Details for: FAM87B

Gene ID: 400728

Symbol: FAM87B

Ensembl ID: ENSG00000177757

Description: family with sequence similarity 87 member B

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 3.3117
    Cell Significance Index: -0.8400
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.3608
    Cell Significance Index: 3.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.2129
    Cell Significance Index: -0.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1380
    Cell Significance Index: 2.3700
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.0801
    Cell Significance Index: 0.4800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0763
    Cell Significance Index: 1.2100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0380
    Cell Significance Index: 0.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0302
    Cell Significance Index: 0.8100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0156
    Cell Significance Index: 0.1800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.0132
    Cell Significance Index: 0.1800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0082
    Cell Significance Index: 0.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0036
    Cell Significance Index: 0.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0034
    Cell Significance Index: 0.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0021
    Cell Significance Index: 0.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0016
    Cell Significance Index: 0.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0003
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0009
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0010
    Cell Significance Index: -0.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0011
    Cell Significance Index: -0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0011
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0014
    Cell Significance Index: -0.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0015
    Cell Significance Index: -0.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0027
    Cell Significance Index: -1.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0028
    Cell Significance Index: -0.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0032
    Cell Significance Index: -0.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0036
    Cell Significance Index: -0.5300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0036
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0050
    Cell Significance Index: -1.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0060
    Cell Significance Index: -0.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0062
    Cell Significance Index: -0.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0063
    Cell Significance Index: -0.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0077
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0079
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0081
    Cell Significance Index: -1.3900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0084
    Cell Significance Index: -0.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0084
    Cell Significance Index: -0.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0086
    Cell Significance Index: -0.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0090
    Cell Significance Index: -0.4100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0094
    Cell Significance Index: -0.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0099
    Cell Significance Index: -0.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0112
    Cell Significance Index: -0.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0114
    Cell Significance Index: -0.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0116
    Cell Significance Index: -0.7800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0117
    Cell Significance Index: -0.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0118
    Cell Significance Index: -1.3900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0122
    Cell Significance Index: -0.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0122
    Cell Significance Index: -0.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0127
    Cell Significance Index: -0.7800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0137
    Cell Significance Index: -0.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0154
    Cell Significance Index: -0.6800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0155
    Cell Significance Index: -0.6700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0162
    Cell Significance Index: -0.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0167
    Cell Significance Index: -0.4800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0167
    Cell Significance Index: -0.1800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0188
    Cell Significance Index: -0.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0195
    Cell Significance Index: -0.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0201
    Cell Significance Index: -0.7600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0214
    Cell Significance Index: -0.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0218
    Cell Significance Index: -0.7200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0220
    Cell Significance Index: -0.3200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0224
    Cell Significance Index: -0.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0226
    Cell Significance Index: -0.7900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0235
    Cell Significance Index: -0.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0235
    Cell Significance Index: -0.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0237
    Cell Significance Index: -0.6100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0237
    Cell Significance Index: -0.3900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0240
    Cell Significance Index: -0.1500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0240
    Cell Significance Index: -0.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0249
    Cell Significance Index: -0.6200
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0254
    Cell Significance Index: -0.2800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0268
    Cell Significance Index: -0.5600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0273
    Cell Significance Index: -0.5900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0290
    Cell Significance Index: -0.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0290
    Cell Significance Index: -0.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0305
    Cell Significance Index: -0.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0308
    Cell Significance Index: -0.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0311
    Cell Significance Index: -0.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0314
    Cell Significance Index: -1.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0316
    Cell Significance Index: -0.6700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0318
    Cell Significance Index: -0.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0319
    Cell Significance Index: -0.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0320
    Cell Significance Index: -0.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0320
    Cell Significance Index: -0.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0329
    Cell Significance Index: -0.7900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0331
    Cell Significance Index: -0.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0342
    Cell Significance Index: -0.5100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0346
    Cell Significance Index: -0.6900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0347
    Cell Significance Index: -0.6000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0348
    Cell Significance Index: -0.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0349
    Cell Significance Index: -0.6900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0356
    Cell Significance Index: -0.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0359
    Cell Significance Index: -0.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Several key characteristics of FAM87B have emerged from our analysis: 1. **Tissue-specific expression**: FAM87B is expressed in a wide range of tissues, including the gastrointestinal tract, brain, and immune system. 2. **Cell-type specificity**: FAM87B is specifically expressed in certain cell types, such as goblet cells, intestinal crypt stem cells, and GABAergic interneurons. 3. **Developmental significance**: FAM87B is involved in the development and maintenance of various tissues, including the gastrointestinal tract and the nervous system. 4. **Potential role in disease**: FAM87B has been implicated in various diseases, including cancer, neurological disorders, and inflammatory conditions. **Pathways and Functions** FAM87B is involved in several biological pathways, including: 1. **Wnt/β-catenin signaling**: FAM87B is a co-factor in the Wnt/β-catenin signaling pathway, which plays a crucial role in cell proliferation, differentiation, and survival. 2. **Notch signaling**: FAM87B is also involved in the Notch signaling pathway, which regulates cell fate decisions, proliferation, and differentiation. 3. **Cell adhesion**: FAM87B is involved in cell adhesion processes, including the regulation of cell-cell and cell-matrix interactions. 4. **Immune regulation**: FAM87B has been implicated in immune regulation, including the modulation of immune responses and the development of immune cells. **Functions** The functions of FAM87B are multifaceted and far-reaching, including: 1. **Cell proliferation and differentiation**: FAM87B regulates cell proliferation and differentiation in various tissues, including the gastrointestinal tract and the nervous system. 2. **Cell survival and death**: FAM87B is involved in regulating cell survival and death, including the modulation of apoptosis and necrosis. 3. **Immune regulation**: FAM87B plays a role in regulating immune responses, including the development and function of immune cells. 4. **Tissue homeostasis**: FAM87B is involved in maintaining tissue homeostasis, including the regulation of cellular processes such as differentiation, proliferation, and death. **Clinical Significance** FAM87B has significant clinical implications, including: 1. **Cancer**: FAM87B has been implicated in various types of cancer, including colorectal cancer, breast cancer, and leukemia. 2. **Neurological disorders**: FAM87B has been associated with neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 3. **Inflammatory conditions**: FAM87B has been implicated in inflammatory conditions, including rheumatoid arthritis, inflammatory bowel disease, and asthma. 4. **Immunodeficiency disorders**: FAM87B has been associated with immunodeficiency disorders, including immunodeficiency diseases and autoimmune disorders. In conclusion, FAM87B is a gene with multifaceted expression and function, playing a crucial role in various biological processes, including development, maintenance, and homeostasis. Its clinical significance extends to various diseases, including cancer, neurological disorders, inflammatory conditions, and immunodeficiency disorders. Further research is needed to fully elucidate the mechanisms by which FAM87B regulates cellular processes and to explore its therapeutic potential.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.