Details for: TBC1D3B

Gene ID: 414059

Symbol: TBC1D3B

Ensembl ID: ENSG00000274808

Description: TBC1 domain family member 3B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6523
    Cell Significance Index: 15.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0963
    Cell Significance Index: 2.4800
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.0733
    Cell Significance Index: 0.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0722
    Cell Significance Index: 1.8000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0663
    Cell Significance Index: 0.8200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0520
    Cell Significance Index: 0.6800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0485
    Cell Significance Index: 0.1300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0464
    Cell Significance Index: 0.4800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0457
    Cell Significance Index: 0.6500
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.0441
    Cell Significance Index: 0.4200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0316
    Cell Significance Index: 0.2100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: 0.0276
    Cell Significance Index: 0.3400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0096
    Cell Significance Index: 0.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0076
    Cell Significance Index: 0.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0061
    Cell Significance Index: 0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0033
    Cell Significance Index: 0.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0029
    Cell Significance Index: 1.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0027
    Cell Significance Index: 0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0007
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0011
    Cell Significance Index: -0.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0021
    Cell Significance Index: -0.1100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0032
    Cell Significance Index: -0.4600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0036
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0037
    Cell Significance Index: -0.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0039
    Cell Significance Index: -0.2000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0041
    Cell Significance Index: -0.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0041
    Cell Significance Index: -0.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0045
    Cell Significance Index: -0.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0048
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0055
    Cell Significance Index: -0.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0061
    Cell Significance Index: -0.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0065
    Cell Significance Index: -0.1100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0090
    Cell Significance Index: -0.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0091
    Cell Significance Index: -0.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0092
    Cell Significance Index: -0.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0103
    Cell Significance Index: -0.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0120
    Cell Significance Index: -0.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0120
    Cell Significance Index: -0.3200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0125
    Cell Significance Index: -0.1600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0141
    Cell Significance Index: -0.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0147
    Cell Significance Index: -0.6900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0151
    Cell Significance Index: -0.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0153
    Cell Significance Index: -0.3300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0155
    Cell Significance Index: -0.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0165
    Cell Significance Index: -0.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0169
    Cell Significance Index: -0.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0171
    Cell Significance Index: -0.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0174
    Cell Significance Index: -0.5000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0182
    Cell Significance Index: -0.3600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0187
    Cell Significance Index: -0.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0190
    Cell Significance Index: -0.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0194
    Cell Significance Index: -0.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0195
    Cell Significance Index: -0.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0199
    Cell Significance Index: -0.7300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0206
    Cell Significance Index: -0.4300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0206
    Cell Significance Index: -0.2600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0208
    Cell Significance Index: -0.4100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0209
    Cell Significance Index: -0.5100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0211
    Cell Significance Index: -0.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0217
    Cell Significance Index: -0.3200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0221
    Cell Significance Index: -0.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0227
    Cell Significance Index: -0.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0227
    Cell Significance Index: -0.4700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0228
    Cell Significance Index: -0.3700
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0230
    Cell Significance Index: -0.1900
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.0231
    Cell Significance Index: -0.2500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0231
    Cell Significance Index: -0.4000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0232
    Cell Significance Index: -0.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0241
    Cell Significance Index: -0.4700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0243
    Cell Significance Index: -0.2200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0248
    Cell Significance Index: -0.2200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0252
    Cell Significance Index: -0.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0262
    Cell Significance Index: -0.7500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0274
    Cell Significance Index: -0.3600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0277
    Cell Significance Index: -0.4200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0280
    Cell Significance Index: -0.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0282
    Cell Significance Index: -0.5900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0285
    Cell Significance Index: -0.3800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0289
    Cell Significance Index: -0.3600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0291
    Cell Significance Index: -0.5800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0304
    Cell Significance Index: -0.3900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0305
    Cell Significance Index: -0.4000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0312
    Cell Significance Index: -0.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0313
    Cell Significance Index: -0.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0319
    Cell Significance Index: -0.5900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0319
    Cell Significance Index: -0.4300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0321
    Cell Significance Index: -0.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TBC1D3B is a member of the TBC1 domain family, which is characterized by the presence of a TBC1 domain, a GTPase-activating protein (GAP) domain, and a pleckstrin homology (PH) domain. The protein encoded by TBC1D3B is a GTPase activator, which means it regulates the activity of GTPases, a family of proteins involved in various cellular processes, including signal transduction and membrane trafficking. The protein's expression is widespread, with significant levels detected in goblet cells, intestinal crypt stem cells, absorptive cells, and other cell types in the intestinal epithelium. **Pathways and Functions:** TBC1D3B is involved in several key pathways, including: 1. **Activation of GTPase activity**: TBC1D3B regulates the activity of GTPases, which are essential for various cellular processes, including signal transduction, membrane trafficking, and cytoskeletal dynamics. 2. **GTPase activator activity**: The protein encoded by TBC1D3B acts as a GTPase activator, which means it enhances the activity of GTPases, leading to the regulation of downstream signaling pathways. 3. **Plasma membrane dynamics**: TBC1D3B is involved in regulating plasma membrane dynamics, including endocytosis, exocytosis, and cell migration. **Clinical Significance:** Recent studies have highlighted the clinical significance of TBC1D3B in various diseases, including: 1. **Cancer**: TBC1D3B is overexpressed in several types of cancer, including colorectal cancer, breast cancer, and lung cancer. The protein's expression is associated with poor prognosis and tumor progression. 2. **Inflammatory disorders**: TBC1D3B is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in various inflammatory disorders, including Crohn's disease and ulcerative colitis. 3. **Neurological disorders**: TBC1D3B is also involved in the regulation of neuronal function and synaptic plasticity, and its dysregulation has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, TBC1D3B is a critical gene involved in various cellular processes, including the regulation of GTPase activity and plasma membrane dynamics. Its dysregulation has been implicated in various diseases, including cancer, inflammatory disorders, and neurological disorders. Further studies are needed to fully understand the role of TBC1D3B in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3719974045

Symbol: TBC3B_HUMAN

Name: TBC1 domain family member 3B

UniProtKB Accession Codes:

A6NDS4 A8K892

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 2 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21030649

Title: Diversity of human copy number variation and multicopy genes.

PubMed ID: 21030649

DOI: 10.1126/science.1197005

Sequence Information:

  • Length: 549
  • Mass: 62320
  • Checksum: 6AA476A73DAE152B
  • Sequence:
    • MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG IVHETELPPL 
TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDRAYK GMPMNIRGPM WSVLLNIEEM 
KLKNPGRYQI MKEKGKRSSE HIQRIDRDIS GTLRKHMFFR DRYGTKQREL LHILLAYEEY 
NPEVGYCRDL SHIAALFLLY LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE 
HVVATSQSKT MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI 
TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL TRKQGDLPPP 
AKPEQGSSAS RPVPASRGRK TLCKGDRQAP PGPPARFPRP IWSASPPRAP RSSTPCPGGA 
VREDTYPVGT QGVPSPALAQ GGPQGSWRFL QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV 
RAISQEDQLA PCWQAEHPAE RVRSAFAAPS TDSDQGTPFR ARDEQQCAPT SGPCLCGLHL 
ESSQFPPGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.