Details for: KRT83

Gene ID: 3889

Symbol: KRT83

Ensembl ID: ENSG00000170523

Description: keratin 83

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 4.1696
    Cell Significance Index: 4.8000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.6460
    Cell Significance Index: 67.4200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.4474
    Cell Significance Index: 41.8400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9541
    Cell Significance Index: 23.1100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.3525
    Cell Significance Index: 3.7900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3301
    Cell Significance Index: 3.0400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.2735
    Cell Significance Index: 1.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2037
    Cell Significance Index: 10.5800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1804
    Cell Significance Index: 2.2800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1790
    Cell Significance Index: 2.0000
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.1083
    Cell Significance Index: 1.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1077
    Cell Significance Index: 1.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0798
    Cell Significance Index: 35.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0758
    Cell Significance Index: 1.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0579
    Cell Significance Index: 0.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0329
    Cell Significance Index: 5.9300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0273
    Cell Significance Index: 0.2900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0240
    Cell Significance Index: 0.3100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0152
    Cell Significance Index: 0.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0078
    Cell Significance Index: 1.0100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0048
    Cell Significance Index: 0.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0038
    Cell Significance Index: 0.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0019
    Cell Significance Index: 0.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0005
    Cell Significance Index: -0.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0010
    Cell Significance Index: -0.0700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0015
    Cell Significance Index: -0.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0017
    Cell Significance Index: -0.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0021
    Cell Significance Index: -0.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0024
    Cell Significance Index: -0.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0029
    Cell Significance Index: -1.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0031
    Cell Significance Index: -0.6300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0036
    Cell Significance Index: -0.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0038
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0042
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0062
    Cell Significance Index: -1.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0066
    Cell Significance Index: -0.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0075
    Cell Significance Index: -1.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0083
    Cell Significance Index: -0.3400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0086
    Cell Significance Index: -0.1400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0099
    Cell Significance Index: -0.1300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0099
    Cell Significance Index: -0.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0106
    Cell Significance Index: -0.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0122
    Cell Significance Index: -0.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0130
    Cell Significance Index: -0.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0154
    Cell Significance Index: -0.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0157
    Cell Significance Index: -0.7100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0158
    Cell Significance Index: -0.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0160
    Cell Significance Index: -0.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0180
    Cell Significance Index: -0.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0185
    Cell Significance Index: -1.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0196
    Cell Significance Index: -1.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0212
    Cell Significance Index: -0.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0213
    Cell Significance Index: -0.6800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0224
    Cell Significance Index: -0.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0226
    Cell Significance Index: -0.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0226
    Cell Significance Index: -1.0000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0226
    Cell Significance Index: -0.2400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0237
    Cell Significance Index: -0.2800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0241
    Cell Significance Index: -0.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0250
    Cell Significance Index: -0.6200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0252
    Cell Significance Index: -0.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0258
    Cell Significance Index: -0.5400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0259
    Cell Significance Index: -0.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0276
    Cell Significance Index: -0.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0277
    Cell Significance Index: -1.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0279
    Cell Significance Index: -0.4800
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0280
    Cell Significance Index: -0.2900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0287
    Cell Significance Index: -0.4300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0293
    Cell Significance Index: -0.3900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0303
    Cell Significance Index: -0.3200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0314
    Cell Significance Index: -0.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0316
    Cell Significance Index: -0.7900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0317
    Cell Significance Index: -0.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0321
    Cell Significance Index: -0.9200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0324
    Cell Significance Index: -0.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0329
    Cell Significance Index: -0.8800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0338
    Cell Significance Index: -0.4800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0340
    Cell Significance Index: -0.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0350
    Cell Significance Index: -0.5900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0357
    Cell Significance Index: -0.8700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0362
    Cell Significance Index: -0.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0371
    Cell Significance Index: -0.7700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0373
    Cell Significance Index: -0.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0377
    Cell Significance Index: -0.8700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0384
    Cell Significance Index: -0.7600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0386
    Cell Significance Index: -0.5700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0404
    Cell Significance Index: -0.5300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0418
    Cell Significance Index: -0.5300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0432
    Cell Significance Index: -0.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0433
    Cell Significance Index: -0.9200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0433
    Cell Significance Index: -0.8700
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: -0.0452
    Cell Significance Index: -0.3700
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0452
    Cell Significance Index: -0.4000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0455
    Cell Significance Index: -0.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0463
    Cell Significance Index: -1.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT83 belongs to the type II keratin family, which is primarily expressed in the epidermis and is involved in the formation of the cornified envelope, a critical component of the skin's barrier function. This protein is characterized by its ability to interact with other keratin proteins, forming a network of filaments that provide structural support to cells. KRT83 is also involved in the regulation of cell differentiation, migration, and death, highlighting its importance in the development and maintenance of the epidermis. **Pathways and Functions:** The pathways and functions of KRT83 are multifaceted and interconnected. The protein is involved in: 1. **Epidermal development:** KRT83 plays a crucial role in the development of the epidermis, particularly during embryogenesis and the formation of the cornified envelope. 2. **Keratinization:** KRT83 is essential for the process of keratinization, which involves the transformation of skin cells into a more mature, keratinized state. 3. **Intermediate filament organization:** KRT83 interacts with other keratin proteins to form a network of filaments that provide structural support to cells. 4. **Protein binding:** KRT83 binds to various proteins, including other keratins, cytokines, and growth factors, regulating cell signaling and interactions. **Clinical Significance:** Dysregulation of KRT83 has been implicated in various skin disorders, including: 1. **Eczema:** Mutations in the KRT83 gene have been associated with atopic dermatitis, a chronic skin condition characterized by inflammation and skin barrier dysfunction. 2. **Psoriasis:** Abnormal expression of KRT83 has been linked to psoriasis, a chronic autoimmune skin condition characterized by skin cell proliferation and inflammation. 3. **Cancer:** Altered expression of KRT83 has been observed in various types of skin cancer, including squamous cell carcinoma and basal cell carcinoma. 4. **Wound healing:** KRT83 plays a critical role in the wound healing process, particularly in the formation of the epidermal barrier. In conclusion, KRT83 is a vital component of the epidermis, playing a crucial role in its development, maintenance, and function. Understanding the pathways and functions of KRT83 is essential for the diagnosis and treatment of various skin disorders, highlighting the importance of this protein in the field of immunology and dermatology.

