.4400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0324
    Cell Significance Index: 0.4600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0082
    Cell Significance Index: 0.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0081
    Cell Significance Index: 0.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0039
    Cell Significance Index: 0.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0018
    Cell Significance Index: 0.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0008
    Cell Significance Index: -0.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0017
    Cell Significance Index: -2.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0021
    Cell Significance Index: -1.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0030
    Cell Significance Index: -0.8500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0041
    Cell Significance Index: -1.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0048
    Cell Significance Index: -0.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0071
    Cell Significance Index: -1.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0085
    Cell Significance Index: -1.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0087
    Cell Significance Index: -1.5600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0104
    Cell Significance Index: -0.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0105
    Cell Significance Index: -1.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0137
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0148
    Cell Significance Index: -1.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0158
    Cell Significance Index: -1.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0226
    Cell Significance Index: -0.8300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0267
    Cell Significance Index: -0.2800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0273
    Cell Significance Index: -0.2400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0283
    Cell Significance Index: -0.4800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0290
    Cell Significance Index: -0.3200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0314
    Cell Significance Index: -0.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0319
    Cell Significance Index: -1.6600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0338
    Cell Significance Index: -0.4300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0348
    Cell Significance Index: -0.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0362
    Cell Significance Index: -1.7000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0364
    Cell Significance Index: -0.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0384
    Cell Significance Index: -0.5500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0399
    Cell Significance Index: -0.3300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0400
    Cell Significance Index: -0.3500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0418
    Cell Significance Index: -0.2800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0421
    Cell Significance Index: -0.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0437
    Cell Significance Index: -1.5300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0445
    Cell Significance Index: -0.2300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0461
    Cell Significance Index: -0.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0465
    Cell Significance Index: -0.7800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0482
    Cell Significance Index: -0.5200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0489
    Cell Significance Index: -0.6200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0493
    Cell Significance Index: -0.5300
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0496
    Cell Significance Index: -0.4600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0497
    Cell Significance Index: -0.6000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0525
    Cell Significance Index: -0.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0538
    Cell Significance Index: -1.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0546
    Cell Significance Index: -1.7400
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0549
    Cell Significance Index: -0.5600
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0552
    Cell Significance Index: -0.5900
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.0555
    Cell Significance Index: -0.5200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0557
    Cell Significance Index: -0.5000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0560
    Cell Significance Index: -0.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0564
    Cell Significance Index: -1.5100
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0580
    Cell Significance Index: -0.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0594
    Cell Significance Index: -2.2500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0596
    Cell Significance Index: -0.6000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0599
    Cell Significance Index: -0.9700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0600
    Cell Significance Index: -0.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0605
    Cell Significance Index: -1.6200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0631
    Cell Significance Index: -1.5800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0646
    Cell Significance Index: -0.6700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0683
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: -0.0702
    Cell Significance Index: -0.5400
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0703
    Cell Significance Index: -0.5400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0722
    Cell Significance Index: -1.8000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0742
    Cell Significance Index: -1.8900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0743
    Cell Significance Index: -2.3500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0745
    Cell Significance Index: -0.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0767
    Cell Significance Index: -1.6800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0781
    Cell Significance Index: -0.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0813
    Cell Significance Index: -2.3300
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0814
    Cell Significance Index: -0.7800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0830
    Cell Significance Index: -1.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0852
    Cell Significance Index: -1.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0853
    Cell Significance Index: -1.8100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0853
    Cell Significance Index: -1.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0921
    Cell Significance Index: -1.8500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0933
    Cell Significance Index: -2.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0936
    Cell Significance Index: -1.8500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0940
    Cell Significance Index: -1.8500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0948
    Cell Significance Index: -1.0500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1001
    Cell Significance Index: -1.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT34 is a type II keratin, which is distinct from type I keratins that are more abundant in the cytoskeleton. Type II keratins, including KRT34, are primarily localized to the cytoskeleton of epithelial cells and play a crucial role in maintaining cell integrity, structure, and function. KRT34 is specifically expressed in various epithelial tissues, including the skin, intestine, and brain, where it contributes to the formation of the cornified envelope, a critical component of the epidermal barrier. **Pathways and Functions:** KRT34 is involved in several key signaling pathways that regulate epithelial cell biology, including: 1. **Keratinization**: KRT34 is essential for the formation of the cornified envelope, a process that involves the cross-linking of keratin filaments to provide mechanical strength to the epidermal barrier. 2. **Cytoskeleton organization**: KRT34 interacts with other intermediate filaments, such as vimentin and lamin, to maintain the structural integrity of epithelial cells. 3. **Epithelial cell differentiation**: KRT34 is involved in the regulation of epithelial cell differentiation, particularly during the development of the epidermis and the intestine. 4. **Protein binding**: KRT34 interacts with various proteins, including keratins, lamin, and cytoskeletal proteins, to regulate cell signaling and cytoskeletal dynamics. **Clinical Significance:** Dysregulation of KRT34 has been implicated in various diseases, including: 1. **Epidermolysis bullosa simplex**: A genetic disorder characterized by blistering skin lesions, which is caused by mutations in the KRT5 gene, a closely related gene to KRT34. 2. **Keratinocyte proliferation disorders**: Abnormalities in KRT34 expression have been linked to keratinocyte proliferation disorders, such as epidermal hyperplasia and squamous cell carcinoma. 3. **Neurological disorders**: KRT34 has been implicated in the development of neurological disorders, including cerebral cortex GABAergic interneuron dysfunction, which is associated with autism spectrum disorder. In conclusion, KRT34 plays a critical role in epithelial cell biology, particularly in the context of keratinization and epidermal development. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease. Further research is needed to elucidate the mechanisms underlying KRT34's functions and to explore its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.