Details for: KRT81

Gene ID: 3887

Symbol: KRT81

Ensembl ID: ENSG00000205426

Description: keratin 81

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.38
    Marker Score: 2981
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.76
    Marker Score: 7615
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.65
    Marker Score: 941
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.35
    Marker Score: 2369
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1995
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.78
    Marker Score: 1974
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.34
    Marker Score: 302
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.3
    Marker Score: 542.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4817
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.8
    Marker Score: 5325
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 512
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.5
    Marker Score: 889
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.5
    Marker Score: 2462
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.4
    Marker Score: 87
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.35
    Marker Score: 5458
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.32
    Marker Score: 184
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.3
    Marker Score: 379
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.29
    Marker Score: 556
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.26
    Marker Score: 111
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.26
    Marker Score: 156
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.21
    Marker Score: 76
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.21
    Marker Score: 268
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.2
    Marker Score: 158
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.2
    Marker Score: 134
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 93
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.16
    Marker Score: 335
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.16
    Marker Score: 147
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.16
    Marker Score: 44
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.16
    Marker Score: 354
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.15
    Marker Score: 160
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.15
    Marker Score: 876
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.13
    Marker Score: 107
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.13
    Marker Score: 39
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.12
    Marker Score: 472
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.12
    Marker Score: 347
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.11
    Marker Score: 58
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.11
    Marker Score: 435
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 182
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.1
    Marker Score: 147
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.1
    Marker Score: 288
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.1
    Marker Score: 88.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.1
    Marker Score: 202
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.09
    Marker Score: 3210.5
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 102
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.09
    Marker Score: 1219
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 89.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.08
    Marker Score: 93
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.08
    Marker Score: 38
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.08
    Marker Score: 129
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.08
    Marker Score: 234
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.08
    Marker Score: 109
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 33

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** * KRT81 is a transmembrane protein that is expressed in the cytoplasm of cells. * It is a type II keratin, which is a family of keratin proteins that are involved in the formation of the cornified envelope. * KRT81 is a highly conserved protein, with a similar sequence in humans, mice, and rats. * It is expressed in a variety of cell types, including erythrocyte, decidual natural killer cell, human, mammary gland epithelial cell, blood vessel endothelial cell, enterocyte of epithelium of large intestine, intraepithelial lymphocyte, colon goblet cell, granulocyte monocyte progenitor cell, NKp44-positive group 3 innate lymphoid cell, human, and megakaryocyte-erythroid progenitor cell. **Pathways and functions** * KRT81 is involved in the formation of the cornified envelope. The cornified envelope is a protective barrier that surrounds cells in the skin and other tissues. It is composed of a network of type I and type II keratins, which are transmembrane proteins that are held together by disulfide bonds. * KRT81 is also involved in the organization of intermediate filaments. Intermediate filaments are protein structures that help to maintain the integrity of cell structures. They are composed of a family of keratin proteins, including KRT81. * KRT81 is a key regulator of the differentiation and survival of skin cells. It is expressed in skin cells that are committed to forming the cornified envelope, and it is downregulated in cells that are committed to forming the basal layer. **Clinical significance** Mutations in the KRT81 gene have been linked to a number of skin disorders, including psoriasis and acne. In psoriasis, the cornified envelope is damaged, leading to inflammation and pain. In acne, the formation of the cornified envelope is impaired, leading to the formation of pimples.

Genular Protein ID: 3691718819

Symbol: KRT81_HUMAN

Name: Keratin, type II cuticular Hb1

UniProtKB Accession Codes:

Q14533 Q14846 Q16274 Q17R48 Q8WU52 Q9BR74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9457912

Title: Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle.

PubMed ID: 9457912

DOI: 10.1046/j.1523-1747.1998.00097.x

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7556444

Title: Sequence data and chromosomal localization of human type I and type II hair keratin genes.

PubMed ID: 7556444

DOI: 10.1006/excr.1995.1326

PubMed ID: 7490069

Title: Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.

PubMed ID: 7490069

DOI: 10.1006/geno.1995.1163

PubMed ID: 7528047

Title: Sequence and expression of human hair keratin genes.

PubMed ID: 7528047

DOI: 10.1016/0923-1811(94)90046-9

PubMed ID: 9402962

Title: A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.

PubMed ID: 9402962

DOI: 10.1007/s004390050607

PubMed ID: 9665406

Title: A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.

PubMed ID: 9665406

DOI: 10.1046/j.1523-1747.1998.00234.x

PubMed ID: 25557232

Title: Novel KRT83 and KRT86 mutations associated with monilethrix.

PubMed ID: 25557232

DOI: 10.1111/exd.12624

Sequence Information:

  • Length: 505
  • Mass: 54928
  • Checksum: 6CD174038C3B6C27
  • Sequence:
    • MTCGSGFGGR AFSCISACGP RPGRCCITAA PYRGISCYRG LTGGFGSHSV CGGFRAGSCG 
RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KSLNSRFAAF 
IDKVRFLEQQ NKLLETKLQF YQNRECCQSN LEPLFEGYIE TLRREAECVE ADSGRLASEL 
NHVQEVLEGY KKKYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR 
RLYEEEILIL QSHISDTSVV VKLDNSRDLN MDCIIAEIKA QYDDIVTRSR AEAESWYRSK 
CEEMKATVIR HGETLRRTKE EINELNRMIQ RLTAEVENAK CQNSKLEAAV AQSEQQGEAA 
LSDARCKLAE LEGALQKAKQ DMACLIREYQ EVMNSKLGLD IEIATYRRLL EGEEQRLCEG 
IGAVNVCVSS SRGGVVCGDL CVSGSRPVTG SVCSAPCNGN VAVSTGLCAP CGQLNTTCGG 
GSCGVGSCGI SSLGVGSCGS SCRKC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.