Genular Protein ID: 4210837185

Symbol: KRT83_HUMAN

Name: Keratin, type II cuticular Hb3

UniProtKB Accession Codes:

P78385 A1A4S9 B2RC21 Q6NT21 Q9NSB3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9084137

Title: Sequences and differential expression of three novel human type-II hair keratins.

PubMed ID: 9084137

DOI: 10.1046/j.1432-0436.1997.6130187.x

PubMed ID: 10692104

Title: Characterization of a 300 kbp region of human DNA containing the type II hair keratin.

PubMed ID: 10692104

DOI: 10.1046/j.1523-1747.2000.00910.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27965375

Title: and is allelic with dominant monilethrix.

PubMed ID: 27965375

DOI: 10.1136/jmedgenet-2016-104107

PubMed ID: 15744029

Title: A missense mutation in the type II hair keratin hHb3 is associated with monilethrix.

PubMed ID: 15744029

DOI: 10.1136/jmg.2004.021030

PubMed ID: 25557232

Title: Novel KRT83 and KRT86 mutations associated with monilethrix.

PubMed ID: 25557232

DOI: 10.1111/exd.12624

Sequence Information:

  • Length: 493
  • Mass: 54195
  • Checksum: 73BE2DA2C93F3EB6
  • Sequence:
    • MTCGFNSIGC GFRPGNFSCV SACGPRPSRC CITAAPYRGI SCYRGLTGGF GSHSVCGGFR 
AGSCGRSFGY RSGGVCGPSP PCITTVSVNE SLLTPLNLEI DPNAQCVKQE EKEQIKSLNS 
RFAAFIDKVR FLEQQNKLLE TKLQFYQNRE CCQSNLEPLF AGYIETLRRE AECVEADSGR 
LASELNHVQE VLEGYKKKYE EEVALRATAE NEFVALKKDV DCAYLRKSDL EANVEALIQE 
IDFLRRLYEE EIRILQSHIS DTSVVVKLDN SRDLNMDCIV AEIKAQYDDI ATRSRAEAES 
WYRSKCEEMK ATVIRHGETL RRTKEEINEL NRMIQRLTAE VENAKCQNSK LEAAVAQSEQ 
QGEAALSDAR CKLAELEGAL QKAKQDMACL IREYQEVMNS KLGLDIEIAT YRRLLEGEEQ 
RLCEGVEAVN VCVSSSRGGV VCGDLCVSGS RPVTGSVCSA PCNGNLVVST GLCKPCGQLN 
TTCGGGSCGQ GRH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.