Details for: KRT83

Gene ID: 3889

Symbol: KRT83

Ensembl ID: ENSG00000170523

Description: keratin 83

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.99
    Marker Score: 2765
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.37
    Marker Score: 2386.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1519
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2222
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.84
    Marker Score: 1043
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.81
    Marker Score: 2499
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.67
    Marker Score: 2172
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.52
    Marker Score: 801
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.24
    Marker Score: 1182
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.07
    Marker Score: 624
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.97
    Marker Score: 406
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.96
    Marker Score: 733
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 493
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1278
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1198
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11356
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 690
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 468.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.68
    Marker Score: 1288
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.68
    Marker Score: 406
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 527
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.57
    Marker Score: 348
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 481
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.47
    Marker Score: 3035
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 891
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 378
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 378
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 163
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.34
    Marker Score: 142.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.28
    Marker Score: 587.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.27
    Marker Score: 1648
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.27
    Marker Score: 282
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.25
    Marker Score: 439
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 108
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.19
    Marker Score: 72
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 130
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.11
    Marker Score: 190
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.09
    Marker Score: 251
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.09
    Marker Score: 223
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.09
    Marker Score: 139
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.09
    Marker Score: 158
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.07
    Marker Score: 92
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 122
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 21.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 136
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.05
    Marker Score: 19.5
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.05
    Marker Score: 23.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.05
    Marker Score: 124
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 66
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.05
    Marker Score: 444
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.05
    Marker Score: 39.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.05
    Marker Score: 130
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.04
    Marker Score: 19.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.03
    Marker Score: 296
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.03
    Marker Score: 104

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Other Information

**Key characteristics** * KRT83 is a transmembrane protein that is expressed in the skin and hair. * It is a type II keratin, which is the most common type of keratin in mammals. * KRT83 is a highly conserved protein, with a similar sequence found in humans, mice, and rats. * It is involved in the formation of the cornified envelope, which is a protective barrier that surrounds the skin and hair. * KRT83 is also involved in the intermediate filament organization, which is a complex network of protein filaments that helps to maintain the integrity of the skin and hair. * It is also involved in hair cycle regulation, as it is expressed in hair follicles and is important for the growth and development of hair. **Pathways and functions** * KRT83 is involved in the formation of the cornified envelope. * It is also involved in the intermediate filament organization, which is a complex network of protein filaments that helps to maintain the integrity of the skin and hair. * It is also involved in hair cycle regulation, as it is expressed in hair follicles and is important for the growth and development of hair. **Clinical significance** Mutations in the KRT83 gene have been linked to a number of skin conditions, including psoriasis, eczema, and keratosis Pilaris. These conditions are characterized by inflammation, redness, and scaling of the skin. KRT83 mutations can also lead to hair loss, dryness, and brittle hair.

Genular Protein ID: 4210837185

Symbol: KRT83_HUMAN

Name: Keratin, type II cuticular Hb3

UniProtKB Accession Codes:

P78385 A1A4S9 B2RC21 Q6NT21 Q9NSB3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9084137

Title: Sequences and differential expression of three novel human type-II hair keratins.

PubMed ID: 9084137

DOI: 10.1046/j.1432-0436.1997.6130187.x

PubMed ID: 10692104

Title: Characterization of a 300 kbp region of human DNA containing the type II hair keratin.

PubMed ID: 10692104

DOI: 10.1046/j.1523-1747.2000.00910.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27965375

Title: and is allelic with dominant monilethrix.

PubMed ID: 27965375

DOI: 10.1136/jmedgenet-2016-104107

PubMed ID: 15744029

Title: A missense mutation in the type II hair keratin hHb3 is associated with monilethrix.

PubMed ID: 15744029

DOI: 10.1136/jmg.2004.021030

PubMed ID: 25557232

Title: Novel KRT83 and KRT86 mutations associated with monilethrix.

PubMed ID: 25557232

DOI: 10.1111/exd.12624

Sequence Information:

  • Length: 493
  • Mass: 54195
  • Checksum: 73BE2DA2C93F3EB6
  • Sequence:
    • MTCGFNSIGC GFRPGNFSCV SACGPRPSRC CITAAPYRGI SCYRGLTGGF GSHSVCGGFR 
AGSCGRSFGY RSGGVCGPSP PCITTVSVNE SLLTPLNLEI DPNAQCVKQE EKEQIKSLNS 
RFAAFIDKVR FLEQQNKLLE TKLQFYQNRE CCQSNLEPLF AGYIETLRRE AECVEADSGR 
LASELNHVQE VLEGYKKKYE EEVALRATAE NEFVALKKDV DCAYLRKSDL EANVEALIQE 
IDFLRRLYEE EIRILQSHIS DTSVVVKLDN SRDLNMDCIV AEIKAQYDDI ATRSRAEAES 
WYRSKCEEMK ATVIRHGETL RRTKEEINEL NRMIQRLTAE VENAKCQNSK LEAAVAQSEQ 
QGEAALSDAR CKLAELEGAL QKAKQDMACL IREYQEVMNS KLGLDIEIAT YRRLLEGEEQ 
RLCEGVEAVN VCVSSSRGGV VCGDLCVSGS RPVTGSVCSA PCNGNLVVST GLCKPCGQLN 
TTCGGGSCGQ GRH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.